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Effect of Bee Venom Death Receptor Dependent Apoptosis and JAK2/STAT3 Pathway in the Ovarian Cancer (난소암에서 봉독이 세포자멸사와 JAK2/STAT3 Pathway의 억제에 미치는 영향)

  • Ahn, Byeong-Joon;Song, Ho-Sueb
    • Journal of Acupuncture Research
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    • v.29 no.1
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    • pp.47-59
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    • 2012
  • 목적 : 이 연구는 봉독이 사람의 난소암 세포인 SKOV3와 PA-1에서 death receptor의 발현을 높여 세포자멸사를 촉진함으로써 암세포의 성장을 억제하는지 밝히고자 하였다. 방법 : 난소암의 세포자멸사의 관찰에는 DAPI, TUNEL staining assay를 시행하였으며, 세포자멸사 조절 단백질의 변동 관찰에는 western blot analysis를 시행하였고, 난소암 세포에서 death receptor의 변화를 관찰하기 위해 RT-PCR analysis를 시행하였다. 결과 : 1. DAPI, TUNEL staining assay 결과, 봉독은 투여량에 따라 세포자멸사의 유도를 통해 SKOV3와 PA-1 난소암세포의 증식을 억제하였고, 세포자멸사와 동반하여 DR4와 DR6의 발현이 두 암세포 모두에서 증가하였고, DR3의 출현은 PA-1 세포에서 증가하였다. 2. Death Receptor의 발현 증가에 따라 caspase-3, 8, 9 and Bax를 포함하는 세포자멸사 촉진 단백질의 발현이 동반하여 상승하였고 JAK2, STAT3의 인산화와 Bcl-2의 발현은 억제되었다. 3. siRNA 처리 시 봉독에 의한 DR3, DR4, DR6 발현증가와 STAT3의 활성억제가 역전되었다. 결론 : 이러한 결과는 봉독이 난소암 세포에서 DR3, DR4, DR6의 증가와 JAK2/STAT3 pathway의 억제를 통하여 세포자멸사를 유발한다는 것을 시사하며, 난소암의 예방과 치료에 효과적으로 활용될 수 있을 것으로 기대된다.

Autonomous Vehicle Tracking Using Two TDNN Neural Networks (뉴럴네트워크를 이용한 무인 전방차량 추적방법)

  • Lee, Hee-Man
    • The Transactions of the Korea Information Processing Society
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    • v.3 no.5
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    • pp.1037-1045
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    • 1996
  • In this paper, the parallel model for stereo camera is employed to find the heralding angle and the distance between a leading vehicle and the following vehicle, BART(Binocular Autonomous Research Team vehicle). Two TDNNs (Time Delay Neural Network) such as S-TDNN and A-TDNN are introduced to control BART. S-TDNN controls the speed of the following vehicle while A-TDNN controls the steering angle of BATR. A human drives BART to collect data which are used for training the said neural networks. The trained networks performed the vehicle tracking function satisfactorily under the same driving conditions performed by the human driver. The neural network approach has good portability which decreases costs and saves development time for the different types of vehicles.

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지식 $365^+$: 평가원 리포트1 - 돼지 작업방법(박피.탕박)별 두수와 경락가격 추이

  • Kim, Hyo-Seon
    • KAPE Magazine
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    • s.190
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    • pp.6-9
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    • 2012
  • $\blacktriangleright$ 돼지도체 등급판정두수 중 박피도체가 차지하는 비율은 매년 감소하여 '12년 4월말 기준 3.9%임. - 박피 작업장수 및 도매시장 상장두수 감소 $\blacktriangleright$ 돼지도체 등급판정두수 중 상장두수는 매년 감소하여 '12년 4월 현재 9.1%임. - 돼지도체 유통물량 중 9.1%가 전체 돼지도체 거래가격이 결정되는 구조 $\blacktriangleright$ 도매시장 상장두수 중 박피는 '00년 70.0%(2,136천 두)에서 '10년 40.4% (652천 두)로 29.6%P(1,484)가 감소하였으며, '12년 4월 현재 29.8%임. - 탕박 상장두수는 1,200천두 이상까지 증가한 적도 있지만 '10년까지 900천두 이상 수준을 유지하였음 $\blacktriangleright$ 도매시장 상장물량과 일반작업장 물량의 등급별 출현율 비교시 일반작업장물량의 상위등급 출현율이 높음. $\blacktriangleright$ 돼지도체 kg당 경락가격이 3,000원대 이상이 형성된 '04년 이후 박피 탕박간 경락가격 차이는 269~341원/kg로 분석되었음. $\blacktriangleright$ 박피 작업두수(비율) 및 상장 경매물량 감소에 따른 박피 상장 경매물량 변화에 따라 가격 민감성이 커짐. - 탕박은 박피보다 상장물량이 2배 이상이고 상장물량 변화에 따른 가격 민감성이 작아 박피와 탕박의 경락가격의 변동(상승 하락)폭의 차이가 발생하여 박피와 탕박간의 가격 역전현상이 발생.

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Failure Detection of Motors using Artifical Neural Networks (신경회로망을 이용한 전동기의 고장 부분 탐지)

  • 이권현;강희조
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.17 no.1
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    • pp.47-57
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    • 1992
  • Subject of this work is the application of neural networks for the signal(motor noise)recognition systems which detects motor failures and employs different signal(noise). Charaoteristics that re-sult from damaghe part and measure of motor construction during working. The four layers neural networks is applied to this examination. And consists of one input layer, two hidden layers, and one output layer, and learns by the back propagation algorithm.The results of this examination show that it the construction and the output power of the testmotor and learning motor are compatible, the damaged part of the testmotor are detected correctly in the system on the other hand, if the motors have different constrcotion but similar output power each other, mislesding results are obtained in this system.

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The Purification of Decontamination Liquid Waste by Electrosorption (전기적 흡 . 탕착에 의한 제염폐액의 정화처리기술)

  • 정종헌;문제권;김규남;이성호;이상문
    • Resources Recycling
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    • v.8 no.3
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    • pp.18-25
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    • 1999
  • The study on the electrosorption of cobalt ions onto a porous activated carbon fiber (ACF) was performed to treat radioactive liquid wastes resulting from chemical or electrochemical decontamination and to regenerate the spent carbon electrode, Cyclic voltammetry was investigated on a rotating-disk electrode (RDE) to determine the region of potentials within which only double-layer charging should occur. The application of an electric potential increased the sorption of the cobalt ions. The adsorbed cobalt Ions could be released into the solution by reversing the appling potential, showing the reversibility of the process.

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Outbreak of Bovine Viral Diarrhea Virus in Korean Indigenous Calf (한우송아지에서 소 바이러스성 설사병 바이러스 발생)

  • Song, Moo-Chan;Choi, Kyoung-Seong
    • Journal of Veterinary Clinics
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    • v.26 no.6
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    • pp.578-581
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    • 2009
  • A 25-day-old, Korean indigenous calf was presented with a 10 days history of respiratory disorders and bloody diarrhea, and died. This calf was extremely unthrifty compared to others and had evidence of chronic diarrhea based on matting of feces in the hair of the tail and perineum. Ecchymotic hemorrhages were observed on multiple organs at necropsy. Bovine viral diarrhea virus (BVDV) infection was identified by RT-PCR. The phylogenetic analysis showed that this case belonged to BVDV-2a subgroup and was related to highly pathogenic USA isolate 890 (U18059). This case provided evidence for circulation of BVDV-2 in Republic of Korea. The occurrence of BVDV-2 was also reconfirmed.

Seismic Response of CWR on HSR Bridge Considering Derailment Inducing Factors (탈선취약요소를 고려한 고속철도교량 장대레일 지진응답 평가)

  • Yi, Jang-Seok;Kim, Dae-Sang
    • Journal of the Earthquake Engineering Society of Korea
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    • v.13 no.3
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    • pp.29-38
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    • 2009
  • n the event of an earthquake, additional stresses can occur in the continuous welded rails (CWR) of High-speed railway (HSR) bridges due to relative displacements at expansion joints, and this stress can cause derailment. The amplification of ground motion occurs as a result of site effects, and this is pronounced at the site of a soft surface soil layer and of a rigid surface soil layer over a soft one. As a result, the amplified ground motion leads to an amplified seismic response in HSR bridges. A change in bridge pier height affects the seismic behavior of the bridge. A HSR bridge with gravel ballast tracks will show different dynamic behavior during an earthquake than one with concrete ballast tracks. The seismic responses of HSR bridges and their CWR are analyzed considering the derailment-inducing factors.

A Study on the Vibration Characteristics of 2-phase Linear Stepping Motor (2相 Linear Stepping Motor의 진동특성에 관한 연구)

  • 오홍석;김동희;이상호;정도영;김춘삼
    • The Transactions of the Korean Institute of Power Electronics
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    • v.4 no.6
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    • pp.554-560
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    • 1999
  • In this paper, a vibration suppression method using an energy stored in winding inductance and an induced v voltage of the Linear Stepping Motor(LSM) is shown, and it is applied to a new one-phase excitation method A And a magnetic equivalent circuit is based on the structure of the LSM, and then the electric equivalent circuit of the LSM is derived by solving equations for the magnetic equivalent circuit. Several dynamic characteristics of the LSM are analyzed by the ACSL with the voltage equations, the force equations and the kinetic equation, a and are measured by experimental system.

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Parameter Estimation of Recurrent Neural Networks Using A Unscented Kalman Filter Training Algorithm and Its Applications to Nonlinear Channel Equalization (언센티드 칼만필터 훈련 알고리즘에 의한 순환신경망의 파라미터 추정 및 비선형 채널 등화에의 응용)

  • Kwon Oh-Shin
    • Journal of the Korean Institute of Intelligent Systems
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    • v.15 no.5
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    • pp.552-559
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    • 2005
  • Recurrent neural networks(RNNs) trained with gradient based such as real time recurrent learning(RTRL) has a drawback of slor convergence rate. This algorithm also needs the derivative calculation which is not trivialized in error back propagation process. In this paper a derivative free Kalman filter, so called the unscented Kalman filter(UKF), for training a fully connected RNN is presented in a state space formulation of the system. A derivative free Kalman filler learning algorithm makes the RNN have fast convergence speed and good tracking performance without the derivative computation. Through experiments of nonlinear channel equalization, performance of the RNNs with a derivative free Kalman filter teaming algorithm is evaluated.

Reduction of Discontinuity by Using Converging Pick-Up in Remapped Three-Dimensional Integral Imaging (집적영상에서 기본영상 재배열시 수렴광축을 이용한 불연속성 개선)

  • Yu, Hyun-Woo;Seo, Kwang-Beom;Lee, Ho-Chul;Cha, Sungdo;Shin, Seung-Ho
    • Korean Journal of Optics and Photonics
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    • v.30 no.3
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    • pp.106-113
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    • 2019
  • When elemental images are remapped to solve the depth conversion in integral imaging, the integrated image is inevitably accompanied by discontinuity. This paper analyzes the discontinuity factor caused by elemental-image remapping, to validate the reduction of the discontinuity through converging pick-up and reconstruction of the three-dimensional image in real and virtual modes simultaneously. The validity of the proposed method is quantitatively verified when compared with the conventional parallel pick-up.