• Journal of radiological science and technology
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• v.36 no.2
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• pp.165-173
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• 2013

This study was the estimation of the dose distribution for proton, prompt gamma rays and proton induced neutron particles, in case of exposing the proton beam to polymer gel dosimeter and water phantom. The polymer gel dosimeter was compositeness material of Gelatin, Methacrylic acid, Hydroquinone, Tetrakis and Distilled water. The density of gel dosimeter was $1.04g/cm^3$ which was similar to water. The 72, 116 and 140 MeV proton beams were used in the simulation. Proton beam interacted with the nuclei of the phantom and the nuclei in excited states emitted prompt gamma rays and proton induced neutron particles during the process of de-excitation. The proton particles, prompt gamma rays, proton induced neutron particles were detected by polymer gel dosimeter and water phantom, respectively. The gap of the axis for gel was 2 mm. The Bragg-peak for proton particles in gel dosimeter was similar to water phantom. The dose distribution for proton and prompt gamma rays in gel dosimeter and water phantom was approximately identical in case of 72, 116 and 140 MeV for proton beam. However, in case of proton induced neutron particles for 72, 116 and 140 MeV proton beam, particles were not detected in gel dosimeter, while the Water phantom absorbed neutron particles. Considering the resulting data, gel dosimeter which was developed in the normoxic state attentively detected the dose distribution for proton beam exposure except proton induced neutron particles.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2004.11a
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• pp.69-71
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• 2004

The proton therapy of radiation therapy methods using Bragg Peak which is proton beam's characteristic dose distribution can give a normal tissue lower dose than cancer, comparing with the former existing radiation therapy methods. For exact treatment and patient' safety, we need to know proton beam's position in body, but a proton beam completely stops at treatment region and proton beam's range is uncertainly made by the variety of organs having each different density, so we aren't able to find a proton beam' position by suitable methods yet. With Monte Carlo Computing Method, as a result that we had simulated prompt gamma detection system using correlation of proton beam's absorbed dose distribution about water and prompt gamma distribution by nuclear interaction occurred by collisions of proton and water's hydrogen atoms, we could confirm that a proton beam's position was able to detect by using simulated prompt gamma detection system in body on the real-time

• Progress in Medical Physics
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• v.15 no.3
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• pp.140-148
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• 2004

The absorbed dose for proton beam in water was calculated using the PTRAN code system. The proton interactions with water and the description on absorbed dose calculations are discussed, and the file structure and an execution example of the PTRAN codes are described. For 60, 100, 150, 200, and 250 MeV proton beams it is demonstrated that the absorbed dose is determined from the sum of Coulomb interactions and nuclear reactions, and that the Bragg peak feature depends On the energy straggling and multiple scattering. The PTRAN code was useful for studying the fundamental mechanism of the absorbed dose to water for clinical proton beams.

• 대한방사선방어학회:학술대회논문집
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• 2009.11a
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• pp.50-51
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• 2009

• Proceedings of the Korean Society of Medical Physics Conference
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• 2005.04a
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• pp.100-102
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• 2005

양성자 빔을 이용한 치료는 종양부위에 높은 선량을 균일하게 전달하고 정상세포에는 적은 선량을 전달할 수 있어 암치료 효과가 높으나 정확한 치료와 환자의 안전을 위해서는 양성자선량의 급락지점을 정확히 아는 것이 중요하다. 본 연구에서는 양성자와 물질과의 핵반응으로 직각방향으로 방출되는 즉발감마선을 측정하여 양성자선량 급락지점을 측정할 수 있는 검출시스템을 몬테칼로 전산코드로 전산모사하였으며, 70MeV 단일에너지 빔과 최대에너지가 70MeV인 SOBP 빔을 모의피폭체인 물팬텀에 조사하고 검출시스템을 통해 직각방향으로 방출되는 즉발감마선의 분포를 계산하였다. 모의피폭체 안에서의 양성자선량의 분포와 측정된 즉발감마선의 분포를 서로 비교하여 두 분포 사이의 상관관계를 찾고 이 상관관계를 이용하여 양성자선량 급락지점을 결정할 수 있음을 확인할 수 있었다.

• 대한방사선방어학회:학술대회논문집
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• 2011.11a
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• pp.148-149
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• 2011

• Progress in Medical Physics
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• v.26 no.1
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• pp.42-51
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• 2015

In proton therapy, verification of proton dose distribution is important to treat cancer precisely and to enhance patients' safety. To verify proton dose distribution, in a previous study, our team incorporated a vertically-aligned one-dimensional array detection system. We measured 2D prompt-gamma distribution moving the developed detection system in the longitudinal direction and verified similarity between 2D prompt-gamma distribution and 2D proton dose distribution. In the present, we have developed two-dimension prompt-gamma measurement system consisted of a 2D parallel-hole collimator, 2D array-type NaI(Tl) scintillators, and multi-anode PMT (MA-PMT) to measure 2D prompt-gamma distribution in real time. The developed measurement system was tested with $^{22}Na$ (0.511 and 1.275 MeV) and $^{137}Cs$ (0.662 MeV) gamma sources, and the energy resolutions of 0.511, 0.662 and 1.275 MeV were $10.9%{\pm}0.23p%$, $9.8%{\pm}0.18p%$ and $6.4%{\pm}0.24p%$, respectively. Further, the energy resolution of the high gamma energy (3.416 MeV) of double escape peak from Am-Be source was $11.4%{\pm}3.6p%$. To estimate the performance of the developed measurement system, we measured 2D prompt-gamma distribution generated by PMMA phantom irradiated with 45 MeV proton beam of 0.5 nA. As a result of comparing a EBT film result, 2D prompt-gamma distribution measured for $9{\times}10^9$ protons is similar to 2D proton dose distribution. In addition, the 45 MeV estimated beam range by profile distribution of 2D prompt gamma distribution was $17.0{\pm}0.4mm$ and was intimately related with the proton beam range of 17.4 mm.

• Progress in Medical Physics
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• v.23 no.3
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• pp.162-168
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• 2012

In proton therapy, in vivo dose verification is one of the most important parts to fully utilize characteristics of proton dose distribution concentrating high dose with steep gradient and guarantee the patient safety. Currently, in order to image the proton dose distribution, a prompt gamma distribution detection system, which consists of an array of multiple CsI(Tl) scintillation detectors in the vertical direction, a collimator, and a multi-channel DAQ system is under development. In the present study, the optimal design of prompt gamma distribution detection system was studied by Monte Carlo simulations using the MCNPX code. For effective measurement of high-energy prompt gammas with enough imaging resolution, the dimensions of the CsI(Tl) scintillator was determined to be $6{\times}6{\times}50mm^3$. In order to maximize the detection efficiency for prompt gammas while minimizing the contribution of background gammas generated by neutron captures, the hole size and the length of the collimator were optimized as $6{\times}6mm^2$ and 150 mm, respectively. Finally, the performance of the detection system optimized in the present study was predicted by Monte Carlo simulations for a 150 MeV proton beam. Our result shows that the detection system in the optimal dimensions can effectively measure the 2D prompt gamma distribution and determine the beam range within 1 mm errors for 150 MeV proton beam.

• Journal of the Korean Society of Radiology
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• v.15 no.6
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• pp.771-779
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• 2021

It is necessary to overlap several peaks to form spread out Bragg peak (SOBP) in order to cover the tumor volume because a mono-energetic proton beam forms a narrow Bragg peak. The tumor density has been considered as a brain tissue and then the absorbed dose of the tumor is calculated using Monte Carlo simulations. However, densities of tumors were not a constant. In this study, the SOBP of proton beams was calculated according to changing density of tumors by using Geant4. Tumors were selected as 10 mm and 20 mm width which were the treatment range in the brain phantom. The energies and relative weights of the proton beams were calculated using mathematical formula to form the SOBP suitable for the location and size of the tumor. As the density of the tumor was increased, the 95% modulation range and the practical range were decreased, and average absorbed dose in the 95% modulation range was increased. The change of the tumor density affects the dose distribution of the proton beams, which results in short SOBP within the tumor volume. The consideration of the tumor density affects the determination of the range, so that the margin of the treatment volume can be minimized, and the advantages of proton therapy can be maximized.

• Journal of radiological science and technology
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• v.40 no.4
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• pp.621-626
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• 2017

In this paper, an optical dosimetric system for radiation dose measurement is developed and characterized for 100 MeV proton beams in KOMAC(Korea Multi-Purpose Accelerator Complex). The system consists of 10 wt% Ultima GoldTM liquid organic scintillator in the ethanol, a camera lens(50 mm / f1.8), and a high sensitivity CMOS(complementary metal-oxide-semiconductor) camera (ASI120MM, ZWO Co.). The FOV(field of view) of the system is designed to be 150 mm at a distance of 2 m. This system showed sufficient linearity in the range of 1~40 Gy for the 100 MeV proton beams in KOMAC. We also successfully got the percentage depth dose and the isodose curves of the 100 MeV proton beams from the captured images. Because the solvent is not a human tissue equivalent material, we can not directly measure the absorbed dose of the human body. Through this study, we have established the optical dosimetric procedure and propose a new volume dose assessment method.