• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.4
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• pp.122-129
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• 2015

Objectives : We performed a retrospective study to verify the effects of Chungan-tang and acupuncture in acne patients.Methods : This study included patients with facial acne who visited to six branch of clinics in 2014. They were evaluated by Korean Acne Grading System (KAGS) before and after treatment.Results : The average grade of KAGS was 4.02±1.120 at before treatment and 1.30±0.867 at after treatment. 64 patients were classified as three groups by treatment period and KAGS grade significantly decreased in all groups. Six skin symptoms such as heat, blush, dryness, itch, prick, pain also significantly improved.Conclusions : This results may provide that Korean medical treatments including Chungan-tang and acupuncture have effects on improving acne.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.26 no.4
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• pp.127-134
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• 2013

Objective : Acne is very common disease, it can leave permanent scars. However, there are few reports about it in oriental medicine academia. This study performed to evaluate the effect of reconstruction of skin scars and auto microneedle therapy system on acne scars. Methods : Six patients were treated by using reconstruction of skin scars and auto microneedle therapy system. We compared the degree of treatment of acne scars on pre and post case photos and Qualitative Global Acne Scarring Grading System(QGASC). Satisfaction degree were asked from the patients. Results & Conclusion : After comparing case photos and QGASC, observing patients satisfaction, it can be considered that reconstruction of skin scars and auto microneedle therapy system to be valid acne scars treatment.

• The Korea Journal of Herbology
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• v.25 no.2
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• pp.65-70
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• 2010

Objectives : Biological activities of marine resources have been rarely evaluated compared with other herbal medicines. In the present study, we aimed to evaluate antimicrobial activities of aqueous and ethanolic extracts of five marine resources(Porphyra tenera, Laminariae Thallus, Sargassum, Ostreae Concha, Maliotidis Concha) against Propionibacterium acnes. Methods : Aqueous axtracts of five marine resources were prepared by decocting in tenfold tap water for 3 h. Etanolic extracts were obtained by extracting five marine resources with tenfold ethanol for 72 h at room temperature. The zone of growth inhibition and minimum inhibitory concentration (MIC) were determined against P. acnes after incubation for 48 h under anaerobic condition. Results : Ethanolic extracts of Porphyra tenera exhibited potent antimicrobial effects(MIC $62.5\;{\mu}g/m{\ell}$ against KCTC3320, MIC $31.25\;{\mu}g/m{\ell}$ against KCTC5527). However, all aqueous extracts tested had no effects on the growth inhibition of P. acnes. In addition, four ethanolic extracts except Porphyra tenera showed little inhibitory effect. Conclusions : These results indicate that ethanolic extracts of Porphyra tenera has antimicrobial activities against P. acnes and also warrant further development of Porphyra tenera extracts as a natural anti-acne agent.

• The Korea Journal of Herbology
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• v.25 no.2
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• pp.11-19
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• 2010

Objective : I want to examine the antimicrobial activity of Samhwangsasimtang against pseudomonas aeruginosa 38 isolated from an acne patient. Method : Antimicrobial activity was assayed through the hot water extract from Samhwangsasimtang against pseudomonas aeruginosa 38 isolated from an acne patient. Result : The size of inhibition zone of Samhwangsasimtang extract was $12.6\;{\pm}\;0.04\;mm$. The optimal pH and temperature for the growth of isolated pseudomonas aeruginosa 38 were 6.0 and $37^{\circ}C$, respectively. The minimum inhibitory concentration of Samhwangsasimtang extract was $10\;{\pm}\;0.06\;{\mu\ell}$ and the antimicrobial activity of Samhwangsasimtang extract was not destroyed by the heat ($121^{\circ}C$ for 15 min) and not affected by pH. Conclusion : Reviewing this experimental result, it appeared that Samhwangsasimtang had efficacy against pseudomonas aeruginosa 38 isolated from an acne patient.

• Clean Technology
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• v.14 no.3
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• pp.153-159
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• 2008

The solubility of triclosan, an anti-acne agent was measured in supercritical carbon dioxide ($scCO_2$) with a variable volume view cell at 313.15, 323.15, and 333.15 K and at pressures between 10 and 40 MPa. We successfully correlated triclosan solubility in $scCO_2$ using the quasi-chemical nonrandom lattice fluid (QLF) equation of state. Triclosan was micronized using the rapid expansion of supercritical solutions (RESS) process. The effects of temperature and pressure on particle size were investigated using phase behavior data and correlated results from the QLF model.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.2
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• pp.130-141
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• 2016

Objectives : This study was to performed to investigate the effect of herbal steam therapy on acne vulgaris. Methods : 6 patients with acne vulgaris were treated with korean medicine therapy (herbal medicine and acupunture) including herbal steam therapy. We evaluated the effect by Korean Acne Grading System(KAGS) and Pictures. Results : After treatment, the KAGS Grade of all patients treated with korean medicine therapy including herbal steam therapy is 1. Based on this, we could find that korean medicine therapy including herbal steam therapy is effective and available to ameliorate for the symptoms of acne vulgaris. Conclusions : This clinical cases study shows us that korean medicine therapy including herbal steam therapy seem to be effective to improve symptoms of acne vulgaris. Further studies will be needed to identify herbal steam therapy is beneficial to acne vulgaris.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.2
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• pp.106-111
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• 2016

Objective : The aim of this study is to report the effect of Hani-maehwa laser(fractional mode) treatment on acne scar. Methods : The patient with atrophic facial acne scars was treated with 5 sessions of laser therapy at 4-week intervals. The therapeutic response to treatment was assessed at 3 months after last laser session. The treatment effect was evaluated by standardized photography, anti aging, skin brightness and flatness. That was measured by micro fluorescence measurement camera(ECO SKIN, Cuvitz Inc.) in 16(left zygoma) and 26(right zygoma) spot. And side effects were also checked. Results : Atrophic facial acne scars have improved markedly. Anti aging, skin brightness and flatness were improved. Especially anti aging and flatness were noticeably improved. Adverse effects were not reported.Conclusions : Korean medicine cautery method applies to high level laser(CO₂ Hani-maehwa laser). These are different designs but same principle. It can be considered that laser therapy is effective method for treating acne scars.

• Korean Journal of Medicinal Crop Science
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• v.24 no.2
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• pp.129-135
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• 2016

Background: In this study, we investigated the antibacterial and nitric oxide (NO) production inhibitory activities of 75% ethanol extract of Prunus sargentii branches and its fractions against acne pathogens. Methods and Results: The antibacterial activity against acne causing pathogens was determined using the disc diffusion assay. The ethyl acetate fraction showed higher activities against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis than those shown by other fractions. In the DPPH radical and NO scavenging assays, the butanol fraction showed strong DPPH radical and NO scavenging abilities. These activities were related to the total polyphenol and flavonoid contents of butanol fraction. On the other hand, the chloroform and ethyl acetate fractions exhibited the highest NO production inhibitory activity in Lipopolysaccharide (LPS)-stimulated Raw 264.7 cells compared to those exhibited by other fractions. Conclusions: The extract and its ethyl acetate fraction from the branches of P. sargentii exhibited antibacterial activity and could be used as functional materials in antimicrobial related fields. Moreover, the chloroform and ethyl acetate fractions are potential antiinflammatory agents and butanol fraction acts as an effective radical scavenger.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.1
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• pp.126-135
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• 2017

Objectives : The purpose of this study was to evaluate the therapeutic efficacy of Sae-ssack(sprout) therapy on atrophic acne scars. Methods : Twenty patients had atrophic acne scars on the face were treated with Sae-ssack therapy. Sae-ssack therapy consists of a total of three treatments, a first-stage Sae-ssack acupuncture, a second-stage texture treatment, and a third-stage anti-pigmentation therapy. The evaluation of the treatment effect was made by the Korean medical doctor who did not participate in the procedure, and the PGA(Physician's Global Assessment), QGASC(Qualitative Global Acne Scarring Grade System) and patient satisfaction were used as the evaluation index. Results and Conclusions : According to the above indicates, the Sae-ssack therapy was evaluated to be effective in the repair of atrophic acne scars. There were no visible or consistent side effects and patient satisfaction was also very high.

• Korean Journal of Microbiology
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• v.53 no.2
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• pp.126-128
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• 2017

Cutibacterium acnes (formerly Propionibacterium acnes) is an anaerobic, Gram-positive rod and that is a normal flora of human skin and mucosal surface as well as an opportunistic pathogen related to acnes vulgaris, sarcoidosis, brain abscess, endocarditis, periodontitis, and endodontic infections. C. acnes KCOM 1861 (= ChDC B594) was isolated from a human jaw osteomyelitis lesion. Here, we present the complete genome sequence of C. acnes KCOM 1861.