Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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The Effects of Cimicifuga Racemosa Extracts on the Inhibition of Catecholamine Secretion in Bovine Chromaffin Cells

부신수질 크로마핀(Chromaffin) 세포를 이용한 승마 추출무의 카테콜라민 분비 저해작용

  • Woo, Kyung-Chul (School of Life and Food Science, Handong Global University) ;
  • Suh, Byung-Sun (School of Life and Food Science, Handong Global University)
  • 우경철 (한동대학교 생명식품과학부 생의학 연구실) ;
  • 서병선 (한동대학교 생명식품과학부 생의학 연구실)
  • Published : 2003.12.30
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Abstract

Extracts of Black cohosh (Cimicifugae rhizoma) have been used for the treatment of climacteric complaints for decades. A significant number of woman entering menopause exhibit the following symptoms: getting hot flushes, night sweats, irritability, depression, and anxiety, A reduction of the frequency of hot flushes equivalents and hints on the antidepressant activity of Cimcifuga extracts. In the present work, we have screened several 80% ethanol extracts from medicinal plants and found that the extracts from Cimicifugae Rhizoma(Black cohosh:승마) have inhibitory effect on catecholamine secretion in bovine chromaffin cell. Since this extract inhibited 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP)-induced catecholamine secretion, but did not inhibit KCl, bradykinin, and veratridine-evoked case, this inhibitory effect is mediated by nicotinic acetylcholine receptors with noncompetitive manner.

Keywords

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