• Journal of Life Science
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• v.28 no.12
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• pp.1536-1544
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• 2018

Depression is a common, serious, and recurring mental disorder. The pathogenesis of depression involves many factors such as environmental factor, genetic factor and alteration of structure and function in neurobiological systems. Increasing evidence supports that epigenetic alteration may be associated with depression. The epigenetics is explained as the mechanisms by which environmental factor causes changes in chromatin structure and alters gene expression without changing DNA base sequence. DNA methylation and histone modification involving histone acetylation and methylation are the main epigenetic mechanisms. Animal studies have shown that stressful environment such as early life stress can leave persistent epigenetic marks in the genome, which alter gene expression and influence neural and behavioral function through adulthood. A potentially important gene in depression is brain-derived neurotrophic factor (BDNF). BDNF plays a central role in depression and antidepressant action. In studies of the rodent, exposure to stress at prenatal, postnatal, and adult stages alters BDNF expression through histone modification and DNA methylation of the BDNF gene which results in anxiety and depressive-like behavior. This review discusses recent advances in the study of the epigenetic mechanisms that contribute to depression, particularly histone modification and DNA methylation of the BDNF gene, that may help in the development of new targets for depression treatment.

• Journal of Industrial Convergence
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• v.17 no.2
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• pp.9-14
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• 2019

This study was carried out to investigate how the basic plan of the Saemangeum development project that has been developed by the government since 1991 has been changed and to present a new development strategy by analyzing the future value and tourism resource value of Saemangeum development. The research methodology is based on the in - depth analysis methodology of the time series research materials and press releases published by the Saemangeum Development Administration, which oversees the development of Saemangeum. The government announced a plan to significantly reduce agricultural land and increase the proportion of non-agricultural land to 70% in order to create a multifunctional complex. After that, the government revised the basic plan of Saemangeum in 2014 and changed the plan to tailor the investment demand in order to cultivate investment demand, and introduced the special economic cooperation system for global economic cooperation. Therefore, the purpose of this paper is to analyze the process of Saemangeum development to date and to evaluate the value of Saemangeum development as a tourism resource, centered on the Master Plan of the Saemangeum Development Project changed by the government. Based on the results of this analysis, I would like to present the vision of Saemangeum tourism development considering Saemangeum 's environment and characteristics of the surrounding scenery by referring to trends and similar cases of international tourism.

• Journal of Industrial Convergence
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• v.17 no.2
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• pp.29-34
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• 2019

The purpose of this study is to analyze the achievements of employment support by the government support specialization project. The data used in this study are based on the comparison of 5 - year employment support field and the operation results of the program until 2014-2018. The results of the study are as follows. First, the overall employment rate of the university has been continuously increased. Especially, the employment rate of the specialization department has been higher than the employment rate of the non - specialization department. Second, as a result of the analysis of the employment capacity strengthening index and the learning capacity strengthening index, it showed a steady increase in each year and contributed to the cultivation of customized talents required by the local society and the national industry. Third, as a result of analyzing the satisfaction of students who are business users, it was confirmed that the business reflecting the demands of the consumers was realized. Fourth, the continuous improvement of the business and the reflux have made the infrastructure of the employment support project more advanced and the system of supporting employment of the university systematically established. In conclusion, the result of the employment support project according to the specialization program showed excellent results and it is necessary to complement theses results when establishing related business plan in the future.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.10a
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• pp.981-984
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• 2014

Volumetric measurement of hippocampus using IBASPM, the 20's normal adults 10 people's brain images were acquired in order to assess the changes according to the type of the Atlas. Images was obtained using MPRAGE of a 3-D gradient echo pulse sequence on Head matrix coil of 1.5T MRI system. The results of Paired t-test using obtained volume of hippocampus depending on the type of the Atlas, Atlas69-Altas84, Atlas69-Atlas116(p=0.729, 0.729) in the left hippocampus and Atlas69-Atlas84, Atlas69-Atlas116(p=0.219, 0.219) in right hippocampal formation were no significant differences but in the area except this, there was significant difference(p=0.000). The volume of the hippocampus using Atlas84 and Atlas116, represented the same value and there was no significant difference. In the image analysis using the overlay of atlas image and original image, Atlas71 could be found that the area of hippocampus did mismatch. In the case of atlas used in this study, because it has been developed by the westerners, there are differences between brain of asian. It would be needed to development of new Atlas for high accuracy measurement of the volume of hippocampus.

• Science of Emotion and Sensibility
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• v.22 no.1
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• pp.45-54
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• 2019

Empathy has been observed to be pivotal in enhancing both social relations and the efficiency of task performance. Empathetic interaction has been shown to begin with individuals mirroring each other's facial expressions, vocal tone, actions, and so on. The internal responses of the cardiovascular activity of people engaged in empathetic interaction are also known to be synchronized. This study attempted to objectively and quantitatively define the rules of empathy with regard to the synchronization of cardiac rhythm between persons. Seventy-four subjects participated in the investigation and were paired to imitate the facial expressions of their partner. An electrocardiogram (ECG) measurement was taken as the participants conducted the task. Quantitative indicators were extracted from the heart rhythm pattern (HRP) and the heart rhythm coherence (HRC) to determine the difference of synchronization of heart rhythms between two individuals as they pertained to empathy. Statistical significance was confirmed by an independent sample t-test. The HRP and HRC correlation(r) between persons increased significantly with empathy in comparison to an interaction that was not empathetic. A difference of the standard deviation of NN intervals (SDNN) and the dominant peak frequency decreased. Therefore, significant parameters to evaluate empathy have been proposed through a step-wise discrimination analysis. Empathic interactions may thus be managed and monitored for high quality social interaction and communication.

• Science of Emotion and Sensibility
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• v.21 no.4
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• pp.43-54
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• 2018

The aim of this study is to determine the effect of motion sickness on pupil rhythm. Sixteen volunteers of both genders (8 male, 8 female, mean age $25.67{\pm}2.43$ years) experienced VR contents in both 2D and HMD versions for 15 minutes, and their pupillary rhythms were compared. The irregular pattern of the pupillary rhythms, as demonstrated by increasing mean pupil diameter (mPD) and standard deviation of the pupil diameter (sPD), revealed motion sickness after experiencing HMD condition. The pupillary response is strongly related to the cognitive load, and the motion sickness can be interpreted as a change in the cognitive load caused by the increasing volume of visual information that must be processed and the conflict or inconsistency between different sensory modalities. The method proposed in this study could be a non-contact measurement method for the monitoring of motion sickness using a web-camera rather than previous sensor-based methods.

• Science of Emotion and Sensibility
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• v.22 no.2
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• pp.49-58
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• 2019

In the era of the 4th Industrial Revolution, artificial intelligence (AI) has become one of the core technologies in terms of the business strategy among information technology companies. Both international and domestic major portal companies are launching AI search services. These AI search services utilize voice, images, and other unstructured data to provide different experiences from existing text-based search services. An unfamiliar experience is a factor that can hinder the usability of the service. Therefore, the usability testing of the AI search services is necessary. This study examines the usability of the AI search service on the Naver App 8.9.3 beta version by comparing it with the search services of the current Naver App and targets 30 people in their 20s and 30s, who have experience using Naver apps. The usability of Smart Lens, Smart Voice, Smart Around, and AiRS, which are the Naver App beta versions of their artificial intelligence search service, is evaluated and statistically significant usability changes are revealed. Smart Lens, Smart Voice, and Smart Around exhibited positive changes, whereas AiRS exhibited negative changes in terms of usability. This study evaluates the change in usability according to the application of the artificial intelligence search services and investigates the correlation between the evaluation factors. The obtained data are expected to be useful for the usability evaluation of services that use AI.

• The Journal of Korean Association of Computer Education
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• v.22 no.5
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• pp.51-65
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• 2019

This study aims to provide educational implications for more strategic online software education by the types of online learning according to learners' self-regulated learning characteristics in the online software education environment and examining the characteristics of each type. For this, variables related to self-regulated learning characteristic were extracted from the log data of 809 students participating in the online software learning program of K University, and then analyzed using hierarchical cluster analysis. Based on hierarchical cluster analysis learner clusters according to the characteristics of self-regulated learning were derived and the differences between learners' learning characteristics and learning results according to cluster types were examined. As a result, the types of self-regulated learning of online software learners were classified as 'high level self-regulated learning type (group 1)', 'medium level self-regulated learning type (group 2)', and 'low level self-regulated learning type (group 3)'. The achievement level was found to be highest in 'high-level self-regulated learning type (group 1)' and 'low-level self-regulated learning type (group 3)' was the lowest. Based on these results, the implications for effective online software education were suggested.

• Korean Journal of Heritage: History & Science
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• v.51 no.2
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• pp.92-107
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• 2018

In 2013~2016, gilt-bronze shoes were excavated from the ancient tombs in Jeongchon Village located at Bogam-ri, Dasi-myeon in Naju. They are estimated to have been made in the late 5th or early 6th centuries. The gilt-bronze shoes are significant in that they serve to explicate the relationship between the center of Baekje and the local forces in the Yeongsan River Basin. This study's specific focus was the gilt-bronze shoes from the ancient tombs in Jeongchon Village. Based on the findings, a restoration drawing was designed and restored products were manufactured by considering metalwork techniques used to manufacture the original ones. At first, manufacturing techniques were tested by using a scientific analysis and visual observation. The manufacturing method, structures, and patterns of the gilt-bronze shoes were closely examined. Then, a design drawing of gilt-bronze shoes was created through field measurement and they were recreated on the basis of the analysis. The original form of the restored products were manufactured through cutting out the outward form, bore carving, engraving, molding, plating, and an assembly process. In the restoration process, this study examined the formal characteristics of gilt-bronze shoes, manufacturing techniques, and archetypes during Baekje's late Hanseong era. Products restored from this study are expected to be used as achievements for more easily understanding the culture of Baekje.

• Korean Journal of Heritage: History & Science
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• v.49 no.4
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• pp.22-37
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• 2016

This research sought to examine the strategies of cultural heritage proving the negative history to be registered as world heritage, among the World Heritages registered in UNESCO. Therefore, to comprehend "negative history"and the heritages with "instructive value," the new term of "Remembrance Heritage"was suggested, and such cases of world heritage were analyzed. Especially by analyzing the criteria of being registered by focusing on the cases of similar World Heritages with similar historical background or form as Korean DMZ, the criteria of OUV that may be applied when Korean DMZ is promoted to be registered as World Heritage. The research results may be summarized as the following. First of all, Remembrance Heritage is a place in which events of universal significance have occurred, rather than the historical, artistic, landscape, and scholastic value of the heritage itself, and was evaluated as architecture, landscape, or place in which the events or historical steps could be verified through architectural, landscape, archaeological or technical means. Secondly, Remembrance Heritage was often applied to be registered with the criterion (vi), and criterion (iii) or criterion (iv). Thirdly, in case of the Korean DMZ, application of criterion (iv) as heritage proving the age of cold war and criterion (vi) as symbolic value of peace may be possible.