• Journal of Gastric Cancer
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• v.9 no.4
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• pp.159-166
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• 2009

Purpose: We evaluated the efficacy and prognostic predictability of the $7^{th}$ UICC TNM classification compared to $6^{th}$ UICC TNM classification in patients with gastric cancer. Materials and Methods: Between June 1992 and December 2006, 1,633 patients with gastric cancer who had undergone gastric surgery and who had been analyzed by the $6^{th}$ UICC method were analyzed using the new $7^{th}$ UICC system. Results: Significant differences in 5-year survival rates were observed for $7^{th}$ UICC N0, N1, N2, N3a, and N3b compared to $6^{th}$ UICC. There were no significant differences in 5-year survival rates between T2 and T3. Distinct survival differences were present between stage III (IIIa, IIIb, and IIIc) and stage IV in $7^{th}$ UICC. Significant differences in 5-year survival rates were not expected for Ia versus Ib, Ib versus IIa, and IIb versus IIIa. The survival rates for the same stages were not homogeneously differentiated by $7^{th}$ UICC except for stage IV. Conclusion: The $7^{th}$ UICC classification system is not better able to predict patient survival compared to 6th UICC in patients with gastric cancer, but is better for accurate prognosis of patients with stage IV gastric cancer.

• Korean Chemical Engineering Research
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• v.55 no.3
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• pp.369-378
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• 2017

Vascular endotherial growth factor (VEGF) is a potent mitogen that stimulates vascular permeability and angiogenesis and has a potential in therapeutic applications. An industrial production method that provides high yield as well as purity is needed. Researches for various factors of mild solubilization with combination of ubiquitin fusion protein to increase solubility were carried out as well as by changing pH and denaturant concentration. Usage of pET28-a bacteral expression vector in BL21 (DE3) host cell was capable of producing approximately 14 g/L VEGF fusion protein in 20L fermentor. A purification process consisting of four chromatography steps including refolding and digestion with UBP1 resulted in mild solublization under the conditions of 2M urea and pH 10.0 due to ubiquitin fusion tag protein that increases in solubility of target protein VEGF. High yield of refolding and dimerization could be obtained between two step Ni-affinity chromatography. Multimeric and misfolded proteins and endotoxin were removed by DEAE anion exchange chromatography. Final monomers were removed from dimers by gel filtration chromatography. Characterization analysis of purified dimeric VEGF was performed using SDS-PAGE and RP-HPLC with a purity of 97%.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38B no.12
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• pp.944-953
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• 2013

Recently, a storage media is becoming smaller and storage capacity is also becoming larger than before. However, important data was leaked through a small storage media. To solve these serious problem, many security companies manufacture secure USBs with secure function, such as data encryption, user authentication, not copying data, and management system for secure USB, etc. But various attacks, such as extracting flash memory from USBs, password hacking or memory dump, and bypassing fingerprint authentication, have appeared. Therefore, security techniques related to secure USBs have to concern many threats for them. The basic components for a secure USB are secure authentication and data encryption techniques. Though existing secure USBs applied password based user authentication, it is necessary to develop more secure authentication because many threats have appeared. And encryption chipsets are used for data encryption however we also concern key managements. Therefore, this paper suggests mutual device authentication based on PUF (Physical Unclonable Function) between USBs and the authentication server and key management without storing the secret key. Moreover, secure USB is systematically managed with metadata and authentication information stored in authentication server.

• Journal of the Korea Concrete Institute
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• v.18 no.6 s.96
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• pp.819-825
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• 2006

The objective of the present study is to verify the validity of a new truss model for evaluating the contribution by arch action to shear resistance in shear-critical reinforced concrete beams. The new truss model is based on the relationship between shear and bending moment in a beam subjected to combined shear and bending. The compatibility condition of the shear deformation that deviates from Bernoulli bending plane is formulated utilizing the smeared truss idealization with an inclined compression chord. The Modified Compression Filed Theory is employed to calculate the shear deformation of the web, and the relative axial displacements of the compression and the tension chord by the shear flow are also calculated. From this shear compatibility condition in a beam, the shear contribution by the arch action is numerically decoupled. Then the validity of the model is examined by applying the model to some selected test beams in literatures. On the basis of the analytical results, the contribution by the web to shear resistance can be constant and have an excellent linear correlation with the web reinforcement ratio. The present decoupling approach may provide a simple way for the assessment of the role of each parameter or mechanism that affects the ultimate shear behavior of reinforced concrete beams.

• The Korean Journal of Ecology
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• v.22 no.3
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• pp.119-129
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• 1999

The bryophyte communities on the forest floor of the mixed coniferous and deciduous broad-leaf forest and the evergreen coniferous forest of cool temperate and subalpine zones in Mts. Taebaek, Odae and Sulak of Tabaek Range were investigated from. the numerical and phytosociological viewpoints. As a result, four bryophyte communities were recognized there, considering the species composition of vascular vegetation; A. Thuja koraiensis-Abies nephrolepis/Taxus caespitosa-Pinus pumila/Hylocomium splendens-Pleurozium schreberi community, B: Sasamorpha borealis-Abies nephrolepis/Plagiomnium cuspidatum- Aulacomnium heterostichum community, C. Abies holophylla-Abies nephrolepis/Thuidium recognitum-Trachycystis immarginata cristatus community, D. Meehania urticifolia-Abies nephrolepis/Hylocomiopsis ovicarpa-Taxiphyllum aomoriense community. Among these, the community A was distributed in higher altitudes and characterized by the species group of the holarctic elements, e.g. Hylocomium splendens, Pleurozium schreberi, Dicranum majus, etc. limited in subarctic; subalpine and arctic; alpine zones and was confirmed as synusies of the Thujo-Abietetum nephrolepidis Song 1991 and Taxo-Pinetum pumilae Song 1985 belonging the Vaccinio-Piceetea Br.-Bl. 1939. In contrast the communities B, C and D were distributed in the mixed coniferous and deciduous broad-leaf forest of lower altitudes and characterized by the elements of the cool temperate; montane zone. They were confirmed as synusies belonging to the Corylo-Quercetum mongolicae Song 1988. By the result of the numerical syntaxonomical analysis such as cluster analysis, interspecific association, PCA, the communities were largely divided into the two types. The two types coincided with the community units or the diagnostic species of the bryophyte communities of the subalpine zone and the montane zone, respectively. Also the analysis revealed that the division of the above two forest zones are justifiable. Up to date many investigator have described the coniferous forest distibuted above 1000m in Taebaek mountains as the forest vegetation of subalpine zone. However, from the results of the present study, the boundary of the mixed forest and the true subalpine coniferous forest was elucidated to be ca. 1,500 m phytosociologically. Species richness was the highest in the community A, and the other four communities showed a similar species richness.

• Journal of the Korean Electrochemical Society
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• v.19 no.1
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• pp.14-20
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• 2016

Vanadium redox flow battery (VRFB) is an energy conversion device in which charging and discharging are alternatively carried out by oxidation and reduction reactions of vanadium ions with different oxidation states. VRFB consists of electrolyte, electrode, ion-exchange membrane, etc. The role of ion-exchange membranes in VRFB separates anolyte and catholyte and provides a high conductivity to hydrogen ions. Recently much attention has been devoted to develop ideal ion-exchange membranes for VRFB. A number of developed ion-exchange membranes should be evaluated to find out ideal ion-exchange membranes for VRFB. Long-term durability test is a crucial characterization of ion-exchange membranes for commercialization, but is very time-consuming. In this study, the life time prediction protocol of ion-exchange membranes in VRFB cell tests was developed through short-term single cell performance evaluation (real total operation time, 87.5 hrs) at three different current densities. We confirmed a decrease in test time up to 96.2% of real durability tests (expected total operation time, 2,296 hrs) and 5~6% of relative error discrepancy between the predicted and the real life time in a unit cell.

• Journal of Advanced Marine Engineering and Technology
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• v.38 no.9
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• pp.1070-1074
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• 2014

According to IEEE 1662(2009), IPS is a power system where all prime movers produce electrical power that is shared among propulsion, mission, and ship service loads. Discriminating attributes of integrated power systems are flexibility of movers' arrangements, mechanical decoupling between prime movers and propulsors, an increased level of energy conversion and transmission redundancy, and flexibility of redistributing available electrical power for future electronic weapons. IPS could have various steps of power that can be produced at optimal load of movers. In this study, an evaluation method for optimal arrangement of movers was investigated when an IPS warship is projected. The two factors are utilized for the quantitative analysis which are the weight of system as the fighting power and the fuel consumption per year as the economic feasibility. And also the ways for arrangement of system were studied according to existence of small diesel generator. The evaluation method that decides the optimization level is based on the DEA(Data Envelopment Analysis)

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.880-894
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• 2010

The Grout injected precast pile is widely used in rapid-transit railway bridge recently. The existing portland cement of well used filling at injected precast method that with low strength and environmental pollution, unstable in which ground water contamination by cement flow out, ground relaxation by water down, decrease of horizontality resistance and durability and load transfer divide etc. In particular, as in rapid-transit railway bridge need to secure safety from different angle with vibration of high speed train, horizontal force when train stop and earthquake. Works of foundation construction consider to requirements of the times to coal yard green growth. Together, new green foundation method for possible economics and securing of reduce the term of works are material to developments. Therefore, we carried out study that it is using and development new concept environment - friendly filling include durability and earthquake resistance, for secure safety and minimize environment pollution. To achieve this, we carried out difference tests that new green fillings of underwater concrete, high liquidity, high viscosity, early stiffness as compared to existing portland cement fillings. As results, new green filling have outstanding application at precast pile method and micropile construction method with vertical bearing capacity, horizontal bearing capacity and many case. From now on we will be looking forward to development of new environment-friendly foundation method from various further studies.

• Journal of Dairy Science and Biotechnology
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• v.38 no.2
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• pp.70-88
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• 2020

Lactic acid bacteria (LAB) form an essential part of the intestinal microbiota of the human body and possess the ability to stabilize the intestinal microbiota, strengthen immunity, and promote digestion as well as intestinal synthesis of vitamins, amino acids, and proteins. Hence, LAB are currently widely used in various products. However, due to the indiscriminate overuse of antibiotics in humans and livestock, bacterial resistance to antibiotics has been increasing rapidly, which has led to serious problems in the treatment of bacterial infections. Additionally, several reports have revealed that antibiotic-resistant LAB may infect people whose immune systems are not fully developed or whose immune systems are temporarily weakened. Therefore, it is imperative to consider the possibility of antibiotic-resistant LAB causing diseases in humans and animals, investigate the mechanism of action between antibiotics and LAB, and determine the relevant regulations for the safe use of LAB.

• Journal of fish pathology
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• v.18 no.2
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• pp.167-178
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• 2005

Streptococcus iniae is one of the major bacterial pathogens of cultured olive flounder, Paralichthys olivaceus in Korea. This study was carried out to investigate the interaction between morphological characteristics and immune response such as phagocytosis and serum killing activity. They were differentiated phenotypically into two groups, the viscous colonies and the non-viscous colonies, but the strains in both groups were similar in physiological and biochemical characteristics. Electron microscopic examination of the viscous form revealed thick, electron-dense exopolysaccharide materials surrounding polycationic ferritin-stained cells, while the exopolysaccharide material was absent around the non-viscous form of S. iniae. The viscous type strains were disclosed more virulent than those of non-viscous type for olive flounder. The viscous strains were resistant to normal serum killing activity, while the non-viscous strains were susceptible to bactericidal activity of normal serum from olive flounder. The viscous strains were more resistant to opsonophagocytosis and decreased the chemiluminescence response of head kidney macrophages of olive flounder. All of the tested non-viscous S. iniae strains were efficiently destroyed by the macrophage after phagocytosis. Both the viscous and the non-viscous strains invaded and replicated in cultured fish cell line (CHSE-2l4). This cellular invasion may contribute to the pathogenesis of invasive S. iniae infection.