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http://dx.doi.org/10.3746/jkfn.2014.43.6.799

Anti-amnesic Effect of Eriobotrya japonica Leaf Extract on Scopolamine-induced Memory Impairment in Rats  

Bae, Donghyuck (Jeollanamdo Institute of Natural Resources Research)
Kim, Jihye (Jeollanamdo Institute of Natural Resources Research)
Na, Ju-Ryun (Jeollanamdo Institute of Natural Resources Research)
Kim, Yujin (Jeollanamdo Institute of Natural Resources Research)
Lee, Joon-Yeol (Korea INS Pharm Research Institute)
Kim, Sunoh (Jeollanamdo Institute of Natural Resources Research)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.43, no.6, 2014 , pp. 799-806 More about this Journal
Abstract
The present study was conducted to evaluate the effects of extract from Eriobotrya japonica leaves (EJE) on cognitive impairment induced by scopolamine, a muscarinic antagonist, in rats. Scopolamine injection (1 mg/kg, i.p.) impaired performance in rats in the passive avoidance test as well as in water maze test and severely reduced cholinergic system reactivity, as indicated by reduced acetylcholine levels and increased acetylcholinesterase activity. Daily administration of EJE significantly increased step-through latency in the passive avoidance test, reduced escape latency, and increased time spent in the platform quadrant in the Morris water maze test. EJE protected against scopolamine-induced cholinergic system deficit, including reduced acetylcholine levels and increased acetylcholinesterase activity in whole brain homogenates. These results suggest that EJE provides a significant anti-amnesic effect against scopolamine-induced cholinergic system deficits and cognitive impairment.
Keywords
anti-amnesia; scopolamine; cognitive impairment; Eriobotrya japonica;
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