• Korean Journal of Clinical Laboratory Science
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• v.53 no.3
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• pp.249-256
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• 2021

Asthma is a chronic inflammatory airway disease. There are many factors including genetic and environmental factors that influence asthma. The mitogen-activated protein kinase (MAPK) pathway is involved in maintaining the T helper cells 1 and 2 (Th1/Th2) balance and plays an important role in the development of asthma. In this study, the correlation between the NDFIP2 gene that regulates the MAPK pathway and asthma was analyzed. The genetic polymorphism of the NDFIP2 gene was analyzed between 193 asthma patients and 3,228 healthy controls in Korea. As a result, 4 single nucleotide polymorphisms (SNPs) showed a significant correlation (P<0.05) and high relative risk with asthma. Among them, rs2783122 of NDFIP2 showed a statistically significant association with asthma (P-value=9.76×10^-6, odds ratio (OR)=1.67, 95% confidence interval (CI)=1.33~2.10). In the SNP imputation on the NDFIP2, 16 SNPs were discovered, and all of them showed significant correlation with asthma and high odds ratio. The genotype-based mRNA expression analysis revealed that the group of minor alleles of rs1408049 showed increased mRNA expression. Increased NDFIP2 expression causes the activation of the MAPK pathway, and this may influence the development of asthma. In conclusion, the polymorphisms of NDFIP2 are associated with asthma development and this can provide the basis for new guidelines for the management of asthma in the Korean population.

• Proceedings of the Korean Society of Computer Information Conference
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• 2022.07a
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• pp.49-52
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• 2022

건물 외벽에 발생하는 균열은 시설물 구조 안전에 영향을 미치며 그 크기에 따라 위험도가 달라진다. 이에 따라 전문검사관의 현장 점검을 통해 발생 균열 두께를 정밀하게 측정할 필요가 있고 최근에는 이러한 현장 안전점검에 인공지능을 도입하려는 추세다. 그러나 기존의 균열 데이터셋은 주로 콘크리트에만 한정되어 다양한 외벽에 강인한 모델을 구축하기 어렵고 균열 두께를 측정하기 위해 정확한 마스크(Mask) 정보가 필요하나 이를 만족하는 데이터셋이 부재하다. 본 논문에서는 다양한 외벽에 강인한 균열 구획화 모델을 목적으로 2,744장의 이미지를 촬영하고 매직 완드 기법으로 라벨링을 진행해 데이터셋을 구축 후, 이를 바탕으로 딥러닝 기반 균열 구획화 모델을 개발했다. UNet-ResNet50을 최종모델로 선정 및 개발 결과, 테스트 데이터셋에 대해 81.22%의 class IoU 성능을 보였다. 본 연구의 기술을 바탕으로 균열 두께를 측정하여 건축물 안전점검에 활용될 수 있기를 기대한다.

• Journal of the Korean Society of Radiology
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• v.82 no.1
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• pp.12-28
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• 2021

Mammography is the primary imaging modality for breast cancer detection; however, a high level of expertise is needed for its interpretation. To overcome this difficulty, artificial intelligence (AI) algorithms for breast cancer detection have recently been investigated. In this review, we describe the characteristics of AI algorithms compared to conventional computer-aided diagnosis software and share our thoughts on the best methods to develop and validate the algorithms. Additionally, several AI algorithms have introduced for triaging screening mammograms, breast density assessment, and prediction of breast cancer risk have been introduced. Finally, we emphasize the need for interest and guidance from radiologists regarding AI research in mammography, considering the possibility that AI will be introduced shortly into clinical practice.

• The Journal of the Korea Contents Association
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• v.19 no.2
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• pp.204-209
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• 2019

This study is to develop an oral healthcare program for students with intellectual disabilities, who were in high-school grades in Special School C located in North Chungcheong Province, and to examine its effect after applying the program. The program effect was the index of oral environment care ability and the score of dental caries risk per each session. In addition, images were taken for phase-contrast microscopy. The PHP index before and after the oral healthcare program and the risk of dental caries decreased but showed no significant difference. An observation on phase-contrast microscopy revealed that the number of cocci decreased at the third session compared to that in the first session, and almost no bacillus was observed. The oral healthcare program, would be able to improve the oral environment care ability of students with intellectual disabilities and lower the risk of dental caries.

• Journal of agricultural medicine and community health
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• v.39 no.1
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• pp.25-36
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• 2014

Objectives: The objective of this study was to investigate the relationship between coronary artery calcification and risk factors of cardiovascular disease with multidetector computed tomography. Methods: Data were collected from 5,899 males between 30 and 59 years old by interview, survey, physical examination, blood test, and multidetector computed tomography in the university hospital from January 2010 to December 2011. We confirmed the coronary artery calcium scores of subjects by multidetector computed tomography and identified risk factors of cardiovascular disorders. We investigated the relationship between coronary artery calcification and risk factors of cardiovascular disorders. Results: Mean calcium score of the coronary arteries in 5,899 participants was 8.20, and 773 participants (13.1%) exhibited coronary artery calcification. The presence of coronary artery calcification was correlated to risk factors of cardiovascular disease (age, blood pressure, triglyceride, HDL cholesterol, LDL cholesterol, glucose, Apolipoprotein A-1, Apolipoprotein B, body mass index, waist circumference) and risk assessment tools of cardiovascular disorders. Significant predicted factors of coronary artery calcification had different patterns in each age group (30-39, 40-49, 50-59 years old). Conclusions: We confirmed the relationship between coronary artery calcification and either typical risk factors of cardiovascular disease or risk assessment tools of cardiovascular disease. In addition, we also observed that the pattern of these factors varied according to age. Therefore, age-related variation needs to be considered in management strategies to prevent cardiovascular disease.

• Journal of the korean academy of Pediatric Dentistry
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• v.44 no.3
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• pp.298-305
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• 2017

This study aimed to compare chair-side test results for caries risk assessment and evaluate how well the tests reflect caries experience. The study was conducted on children aged < 6 years in primary dentition. Dental examination of children was conducted to determine the dmft index and subjects were divided into two groups : group I (dmft < 6), group II (dmft > 6). This study used four kinds of test kits (Plaque-check PH kit, Saliva-check buffer kit, Saliva-check mutans kit, Cytoperio analysis system). Saliva buffer capacity was significantly low in the high caries experience group (dmft > 6) and correlated with dmft index. Saliva pH level correlated significantly with saliva buffer capacity. The results showed that plaque pH and saliva pH levels had no correlation with dmft index. The Streptococcus mutans level measured by using the Saliva-check mutans and Cytoperio analysis system did not correlate with dmft index.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.05a
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• pp.666-668
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• 2013

Recently, the kind and number of malicious code, which operates in Operation System of smart devices, are rapidly increasing along with the fast supplement of smart devices. Especially, smart devices based on Android OS have high potential of danger to expose to malicious code as it has an easy access to system authority. When using intent, the global message system provided from Android, inter approach between applications is available, and possible to access to created data by the device. Intent provides convenience to application development in the aspect of reusability of component however, it could be appointed as a risk element in security-wise. Therefore, if intent is used in malicious purpose, it is easy to lead the condition where is weak on security. That is, it is possible to control as accessing to resources which application is carrying to operate by receiving intents as making smart device uncontrollable or consuming system resources. Especially, in case of system authority is achieved, the risks such as smart device control or personal information exposure become bigger when misusing broadcast intent through malicious code. This paper proposes a corresponding method of security vulnerability of Android intent that monitors the appearance of intent with intent pattern inspection, detects and blocks unidentified pattern intent.

• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.805-809
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• 2007

최근 도시의 발달은 하상공간에 대한 이용도를 높이는 방향으로 개발이 진행되어가는 추세이며, 하상도로 및 하상주차장의 이용은 이제 도시 내에서 이용 가능한 마지막 여유 공간으로 인식될 정도로 그 의존도가 높아져가고 있다. 그러나 하상공간의 활용도가 높아져갈수록 도시홍수의 발생으로 인한 대피문제가 발생하게 되고 돌발홍수로 인하여 하상도로의 차단 혹은 하상 주차장에 주차된 차량의 소거가 늦어지는 경우 고스란히 피해를 보게 되는 등 그 부작용도 계속 증가되고 있다. 도시홍수의 특성을 살펴보면 국지성 돌발 강우에 의한 유량의 급격한 증가와 짧은 유하시간, 작은 유역면적 등에 의하여 주요 예보지점까지의 도달시간이 매우 짧아 수문학적 홍수예측 모형을 이용하여 홍수예측 업무를 수행하는데 선행시간을 충분히 확보할 수 없다는 단점을 지니고 있다. 이에 따라 본 연구에서는 기존의 하천시스템에 대한 설계 등을 목적으로 하여 모형의 적용을 통한 시뮬레이션 기법을 적용하고 이를 통하여 홍수 예경보를 발령하기에는 선행시간의 확보(대피시간의 확보)라는 측면에서 상당한 어려움을 지닐 수 있으므로 시시각각으로 측정되는 실시간 수위측정 자료 및 실시간 강우자료를 이용하여 모형의 수행과정을 생략하고 하천의 수위변동을 직접 예측하고 대피할 수 있는 시나리오 기반의 수문모형을 개발하였다. SPSS를 사용한 통계학적 모형을 대전광역시 3대 하천에 대하여 적용한 결과 예측자료가 실측자료를 고수위 및 저수위 부근에서 정확히 모의하지 못하는 경향이 나타났으나 경계 및 위험수위를 설정하고 이를 넘어가는 시점에 대한 예측을 하는 홍수경보 시점 예측에는 효율적인 적용성을 나타내었다.씬 간편하면서도 정확도가 높아서, 환경방사성 스트론튬의 정량분석에 적절히 사용될 수 있다.e form of Jones matrix, which allows a new interpretation in the conversion efficiency of the thin-film optical waveguides.있다는 장점이 있었다. 따라서 소아에서 복막투석도관 수술 시 복강경적 방법을 이용하는 것이 효율적인 복막 투석을 위해 유용하다고 생각된다.상부 방광천자에 비해 민감도 59.5%(25/42), 특이도 86.6%(13/15)였고 위양성률 13.3%(2/15), 위음성률 40.5%(17/42) 로 정확도가 낮았다. 결론 : 소변을 가리지 못하는 영유아에서 요로 감염을 진단하기 위해서는 도뇨관 채뇨에 비해 초음파 감시하 치골상부 방광천자가 정확하고 안전한 채뇨법으로 권장되어야 한다고 생각한다.應裝置) 및 운용(運用)에 별다른 어려움이 없고, 내열성(耐熱性)이 강(强)하므로 쉬운 조건하(條件下)에서 경제적(經濟的)으로 공업적(工業的) 이용(利用)에 유리(有利)하다고 판단(判斷)되어진다.reatinine은 함량이 적었다. 관능검사결과(官能檢査結果) 자가소화(自家消化)시킨 크릴간장은 효소(酵素)처리한 것이나 재래식 콩간장에 비하여 품질 면에서 손색이 없고 저장성(貯藏性)이 좋은 크릴간장을 제조(製造)할 수 있다는 결론을 얻었다.이 있음을 확인할 수 있었다.에 착안하여 침전시 슬러지층과 상등액의 온도차를 측정하여 대사열량의 발생량을 측정하고 슬러지의 활성을 측정할 수 있는 방법을 개발하였다.enin과 Rhaponticin의 작용(作用)에 의(依)한 것이며,

• Smart Media Journal
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• v.1 no.4
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• pp.52-58
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• 2012

In recent years the combination of IT and BT for U-Healthcare Medical Services has attracted popular attention as an alternative for solving health problems due to aging issue. Active oxygen as free radicals causes unstable state of the body resulting to other disease on which approximate 90% of the diseases are associated with active oxygen. The severity is even higher along with increasing age. Therefore, there is a need for systematic management of active oxygen saturation for the elderly and chronic patients. In this paper, the data about active oxygen measurements from the body measurement is sent to the data storage of medical facilities by the service provider. Medical information is measured by devices provided complying with the standard, support and information using Bluetooth communication. Users can check their health status themselves using the proposed system through 3G/4G mobile devices like smart phone to medical institutions in which the smart phone act as a gateway for medical data transferred from patient to medical institutions and vice versa. Users can get and experience a diagnosis and effective U-Environmental Health Services from Medical institutions anywhere using the proposed built system.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.4
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• pp.291-297
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• 2023

Gastritis is an inflammation of the gastric mucosa and gastric ulcers are a break in the mucosa of the stomach lining. Past research on gastritis and gastric ulcers has been mainly conducted from the perspective that environmental factors are the primary cause of these gastric diseases. However, recently the importance of genetic factors has been emphasized due to current developments in genetic research. The SLC25A26 gene is believed to be associated with the accumulation of reactive oxygen species. Oxidative stress promotes an inflammatory response, which increases the production of free radicals and causes cellular damage, and these lead to the development of gastric diseases. In this study, the correlation between SLC25A26 and gastric diseases was analyzed. Polymorphisms in SLC25A26 were analyzed in 1,369 domestic gastric disease patients and 7,471 healthy controls. As a result, 11 single nucleotide polymorphisms (SNPs) (in the genotype) and 13 SNPs (in the imputation) showed statistical significance (P<0.05), and high relative risk of gastric diseases. Among them, the rs13874 allele of SLC25A26 showed a highly significant association with gastric diseases. In the genotype-based mRNA expression analysis, the minor allele (C) group showed increased mRNA expression and this could increase oxidative stress. In conclusion, SLC25A26 polymorphisms are associated with gastric diseases. These results may provide a basis for new guidelines for gastric disease management in the Korean population.