• Title/Summary/Keyword: 우경철

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The Effects of Cimicifuga Racemosa Extracts on the Inhibition of Catecholamine Secretion in Bovine Chromaffin Cells (부신수질 크로마핀(Chromaffin) 세포를 이용한 승마 추출무의 카테콜라민 분비 저해작용)

  • Woo, Kyung-Chul;Suh, Byung-Sun
    • Korean Journal of Pharmacognosy
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    • v.34 no.4 s.135
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    • pp.318-323
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    • 2003
  • Extracts of Black cohosh (Cimicifugae rhizoma) have been used for the treatment of climacteric complaints for decades. A significant number of woman entering menopause exhibit the following symptoms: getting hot flushes, night sweats, irritability, depression, and anxiety, A reduction of the frequency of hot flushes equivalents and hints on the antidepressant activity of Cimcifuga extracts. In the present work, we have screened several 80% ethanol extracts from medicinal plants and found that the extracts from Cimicifugae Rhizoma(Black cohosh:승마) have inhibitory effect on catecholamine secretion in bovine chromaffin cell. Since this extract inhibited 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP)-induced catecholamine secretion, but did not inhibit KCl, bradykinin, and veratridine-evoked case, this inhibitory effect is mediated by nicotinic acetylcholine receptors with noncompetitive manner.

Antioxidant and Anti-inflammatory Effects of Bletilla striata Reichenbach fil. Fractions as Cosmetic (백급(Bletilla striata Reichenbach fil.) 분획물의 항산화, 항염증 효과와 화장품소재로서의 연구)

  • Yoon, Ji-Hun;Park, Seong-Geun;Lee, Mi-Ji;Park, Jin-Young;Seo, Kyo-Seong;Woo, Kyung-Chul;Lee, Chang-Eon
    • Journal of Life Science
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    • v.23 no.9
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    • pp.1073-1078
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    • 2013
  • The antioxidant and anti-inflammatory effects of active ingredients in cosmetics are very important. The effects are closely related to the prevention of skin aging. Among medicinal plants, Bletilla striata Reichenbach fil. has well-known pharmacological activity. Extracted samples were prepared using sequential fractionation of ethyl acetate, butanol, and water. The antioxidant effect of the fractions was confirmed by DPPH and ABTS+ radical scavenging. Among the various fractions of B. striata Reichenbach fil., ethyl acetate was associated with a reduction in nitric oxide production, which was induced by LPS (lipopolysaccharide) treatment in a dose-dependent manner. In addition, the production of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2), which are upstream regulators of nitric oxide production, was also inhibited. Thus, the ethyl acetate fraction of B. striata Reichenbach fil. appears to be a potential active ingredient for use in cosmetics.

Development of a portable vibration data collection system using high precision acceleration sensors (고정밀 가속도 센서를 이용한 휴대용 진동 데이터 수집 시스템 개발)

  • Kim, Suhee;Sohn, Surgwon;Song, Wongil;Lee, Hyunjun;Woo, Kyungmin;Sohn, Hongsung;An, Gyehong
    • Proceedings of the Korea Information Processing Society Conference
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    • 2014.04a
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    • pp.252-255
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    • 2014
  • 구조적인 한계로 인해 전통적인 진동 측정 시스템의 구축이 곤란할 경우나, 고가의 데이터 수집 시스템을 사용하기가 어려운 상황에 대비하여, 언제 어디서나 용이하게 진동 데이터를 측정하기 위해 휴대용 무선 측정 시스템을 개발한다. 이 연구를 통해 개발한 시스템을 기반으로 기능들을 업그레이드하면 철로 주변의 진동 환경 평가 등을 포함한 다양한 분야에 사용될 수 있으며, 근/원거리 진동 데이터 무선 모니터링 시스템의 개발에 적용될 수 있다.

Fe-doped beta-tricalcium phosphate; crystal structure and biodegradable behavior with various heating temperature (Fe 이온 치환 beta-tricalcium phosphate의 하소 온도에 따른 미세구조 및 분해 특성)

  • Yoo, Kyung-Hyeon;Kim, Hyeonjin;Sun, Woo Gyeong;Yoon, Seog-Young
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.30 no.6
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    • pp.244-250
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    • 2020
  • β-Tricalcium phosphate (β-TCP, Ca3(PO4)2) is a kind of biodegradable calcium phosphate ceramics with chemical and mineral compositions similar to those of bone. It is a potential candidate for bone repair surgery. To improve the bioactivity and osteoinductivity of β-TCP, various ions doped calcium phosphate have been studied. Among them, Iron is a trace element and its deficiency in the human body causes various problems. In this study, we investigated the effect of Fe ions on the structural variation, degradation behavior of β-TCP. Fe-doped β-TCP powders were synthesized by the coprecipitation method, and the heat treatment temperature was set at 925 and 1100℃. The structural analysis was carried out by Rietveld refinement using the X-ray diffraction results. Fe ions existed in a different state (Fe2+ or Fe3+) with different heat treatment temperatures, and the substitution sites (Ca-(4) and Ca-(5)) also changed with temperature. The degradation rate was fastest at Fe-doped β-TCP with heated at 1100℃. The cell viability behavior was also enhanced with the substitution of Fe ions. Therefore, the substitution of Fe ion has accelerated the degradation of β-TCP and improved the biocompatibility. It could be more utilized in biomedical devices.

An Experimental Study on the Applicability of Precious Slag Ball as Vertical Drains (풍쇄전로슬래그의 연직배수재 활용성에 관한 실험적 연구)

  • Kwon, Jeong-Geun;Im, Jong-Chul;Kim, Woo-Kyoung
    • Journal of the Korean GEO-environmental Society
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    • v.12 no.3
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    • pp.37-46
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    • 2011
  • To investigate the applicability of Precious Slag Ball as the alternative material such as vertical drains, it is necessary to check the drainage effect of it in the field construction. In order to attain an successful design it is important to predict problems encountered in field construction. Accordingly, in this study the laboratory tests were executed under different conditions before applying of the field. 4 cases including Precious Slag Ball, sand+Precious Slag Ball, pack Precious Slag Ball and sand as vertical drains were conducted, and under the base of the laboratory tests the field test was executed and analyzed. By the upper results it is apposite to use Precious Slag Ball as vertical drains.

Effect of Radix Aconiti Extract on Cell Cycle Progression in HepG2 Human Hepatoma (HepG2 간암세포주기에 대한 부자 추출물의 효과)

  • Kwon Kang Beom;Kim Eun Kyung;Jeong Eun Sil;Hwang In Jin;Kim Woo Kyung;Sim Jeong Sub;Kim Kang San;Shin Byung Cheul;Song Yong Sun;Ryu Do Gon
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.2
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    • pp.427-430
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    • 2004
  • This study was to investigate the cell cycle arrest effect and its mechanism of Radix Aconiti (RA) extract in HepG2 human hepatoma cells. We used the Flow Cytometer to investigate the effects on cell cycle arrest in RA extract-treated HepG2 cells. And protein levels involved in cell cycle progression such as p53, p21, and p21 are detected by Western blotting method. RA extract induced cell cycle arrest as confirmed by increase of G0/G1 cell population, and the mechanisms were related with up-regulation of p53, p21, p27 protein expressin in HepG2 cells. These results suggest that RA may be a valuable agent for the therapeutic intervention of human hepatomas.