• Tuberculosis and Respiratory Diseases
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• v.60 no.4
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• pp.437-450
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• 2006

Background : Acute respiratory distress syndrome (ARDS) is characterized by severe inflammatory pulmonary edema of unknown pathogenesis. To investigate the pathogenesis of ARDS associated with neutrophilic oxidative stress, the role of phospholipase $A_2$ ($PLA_2$) was evaluated by the inhibition of calcium channel. Methods : In Sprague-Dawley rats, acute lung injury (ALI) was induced by the instillation of E.coli endotoxin (ETX) into the trachea. At the same time, diltiazem was given 60 min prior to tracheal instillation of ETX. Parameters of ALI such as lung and neutrophil $PLA_2$, lung myeloperoxidase (MPO), BAL neutrophils, protein, surfactant were measured. Production of free radicals from neutrophils was measured also. Morphological studies with light microscope and electron microscope were carried out and electron microscopic cytochemistry for detection of free radicals was performed also. Results : Diltiazem had decreased the ALI parameters effectively in ETX given rats and decreased the production of free radicals from neutrophils and lung tissues. Morphological studies denoted the protective effects of diltiazem. Conclusion : Diltiazem, a calcium channel blocker, was effective in amelioration of ALI by the suppression of neutrophilic oxidative stress mediated by $PLA_2$ activation.

• Tuberculosis and Respiratory Diseases
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• v.52 no.1
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• pp.24-36
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• 2002

Background: Bronchial reactivity is known to be a component of airway hyperresponsiveness, a cardinal feature of asthma, with bronchial sensitivity, and is increments in response to induced doses of bronchoconstrictors as manifested by the steepest slope of the dose-response curve. However, there is some controversy regarding methods of measuring bronchial reactivity and clinical impact of such measurements. The purpose of this study was to evaluate the clinical significance and assess the clinical use by analyzing the relationship of the bronchial sensitivity, the clinical severity and the changes in pulmonary function with bronchial reactivity. Method: A total of 116 subjects underwent a methacholine bronchial provocation test. They were divided into 3 groups : mild intermittent, mild persistent, moderate and cough asthma. Severe patients were excluded. Methacholine PC20 was determined from the log dose-response curve and PC40 was determined by one more dose inhalation after PC20. The steepest slope of log dose-response curve, connecting PC20 with PC40, was used to calculate the bronchial reactivity. Body plethysmography and a single breath for the DLCO were done in 43 subjects before and after methacholine test. Results: The average bronchial reactivity was 38.0 in the mild intermittent group, 49.8 in the mild persistent group, 61.0 in the moderate group, and 41.1 in the cough asthma group. There was a weak negative correlation between PC20 and bronchial reactivity. A heightened bronchial reactivity tends to produce an increased clinical severity in patients with a similar bronchial sensitivity and basal spirometric pulmonary function. There were significant correlations between the bronchial reactivity and the initial pulmonary function before the methacholine test in the order of sGaw, Raw, $FEV_1$/FVC, MMFR. There were no correlations between the bronchial sensitivity and the % change in the pulmonary function parameters after the methacholine test. However, there were significant correlations between the bronchial reactivity and the PEF, $FEV_1$, DLCO. Conclusion: There was weak significant negative correlation between the bronchial reactivity and the bronchial sensitivity, and the bronchial reactivity closely reflected the severity of the asthma. Accordingly, measuring both the bronchial sensitivity and the bronchial reactivity can be of assistance in assessing of the ongoing disease severity and in monitoring the effect of therapy.

• Clinical and Experimental Pediatrics
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• v.50 no.5
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• pp.462-468
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• 2007

Purpose : The purpose of this study was to analyze the changes of the late potential of Signal- averaged electrocardiography (SAECG) and Electrocardiography (ECG) parameters during follow up of those who had taken surgical repair of Tetralogy of Fallot (TOF). Methods : Nine patients who had taken surgical repair of TOF since 1985 checked SAECG and standard 12 leads ECG twice in 1999 and 2005 in Kyungpook national university hospital. We evaluated changes of QRS duration, QT interval and JT interval, QRS dispersion, QT dispersion and JT dispersion of standard 12 leads ECG and Filtered QRS (f-QRS), High frequency low amplitude potential (HFLA), Root mean square in terminal 40 ms (RMS) and Mean voltage in terminal 40 ms (MV) of SAECG between in 1999 and 2005. Results : There were significant decrease of JT dispersion ($101.11{\pm}50.11$ vs $71.11{\pm}22.61ms$, P< 0.05) and significant increase of HFLA ($24.67{\pm}13.19$ vs $32.89{\pm}14.21ms$, P<0.05). But there were no significant changes in other parameters. Conclusion : In repaired TOF patients, we evaluated ECG and SAECG to detect possible late complications such as tricuspid regurgitation, right ventricular enlargement, ventricualar arrythmia and sudden death. And there were significant changes of ECG and SAECG in some parameters (JT dispersion, HFLA). But to see the relationships between the changes of these parameters and the long term prognosis, we need to check more patients and longer follow-up.

• KSBB Journal
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• v.11 no.3
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• pp.276-287
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• 1996

Batch suspension cultures of hybridoma cell were performed with various initial glutamine concentrations to investigate the effects of glutamine on cell growth and death, monoclonal antibody production, glucose and glutamine consumption, and the production of lactate and ammonium ion. An mathematical kinetic model was formulated to describe the kinetics of cell growth, the consumption of nutrients (glucose and glutamine), and the production of monoclonal antibody and waste metabolites (lactate and ammonium ion) based on experimental data. An equation for the specific growth rate was developed such that superimposed Monod equation in glucose and glutamine, with non-competitive type inhibition relations in ammonium ion and lactate. The inhibition constant for lactate was inversely proportional to the lactate concentration. The specific death rate was considered to be a function of glucose, glutamine, ammonium ion and lactate concentration.

• Journal of Korean Society of Transportation
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• v.28 no.6
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• pp.159-166
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• 2010

Trip distribution is to connect travel demand for each OD pair based on travel cost, trip production and attraction derived from trip generation step. In real world the travel cost is a function of travel demand, but existing models could not fully consider such functional relation between travel cost and demand, which leads to an equilibrium in trip distribution model. This paper proves the equilibrium trip distribution by using gravity model. In order to obtain such equilibrium this paper also presents a solution algorithm based on fixed point theorem. The algorithm will be tested with an example and confirmed the equilibrium solution of trip distribution.

• Journal of the Korean Electrochemical Society
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• v.4 no.1
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• pp.21-25
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• 2001

This article is concerned with the application of the fractal geometry to interfacial electrochemistry. Especially, we dealt with diffusion kinetics at the fractal electrodes. This article first explained the basic concepts of the Sacral geometry which has proven to be fruitful for modelling rough and irregular surfaces. Finally this article examined the electrochemical responses to various signals under diffusion-limited reactions during diffusion towards the fractal interfaces: The generalised forms, including the fractal dimension of the electrode surfaces, of Cottrell, Sand and Randles-Sevcik equations were theoretically derived and explained in chronoamperomety, chronopotentiometry and linear sweep/cyclic voltammetry, respectively.

• Journal of the Korean Chemical Society
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• v.40 no.6
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• pp.401-408
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• 1996

In general, the high temperature superconductors have two-dimensional anisotropic structures. It is important to investigate the dependence of the critical temperature on the dimensions of the electron's motion. The equation of state for electron gas is deduced which describes the electron's motion in superconductors using the kinetic theory of gas. And the critical temperatures of three, two, and one dimensional gases were calculated. According to these equations, restricting the dimension of the electron's motion induces the increase of the critical temperatures. This implies the possibility that the multi-critical temperature of some superconductors is caused by the change of the dimension related to the pathways of the electron.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.293-293
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• 2022

가뭄은 시간적 지속성이 타 재난에 비해 길고 공간적 피해의 범위와 편차가 크다는 점에서 지역적 특성과 가뭄대응역량에 맞는 적절한 대응과 대책 마련이 필수적이다. 본 연구에서는 선행연구에서 제시된 바 있는 지역적 가뭄복원력평가 방법론을 기준으로, 가뭄복원력 평가 인자의 민감도 분석을 실시하였다. 가뭄복원력평가 인자는 4Rs (Robustness, Redundancy, Resourcefulness, Rapidity)을 기준으로 총 18개의 지표로 구성되어 있으며, 18개 지표를 산출하는 과정에서 활용되는 세부자료는 정량자료 19개와 담당자 설문조사를 통해 산정되는 정성자료 8개를 포함하여 총 28개가 존재한다. 본 연구에서는 국내 지자체의 복원력 평가 결과 기준, 등급별 1-2개 지자체를 민감도 분석의 대상으로 설정하고, 19개 정량자료 각각의 비율적 변화에 따른 복원력 결과의 변동성을 정량화하여 도출하였다. 또한 19개 정량자료 중, 연관성 및 계층적 관계성이 존재하는 주요 자료 그룹을 구분하고, 대상 자료의 동시적, 연쇄적 변화에 따른 복원력 평가 결과의 영향도를 정성, 정량적으로 평가하였다. 분석 결과 가뭄 복원력에 기여하는 인자의 변화에 따라 가뭄 복원력의 증감 정도가 지자체 별도 상이하게 나타남을 확인할 수 있었다. 도출된 민감도 분석 결과는 지자체의 현재 가뭄대응역량지표를 기준으로, 가뭄 복원력을 증가시키기 위한 효율적 대책 및 계획 수립을 위한 의사결정에 활용될 수 있을 것으로 기대된다.

• The Journal of the Convergence on Culture Technology
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• v.10 no.3
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• pp.635-641
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• 2024

Based on Merleau-Ponty and Lakoff's research on the inseparability of body and mind, this thesis seeks to explore the impact of experiences in multi-layered spaces based on media art on the understanding of human existence. The sensory experience provided by media art strengthens the viewer's physical presence and induces a new perception of reality by blurring the boundaries between reality and virtuality. Through this, it shows that it is possible to newly recognize and explore the deep relationship between human existence and the world. This paper analyzes how media art can be an important means of expanding existential experience through the connection between body and mind, and explains how the combination of art and technology contributes to ontological understanding.

• Journal of Korean Tunnelling and Underground Space Association
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• v.15 no.2
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• pp.97-111
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• 2013

It is very important to understand the condition of the surround rock for the successful construction of underground space. Representative methods of estimating the rock mass condition are RMR method and Q-system, and they are applied on design, construction, and maintenance. However, many problems with the accuracy of the measurement method and the subjective viewpoint are questioned continuously, so many researchers have been studied for estimating rock condition from various methods. Most of them show only the local relation and a tendency between site investigation data and rock conditions. In this paper, the relationship between RMR method and electrical resistivity is deducted using the analytical equation derived theoretically from electric field analysis on jointed rock mass. And also, probabilistic relationship between RMR method and electrical resistivity is deducted for the increase of accuracy. If a suggested method is applied with the conventional method for estimating the rock condition, it will be helpful to estimate RMR values on the field.