Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Combination Therapy with Ciclosporine, Ketoconazole and 0.1% Tacrolimus Ointment for Fast Reduction of Perianal Fistulae Lesions in Three Military Working Dogs

싸이클로스포린, 케토코나졸, 0.1% 타크로리무스 연고제제로 병용 치료한 군 사역견의 항문주위 누공 3례

  • Seo, Kyoung-Won (College of Veterinary Medicine, Seoul National University) ;
  • Ahn, Jin-Ok (College of Veterinary Medicine, Seoul National University) ;
  • Coh, Ye-Rin (College of Veterinary Medicine, Seoul National University) ;
  • Park, Chong-Woo (College of Veterinary Medicine, Seoul National University) ;
  • Chae, Ji-Sang (College of Veterinary Medicine, Seoul National University) ;
  • Hwang, Cheol-Yong (College of Veterinary Medicine, Seoul National University) ;
  • Youn, Hwa-Young (College of Veterinary Medicine, Seoul National University)
  • Accepted : 2010.12.07
  • Published : 2010.12.31
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Abstract

Three military working dogs (MWDs) were diagnosed with perianal fistulae after a complete physical examination and rectal palpation. The initial treatment protocol was used with short-term oral ciclosporine (CyA) and ketoconazole and 0.1% topical tacrolimus ointment. When lesions were nearly healed, treatment was continued with 0.1% tacrolimus ointment only at a lower frequency. The lesions improved significantly within 2-8 weeks with no noticeable side effects. Complete recovery was determined at weeks 13, 6, and 4 for cases 1, 2, and 3, respectively. This combination protocol was effective at resolving or reducing perianal fistulae (PAF) lesions even communicating with anal sacs in three dogs. The major benefit of this protocol was the rapid reduction of fistulae lesions and this could be helpful to extend the pain-free period. Moreover, this protocol appeared cost-saving as well as time-saving option for PAF dogs.

세 마리의 군 사역견이 신체검사와 직장 검사 등을 통해 항문주위 누공으로 진단되었다. 초기 치료는 단기간의 싸이클로스포린과 케토코나졸과 0.1%의 타크로리무스 연고제제로 시작하였다. 병변이 거의 다 치료가 되었을 시점부터 0.1% 타크로리무스 연고제제를 도포 횟수를 줄여서 실시하였다. 세 마리 모두에서 병변은 2-8주 사이에 별다른 부작용을 동반하지 않고 거의 대부분 사라졌으며, 완치는 증례 1, 2, 3에서 각 13, 6, 4주에 이루어졌다. 이 세가지 약물의 병용 프로토콜은 항문낭과도 연결된 항문주위 누공에서도 병변을 해소하는데 효과적이었으며, 특히 초기에 빠른 병변의 해소에 도움이 되어 병변으로부터 발생되는 고통을 경감시켜주는 기간이 늘어나는 것이 강점이라고 할 수 있다. 또한 시간적인 측면 외에도 경제적인 측면에서도 도움이 되므로 개에서 발생하는 항문주위 누공에 효과적인 치료 프로토콜로 유용하게 사용될 수 있을 것으로 사료된다.

Keywords

References

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