• Proceedings of the Korea Contents Association Conference
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• 2019.05a
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• pp.71-72
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• 2019

의학 기술의 발달로 인해 현 사회의 노령 인구가 급증하는 가운데 노화로 인한 노인들의 신체능력 및 인지능력의 저하가 전 세계의 사회적 문제로 자리 잡았다. 인지능력의 저하는 치매로까지 연결될 수 있어 초기에 관리를 하는 것이 매우 중요하며, 인지능력 향상을 목적으로 다양한 콘텐츠가 제작되고 있다. 최근 다양한 분야에서 콘텐츠들이 디지털화를 통해 효용을 높이고 있으나 노인을 위한 콘텐츠는 사용자의 특성상 디지털 콘텐츠로의 전환 및 활성화가 쉽지 않아 아날로그 콘텐츠가 현재까지도 일상 및 병원 치료활동에 주로 활용되고 있는 실정이다. 이에 현재 사용 중인 아날로그 콘텐츠의 사례분석을 통해 노인 콘텐츠의 특성을 파악하고 한계점을 도출해 노인 인지능력 향상을 위한 콘텐츠가 제공해야 하는 특성과 발전해나가야 할 방향성을 제시하고자 하였다. 본 연구는 노인 경도인지장애 개선을 위한 서비스디자인 가이드라인 개발을 위한 선행연구로 수행되었다.

• Knowledge Management Research
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• v.23 no.4
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• pp.69-89
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• 2022

As we enter a super-aged society, senior citizens' health issues are affecting a variety of fields, including medicine, economics, society, and culture. In this study, we intend to draw implications from unstructured data analysis such as text mining and social network analysis in order to apply digital health care service design for improving the cognitive ability of senior citizens. The research procedure of this study improved the service design methodology into a process suited to the analysis of unstructured data, and six steps were applied. Related keywords that exist on social media, focusing on cognitive improvement and healthcare for senior citizens, were collected and analyzed, and based on these results, the direction of healthcare service design for improving on the cognitive abilities of senior citizens was derived. The results of this study are expected to have academic and practical implications for expanding the scope of the use of big data analysis methods and improving existing healthcare service development methodologies.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.5
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• pp.241-251
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• 2019

In the present study, we investigated the effect of microcurrent against cognitive impairment in Alzheimer's disease (AD) mice model. The cognitive impairment was induced by intracerebroventricularly injection of amyloid beta ($A{\beta}$) to ICR mouse brain, and four kinds of micorocurrent wave were applied to AD mice. We observed the improved cognitive ability in microcurrent-applied AD mice through novel object recognition test and Morris water maze test, compared to $A{\beta}$-injected control group. The contents of malondialdehyde generated by $A{\beta}$ in the brain were also reduced by microcurrent application. These effects of microcurrent were related to the modulation of $A{\beta}$ producing and brain-derived neurotrophic factor (BDNF). Microcurrent down-regulated ${\beta}$-secretase, presenilin 1, and presenilin 2 which were related amyloidogenic pathway, and up-regulated human brain-derived neurotrophic factor in the mice brain, especially Wave4 group [STEP FORM wave form (0, 1.5, 3, 5V), wave superposition]. These results suggest that microcurrent application could provide help for improvement learning and memory ability, at least partly.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.6
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• pp.799-806
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• 2014

The present study was conducted to evaluate the effects of extract from Eriobotrya japonica leaves (EJE) on cognitive impairment induced by scopolamine, a muscarinic antagonist, in rats. Scopolamine injection (1 mg/kg, i.p.) impaired performance in rats in the passive avoidance test as well as in water maze test and severely reduced cholinergic system reactivity, as indicated by reduced acetylcholine levels and increased acetylcholinesterase activity. Daily administration of EJE significantly increased step-through latency in the passive avoidance test, reduced escape latency, and increased time spent in the platform quadrant in the Morris water maze test. EJE protected against scopolamine-induced cholinergic system deficit, including reduced acetylcholine levels and increased acetylcholinesterase activity in whole brain homogenates. These results suggest that EJE provides a significant anti-amnesic effect against scopolamine-induced cholinergic system deficits and cognitive impairment.

• Journal of the Korean Applied Science and Technology
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• v.38 no.3
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• pp.727-734
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• 2021

The purpose of this study was to analyze correlation between kinematic variables and ground slope perception ability during golf putting. 16 collegiate golfers were participated. To collect and analyze the kinematic data of putter head, SAMPutt lab was used(70 Hz). It was performed Pearson's correlation analysis using SPSS. The level of significance was at .05. As a results, right was correlated with backswing in flat. Toe-up was correlated with follow-through and left was correlated with aim, backswing, impact, follow-through, and loft in slice 1°. Toe-down was correlated with aim, backswing, impact in slice 2°. Toe-up was correlated with follow-through in hook 2°. In conclusion, it is important to improve the putting stroke through repetitive ground slope perception training.

• The Journal of the Korea institute of electronic communication sciences
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• v.10 no.1
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• pp.125-132
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• 2015

This paper was performed for the older people with cognitive abilities deteriorated, and its effectiveness is analyzed through measurement value of HRV. This paper was investigated the major acupressure that has been used frequently to people who has to decrease cognitive ability in the old documents. We measure the several variation by using a measuring instrument of HRV after performing an operation of acupuncture and moxibustion for elderly degraded cognitive ability. As compared with the measured values, the moxibustion and acupuncture to changes in the autonomic nervous system, heart rate and how it affects the efficacy was measured. As a result of research, acupuncture and moxibustion could be confirmed through the HRV analysis that there is a positive effect on the improvement of cognitive skills.

• Journal of the Korean Applied Science and Technology
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• v.36 no.2
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• pp.468-478
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• 2019

The aim of this study is to evaluate the efficacy of cordyceps militaris extracts for the improvement of cognitive dysfunction in PC12 and BV2 cells. Cordyceps militaris extracts was prepared by extracting with distilled water. Cell viability was assessed by MTT assay using PC12 cells and BV2 cells. Confirmed effects of L-glutamate induced cytotoxicity test, Acetylcoline (ACh) concentration, and Acetylcolinestase (AChE) activity in PC12 cells. Anti-inflammatory activities of cordyceps militaris extracts was measured through changes in the levels of nitric oxide (NO), and prostaglandin E2 ($PGE_2$) on lipopolysaccharide(LPS)-induced BV2 cell. In addition, we measured the expression of $NF-{\kappa}B$, p38, JNK, and caspase-3 in western blot analysis. Cordyceps militaris extracts showed no cytotoxicity at the concentrations of 1, 10, and $100{\mu}g/m{\ell}$ except for the concentration of $200{\mu}g/m{\ell}$. Cordyceps militaris extracts protected the cell and exhibited significant increases in the ACh concentration and a significant decrease in the AChE activity in L-glutamate induced PC12 cells. Moreover, cordyceps militaris extracts inhibited the productions NO, and PGE2 level and the protein expression of $NF-{\kappa}B$, p38, JNK, caspase-3 in LPS-induced BV2 cells. These results indicate that cordyceps militaris extracts possible prevented and improved cognitive dysfuction symptoms. Thus, cordyceps militaris extracts may be a novel natural material option for the improvement of cognitive dysfunction.

• Journal of Nutrition and Health
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• v.40 no.sup
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• pp.50-65
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• 2007

감미료는 감각을 만족시키는 기능을 가지며, 에너지를 공급하는 영양적 감미료와 에너지를 공급하지 않는 비 영양적 감미료로 분류 될 수 있다. 영양적 감미료들은(설탕, 과당 등) 미국 식약청에서는 일반적으로 안전하다고 인식(generally recognized as safe, GRAS) 되고 있다. 그러나 감미료 섭취는 적절한 영양섭취와 건강과 관련하여 아직 많은 우려를 가지고 있다. 첨가당으로부터의 에너지 섭취가 총 에너지 섭취의 25% 이상이면 식사의 질(quality)이 낮아진다. 지난 수 십 년 간, 당 섭취가 행동적인 면에 부정적으로 작용한다는 많은 이론들이 대두되었다. 그러나 포도당은 뇌의 주요 에너지원이다. 포도당의 기억력 향상기능은 모든 연령에서 보고되었으며, 특히 젊은 층보다는 노인에서 더 효과적이었다. 특히 적당량으로 섭취하였을 때 포도당의 섭취는 단어기억, 이야기 기억, 24시간 전에 학습한 정보에 대한 기억, 경계(vigilance)의 향상, 반응시간의 단축, 정신적 계산 능력의 향상, 시뮬레이터 조절에서의 실수감소, 스투르프효과(Stroop effect)의 감소, 지능검사의 향상, 실제사건에 대한 기억력 검사와 웩슬러 척도(Wechsler Scale)에서의 향상과 같은 여러 인지능력 검사에서 좋은 영향을 미친다고 한다. 포도당 용액과 간식의 섭취는 기억력을 개선한다. 아침식사를 거르는 것은 아동들에서 낮은 학습능력을 보인다. 인지능력 변화와 관련 있는 식이는 뇌에 포도당을 공급하는 것과 관련 있다. 과당도 동물실험에서 기억력을 향상시키는 기능이 있다는 것을 보여주고 있다. 본 논문은 당 섭취가 인지능력에 미치는 영향에 대한 과학적인 연구들을 종합하여 정리한 것이다.

• The Journal of the Korea Contents Association
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• v.20 no.3
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• pp.298-308
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• 2020

This study was designed to verify reliability and feasibility by analyzing elderly drivers' ability test tools for older drivers aged 65 or older, which were improved in 2018 and are currently being conducted by the Korea Highway Traffic Authority. Only those aged 65 or older who voluntarily applied to the elderly driving ability evaluation system implemented by the Seoul branch of the Korea Highway Traffic Authority. The research was conducted for about 50 days until Aug. 31, 2018, starting with the registration and inspection of the first study subjects. The analysis performed a correlation analysis with existing tools and cognitive testing tools (MMSE_K) to determine their feasibility and reliability as an improved tool in 2018. As a result, the first, the speed distance, time-space memory, and dispersionism of each sub-component of the old version showed statistically significant static correlation with the sub-factor of the current version. Persistence, on the other hand, was not statistically significant to the current version. The limitations of this study were as follows. Most of the people in the study were highly educated and residents in the metropolitan area. Therefore, it is likely that the results of MSE_K, which checks cognitive and judgment skills, have been upgraded. Also, cognitive tools that are measured by computers are likely to have real measurement errors for generations who are not familiar with computers. Therefore, it is expected that improvement and development of tools for improving the limit points at the site and assessing actual operation capability will be required.

• Journal of Applied Biological Chemistry
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• v.64 no.3
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• pp.299-307
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• 2021

Accumulation of amyloid beta (Aβ) and oxidative stress are the most common reason of Alzheimer's disease (AD). In the present study, we investigated the cognitive improvement effects of butanol (BuOH) fraction from Momordica charantia in Aβ_25-35-induced AD mouse model. To develop an AD mouse model, mice were received injection of Aβ_25-35, and then orally administered BuOH fraction from M. charantia at doses of 100 and 200 mg/kg/day during 14 days. In the T-maze and novel object recognition test, administration of BuOH fraction from M. charantia L. at doses of 100 and 200 mg/kg/day improved spatial ability and novel object recognition by increased explorations of novel route and new object. In addition, BuOH fraction of M. charantia-administered groups improved learning and memory abilities by decreased time to reach hidden platform in Morris water maze test. Oral administration of BuOH fraction from M. charantia significantly inhibited lipid peroxidation and nitric oxide levels in the brain, liver, and kidney compared with Aβ_25-35-induced control group. These results indicated that BuOH fraction of M. charantia improved Aβ_25-35-induced cognitive impairment by attenuating oxidative stress. Therefore, M. charantia could be useful for protection from Aβ_25-35-induced cognitive impairment.