SREBP-1c Ablation Protects Against ER Stress-induced Hepatic Steatosis by Preventing Impaired Fatty Acid Oxidation |
Lee, Young-Seung
(Department of Animal Science, Chonnam National University)
Osborne, Timothy F. (Institute for Fundamental Biomedical Research, Department of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine) Seo, Young-Kyo (Aging Research Center, Korea Research Institute of Bioscience and Biotechnology) Jeon, Tae-Il (Department of Animal Science, Chonnam National University) |
1 | Logette, E., Le Jossic-Corcos, C., Masson, D., Solier, S., Sequeira-Legrand, A., Dugail, I., Lemaire-Ewing, S., Desoche, L., Solary, E. and Corcos, L. 2005. Caspase-2, a novel lipid sensor under the control of sterol regulatory element binding protein 2. Mol. Cell. Biol. 25, 9621-9631. DOI |
2 | Schroder, M. and Kaufman, R. J. 2005. The mammalian unfolded protein response. Annu. Rev. Biochem. 74, 739-789. DOI |
3 | Truong, X. T., Nguyen, T. T. P., Kang, M. J., Jung, C. H., Lee, S., Moon, C., Moon, J. H. and Jeon, T. I. 2019. Pear extract and malaxinic acid reverse obesity, adipose tissue inflammation, and hepatosteatosis in mice. Mol. Nutr. Food Res. 63, e1801347. |
4 | Yang, Q., Kim, Y. S., Lin, Y., Lewis, J., Neckers, L. and Liu, Z. G. 2006. Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK. EMBO Rep. 7, 622-627. DOI |
5 | Ye, J., Rawson, R. B., Komuro, R., Chen, X., Dave, U. P., Prywes, R., Brown, M. S. and Goldstein, J. L. 2000. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol. Cell 6, 1355-1364. DOI |
6 | Chen, J., Fontes, G., Saxena, G., Poitout, V. and Shalev, A. 2010. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes 59, 440-447. DOI |
7 | Djouadi, F., Bonnefont, J. P., Munnich, A. and Bastin, J. 2003. Characterization of fatty acid oxidation in human muscle mitochondria and myoblasts. Mol. Genet. Metab. 78, 112-118. DOI |
8 | Huang, W., Metlakunta, A., Dedousis, N., Zhang, P., Sipula, I., Dube, J. J., Scott, D. K. and O'Doherty, R. M. 2010. Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes 59, 347-357. DOI |
9 | Jo, H., Choe, S. S., Shin, K. C., Jang, H., Lee, J. H., Seong, J. K., Back, S. H. and Kim, J. B. 2013. Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor. Hepatology 57, 1366-1377. DOI |
10 | Lebeaupin, C., Vallee, D., Hazari, Y., Hetz, C., Chevet, E. and Bailly-Maitre, B. 2018. Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease. J. Hepatol. 69, 927-947. DOI |
11 | Lee, A. H., Scapa, E. F., Cohen, D. E. and Glimcher, L. H. 2008. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320, 1492-1496. DOI |
12 | Lin, J. H., Li, H., Yasumura, D., Cohen, H. R., Zhang, C., Panning, B., Shokat, K. M., Lavail, M. M. and Walter, P. 2007. IRE1 signaling affects cell fate during the unfolded protein response. Science 318, 944-949. DOI |
13 | Ning, J., Hong, T., Ward, A., Pi, J., Liu, Z., Liu, H. Y. and Cao, W. 2011. Constitutive role for IRE1alpha-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program. Endocrinology 152, 2247-2255. DOI |
14 | Osborne, T. F. 2000. Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action. J. Biol. Chem. 275, 32379-32382. DOI |
15 | Postic, C. and Girard, J. 2008. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J. Clin. Invest. 118, 829-838. DOI |
16 | Werstuck, G. H., Lentz, S. R., Dayal, S., Hossain, G. S., Sood, S. K., Shi, Y. Y., Zhou, J., Maeda, N., Krisans, S. K., Malinow, M. R. and Austin, R. C. 2001. Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J. Clin. Invest. 107, 1263-1273. DOI |
17 | Jeon, T. I., Esquejo, R. M., Roqueta-Rivera, M., Phelan, P. E., Moon, Y. A., Govindarajan, S. S., Esau, C. C. and Osborne, T. F. 2013. An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis. Cell Metab. 18, 51-61. DOI |
18 | Urano, F., Wang, X., Bertolotti, A., Zhang, Y., Chung, P., Harding, H. P. and Ron, D. 2000. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287, 664-666. DOI |
19 | Seo, Y. K., Chong, H. K., Infante, A. M., Im, S. S., Xie, X. and Osborne, T. F. 2009. Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif. Proc. Natl. Acad. Sci. USA. 106, 13765-13769. DOI |
20 | Palomer, X., Alvarez-Guardia, D., Rodriguez-Calvo, R., Coll, T., Laguna, J. C., Davidson, M. M., Chan, T. O., Feldman, A. M. and Vazquez-Carrera, M. 2009. TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model. Cardiovasc. Res. 81, 703-712. DOI |
21 | Rutkowski, D. T., Wu, J., Back, S. H., Callaghan, M. U., Ferris, S. P., Iqbal, J., Clark, R., Miao, H., Hassler, J. R., Fornek, J., Katze, M. G., Hussain, M. M., Song, B., Swathirajan, J., Wang, J., Yau, G. D. and Kaufman, R. J. 2008. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev. Cell 15, 829-840. DOI |
22 | Kammoun, H. L., Chabanon, H., Hainault, I., Luquet, S., Magnan, C., Koike, T., Ferre, P. and Foufelle, F. 2009. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J. Clin. Invest. 119, 1201-1215. DOI |
23 | Cnop, M., Foufelle, F. and Velloso, L. A. 2012. Endoplasmic reticulum stress, obesity and diabetes. Trends Mol. Med. 18, 59-68. DOI |
24 | Horton, J. D., Bashmakov, Y., Shimomura, I. and Shimano, H. 1998. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc. Natl. Acad. Sci. USA. 95, 5987-5992. DOI |
25 | Hu, P., Han, Z., Couvillon, A. D., Kaufman, R. J. and Exton, J. H. 2006. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol. Cell. Biol. 26, 3071-3084. DOI |
26 | Chen, Y. and Brandizzi, F. 2013. IRE1: ER stress sensor and cell fate executor. Trends Cell Biol. 23, 547-555. DOI |
27 | Osborne, T. F. and Espenshade, P. J. 2009. Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Genes Dev. 23, 2578-2591. DOI |
28 | Inoue, N., Shimano, H., Nakakuki, M., Matsuzaka, T., Nakagawa, Y., Yamamoto, T., Sato, R., Takahashi, A., Sone, H., Yahagi, N., Suzuki, H., Toyoshima, H. and Yamada, N. 2005. Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor. Mol. Cell. Biol. 25, 8938-8947. DOI |
29 | Jeon, T. I. and Osborne, T. F. 2012. SREBPs: metabolic integrators in physiology and metabolism. Trends Endocrinol. Metab. 23, 65-72. DOI |
30 | Martinon, F., Chen, X., Lee, A. H. and Glimcher, L. H. 2010. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat. Immunol. 11, 411-418. DOI |
31 | Shen, J., Chen, X., Hendershot, L. and Prywes, R. 2002. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev. Cell 3, 99-111. DOI |
32 | Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L. and Wymer, M. 2016. Global epidemiology of nonalcoholic fatty liver disease-meta analytic assessment of prevalence, incidence, and outcomes. Hepatology 64, 73-84. DOI |
33 | Li, H., Min, Q., Ouyang, C., Lee, J., He, C., Zou, M. H. and Xie, Z. 2014. AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response. Biochim. Biophys. Acta 1842, 1844-1854. DOI |