• Journal of Korean Ophthalmic Optics Society
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• v.18 no.2
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• pp.93-99
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• 2013

Purpose: The aim of this study was to develop a dry eye test method using a paper based microfluidic device that improves inaccuracy caused by using one of current point-of-care dry eye tests such as Shirmer's. Methods: Wax printed hydrophilic chromatography papers were dyed with anthocyanin extracts to detect colorimetric display of liquid samples with varying pH. Fluid distribution rates were measured using artificial tears and human tears directly from 32 subjects. Results: With Shirmer's, fluid distribution rates with small amount of samples (less than $0.5{\mu}l$) were not displayed. However, with paper based microfluidic device, fluid imbibition distances over time were clearly showed. Also clinical results of dry eye from newly developed paper based microfluidic device showed correlation with the results from tear break up time tests. Conclusions: The newly developed paper based microfluidic devices were easy to use and exhibited more accurate clinical results than current dry eye point of care tests such as Shirmer's.

• Journal of Korean Ophthalmic Optics Society
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• v.10 no.3
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• pp.165-171
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• 2005

The aim of the study was to investigate the diameter and base curve changes of soft contact lens by protein deposition. Soft contact lenses were soaked in artificial tear or protein solution which had the same composition with tear for 2min, 10min, 30min, 1hr, 3hr, 6hr, 12hr, and 24hr. Diameter and base curve changes of soft contact lenses were examined by using the high speed camera(Fastcam ultima 1024). The longer the soaking time of soft contact lenses in the artificial tear, the diameter and base curve changes of soft contact lenses was more increased. In the case of soft contact lenses adsorbed only protein, the similar pattern was shown and the diameter and base curve were decreased. However, the influence of calcium ion was found to be less than that of protein. These results suggest that the tear protein causes the diameter and base curve decrease of soft contact lens, which might be related to the discomfort after soft contact lens wearing.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.4
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• pp.383-390
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• 2011

Purpose: The present study was conducted to investigate whether refractive powers of soft contact lenses were induced by the deposition of tear proteins when wearing soft contact lenses. Methods: The soft contact lenses (material: etafilcon A, hilafilcon A and comfilcon A) with refractive powers of -1.00 D, -3.00 D, -5.00 D and -7.00 D were incubated in artificial tear for 1 day, 3 days, 5 days, 7 days and 14 days, respectively. After incubation, their refractive powers were measured by wet cell method with an auto-lens meter and their protein deposited on the lenses was determined by the method of Lowry. Results: Among three types of soft contact lenses, the most protein deposition was detected in ionic etafilcon A lens material and significant change of its refractive power was manifested. In other words, refractive powers of etafilcon A lenses firstly decreased after 1 day incubation in artificial tear and then gradually increased with increasing incubation period again. The observed change in refractive powers of all diopters of etafilcon A material was beyond the scope of standard error and bigger in the lens with lower optical power. On the other hand, non-ionic hilafilcon A showed less protein deposition as much as about 20% in etafilacon A and statistically significant increase of refractive powers with increasing incubation period in artificial tear. The change in refractive power of hilafilcon A was also beyond the scope of the standard of error when incubating in artificial tear and greater in the lens with lower diopter. The least protein deposit was shown in silicone hydrogel lens material, comfilcon A as approximately 10% of it in etafilcon A, indicating less change in refractive power within the standard range of error. Conclusions: The large change of refractive powers that was beyond the scope of standard error by the deposition of tear proteins on soft contact lenses was differently detected depending on lens materials in the current study. Thus, the deposition of tear proteins induced by longer period of lens wearing may be one of the causes that induces blurred vision, suggesting that soft contact lens wearers with the amount of tear proteins may need to choose proper lens material.

• Journal of Korean Ophthalmic Optics Society
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• v.11 no.2
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• pp.99-107
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• 2006

The purpose of this study was to investigate the cause of discomfort come from wearing of soft contact lens(SCL) exposed to fundamental cosmetics, After SCLs were smeared with skin lotion, essence lotion or nutritional cream, they were exposed to artificial tear for 7 days, and then changes of the adhered protein amount, the transmission of visible light, the wettability and the base curve were estimated. The amount of protein adhered to SCLs were increased 3 times by being exposed to fundamental cosmetics. Moreover, the transmission of visible light of SCL exposed to both nutritional cream and artificial tear was 92.8%, which was 4.7% lower than SCL exposed only to artificial tear. By being exposed to skin lotion, essence lotion or nutritional cream, the contact angle of SCLs were increased up to $7.1^{\circ}$, $7.0^{\circ}$ or $5.7^{\circ}$ and the base curve of SCLs were decreased to 3.2%, 5.1% or 8.3%, respectively.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.4
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• pp.457-463
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• 2013

To determine the impact of artificial tears which include carboxymethyl cellulose on a hydrogel contact lenses. Methods: A contact lenses made of the cross-linking agent, EGDMA (ethylene glycol dimethacrylate) and HEMA (2-hydroxyethyl methacrylate) and with added NVP (n-vinyl-2-pyrrolidone) and MMA (methyl methacrylate) was evaluated for water content, refractive index, spectral transmittance and contact angle of produced contact lens. Results: The physical properties of the sampled copolymerized polymers showed that water content, refractive index, visible ray transmittance and contact angle were in the range of 26.61%~48.58%, 1.422~1.455, 80.8%~91.4% and $33.93^{\circ}{\sim}65.70^{\circ}$, respectively. In addition, after soaking with artificial tears, the water content, refractive index and contact angle were in the range of 24.46%~48.25%, 1.422~1.457, 77.0%~91.0% and $37.25^{\circ}{\sim}77.33^{\circ}$, respectively. The changes of the physical property depending on hydration time and showed an increase of refractive index and contact angle, decrease of water content and visible ray transmittance. Conclusions: Artificial tears which include carboxymethyl cellulose sodium which is used as a wetting agent influenced water content, refractive index, contact angle and spectral transmittance of a hydrogel contact lenses.

• Journal of the Korean Chemical Society
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• v.64 no.2
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• pp.67-73
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• 2020

The study aimed to investigate in vitro lipid deposition of oleic acid, oleic acid methyl ester and cholesterol on a daily disposable (1-day lenses) and 3-days lenses over 3 days and changes of optical characteristics is also investigated. Artificial tear solutions were prepared to simulate actual tear compositions. Two types of contact lenses (1-day lenses (Senofilcon A) and 3-days lenses (silicone tripolymer)) were soaked in the artificial tear solutions within an incubator at 37 ℃ with 150 rpm for 8, 16, 24 hours. Lipid deposition (oleic acid, oleic acid methyl ester and cholesterol) were measured using high performance liquid chromatography (HPLC) instrument. In addition, measurements of oxygen transmissibility, light transmittance and observation of lens surface were conducted. The amount of lipid deposition on the 1-day lenses were 127.55 ㎍/lens for Day 1, 302.96 ㎍/lens, for Day 2, and 353.30 ㎍/lens for Day 3. The 3-days lenses were 46.22 ㎍/lens for Day 1, 66.07 ㎍/lens for Day 2, and 67.45 ㎍/lens for Day 3. Oxygen transmissibility were 81×10^-9(cm/sec)(ml O₂/ml×mmHg)(Baseline) and 48×10^-9(cm/sec)(ml O₂/ml×mmHg) (Day 3) for the 1-day lenses, it were 13.23×10^-9(cm/sec)(ml O₂/ml×mmHg)(Baseline) and 9.6×10^-9(cm/sec)(ml O₂/ml×mmHg) (Day 3) for the 3-days lenses. Transmittance of each lenses were 97.21% (Baseline) and 94.25% (Day 3) for the 1-day lenses, 97.65% (Baseline) and 95.15% (Day 3) for the 3-days lenses. Observation of surface deposition indicated greatest deposition for the 3-days lenses type on Day 3. Lipid deposition for both lens types increased by day and was greater for the 1-day lenses type. Surface deposition appeared to differ as it was greatest for the 3 days lens type, which may suggest other deposits such as protein may be present.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.2
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• pp.179-188
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• 2014

Purpose: The present study was aimed to investigate the cleaning efficacy of multi-purpose solutions containing different types and content of surfactants and their effect on the visible light transmittance of soft lens. Methods: Soft lenses made of different materials (etafilcon A and hilafilcon B) were deposited tear proteins by using the artificial tear and then compared the resulting cleaning efficacy and visible light transmittance after cleaning the lens with 6 types of multi-purpose solutions containing different content of surfactants. Results: The cleaning efficacy of multi-purpose solutions was variously shown as approximately 23~43% according to the active concentration of surfactants and surface tension in multi-purpose solution when etafilcon A lens cleaned with rubbing. The highest cleaning efficacy was detected when cleaned with the multi-purpose solution containing hydrogen peroxide besides surfactant however, the amount of remaining protein was still high on the lens. After washed with multi-purpose solution, the visible light transmittance of lens was in 89.8 to 90.8%. The amount of protein deposited on hilafilcon B lens was very small compared with it on etafilcon A lens even though it was incubated in artificial tears for 7 days, which showed 5~10% of protein amount in etafilcon A lens and the decrease of visible light transmittance was also not significant. In case of rubbing with multi-purpose solution, the cleaning efficacy on hilafilcon B lens was in 45.4 to 67.4% however, the order of cleaning efficacy of multi-purpose solution was different from it on etafilcon A lens. The visible light transmittance of hilafilcon B lens has been restored to the level of new lens. Conclusions: From the result, it is concluded that the appropriate multi-purpose solution should be selected according to the lens material and the amount of protein deposit on the basis of understanding surfactants and active principle for proper care of protein deposit on soft lens and the cleaning with rubbing is more efficient for lens care regardless of manufacturer's guideline.

• Journal of Korean Ophthalmic Optics Society
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• v.10 no.2
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• pp.119-126
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• 2005

The purpose of this study was analyzed to compare on the physical characters of two companies of color contact lenses. Artificial tear solution was used for measuring the rate of protein deposits and wettability. The surface roughness of lenses was measured by SEM(scanning electron microscope, Japan) and AFM(atomic force microscope, MultimodeTM, USA). As a results, The color contact lenses was not different from general soft contact lenses in a respect of other properties. However, the colored contact lenses showed a severe crack on the surface under SEM observation. There was no irregularity on the surface of the colored contact lenses in AFM photograph. The dyes were deposited in inside of lenses by microscope observation.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.428-433
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• 2003

We measured the effect of wettability of six MPSs for RGP(rigid gas permeable) lens. The used MPSs(multipurpose solutions) were OPTI-SOAK(ALCON), SOLO care hard(CIBA Vision), Total care(ALLERGAN), Simplicity(BOSTON), Wetting and Soaking Sol.(Bausch & Lomb) and Aquas-multi(Saehan). These MPSs keeps hydrophilic property of lens surface and increase the effect of cleaning or increase the effect of preservative effect. To compare with the effect of wettability we followed the way of contact angle measurement which was general way to measure wettability and compared lens which was conducted by each MPS made by different companies. As a control, 0.9% NaCl solution and artificial tears were used. The degree of the effect of wettability was decided by contact angle. It is hydrophilic property nearby $0^{\circ}$ of contact angle and it is closed by hydrophobic property as it increases. The results showed that every lens was nearby hydrophilic property within $25\;^{\circ}-36\;^{\circ}$. Also, it was differed by various factors. The surface tension showed various differences between 19.8 and 31.3 mN/m. In the viscosity, MPSs represented the highest viscosity between $4^{\circ}C$ and $20^{\circ}C$. It was much higher than compared with the viscosity of soft lens MPS. This experiment could be used to grasping the interaction between solutions used to MPS and the natural endowments of lens and to considering the relations of different factors effecting the wettability.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.1
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• pp.31-40
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• 2011

Purpose: This study was performed to investigate the actual state about ultrasonic cleaning of soft contact lenses in local optical shops and evaluate the removal effect of protein deposit on soft contact lenses with different lens containers by ultrasonic cleaner for eyeglasses. Methods: The actual state about ultrasonic cleaning of soft contact lenses was surveyed in total 75 local optical shops in Seoul, Korea. The cleaning efficacy of different lens containers was compared by measuring the protein remained on ocufilcon D contact lenses after washing by an ultrasonic cleaner for eyeglasses. The changes on surfaces and wetting angles of ocufilcon D contact lenses by repeat ultrasonication were further investigated. Results: The main purpose to use ultrasonic cleaners in local optical shops was rapid cleaning. The ultrasonic cleaning efficacy of ocufilcon D contact lenses with glass containers was little higher than it with plastic containers, but was not significantly different. The changes on surfaces and wetting angles of ocufilcon D contact lenses in a plastic lens container by repeat ultrasonication such as 30 and/or 60 times were shown. Conclusions: There was not significant difference in cleaning efficacy between glass and plastic lens containers. However, repeat cleaning with ultrasonic cleaner for eyeglasses would be carefully considered since some significant changes in the parameters of lens surface and wetting angles were detected by repeat ultrasonification even when lens containers were used for ocufilcon D contact lens during ultrasonictions.