• Journal of Korean Tunnelling and Underground Space Association
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• v.7 no.2
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• pp.153-163
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• 2005

This paper presents two case studies for tunnelling in Bangkok: a subway tunnel site and a flood diversion tunnel site. The first case study is related to ground displacement response for dual tunnel Bangkok MRT subway. The MRT subway project of Bangkok city consists of dual tunnels about 20 km long with 18 subway stations. The tunnels are seated in the firm first stiff silty clay layer between 15-22 m in depth below ground surface. The behavior of ground deformation response based on instrumentation is presented. The back analysis based on plain strain FEM analysis is also presented and agrees with field performance. The shear strain of FEM analysis is in the range of 0.1-1% and in accordance with the results of self boring pressuremeter tests. Meanwhile, the second case study is related to the EPB tunnelling bored underneath through underground obstruction. The Premprachakorn flood diversion tunnel is the shortcut tunnel to divert the flood water in rainy season into the Choapraya river. The tunnel was bored by means of EPB shield tunnelling in very stiff silty clay layer at about 20-24 m in depth. During flood diversion tunnel bored underneath the existing Bangkok main water supply tunnel and pile foundation of the bridge, instrumentation was monitored and compared with predicted FEM analysis. The prevention risk potential by means of predicting damage assessment is also presented and discussed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.7
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• pp.423-442
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• 2018

This study observes the psychological changes of unemployed people according to their unemployment period. With this what psychological changes they face according to their unemployment period and what psychological characteristics they show, whether if psychological changes and job hunting activities are in relation, and whether if psychological changes affect job hunting activities. The study subjects received unemployment wage and were divided according to before employment, 1~3 months unemployed, and 4 months or more unemployed. An in-depth research of 8 people was conducted within the period of 2017.05~08. The psychological characteristics of people, in the period from when they first sense unemployment possibilities until three months of unemployment, are anger, anxiety, fear, which is a mixed characteristic that does not disappear but continues deepening. In study there was no significant difference in depression, anxiety, anger, social phobia, alcohol, religion factors, low self-esteem, and low self-efficacy in before employment, 1~3 months unemployed, and 4 months or more unemployed. However, the average levels of anger anxiety, depression, and social phobia were higher when the unemployment period was longer and the results of low self-esteem and low self-efficacy support further research.

• Korean Journal of Childcare and Education
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• v.9 no.2
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• pp.285-309
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• 2013

The purpose of this study was to examine the courage of infant & toddler teachers during their care for infants and toddlers in an effort to shed light on the courage of teachers, which has been overlooked so far. It's specifically meant to raise awareness of the necessity of courage as one of virtues that teachers should have to provide quality care. The subjects in this study were four selected infant & toddler teachers at a childcare center. Data were gathered during a 12-week period of time from June to August, 2012, by having in-depth interviews with the teachers. After the collected data were analyzed, the courage that teachers had was categorized into three: being unsparing of oneself, acting according to conscience and sticking to principles, and raising and caring. As for the first, they didn't spare themselves even though there was a danger of physical harm or death. Regarding the second, they held fast to their principles even when it's against the will of the principal and parents, and continued to modify the principles by looking back on themselves. Concerning the third, they did their utmost while they provided toilet training. In the future, the characteristics of courage that infant & toddler teachers should have to take good care of infants and toddlers should be investigated, and courage should be taken seriously as one of virtues. Besides, how to help teachers keep their courage up should carefully be considered.

• Journal of fish pathology
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• v.7 no.2
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• pp.151-160
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• 1994

In order to elucidate the patterns of tissue damage evoked by the scuticociliatids, eighteen fingerlings of Japanese flounder, Paralichthys olivaceus, heavily infected with an unidentified scuticociliatid were histopathologically examined. Skin layer with the underlying musculature were severely necrotized due to the infestation of the ciliates. However in the early lesions, both dermis and myofibres remained relatively intact compared with other surrounding loose connective tissues. Mild damages were found in more dense tissues. One or more scuticociliatids were recognized in the blood and lymph vessels of the loose connective tissues with or without destructive changes. Many of nerve trunks or ganglia were also parasitized with less marked histological damage in the parenchyma. Dura and its adjacent tissues in the spinal cord were severely necrotized with massive accumulation of the ciliates in subdural space. The parasitic invasion in the central nervous system was usually confined to the cortical region. In the gill, variable degenerative changes were occurred due to the invasion of the ciliates recognized in the blood vessels of branchial arches or primary filaments. From these results, it was strongly suggested that the scuticociliatids are very actively penetrated into the deep tissues mainly through the severe destruction of the loose connective tissue components and that the vascular system could play a role in the rapid distribution of the ciliates to the remote tissues or organs.

• Journal of the Korean Geotechnical Society
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• v.19 no.5
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• pp.211-221
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• 2003

At Aspo hard rock laboratory in Sweden, an in-situ heater experiment called "$\"{A}"{s}"{p}"{o}$ Pillar Stability Experiment (APSE)" is prepared to assess capability to predict spatting and stability in a rock mass between deposition holes for radioactive waste. To Predict reasonably fracturing process at rock pillar under a planned configuration before testing, a boundary element code FRACOD has been applied for modelling. The code has been improved to simulate explicitly fracture evolution both at rock boundaries and in intact rocks. A new inverse stress reconstruction technique using boundary element has been also developed to transfer stress field by excavation and thermal loading into the FRACOD model. This article presents the results from predictive modelling far the planned in-situ test condition. Excavation induced stresses might cause slight fracturing in the pillar walls. Typical shear fractures have been initiated and propagated near central pillar walls during 120 days of heating, but overall rock mass remained stable under the considered configuration. The effects of pre-existing joints and properties of fractures are also discussed. It is found from the results that FRACOD can properly model essential rock spatting and propagation at deep tunnels and boreholes.at deep tunnels and boreholes.

• Journal of Life Science
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• v.28 no.4
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• pp.488-495
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• 2018

The p53 gene plays a critical role in the transcriptional regulation of cellular response to stress, DNA damage, hypoxia, and tumor development. Keeping in mind the recently discovered manifold physiological functions of p53, its involvement in the regulation of cancer is not surprising. In about 50% of all human cancers, inactivation of p53's protein function occurs either through mutations in the gene itself or defects in the mechanisms that activate it. This disorder plays a crucial role in tumor evolution by allowing the evasion of a p53-dependent response. Many recent studies have focused on directly targeting p53 mutants by identifying selective, small molecular compounds to deplete them or to restore their tumor-suppressive function. These small molecules should effectively regulate various interactions while maintaining good drug-like properties. Among them, the discovery of the key p53-negative regulator, MDM2, has led to the design of new small molecule inhibitors that block the interaction between p53 and MDM2. Some of these small molecule compounds have now moved from proof-of-concept studies into clinical trials, with prospects for further, more personalized anti-carcinogenic medicines. Here, we review the structural and functional consequences of wild type and mutant p53 as well as the development of therapeutic agents that directly target this gene, and compounds that inhibit the interaction between it and MDM2.

• Journal of Life Science
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• v.30 no.6
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• pp.513-521
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• 2020

B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) is a polycomb group protein and a core component of polycomb repressive complex 1. Initial research into Bmi1 has focused on its role in tumorigenesis, and it is generally accepted that it is important for the proliferation and survival of cancer cells. However, more recent studies have revealed that Bmi1 is downregulated in brains with neurodegenerative disease and that it regulates the function of mitochondria and reactive oxygen species levels. In this study, we tested the therapeutic potential of Bmi1 in pilocarpine-induced seizures in Bmi1-knockout mice. Bmi1 expression transiently increased in the hippocampal CA1 and CA3 and the dentate gyrus following pilocarpine-induced status epilepticus (SE). In terms of seizure behavior, SE induction was 43.14% and 53.57% for Bmi1^+/+ and Bmi1^+/- mice, respectively. However, there was no significant difference in mortality or hippocampal damage between the two groups. Two months after SE induction, the frequency of epileptic seizures in the Bmi1^+/- mice was 50% lower than in the control group, although the difference was not statistically significant. In addition, mossy fiber outgrowth in the Bmi1^+/- mice was significantly higher than in their wild-type littermates. Taken together, these data indicate that reduced Bmi1 activity increases pilocarpine-induced seizure probability and mossy fiber outgrowth.

• Fire Science and Engineering
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• v.20 no.3 s.63
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• pp.42-47
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• 2006

Direct medical control by medical doctors is an essential part of emergency medical services system (EMSS). However, the indications are not specifically defined, even in 119 system with their own medical control team. The Seoul Metropolitan Fire and Disaster Management Department has operated internal medical consultation services on its own since January 2004. Based on the experiences from these services, we reviewed the cases of the direct medical consultation and establish the indications for direct medical control. And we presumed the demand of direct medical control with the established indications. The crews of 119 in Seoul made 793 calls to Medical Control Team during November 2004. We reviewed all of the calls according to the level of consciousness (AVPU), the kinds of emergency care done by crews during transport (10 categories), and the mechanisms of injuries (9 categories). The need for direct medical control was judged by authors with reviewing the records reported by the crews and control teams. Among 23 items, 14 items assigned as the indications, which were abnormal level of consciousness (VPU), 6 kinds of emergency care, and 5 mechanisms of injures. The sum of the three of them, 7,782 cases (45.9%), was in need of direct medical control. In conclusion, about half of the patients transported by 119 crews in Seoul require direct medical control. The need for the direct medical control in Seoul was estimated as many as 260 calls per day. To fulfill the need for direct medical control and to provide a effective medical control, the direct medical control should be accomplished through the communications between the crews and the medical staffs in the local hospitals.

• Journal of Korean Home Economics Education Association
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• v.27 no.3
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• pp.99-119
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• 2015

The purpose of this study is to examine the educational contents of home economics textbooks that solely focus on forming adolescent empowerment. For this, an in-depth content analysis was conducted on the home economics textbooks in Korea and the U.S. The main results of this study are summarized as follows: First, the 23 content elements, which are designed to build adolescent empowerment, were ascertained: nine intrapersonal empowerment elements such as the self-identity, nine interpersonal empowerment elements such as the communication, and five social empowerment elements such as the leadership. Second, based on the content elements selected from above, the textbooks in Korea were observed to deal with 58% of the 23 content elements, while those in the U.S. discussed 90% of the 23 content elements. Korean textbooks primarily focused on helping students understand major concepts, whereas the U.S. textbooks focused primarily on helping students make connections between major concepts and their life. Lastly, both countries put the least amount of weight on social empowerment content elements(Korea: 37%, U.S.: 70%).

• The Journal of Engineering Geology
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• v.17 no.3
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• pp.455-469
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• 2007

The study area, Bonggil-ri, Gyeongju, SE Korea, is composed of Cretaceous sedimentary rocks, and Tertiary igneous rocks and dykes. A research on fracture developing history and density distribution was carried out on well exposed Tertiary granites. The fractures developed in this area have the following sequence; NW-SE trending duo-tile shear bands (set a), NNW-SSE trending extensional fractures (set d), WNW-ESE trending extensional or normal fractures (set b), NE-SW trending right-lateral fractures (set c), WNW-ESE trending reverse fault reactivated from normal faults (set e) and NW-SE trending left-lateral faults reactivated from shear bands (set a) under brittle condition. According to the result of fracture density analysis, the fracture density in this area depends on rock property rather than rock age, and also higher fracture density is observed around fault damage zones. However, this high fracture density may also be related to the cooling process associated with dyke intrusion as well as rock types and fault movement. Regardless of the reason of the high fracture density, high fracture density itself contributes to fluid flow and migration of chemical elements.