• Asia pacific journal of information systems
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• v.17 no.3
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• pp.55-78
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• 2007

Increasingly the information technology (IT) outsourcing phenomenon has been a subject of much academic research. Scholars have argued that knowledge complementarities playa crucial role in forming successful IT outsourcing relationships. However, notwithstanding the fast growth of IT outsourcing, prior studies on IT outsourcing have not included knowledge complementarities in their research design as a determining factor for IT outsourcing effectiveness. Further, the understanding of knowledge complementarities itself remains ambiguous. In this study, the concept of knowledge complementarities is explored in the IT outsourcing context at the firm level. Specifically, it addresses the following questions: what is knowledge complementarities? How does it affect IT outsourcing effectiveness? Is the relationship between knowledge complementarities and IT outsourcing effectiveness influenced by organizational trust between the client and the vendor? Grounded in the relevant theories to knowledge management and IT outsourcing, we develop a research model in which both the main effects of knowledge complementarities and organizational trust and the moderating effect of organizational trust on the relationships between knowledge complementarities and IT outsourcing effectiveness are tested. Within this research model, we develop a second order construct of knowledge complementarities, consisting of complementary business knowledge and complementary IT knowledge as the first order constructs. We have used data from a field study of 103 firms in Korea to test the proposed model. Controlling the effects of conflict resolution efforts, our empirical analysis found significant main effects of knowledge complementarities and organizational trust on IT outsourcing effectiveness. The results suggest that knowledge complementarities between the client and vendor positively contribute to IT outsourcing effectiveness. Specifically, the client needs to have enough IT knowledge to assess the quality of IT outsourcing services provided by the vendor. Meanwhile, the vendor should understand the client's business well enough to provide IT services, Contrary to our expectations, the moderating effect of trust on the relationship between knowledge complementarities and IT outsourcing effectiveness was not supported in this study. The results also show that organizational trust between client and vendor significantly influences IT outsourcing effectiveness. As for contributions of this study, we have not only clarified the concept of knowledge complementarities, but also developed an instrument to measure the concept and empirically validated it. Further, we have tested the idea that knowledge complementarities and trust directly influence IT outsourcing effectiveness and trust moderates the relationship between knowledge complementarities and IT outsourcing effectiveness. Out results prescribe the knowledge complementarities of client and vendor as a useful path to IT outsourcing effectiveness. These findings have important theoretical and practical implications, which are discussed in the paper.

• Journal of Food Hygiene and Safety
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• v.21 no.4
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• pp.269-273
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• 2006

Potassium Sorbate (PS) is a potassium salt version of sorbic acid, which has antimicrobial and fungistatic features in foods. Therefore, PS is used as a food preservative against fungi and mold. PS has been found to be non-toxic even when taken in large quantities given its trait to be broken down in the body into water and carbon dioxide. Gap Junctional Intercellular Communication (GJIC) is essential in the maintenance of tissue homeostasis during development and differentiation. This study was made of the effects of PS on GJIC in WB-F344 rat liver epithelial (WB) cells. We found dramatic decrease of cell viability in time- and dose-dependent manners when WB cells were treated with PS. The effect of PS on GJIC is strong inhibition, and it took place in parallel with a hyperphosphorylation of connexin 43 expression. The finding that PS interferes with gap junction functionality should be considered with respect to the mechanism of PS-induced hepatotoxicity.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.11
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• pp.5005-5011
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• 2011

The purpose of this work is to know the validity of a new stimulation method in cognitive functional imaging using custom-designed images correspond to words or syllables improving the shortcomings of existing method using text. From March 2011 to May five Subjects in need of language related functional MRI scanning were selected and both of text stimulating method and image stimulating method sacanning were carried out three times each. Using 3.0T Philps MRI machine and Invivo Co's Eloquence system, data acquisition was performed with EPI-BOLD technique. Post processing was performed with SPM 99 while the activated signals were determined within 95 percent confidence level.The number of activation clusters and the activation ratio inside ROI were compared. As as result, all of the subject showed activation inside Broca area but it did not have statistical significance. In conclusion, the image sitimulation method has potential because image itself is a common means of recognition and it can be recognised easily even if there language barrier. This stimulation method can be applied to replacing the exising scanning method especially in the elderly, infants, foerigners who may not fully understand about the examination.

• Journal of the Korean Applied Science and Technology
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• v.34 no.4
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• pp.769-777
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• 2017

To research the effects of marigold extract, which is used mixed with calendula extract, on collagen growth and MMP-1 expression in human fibroblast, we measured cytotoxicity, collagen growth and MMP-1 expression by using HDF cells. The result of measurement showed over 80% cell survival rate in $5{\sim}100{\mu}g/mL$ concentration of marigold extract and calendula extract for HDF cells, which indicates there is no cytotoxicity. The result of measuring collagen synthetic abilities showed both types of extract had collagen synthetic ability increase dose dependently, by 25% in $100{\mu}g/mL$ concentration of marigold extract, and by 7% in $100{\mu}g/mL$ concentration of calendula extract. The result of experimenting the effect on MMP-1 expression showed that both types of extract suppress MMP-1 expression. The result of observing phosphorylation of p-JNK and p-ERK, which are known to be involved with MMP-1 expression, revealed that marigold extract effectively suppresses MMP-1 expression through signaling pathway of p-JNK and p-ERK. The above results confirm the wrinkle improvement effect of marigold extract, and furthermore, it can be used as a cosmetic ingredient for anti-aging.

• Journal of Korean Society of Transportation
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• v.23 no.2
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• pp.107-116
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• 2005

The information on travel time in providing the information of traffic to drivers is one of the most important data to control a traffic congestion efficiently. Especially, this information is the major element of route choice of drivers, and based on the premise that it has the high degree of confidence in real situation. This study developed a vehicle arrival time prediction algorithm called as "VAT-DV" for 6 corridors in total 6.1Km of "Nam-san area trffic information system" in order to give an information of congestion to drivers using VMS, ARS, and WEB. The spatial scope of this study is 2.5km~3km sections of each corridor, but there are various situations of traffic flow in a short period because they have signalized intersections in a departure point and an arrival point of each corridor, so they have almost characteristics of interrupted and uninterrupted traffic flow. The algorithm uses the information on a demand volume and a queue length. The demand volume is estimated from density of each points based on the Greenburg model, and the queue length is from the density and speed of each point. In order to settle the variation of the unit time, the result of this algorithm is strategically regulated by importing the AVI(Automatic Vehicle Identification), one of the number plate matching methods. In this study, the AVI travel time information is composed by Hybrid Model in order to use it as the basic parameter to make one travel time in a day using ILD to classify the characteristics of the traffic flow along the queue length. According to the result of this study, in congestion situation, this algorithm has about more than 84% degree of accuracy. Specially, the result of providing the information of "Nam-san area traffic information system" shows that 72.6% of drivers are available.

• Geophysics and Geophysical Exploration
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• v.19 no.4
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• pp.220-227
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• 2016

Marine seismic data have not only primary signals from subsurface but also ghost signals reflected from the sea surface. The ghost decreases temporal resolution of seismic data because it attenuates specific frequency components. For eliminating the ghost signals effectively, the exact ghost delaytimes and reflection coefficients are required. Because of undulation of the sea surface and vertical movements of airguns and streamers, the ghost delaytime varies spatially and randomly while acquiring seismic data. The reflection coefficient is a function of frequency, incidence angle of plane-wave and the sea state. In order to estimate the proper ghost delaytimes considering these characteristics, we compared the ghost delaytimes estimated with L-1 norm, L-2 norm and kurtosis of the deghosted trace and its autocorrelation on synthetic data. L-1 norm of autocorrelation showed a minimal error and the reflection coefficient was calculated using Kirchhoff approximation equation which can handle the effect of wave height. We applied the estimated ghost delaytimes and the calculated reflection coefficients to remove the source and receiver ghost effects. By removing ghost signals, we reconstructed the frequency components attenuated near the notch frequency and produced the migrated stack section with enhanced temporal resolution.

• Food Science and Preservation
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• v.14 no.2
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• pp.136-141
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• 2007

The effects of various concentrations (0.01% 0.02% both v/v) of a Turmeric (Curcuma aromatica Salab.) ethanol extract (CE) on the shelf life of tofu were investigated during tofu storage for 12 d at $25^{\circ}C$. The total number of bacteria in tofu containing 0.02% CE was ca. 100 1,000-fold lower than that of the control after this period Tofu containing CE had a lower pH then did control curd, but was higherin titratable acidity, during the storage period. Measurement of hardness, cohesiveness, and springiness of tofu containing CE were higher than those of control during storage. Each of these parameters of texture value improved (increased) with an increase in the concentration of CE in tofu The degree of whiteness of tofu did not differ between samples with or without CE. The yellowness of tofu increased after addition of CE. The overall acceptability of tofu containing CE was lower than that of control.

• Food Science and Preservation
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• v.17 no.5
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• pp.637-643
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• 2010

We investigated the characteristics of breads containing Schizandra chinensis Baillon (SCB) added as whole powder, as a powder prepared from juice, and as a concentrate prepared from a 95% (v/v) ethanolic fruit extract, added to wheat flour at 0.5% (w/w). Addition of any form of SCB lowered the pH and increased the titratable acidity in both doughs and breads compared with control values, and the whole and juice powders were more effective in this respect than was the concentrated ethanolic extract. Dough volume during fermentation was increased by addition of whole powder and concentrated ethanolic extract, but no baking loss was evident upon addition of any form of SCB. Regarding the bread surface, the lightness (L) value was increased by addition of juice powder and concentrated ethanolic extract, but neither the redness(a) and nor the yellowness (b) values showed such increases. Internal color measurements showed increased '-a-' value upon addition of any form of SCB, and increased '-b-' value when concentrated ethanolic extract was used, however, there were no significant changes in L value. Sensory evaluation of taste, flavor, color, and overall acceptability showed that bread prepared using whole powder was more acceptable than were the other forms.

• Journal of Life Science
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• v.29 no.4
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• pp.499-508
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• 2019

Cancer stem cells (CSCs), which are primarily responsible for metastasis and recurrence, have self-renewal, differentiation, therapeutic resistance, and tumor formation abilities. Numerous studies have demonstrated the signaling pathways essential for the acquisition and maintenance of CSC characteristics, such as WNT/${\beta}$-catenin, Hedgehog, Notch, B lymphoma Mo-MLV insertion region 1 homolog (BMI1), Bone morphogenetic protein (BMP), and TGF-${\beta}$ signals. However, few therapeutic strategies have been developed that can selectively eliminate CSCs. Recently, neutralizing antibodies against Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and Programmed cell death protein 1 (PD-1)/Programmed death-ligand 1 (PD-L1), immune checkpoint inhibitors (ICIs), have shown promising outcomes in clinical trials of melanoma, lung cancer, and pancreatic cancer, as well as in hematologic malignancies. ICIs are considered to outperform conventional anticancer drugs by maintaining long-lasting anti-cancer effects, with less severe side effects. Several studies reported that ICIs successfully blocked CSC properties in head and neck squamous carcinomas, melanomas, and breast cancer. Together, these findings suggest that novel and effective anticancer therapeutic modalities using ICIs for selective elimination of CSCs may be developed in the near future. In this review, we highlight the origin and characteristics of CSCs, together with critical signaling pathways. We also describe progress in ICI-mediated anticancer treatment to date and present perspectives on the development of CSC-targeting ICIs.

• Korean Journal of Remote Sensing
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• v.34 no.6_4
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• pp.1489-1501
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• 2018

In 2016 Kumamoto, Japan, the foreshocks of $M_j$ 6.5 and 6.4, mainshock of $M_j$ 7.3 besides more than 2,000 aftershocks occurred in succession. Large surface deformation occurred due to this serial earthquakes and three-dimensional measurements of the deformation have been presented for the study of fault structures (Baek, 2017). The 3d measurements retrieved from two ascending pairs (20160211_20160602, 20151119_20160616) and a descending pair (20160307_20160418) acquired from ALOS PALSAR-2. In order to avoid mixing ionospheric error components on along-track surface deformation, the descending multiple-aperture interferogram, which do not contain the deformation of aftershocks after 20160418, was utilized. For these reason, there was a temporal discrepancy of about 2 months in extracting the north-south deformation. In this study, we applied a directional filter based ionospheric correction to ascending multiple-aperture interferograms, in order to reduce this discrepancy and understand more accurate fault movements. As a result of the ionospheric correction, an additional displacement signal was observed nearby fault lines. The root-mean-squared errors compared to GPS were about 9.87, 8.13 cm respectively. These results show improvements of 4.8 and 6.4 times after ionospheric correction. We expected that these along-track measurements would be used to decide more accurate movements of faults related to the 2016 Kumamoto Earthquake.