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The Associated Factors with Xerostomia in Patients with Systemic Diseases (일부 전신질환자에서 구강건조증의 관련요인 분석)

  • Kim, Sun-Ju;Choi, Jun-Seon
    • Journal of dental hygiene science
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    • v.13 no.4
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    • pp.386-392
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    • 2013
  • The purpose of this study was to evaluate the factors related to xerostomia in patients with systemic diseases, and the results were analyzed through t-test, ANOVA, and multiple linear regression analysis. There were 62 respondents (56.9%) who reported dry mouth and the season of the most severe dry mouth was reported to be the highest during winter. According to the analysis made in the relationship of xerostomia with the awareness of general health and health behavior, the group that understood their own health poorly, had more than two kinds of diseases, and had been administered more than two kinds of daily medication showed higher xerostomia. Also, those who experienced desperation, had high dryness in other parts of the body, and heavy snoring were more aware of xerostomia (p<0.05). According to the analysis made in the relationship between xerostomia and awareness of oral health state, the group that understood their oral health poorly and had pain in the oral mucous membrane and halitosis was more aware of xerostomia (p<0.05). According to the analysis made in the relationship between quality of life and xerostomia, the group that showed high level of problem in daily living and stress and were self-conscious and felt tense due to halitosis reported more xerostomia (p<0.05). Finally, xerostomia was most correlated with consciousness of the eyes of others due to halitosis followed by the number of transferred systemic diseases and stress level. Based on such results, xerostomia was understood to be an obstacle in maintaining favorable social life and health. Since xerostomia was shown to be related to the number of transferred systemic diseases, the dental professions are asked to further improve their understanding not only on oral health but also systemic diseases. Therefore, these efforts are expected to prevent xerostomia and reduce various complications caused by xerostomia.

A Case of Late-onset Episodic Myopathic Form with Intermittent Rhabdomyolysis of Very-long-chain acyl-coenzyme A Dehydrogenase (VLCAD) Deficiency Diagnosed by Multigene Panel Sequencing (유전자패널 시퀀싱으로 진단된 성인형 very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) 결핍증 증례)

  • Sohn, Young Bae;Ahn, Sunhyun;Jang, Ja-Hyun;Lee, Sae-Mi
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.19 no.1
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    • pp.20-25
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    • 2019
  • Very-long-chain acyl-CoA dehydrogenase (VLCAD) deficiency (OMIM#201475) is an autosomal recessively inherited metabolic disorder of mitochondrial long-chain fatty acid oxidation. The clinical features of VLCAD deficiency is classified by three clinical forms according to the severity. Here, we report a case of later-onset episodic myopathic form of VLCAD deficiency whose diagnosis was confirmed by plasma acylcarnitine analysis and" multigene panel multigene panel sequencing. A 34-year old female patient visited genetics clinic for genetic evaluation for history of recurrent myopathy with intermittent rhabdomyolysis. She suffered first episode of rhabdomyolysis with acute renal failure requiring hemodialysis at twelve years old. After then, she suffered several times of recurrent rhabdomyolysis provoked by prolonged exercise or fasting. Physical and neurologic exam was normal. Serum AST/ALT and creatinine kinase (CK) levels were mildly elevated. However, according to her previous medical records, her AST/ALT, CK were highly elevated when she had rhabdomyolysis. In suspicion of fatty acid oxidation disorder, multigene panel sequencing and plasma acylcarnitine analysis were performed in non-fasting, asymptomatic condition for the differential diagnosis. Plasma acylcarnitine analysis revealed elevated levels of C14:1 ($1.453{\mu}mol/L$; reference, 0.044-0.285), and C14:2 ($0.323{\mu}mol/L$; 0.032-0.301) and upper normal level of C14 ($0.841{\mu}mol/L$; 0.065 -0.920). Two heterozygous mutation in ACADVL were detected by multigene panel sequencing and confirmed by Sanger sequencing: c.[1202G>A(;) 1349G>A] (p.[(Ser 401Asn)(;)(Arg450His)]). Diagnosis of VLCAD deficiency was confirmed and frequent meal with low-fat diet was educated for preventing acute metabolic derangement. Fatty acid oxidation disorders have diagnostic challenges due to their intermittent clinical and laboratorial presentations, especially in milder late-onset forms. We suggest that multigene panel sequencing could be a useful diagnostic tool for the genetically and clinically heterogeneous fatty acid oxidation disorders.

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Clinical Outcomes of Ultrasound-Guided Transmeniscal Injection in Medial Compartment Knee Osteoarthritis (무릎 내측 구획 골관절염에서 초음파 유도하 경 반월상 연골 주사의 임상적 효과)

  • Jung, Eui Yub;Wang, Joon Ho;Lee, Eui-Sub;Lee, Sung-Sahn;So, Sang-Yeon
    • Journal of the Korean Orthopaedic Association
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    • v.55 no.5
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    • pp.418-425
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    • 2020
  • Purpose: The purpose of this study was to introduce the ultrasound-guided transmeniscal injection in medial compartment knee osteoarthritis and analyze the clinical outcomes. Materials and Methods: The electronic medical records of 36 patients with medial compartment knee osteoarthritis who were treated with an ultrasound-guided transmeniscal injection from March 2019 to July 2019 were accessed for this retrospective review. Using an ultrasound guided spinal needle, the patients received an intra-articular steroid injection at the medial compartment of the knee. A physical examination was conducted at the initial visit (pre-injection), and at one week, four weeks, and eight weeks after the injection. The numeric pain rating scale (NRS), Lequesne index, and Western Ontario and McMaster Universities Osteoarthritis (WOMAC) score were measured at each visit and analyzed over time. The percentage change of the patients who revealed substantial improvement was analyzed. The NRS, Lequesne index, and percentage of patients, who revealed substantial improvement over time classified by osteoarthritis grade, were analyzed. Results: The NRS and Lequesne index decreased at one week, four weeks, and eight weeks after the injection compared to the initial baseline, and the pain-relief effect continued without change until eight weeks. The percentage of patients who showed substantial improvement at one, four, and eight weeks was 50.0%, 47.2%, and 52.8%, respectively. The WOMAC scores decreased at one, four, and eight weeks compared to the initial baseline, and the decrease was continued without any difference until eight weeks. The percentage of patients with osteoarthritis stage 1 or 2 who revealed more than substantial improvement was significantly higher at one, four, and eight weeks than those with osteoarthritis stages 3 or 4 (p<0.05). Conclusion: In patients with medial compartment knee osteoarthritis, the pain reduction and functional improvement persisted for at least eight weeks after the ultrasound-guided transmeniscal injection at the medial compartment. In particular, patients with medial compartment osteoarthritis stage 1 or 2 showed more effective pain reduction.

Measurement of Rn-222 Gas Concentration of Newly Constructed Apartment House in Gwangju Gwangsan-Gu (광주광역시 광산구 소재 신축 아파트 라돈가스 농도 계측)

  • Jang, Hee jun;Lee, Sang bock
    • Journal of the Korean Society of Radiology
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    • v.9 no.4
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    • pp.257-261
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    • 2015
  • Radon is produced after the Uranium-238 and thorium-232 undergone radioactive decay process is a colorless, odorless inert gas is stored in a basement or an enclosed space. Building materials are made by a rock or soil materials. Form of radon gas is introduced into the lungs through the respiratory tract and deposited in the lungs or bronchial Daughter nuclides radon causes lung cancer. In this study, To subject the Constructed Apartment in Gwangju Gwangsan-Gu, the position is closed window and opened window was measured using a measuring instrument for radon. The measured results indicate that the measurement was carried out in concentrations of radon gas measured at Newly Constructed Apartment is low than United states in the radon concentration in air public 4 pCi called radon gas baseline maximum allowable concentrations. The exposure caused by radon concentration of new construction apartment when on the measurement results is expected to be insignificant. However, when radon gas like this is that it accumulates in the body and lungs get damaged due to exposure, such as lung cancer often open the windows to reduce the radon concentration measurements, such as in radiation protection aspects to the ventilation to reduce exposure it is considered necessary.

Combination Therapy with Ciclosporine, Ketoconazole and 0.1% Tacrolimus Ointment for Fast Reduction of Perianal Fistulae Lesions in Three Military Working Dogs (싸이클로스포린, 케토코나졸, 0.1% 타크로리무스 연고제제로 병용 치료한 군 사역견의 항문주위 누공 3례)

  • Seo, Kyoung-Won;Ahn, Jin-Ok;Coh, Ye-Rin;Park, Chong-Woo;Chae, Ji-Sang;Hwang, Cheol-Yong;Youn, Hwa-Young
    • Journal of Veterinary Clinics
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    • v.27 no.6
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    • pp.746-750
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    • 2010
  • Three military working dogs (MWDs) were diagnosed with perianal fistulae after a complete physical examination and rectal palpation. The initial treatment protocol was used with short-term oral ciclosporine (CyA) and ketoconazole and 0.1% topical tacrolimus ointment. When lesions were nearly healed, treatment was continued with 0.1% tacrolimus ointment only at a lower frequency. The lesions improved significantly within 2-8 weeks with no noticeable side effects. Complete recovery was determined at weeks 13, 6, and 4 for cases 1, 2, and 3, respectively. This combination protocol was effective at resolving or reducing perianal fistulae (PAF) lesions even communicating with anal sacs in three dogs. The major benefit of this protocol was the rapid reduction of fistulae lesions and this could be helpful to extend the pain-free period. Moreover, this protocol appeared cost-saving as well as time-saving option for PAF dogs.

A study on computer based work by human based on evolutionary biology (진화생물학을 기초로 한 인간의 컴퓨터기반 작업에 관한 연구)

  • Lee, Ook;Choi, Jung-Woon;Choi, Bo-Yoen
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.7
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    • pp.283-304
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    • 2018
  • mankind has evolved to stand upright a million years ago. However entering an industrial society, much has changed in only a few decades. Human beings spend more time sitting down and working, which negatively affects their bodies. Leading medical studies have shown that the prolonged working conditions have significantly affected the causes of adult illnesses that we have known. Human beings have evolved in a moving direction. So, like modern societies, sitting or standing in one space for long periods of time without movement brings various side effects to the body. Reflecting this background, this study has led to think of work in an environment that is taking the evolutionary biology perspective from a traditional standing, standing work environment. They also plan to conduct an experiment to handle work with smartphones in the hopes of expanding their mobile office environment to use smartphones in the field, which is a type of smart work. The study could help build and establish a mobile office environment, a type of smart work. In addition to using smartphones, a working environment can be created that works by moving around. Furthermore, the paradigm of the work environment of businesses and students could be changed.

Self-care Status of the Aged Diabetic Patients with Noncompliance (일개 종합병원에서의 치료 미순응 노인 당뇨병 환자의 자가관리 실태)

  • Kim, So-Mi;Hwang, Tae-Yoon;Nah, Min-Ah;Lee, Kyeong-Soo;Yeom, Seog-Heon
    • Journal of agricultural medicine and community health
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    • v.42 no.4
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    • pp.226-233
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    • 2017
  • Objective: The purpose of this study was to describe and understand self-care status of the aged diabetic patients with noncompliance after hospital discharge. Methods: A qualitative research method was used for the study design. The participants were 15 diabetic patients aged 65 or older who had been admitted more than two times for hyperglycemia in the past 1 year in a general hospital in Daegu. Data were collected from November 1 2015 to March 1 2016 through in-depth personal interview. Results: Patients' knowledge level on causes and symptoms of diabetes was low. Most participants rarely and irregularly checked blood sugar at home. They were under a lot of stress from their family. Due to old age and illness they did not have sufficient physical activity and they have had rarely regular meals. They considered the self-care education program unnecessary and there was limitations of accessibility for education. Conclusions: The aged diabetic patients who had the repeat admission did not perform self-care activities properly and had problems especially in blood glucose check, support from their family, and health education after returning home. More personalized and community-based self-management education programs will be necessary.

A Study on Accident of the Residents in Rural Area (농촌주민의 사고양상에 대한 조사)

  • Nam, Bock-Dong;Lee, Sung-Kook;Kang, Pock-Soo
    • Journal of agricultural medicine and community health
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    • v.8 no.1
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    • pp.12-18
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    • 1983
  • This study was carried out in identify the accidents of the residents in the rural community for a year from January to December in 1980 in the area of Bugae Myun, Gunwee Gun, Kyungpook province in Korea. The annual incidence was 3.9% and there was significant difference between sexes(p < 0.01) ; 5.5% in male, 2.3% in female. The age group of 50-59 showed the highest incidence as 5.7%. In summer the incidence was the highest as 37.5% and in winter, the lowest as 18.7%. Farming tool was the most frequent cause of accident as 44.3% and followed by insecticide and bite of snake and dog, etc. Hands and fingers were the most frequent injured parts as 33.0% and upper extremities(40.3%) were twice as high as the lower ones(20.5%). By kinds of injuries, laceration was highest as 33.0% and followed by contusion(24.4%) and abrasion(15.9%). Average duration of treatment was 6.1 days and most of the cases(85.2%) were within 10 days. Average duration of labor loss was 8 days and 84.6% of the total were less than 10 days. Twenty-six cases had some parts of their bodies lost due to accidents and five cases died from drownina and poisoning.

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Energy Saving Effects of Underground Rock Storage System for Heating of Greenhouse (자갈축열 태양열 온실의 난방에너지 절감효과)

  • 이석건;이종원;이현우;김길동
    • Proceedings of the Korean Society for Bio-Environment Control Conference
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    • 2001.04b
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    • pp.29-30
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    • 2001
  • 자연에너지원중 태양에너지를 이용한 자갈축열 태양열 온실의 난방에너지 절감효과를 분석하기 위하여 야간에 내부설정온도를 18℃로 했을 때의 자갈축열 태양열 온실과 동일한 제원의 대조온실의 난방연료소비량을 비교하였다. 자갈축열 태양열 온실의 경우 난방초기에는 연료가 대조온실에 비해 약 10%정도 더 소모되었으나 2일이 경과한 후에는 점차 난방연료소비량이 감소하였다(Fig. 2) 이러한 결과는 자갈축열 태양열 온실의 경우 주간에 온실에 투여되는 일사에 의해 축열이 이루어 질뿐만 아니라 야간에 난방을 할 경우에도 축열층의 온도가 설정온도에 도달할 때까지 축열이 이루지기 때문인 것으로 분석되었다 (Fig. 1). 3월 10일부터 3월 15일까지 6일간의 난방연료소비량이 대조온실은 167℃였으나, 자갈축열 태양열 온실은 109℃로써 대조온실에 비해 약 35%정도 난방연료 절감효과가 있는 것으로 분석되었다(Fig. 2). 6일간의 난방 후 자갈축열 태양열 온실에 난방을 중단한 결과 온실외부의 최저기온이 -2.4℃일 때 자갈축열 태양열 온실의 내부최저온도는 14℃를 유지하였으며, 이후 계속 난방을 수행하지 않은 상태에서도 주간에 축열효과로 인하여 최저외기온이 3℃전후일 때 자갈축열 태양열 온실의 내부온도는 15℃를 유지하였으나 대조온실은 5℃ 전후였다. 그리고, 일기온차가 심한 3월말에는 야간설정온도가 18℃인 경우에 자갈축열 태양열 온실의 난방연료소비량이 대조온실에 비해 월등히 적음을 알 수 있었다(Fig. 1, 2). 3월에 자갈축열 태양열 온실의 난방연료소비량은 대조온실에 비해 약 50%이상의 절감효과가 있는 것으로 나타났다./TEX>3.1cm, 2cm$\times$4.2cm 순으로 나타났다. 5. 저고리의 옆길이 곡선에 대한 평가는 진종의 중심인 겨드랑이가 5cm인 것이 가장 우수한 것으로 나타났으며, 그 다음으로 4cm, 6cm, 3cm 순으로 나타났다. 6. 이에 위의 항목들을 종합하여 제작한 연구저고리는 등길이가 28cm, 어깨선 위치는 1.75cm, 깃크기는 5cm$\times$21.5cm, 소매통 크기는 3cm$\times$4.3cm, 옆길이 곡선은 5cm로써 그 형태에 따른 신체적합성에 대한 외관 관능검사 결과로 3.83의 평균값으로 나타났고, 심미성에 대한 외관 관능검사를 항목별 평균치 값으로 종합하면 4.00의 값으로 나타났다. 또한 각 부위별 동작적합성 관능검사는 7가지 동작을 부위별 항목 평균치 결과 3.95의 유수한 저고리로 평가되었다. 본 연구 실험 결과 앞으로도 전통 저고리를 피복함에 있어 외관과 동작적합성이 좋은 저고리를 만들기 위해 지속적 연구가 요청된다. turned back than the Korean women's. Based on the above findings, a torso prototype was developed for the Chinese women by setting the body measurements in reference with their average body measurements plus minimum reserve. The reference lines were set for front/back central line, front/

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Dehydration Risk from Age, BMI, and Disease Exposure (연령, BMI, 질병노출로 인한 탈수 위험)

  • Kim, Sun-Hee;Chun, Sung-Soo;Choi, Myung-Sup;Yun, Mi-Eun
    • Korean Public Health Research
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    • v.44 no.4
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    • pp.35-49
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    • 2018
  • Objective : The purpose of this study was to investigate the risk factors of dehydration from the subjects who underwent anthropometric and blood parameters testing during a comprehensive health screening. Methods : For the study analysis, 5,391 samples with valid data of the levels of Sodium($Na^+$), BUN (Blood Urea Nitrogen) and FBS(Fasting Blood Sugar) were selected to calculate a dehydration indicator of plasma osmolality. The study data was collected from the health screening examinees who visited Sahmyook Medical Center Seoul Adventist Hospital Comprehensive Health Check-up Center from 2014.01.01 to 2015.12.31. The relationship between dehydration and age group, BMI, disease exposures(hypertension, diabetes mellitus, dyslipidemia, kidney disorder) were analyzed by gender. Results : The odds ratio of dehydration showed statistical significance from age ${\geq}50$ in both male and female, respectively. The female obese group was vulnerable to dehydration while the male study group showed no statistical significance in the BMI difference. The disease exposed groups(hypertension, diabetes mellitus, dyslipidemia, kidney disorder) were vulnerable to dehydration. Also, the more types of disease carried by the exposed patients, the higher odds ratio and susceptibility to dehydration. Conclusions : Aging, increasing BMI, and exposed to diseases were found to be the risk factors for vulnerability to dehydration. To prevent dehydration, special caution to be taken for those in the ${\geq}50s$ group, along with controlling BMI and chronic diseases. Further studies are suggested to investigate the risk factors of dehydration that may affect increasing plasma osmolality as a potential stimulus mechanism in disease outbreaks.