• The Korean Journal of Medicine
• /
• v.93 no.6
• /
• pp.538-547
• /
• 2018

Background/Aims: The impact of left ventricular (LV) diastolic function and filling pressure on clinical outcomes in young patients with acute myocardial infarction (AMI) has been poorly studied. Therefore, the aim of this study was to investigate the impact of LV diastolic function and LV filling pressure on major adverse cardiac events (MACEs) in young patients with AMI. Methods: A total of 200 young patients (males < 45 year, females < 55 year) with AMI were divided into two groups according to the diastolic function; normal (n = 46, $39.5{\pm}5.3$ years) versus abnormal (n = 154, $43.5{\pm}5.1$ years). Results: Despite regional wall motion abnormalities, normal LV diastolic function was not uncommon in young AMI patients (23.0%). During the 40 months of clinical follow-up, MACEs developed in 26 patients (13.0%); 14 re-percutaneous coronary intervention (7.0%), 8 recurrent MI (4.0%), and 4 deaths (2.0%). MACEs did not differ between the normal and abnormal diastolic function group (13.6% vs. 10.9%, p = 0.810), but MACEs were significantly higher in the high LV filling pressure group than the normal LV filling pressure group (36.8% vs. 10.5%, p < 0.001). On multivariate analysis, high LV filling pressure was an independent predictor of MACEs (hazard ratio 3.022, 95% confidence interval 1.200-7.612, p = 0.019). Conclusions: This study suggested that measurement of the LV filling pressure (E/e' ratio) would be useful in the risk stratification of young patients with AMI. However, it would be necessary to monitor this category of patient more carefully.

• The Korean Journal of Physiology
• /
• v.24 no.1
• /
• pp.91-102
• /
• 1990

The effects of extracellular $Ca^{2+}$ and various $Ca^{2+}$ antagonists on endothelium-dependent relaxation to acetylcholine were studied in the isolated rabbit thoracic aorta in order to elucidate the control mechanism of endothelium derived relaxing factor (EDRF) release. Endothelium was removed from aortic strips by gentle rubbing with cotton ball. The effect of hemoglobin on basal tension was also observed with hemolysate. The results obtained were as follows: 1) Endothelium-dependent relaxation (EDR) to acetylcholine (ACh) showed biphasic pattern; the initial rapid relaxation phase and the late slow relaxation phase. 2) With the depletion of the extracellular $Ca^{2+}$, EDR was gradually suppressed, especially the late slow relaxation. 3) Verapamil, nifedipine, $Mn^{2+}$ and $Cd^{2+}$ had not any effect on EDR, while $La^{3+}$ and $Co^{2+}$ suppressed EDR completely. 4) The resting tension of the strips with rubbed endothelium was not altered by the addition of hemoglobin. That of the strips with intact endothelium, however, was enhanced and EDR to ACh was completely blocked From these results, we suggest that extracellular $Ca^{2+}$ is necessary for ACh-induced slow relaxation while $Ca^{2+}$ antagonists have not any effect on EDR.

• The Journal of the Korea Contents Association
• /
• v.9 no.7
• /
• pp.225-232
• /
• 2009

This study conducted the following experiment to examine effects of cardiovascular function on lumbar stabilization exercise(LSE) in floor or swiss ball. This experiment was conducted to compare heart rate, systolic blood pressure, diastolic blood pressure and peripheral vascular oxygen saturation effects by lumbar stabilization exercise in floor or swiss ball with 18 normal adult and it divided 9 subjects. experiment group (1) is applying LSE on floor group and (2) is applying LSE on swiss ball group. Heart rate was measured by portable heart rate manometer, blood pressure was measured by hemodynamometer, and peripheral vascular oxygen concentration was measured using a computerized NURYTEC measuring apparatus analysis. These result lead us to the conclusion that systolic blood pressure and peripheral vascular oxygen concentration were influenced by LSE. but there was not differential effect between each groups. These results suggest that LSE has the capability to improve heart rate, blood pressure, peripheral vascular oxygen concentration. Consequently, LSE would be lead to increment of cardiovascular function.

• Journal of Digital Convergence
• /
• v.15 no.5
• /
• pp.471-478
• /
• 2017

The purpose of this study was to investigate the changes of blood pressure and total cholesterol after eating Hizikia fusiforme for 8 weeks with 100g of rice per day. As a result, the systolic blood pressure of the group ingesting Hizikia fusiforme significantly decreased. Second, diastolic blood pressure decreased significantly in both groups, but there was no difference between groups. Third, the systolic - diastolic blood pressure difference showed a significant decrease in the group of ingestion of Hizikia fusiforme, while that of the group without intake of Hizikia fusiforme increased. Fourth, total cholesterol decreased significantly in the group consuming Hizikia fusiforme but increased in the group not consuming Hizikia fusiforme. The above results indicate that total intake of 100 g of dried Hizikia fusiforme per day was effective in decreasing total cholesterol and reducing systolic blood pressure.

• 건강소식
• /
• v.35 no.3
• /
• pp.42-43
• /
• 2011

2008년 한국건강관리협회 건강증진의원을 통해 근로자 건강검진을 받은 50~59세 검진자는 40,786명으로 남성은 23,281명, 여성은 17,505명이다. 그중 심전도 검사를 받은 50대 검진자 40,587명 중 14.6%가 질환의심을 보였고, 혈압 측정을 한 40,742명 중 11.6%가 수축기 혈압에서, 10.9%가 이완기 혈압에서 질환의심을 보였다.

• Journal of the Korean Chemical Society
• /
• v.36 no.1
• /
• pp.33-37
• /
• 1992

Information about $^{14}N$ relaxation rates is obtained for thioacetamide (TA) in acetone from a detailed line-shape analysis of the $^1H$ resonance signal of $NH_2$ group. The effect of pressure and of temperature were investigated, and activation energies for molecular reorientation are given. And also $^1H$ relaxation rates of $NH_2$ group of TA as a function of pressure and temperature are obtained. These results are discussed with the results for the $^{14}N$ relaxation of amine group.

• Journal of the Korean Applied Science and Technology
• /
• v.35 no.4
• /
• pp.1175-1184
• /
• 2018

The purpose of this study was to investigate effects of 12-weeks finswimming exercise on electroencephalogram(EEG), SBP, DBP, and RHR in male adolescents. Eighteen male adolescents participated in this study. They were separated into a Control group(CG; n=9) and Finswimming training group(FG; n=9). FG participated in Finswimming training for 12weeks, 60 minutes per day, 3 times a week. All data of electroencephalogram were analyzed by repeated measures two-way ANOVA and Data of SBP, DBP and RHR were analyzed by ANCOVA and Paired t-test. As a result, Alpha and SMR waves were significantly increased in FG; however, Alpha wave was significantly decreased in CG and Theta wave was significantly decreased in FG. There were significant interaction in Alpha, Theta, and SMR waves. SBP, DBP, and RHR were significantly decreased in FG and there were significant differences of RHR and SBP between groups; otherwise, there were no significant differences of DBP between groups. The results of this study showed that 12 weeks of Finswimming training positively effects on electroencephalogram(EEG), SBP, DBP, and RHR in male adolescents.

• Pediatric Infection and Vaccine
• /
• v.22 no.3
• /
• pp.206-209
• /
• 2015

We report the case of a 7-year-old boy who showed treatment-nonresponsive hypotension (59/29 mmHg) and decreased left ventricular systolic function (fractional shortening 22%) in the acute stage of Kawasaki disease (KD). The present case serves to highlight that methylprednisolone pulse therapy should be considered in patients with intravenous immunoglobulin nonresponsive symptomatic myocarditis during the acute stage of KD.

• Clinical and Experimental Pediatrics
• /
• v.53 no.1
• /
• pp.72-79
• /
• 2010

Purpose: Left ventricular (LV) hypertrophy and impaired diastolic function may occur early in systemic hypertension. Diastolic dysfunction is associated with increased cardiovascular risk. Tissue Doppler imaging (TDI)-derived tissue velocity and strain rate are new parameters for assessing diastolic dysfunction. The aim of this study is to determine whether TDI and strain rate imaging (SRI) would improve the ability to recognize early impaired diastolic and systolic functions compared with conventional echocardiography in hypertensive adolescents. Methods: We included 38 hypertensive patients with systolic blood pressure above 140 mmHg or diastolic blood pressure above 90 mmHg. Ejection fraction and myocardial performance index (MPI) were estimated by conventional echocardiography. Peak systolic myocardial velocity, early diastolic myocardial velocity (Em), and peak late diastolic myocardial velocity (Am) were obtained by using TDI and SRI. Results: In the hypertensive group, interventricular septal thickness was significantly increased on M-mode echocardiography. Em/Am was significantly decreased at the mitral valve annulus. Among hypertensive subjects, the E strain rate at basal, mid, and apex was significantly decreased. Systolic strain was significantly decreased at the septum in the hypertensive group. Conclusion: Strain rate might be a useful new parameter for the quantification of both regional and global LV functions and could be used in long-term follow up in hypertensive patients. Early identification by SRI of subjects at risk for hypertensive and ventricular dysfunction may help to stratify risk and guide therapy. Further studies, including serial assessment of LV structure and function in a larger number of adolescents with hypertension, is necessary.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.35 no.10
• /
• pp.1371-1377
• /
• 2006

Gene polymorphisms that are associated with sodium homeostasis in the body, such as $\alpha-adducin$ (ADDI, Gly460Trp), angiotensinogen (AGT, Met235Thr), and angiotensin converting enzyme (ACE, Ins/Del) may increase the risk for the development of hypertension. The purpose of this study was to elucidate the relationship between the singular and combined effects of ADD1, AGT, ACE genotypes, and blood pressure in elderly population. Moreover, we examined the interaction of sodium intake and polymorphisms of aforementioned genes and their effects on blood pressure. Among one hundred and nine female subjects, aged 60 and over (mean 75.9 yr), the major alleles for ADD1, AGT, and ACE polymorphisms in the studied population were Gly (66.1%), Thr (64.2%), Ins (83.5%), respectively. Analysis on the combined effects of genetic variation showed that subjects who were both ADD1 Trp/Trp and ACE Del/Del homozygotes had significantly higher systolic blood pressure (p=0.01). Similarly, ACE Del/Del homozygotes who had AGT Met allele had significantly higher diastolic blood pressure (p<0.001). However, in single-gene analyses, no association was found between any specific genotype and blood pressure. In subjects with low sodium intake, ADD1 Trp/Trp homozygotes had significantly higher systolic blood pressure than subjects who had ADD1 Gly allele (138 mmHg vs. 127 mmHg, p=0.03). There was no difference in blood pressure between ADD1 Trp/Trp and ADD1 Gly/Gly or Gly/Trp, in subjects with high sodium intake. In summary, this study shows that interactions between the ADD1, AGT and ACE genes influence systolic and diastolic blood pressure in elderly subjects, and dietary sodium intake can modulate the effects of ADD1 Gly460Trp polymorphisms on systolic blood pres sure.