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The Effects of Cimicifuga Racemosa Extracts on the Inhibition of Catecholamine Secretion in Bovine Chromaffin Cells  

Woo, Kyung-Chul (School of Life and Food Science, Handong Global University)
Suh, Byung-Sun (School of Life and Food Science, Handong Global University)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.4, 2003 , pp. 318-323 More about this Journal
Abstract
Extracts of Black cohosh (Cimicifugae rhizoma) have been used for the treatment of climacteric complaints for decades. A significant number of woman entering menopause exhibit the following symptoms: getting hot flushes, night sweats, irritability, depression, and anxiety, A reduction of the frequency of hot flushes equivalents and hints on the antidepressant activity of Cimcifuga extracts. In the present work, we have screened several 80% ethanol extracts from medicinal plants and found that the extracts from Cimicifugae Rhizoma(Black cohosh:승마) have inhibitory effect on catecholamine secretion in bovine chromaffin cell. Since this extract inhibited 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP)-induced catecholamine secretion, but did not inhibit KCl, bradykinin, and veratridine-evoked case, this inhibitory effect is mediated by nicotinic acetylcholine receptors with noncompetitive manner.
Keywords
Black cohosh; Cimicifugae Rhizoma; Nicotinic acetylcholin receptor (nAChR); Catecholamine (CA); Bradykinin Receptor (BR); Voltage-sensitive calcium channels (VSCC);
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