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http://dx.doi.org/10.5762/KAIS.2019.20.5.241

Effect of Microcurrent Wave Superposition on Cognitive Improvement in Alzheimer's Disease Mice Model  

Kim, Min Jeong (Department of Food Science and Nutrition, Pusan National University)
Lee, Ah Young (Department of Food Science, Gyeongnam National University of Science and Technology)
Cho, Dong Shik (Natural Well Tech. Co. Ltd)
Cho, Eun Ju (Department of Food Science and Nutrition, Pusan National University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.20, no.5, 2019 , pp. 241-251 More about this Journal
Abstract
In the present study, we investigated the effect of microcurrent against cognitive impairment in Alzheimer's disease (AD) mice model. The cognitive impairment was induced by intracerebroventricularly injection of amyloid beta ($A{\beta}$) to ICR mouse brain, and four kinds of micorocurrent wave were applied to AD mice. We observed the improved cognitive ability in microcurrent-applied AD mice through novel object recognition test and Morris water maze test, compared to $A{\beta}$-injected control group. The contents of malondialdehyde generated by $A{\beta}$ in the brain were also reduced by microcurrent application. These effects of microcurrent were related to the modulation of $A{\beta}$ producing and brain-derived neurotrophic factor (BDNF). Microcurrent down-regulated ${\beta}$-secretase, presenilin 1, and presenilin 2 which were related amyloidogenic pathway, and up-regulated human brain-derived neurotrophic factor in the mice brain, especially Wave4 group [STEP FORM wave form (0, 1.5, 3, 5V), wave superposition]. These results suggest that microcurrent application could provide help for improvement learning and memory ability, at least partly.
Keywords
Microcurrent; Alzheimer's Disease; Cognitive Ability; Amyloid Beta; Mouse;
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