• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.7
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• pp.1582-1587
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• 2005

In coagulant control of water treatment plants, rule extraction, one of datamining categories, was performed for coagulant control of a water treatment plant. Clustering methods were applied to extract control rules from data. These control rules can be used for fully automation of water treatment plants instead of operator's knowledge for plant control. To perform fuzzy clustering, there are some coefficients to be determined and these kinds of studies have been performed over decades such as clustering indices. In this study, statistical indices were taken to calculate the number of clusters. Simultaneously, seed points were found out based on hierarchical clustering. These statistical approaches give information about features of clusters, so it can reduce computing cost and increase accuracy of clustering. The proposed algorithm can play an important role in datamining and knowledge discovery.

• Journal of Food Hygiene and Safety
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• v.13 no.4
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• pp.355-359
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• 1998

Platelet activation is originated by the intracellular or/and extracellular $Ca^{2+}$. Agonist-induced $Ca^{2+}$ entry through a plasma-membrane pathway has been reported repeatedly, but the mechanisms has proven harder to elucidate. Recently, a number of natural products have been isolated from medicinal plants and marine organisms and have proved to be useful chemical tools for resolving the mechanism of cellular functions. In an attempt to understand the mechanism of platelet activation in Bupleuri Radix, we have studied some aspects of the isolation of active components and their dependence of external $Ca^{2+}$> on platelet activation. Acetone extract of Bupleuri Radix has the most activity on platelet activation and it's active components were identified as saikosaponin a and d. Their optimal concentration was respectively $20\;\mu\textrm{g}/ml$ and $5\;\mu\textrm{g}/ml$ and their platelet activation was not dependent on external $Ca^{2+}$>, whereas optimal concentration of each agonist was arachidonic acid ($10\;\mu\textrm{M}$), collagen ($10\;\mu\textrm{M}/ml$), thrombin (0.1 unit/mi), PAF (5 nM), PMA ($5\;\mu\textrm{M}$), ionophore A23187 ($2\;\mu\textrm{g}$) and their dependence of external $Ca^{2+}$> on platelet activation appeared to thrombin > collagen $\geq$ PAF > PMA > arachdonic acid> ionophore A23187. These results suggest that saikosaponin is different from each agonists in the dependence of external $Ca^{2+}$ on platelet activation.

• KSBB Journal
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• v.10 no.4
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• pp.421-427
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• 1995

A fungal strain, designated Aspevgillus sp. JS-42, was isolated and shown to produce an extracellular polysaccharide used as a bioflocsulant. The optimal medium composition for the production of flocculant with Aspergillus sp. JS-42 was glucose 3.0%, yeast extract 0.2%, $(NH_4)_2S0_4 0.1%, CaCI_2.2H_2 0.05%$ in distilled water. The optimum culture temperature and optimum culture pH for the production of the flocculant were $25^{\circ}C$ and pH 7.0, respectively. The highest production of flocculant was observed after 90 hours of cultivation at the optimal condition. The flocculant could efficiently flocculaled the tested solids suspended in aqueous solution and was stable at high temperature($100^{\circ}C$) and to pH range of from 2 to 10. The flocculant seems to be a kind of high viscous polysaccharide.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.19 no.1
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• pp.16-28
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• 2007

The results of experimental investigation of coherent structures beneath wind-generated waves in deep water are presented. Vorticity fields of deepwater wind waves were visualized by analyzing the velocity fields obtained by PIV measurements under different wind and fetch conditions. In addition, spatio-temporal evolution of the coherent structures and subsequent changes in vertical profiles of the instantaneous vorticity were qualitatively examined. It was found that a coherent structure is formed right underneath the wave crest and traveled in phase with the surface wave. The direction of rotation of the coherent structure was contrary to the wave orbital motion when wind speed is less than 10 m/s, while was same as the wave orbital motion when wind speed is approximately 13 m/s and wave breaking occurs at the wave crest. In the near-surface region, complex vortex-vortex interactions were observed according to the traveling of the coherent structure. In contrast, coherent structures far below the water surface changed little due to weak influence of orbital motion by the surface waves.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2000.04a
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• pp.50-54
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• 2000

• Korean Journal of Clinical Laboratory Science
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• v.51 no.1
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• pp.34-41
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• 2019

Platelet aggregation is essential for the formation of a hemostatic plug in the case of blood vessel damage. On the other hand, excessive platelet aggregation may cause cardiovascular disorders, such as thrombosis, atherosclerosis, and myocardial infarction. Scopoletin, which found in the root of plants in the genus Scopolia or Artemisia, has anti-coagulation and anti-malaria effects. This study examined the effects of scopoletin on human platelet aggregation induced by collagen. Scopoletin had anti-platelet effects via the down-regulation of thromboxane $A_2$ ($TXA_2$) production and intracellular $Ca^{2+}$ mobilization ($[Ca^{2+}]_i$), which are aggregation-inducing molecules produced in activated platelets. On the other hand, scopoletin increased both the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) levels, which are known as intracellular $Ca^{2+}$-antagonists and aggregation-inhibiting molecules. In particular, scopoletin increased the potently cAMP level more than cGMP, which led to suppressed fibrinogen binding to ${\alpha}IIb/{\beta}_3$ in collagen-induced human platelet aggregation. In addition, scopoletin inhibited collagen-elevated adenosine triphosphate (ATP) release in a dose-dependent manner. The results suggest that aggregation amplification through granule secretion is inhibited by scopoletin. Therefore, scopoletin has potent anti-platelet effects and may have potential for the prevention of platelet-derived vascular diseases.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.122-127
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• 2023

Cardiovascular disease (CVD) is increasingly increasing as the main cause of death worldwide, and activation of platelet in vascular damage is one of the important causes of CVD. In recent, there is a growing interest in anti-thrombotic materials through platelet suppression, and efforts are being made to reduce side effects by using natural bioactive compounds. Known as one of the Flavonoids, hydroxygenkwanin (HGK) is a purified substance in Daphne Genkwa, which is known to have antibacterial, anti-inflammatory and anti-cancer effects, and has been reported to serve as an inhibitor of tissue factor that prevents thrombosis, but its anti-platelet effects and the action mechanisms is not known. In this study, we confirmed that the effects of HGK on the collagen-induced human platelets activation. HGK suppressed phosphorylation of PI3K/AKT and mitogen-activated protein kinases during platelet signaling, and reduced granule secretion in platelets such as ATP and serotonin. In addition, HGK inhibited the phosphorylation of cPLA₂ and strongly undermined the production of TXA₂, which is a powerful aggregation amplifier. As a result, the platelet aggregation derived by Collagen, a cohesive induced substance, was strongly suppressed by HGK to an IC₅₀ of 86.36 µM. Therefore, HGK might be worth the antithrombotic substance that inhibits the activation and aggregation of human platelets that occur through blood vessel damage.

• Journal of Korean Society of Environmental Engineers
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• v.22 no.12
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• pp.2135-2139
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• 2000

The coagulation of anionic colloidal particles by the cyanoguanidine(CG)-formaldehyde resin has been reported to be caused by an electrostatic interaction of the diaminomethylene urea (DU) cation with an anionic surface charge of particles. In this research, 100~500 nm sized cationic cyanoguanidine-formaldehyde resin was synthesized to coagulate anionic dye wastewater, and the results showed that the less pH of aqueous cyanoguanidine-formaldehyde resin solution was, the higher Zeta potential of that was. In case of coagulating 0.4 g/L reactive dye by cyanoguanidine-formaldehyde resin at pH 3, 5, 7, 9, and 11, COD removal and the percent decolorization of synthetic dye wastewater at pH 3 are higher than those of other pH conditions. The COD removal and the percent decolorization of synthetic dye wastewater were 74% and 90% at 400 ppm, pH 3.

• Proceedings of the Korean Society of Marine Engineers Conference
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• 2006.06a
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• pp.325-326
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• 2006

현 화학플랜트에서 사용되고 있는 ABS 수지 응집 공정의 경우 교반기 내부의 불균일한 유동분포와 유동메커니즘의 문제점은 공정 제품의 생산성을 저하 시키는 원인으로 작용하고 있다. 그러나 우수한 성능의 산업용 교반기를 설계하기 위해선 반드시 교반성능에 영향을 미치는 다양한 내부의 유동특성의 정량적인 실험 데이터 확보가 필요하나, 3차원적 비정상 특성을 나타내는 복잡한 구조의 내부 유동특성에 관한 정량적 해석은 현재까지도 상당한 어려운 문제로 남아있다. 이에 이런 문제점을 개선하여 생산성을 향상시키기 위해서는 PIV 기법을 이용한 교반기 내부의 유동분포와 유동메커니즘을 규명하여 교반기 내부의 최적화된 유동을 형성시키는 임펠러의 형상을 개발하고자 한다.

• The KIPS Transactions:PartD
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• v.12D no.7 s.103
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• pp.957-964
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• 2005

According to rapid growth of web environment, user interface design needs to support the complex interactions between human and computer. In the paper we suggest the object modeling method for Qualify Improvement of User Interface. We propose the 4 business event's object modeling phases such as business event object modeling, task object modeling, transaction object modeling, and form object modeling to enhance visual cohesion of UI. As a result, this 4 phases in this paper allows us to enhance visual cohesion of User Interface prototype. We have found that the visual cohesion of business events become strong and unskilled designer can develope the qualified user interface prototype. And it also improves understanding of business task and reduces prototype system development iteration.