• Journal of Life Science
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• v.31 no.9
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• pp.796-805
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• 2021

Hepatic endoplasmic reticulum (ER) stress contributes to the development of steatosis and insulin resistance. The components of unfolded protein response (UPR) regulate lipid metabolism. Recent studies have reported an association between ER stress and aberrant cellular lipid control; moreover, research has confirmed the involvement of sterol regulatory element-binding proteins (SREBPs)-the central regulators of lipid metabolism-in the process. However, the exact role of SREBPs in controlling lipid metabolism during ER stress and its contribution to fatty liver disease remain unknown. Here, we show that SREBP-1c deficiency protects against ER stress-induced hepatic steatosis in mice by regulating UPR, inflammation, and fatty acid oxidation. SREBP-1c directly regulated inositol-requiring kinase 1α (IRE1α) expression and mediated ER stress-induced tumor necrosis factor-α activation, leading to a reduction in expression of peroxisome proliferator-activated receptor γ coactivator 1-α and subsequent impairment of fatty acid oxidation. However, the genetic ablation of SREBP-1c prevented these events, alleviating hepatic inflammation and steatosis. Although the mechanism by which SREBP-1c deficiency prevents ER stress-induced inflammatory signaling remains to be elucidated, alteration of the IRE1α signal in SREBP-1c-depleted Kupffer cells might be involved in the signaling. Overall, the results suggest that SREBP-1c plays a crucial role in the regulation of UPR and inflammation in ER stress-induced hepatic steatosis.

• Journal of Music and Human Behavior
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• v.9 no.1
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• pp.1-19
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• 2012

The purpose of this research was to investigate the musical activities and musical preference according to coping strategy of university students. The survey was conducted to 200 students and the data of 168 was analysed. The results of the research are as follows. First, the number of problem-solving coping was the highest, and the number of emotional-alleviate coping was the lowest. And coping strategy between male and female student showed a significant difference. Second, music listening was the most preferred activity. There was a significant difference in the most preferred activity between male and female students, also between active and inactive coping strategy. However, the most doing activity between music major students and non-music major students showed a significant difference. In addition, there was a significant differences in the purpose of playing instruments between male and female students and among academic year. Third, Korean-pop was the most preferred genre. Result showed a significant difference in preferred musical elements between male and female students. There were genre, melody, loudness, and theme of lyric. Meanwhile, preferred musical elements between active and inactive coping strategy showed a statistical differences. There were rhythm, timbre, and medium of listening. Finally, there were statistical differences in the preferred harmony and familiarity between music major students and non-music major students.

• Journal of Hospice and Palliative Care
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• v.18 no.2
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• pp.148-155
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• 2015

Purpose: The purpose of this study is to examine how wish granting influences children with life-threatening medical conditions when it comes to their adaptation to disease with a focus on the mediating effect of resilience and stress caused by disease. Methods: From January 2, 2015 through January 12, 2015, a survey was conducted on 292 children with life-threatening diseases whose wishes were granted through Make-A-Wish Korea. The data were collected using the impact of a wish scale, the Children's Adjustment to Cancer Inventory, the Childhood Cancer Stressor Inventory, and the resilience scale in children with chronic illness. The data were analyzed using SPSS/WIN 20.0 and Amos 21.0. Results: Satisfaction with the wish granting program enhances resilience, and resilience affects stress caused by medical conditions as well as adaptation to disease. Also, stress caused by medical conditions influences adaptation to disease. Conclusion: Wish granting is effective in both facilitating chronically ill children to adjust to disease and reduce their stress from disease. Thus, children with life-threatening medical conditions could be assisted or motivated to adjust to disease by improving satisfaction achieved by wish granting.

• The Journal of the Korea Contents Association
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• v.15 no.6
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• pp.379-391
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• 2015

This study aims to understand family support and self-efficacy-mediated structural relation of college students' unemployment stress with their adaptation to school life. Findings of the research are summarized as follows. The study looked into how unemployment stress would directly affect self-efficacy, family support and adaptation to school life. It was found that the unemployment stress would have immediate negative effects on the self-efficacy, family support and adaptation to school life. In addition, the study noticed that with both family support and self-efficacy applied as mediating factors, unemployment stress influences college students' adaptation to school life indirectly and negatively. After the investigation on the immediate effects of family support in relation to the self-efficacy, the study indicated that family support has an immediate positive influence on the self-efficacy. In terms of self-efficacy, it appeared to affect adaptation to school life both positively and directly but, its indirect effects on the adaptation to school life was not confirmed. The study failed to find any direct influence of the family support on adaptation to school life but learned that the family support causes an indirect positive effect through self-efficacy, the mediating factor. In conclusion, the study suggests that adaptation to school life improves as long as unemployment stress decreases, while the family support and the self-efficacy are enhanced.

• Korean Journal of Materials Research
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• v.1 no.1
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• pp.46-53
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• 1991

The stress of PSG (Phosphosilicate glass), USG (Undoped-silicate grass) and SiN films, which are mainly used as passivation layers in semiconductor memory devices, deposited by CVD methods has been studied as a function of film thickness and holding time in air. The stress of the PSG film or the USG film is increased in tensile state with increasing film thickness. On the other hand the stress level of the SiN film in compressive stress does not change as film thickness changes. The stress of PSG film shows the drastic change from the tensile stress to the compressive stress after the film is left 2 days in air. FTIR spectra indicated that the stress variation was due to the penetration of water molecule. It looks possible to recover the stress of about $2.5{\times}{10^9}dyne/cm^2$ by annealing treatment at $300^{\circ}C$ for 20min. The total stress of multi-layered films having the PSG film is determined mainly by the stress variation of PSG layer with holding time. The total stress of multi-layered film appears to have a functional relationship with the stress in the thickness of each film. The resistance against stress-migration of sputtered Al line increases with increasing the tensile stress for the PSG film or the USG film.

• Korean Journal of Plant Resources
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• v.21 no.5
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• pp.395-401
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• 2008

Flavonoids are ubiquitous substances in fruits and vegetables. A main subgroup of the flavonoids are the flavonols, of which quercetin and kaempferol are the major representatives in foods. They are used in food supplements at high doses, because of their preventive effects on degenerative diseases. The aim of this study was to determine the combined and separate effects of kaempferol and quercetin on oxidative stress in cow pulmonary artery endothelium (CPAE) cells over a broad concentration range. The results demonstrate that cell viability was greatly increased in kaempferol and quercetin treated cells whether $H_{2}O_{2}$-treated or not. Cell viability also increased when treated with flavonols in the absence of oxidative stress. Both preincubation and simultaneous incubation with kaempferol and quercetin protected against the loss of cell viability induced by 1mM $H_{2}O_{2}(5h)$. Protective effects of flavonols against oxidative stress were shown to depend on the treated flavonol concentrations. No protective effect was shown under low concentration treatment and cell viability increased 1.6 times at $200{\mu}M$ relative to the control group. At the highest flavonol concentration of $300{\mu}M$, the increased cell viability by flavonol treatment was decreased to almost half of the maximum values. Combined treatments with kaempferol and quercetin showed more protective effects against oxidative stress by $H_{2}O_{2}$ than the separate effects of each flavonol. In conclusion, the protective effect of kaempferol and quercetin against oxidative stress was very pronounced but high concentrations of flavonols can also induce cell cytotoxicity.

• Research in Plant Disease
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• v.24 no.3
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• pp.221-232
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• 2018

Rhizobacteria play important roles in plant growth and health enhancement and render them resistant to not only biotic stresses but also abiotic stresses, such as low/high temperature, drought, and salinity. This study aimed to select plant growth promoting rhizobacteria (PGPR) with the capability to mitigate biotic and abiotic stress effects on tomato plants. We isolated a novel PGPR strain, Variovorax sp. PMC12 from tomato rhizosphere. An in vitro assay indicated that strain PMC12 produced ammonia, indole-3-acetic acid (IAA), siderophore, and 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase, which are well-known traits of PGPR. The aboveground fresh weight was significantly higher in tomato plants treated with strain PMC12 than in non-treated tomato plants under various abiotic stress conditions including salinity, low temperature, and drought. Furthermore, strain PMC12 also enhanced the resistance to bacterial wilt disease caused by Ralstonia solanacearum. Taken together, these results indicated that strain PMC12 is a promising biocontrol agent and a biostimulant to reduce the susceptibility of plants to both abiotic and biotic stresses.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.449-458
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• 2017

This research is a descriptive correlation research for comprehending the end of life care stresses, work environment, and reduction of nurses in geriatric hospitals and analyzing the factors influencing their burnout. We recruited 195 nurses from 8 geriatric hospitals in B metropolitan city and collected data on the end of life care stress, work environment and reduction using organized questionnaires. The data were analyzed with SPSS WIN 21.0 program. The average grade of end life care stress was $3.84{\pm}0.56$, nursing work environment $3.25{\pm}0.60$, and burnout $2.93{\pm}0.52$. There was a positive correlation between the end of life care stress and reduction(r=.206, p=.004) but a negative correlation between nursing work environment and reduction(r=-.431, p<.001). The most influential factor on the reduction was nursing satisfaction(${\beta}=-.302$), followed by work environment(${\beta}=-.294$), age(${\beta}=.286$), duty style(${\beta}=-.17$), and end of life care stress(${\beta}=.164$). The overall explanatory power was 41.2%.These results suggest that in order to minimize the reduction of nurses in geriatric hospitals, the provision of a supportive work environment which enhances their pride and responsibility as a nurse and offers incentives is required with effective distribution of duties, development of the end of life nursing education and administrative tools for reducing their stress.

• Journal of the Korean Applied Science and Technology
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• v.40 no.3
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• pp.363-373
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• 2023

This purpose of this study was to survey sense of self-control, social support and daily stress in female highschool students and to identify variables influencing daily stress. Data were collected 164 female highschool students. Data were handled statistics using t-test, ANOVA, Scheffe's test, Pearson's correlation coefficient and Stepwise Regression Analysis. The mean score of sense of self-control was 20.47±3.86. There was statistically significant difference in sense of self-control on factor such as satisfaction of school life. The mean score of social support was 105.88±19.63. There were statistically significant difference in social support on variables such as satisfaction of school life, parental rearing attitudes. The mean score of daily stress was 58.96±17.33. There was statistically significant difference in daily stress on factors such as relationship with school fellow, satisfaction of school life and parental rearing attitudes. Daily stress was negatively correlated with sense of self-control and social support. Sense of self-control was positively correlated with social support. Factor influencing daily stress were social support, sense of self-control, which explained 45%. Further study with careful sampling will be needed to reduce the daily stress of highschool students.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.201-208
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• 2023

This study is a empirical study to investigate the mediating effect of self-efficacy and social support in the relationship between SNS use time and acculturation stress for Chinese students. A survey was conducted from April 1 to 12, 2022 on 239 Chinese students from universities across the country using Wenjuanxing questionnaires. Descriptive statistics analysis and Baron and Kenny hierarchical regression analysis were performed on the collected data using SPSS 26.0, and bootstrapping was performed to verify the mediating effect. As a result of the study, SNS use time had a significant effect on the self-efficacy and social support. The acculturation stress was significantly influenced by SNS use time, self-efficacy, and social support. SNS use time had a significant effect on acculturation stress, and self-efficacy and social support had a partial mediating effect in the relationship between SNS use time and acculturation stress. Therefore, based on the above research, SNS can be used to develop the projects for International students to enhance their cultural adaptative ability and thus alleviate the acculturation stress. This study can serve as the foundational and supplementary materials for the follow-up study of SNS and acculturation stress.