• The Korean Journal of Zoology
• /
• v.34 no.3
• /
• pp.382-388
• /
• 1991

쥐의 교핵내에서 대뇌피질(또는 소뇌핵) 면면시 소뇌교핵계(또는 대뇌교핵계)의 연접구조의 변화에 대한 전자현미경적 관찰결과, 대뇌교핵계의 수입로 차단의 경우 소뇌교핵계의 신경섬유는 교핵세포의 원위 가지돌기쪽으로 발아하며, 소뇌핵 병변시 서뇌교핵계의 신경섬유는 근위가지돌기와 연접을 형성하거나 또는 여러개의 가지돌기 부속물들과 사구체형 연접복합체를 형성함이 밝혀졌다. 이상의 연구는 광학현미경적 관찰에서 언급된 대뇌피질(또는 소뇌핵) 병변에 따른 교핵내 신경종말의 밀도증가에 대한 보고를 뒷받침해주며, 소뇌핵 병변시 운동결핍증의 시간경과에 따른 회복에 대한 신경해부학적 근거를 제시한다.

• Journal of Biosystems Engineering
• /
• v.15 no.3
• /
• pp.186-198
• /
• 1990

인간 소뇌의 구조와 기능을 간략하게 수학적으로 모델링하여 입력에 따른 시스템의 적정 출력을 학습에 의한 적응 제어 방식으로 추출해 내는 소뇌모델 대수제어기(CMAC : Cerebellar Model Arithmetic Controller)가 제안되었다. 본 논문에서는 연구개발된 기존 신경회로망과의 비교 분석에 의거하여, 소뇌모델 대수제어기 대신 네트의 특성에 따라 소뇌모델 선형조합 신경망(CMLAN : Cerebellum Model Linear Associator Network)이라 하였다. 소뇌모델 선형조합 신경망은 시스템의 제어 함수치를 결정하는 데 있어, 기존의 제어방식이 시스템의 모델링을 기초로 하여 알고리즘에 의한 수치해석적 또는 분석적 기법으로 모델 해를 산출하는 것과 달리, 학습을 통하여 저장되는 분산기억 소자들의 함수치를 선형적으로 조합함으로써 시스템의 입출력을 결정한다. 분산기억 소자로의 함수치 산정 및 저장은 소뇌모델 선형조합 신경망이 갖는 고유의 구조적 상태공간 매핑(State Space Mapping)과 델타규칙(Delta Rule)에 의거한 시스템의 입출력 상태함수의 학습으로써 수행된다. 본 논문을 통하여 소뇌모델 선형조합신경망의 구조적 특성, 학습 성질과 상태공간 설정 및 시스템의 수렴성을 규명하였다. 또한 기존의 최대 편차수정 학습 알고리즘이 갖는 비능률성 및 적용 제한성을 극복한 효율적 학습 알고리즘들을 제시하였다. 언급한 신경망의 특성 및 제안된 학습 알고리즘들의 능률성을 다양한 학습이득(Learning Gain)하에서 비선형 함수를 컴퓨터로 모의 시험하여 예시하였다.

• The Journal of the Korea Contents Association
• /
• v.15 no.6
• /
• pp.276-282
• /
• 2015

Fetal cerebellum is grow depending on the gestational age, measurement of transverse cerebellar diameter(TCD) is being used import indicator of fetal growth prediction in clinical. In this study, the subjects were normal pregnant women 20~37 week of gestation, and the volume scan was conducted on the 340 subjects. The research reports was indicated by regression curve the growth of fetal TCD in accordance with the gestational age. It got to the value of the results from a linear regression equation. Measurement fetal TCD using 3D US was statistically significant(p<0.001) and useful in the prediction of gestational age. TCD increases with gestational age can also distinguish between the normal fetal and prediction of accurate gestational age of fetal growth retardation. If the basic data of the present study, ongoing research is performed, the TCD using by 3D US are expected to be usefully applied in the correct prediction gestational age.

• The Korean Journal of Nuclear Medicine
• /
• v.35 no.1
• /
• pp.12-22
• /
• 2001

Purpose: The ictal perfusion patterns of cerebellum and basal ganglia have not been systematically investigated in patients with temporal lobe epilepsy (TLE). Their ictal perfusion patterns were analyzed in relation with temporal lobe and frontal lobe hyperperfusion during TLE seizures using SPECT subtraction. Materials and Methods: Thirty-three TLE patients had interictal and ictal SPECT, video-EEG monitoring, SPGR MRI, and SPECT subtraction with MRI co-registration. Results: The vermian cerebellar hyperperfusion (CH) was observed in 26 patients (78.8%) and hemispheric CH in 25 (75.8%). Compared to the side of epileptogenic temporal lobe, there were seven ipsilateral hemispheric CH (28.0%), fifteen contralateral hemispheric CH (60.0%) and three bilateral hemispheric CH (12.0%). CH was more frequently observed in patients with additional frontal hyperperfusion (14/15, 93.3%) than in patients without frontal hyperperfusion (11/18, 61.1%). The basal ganglia hyperperfusion (BGH) was seen in 11 of the 15 patients with frontotemporal hyperperfusion (73.3%) and 11 of the 18 with temporal hyperperfusion only (61.1%). In 17 patients with unilateral BGH, contralateral CH to the BGH was observed in 14 (82.5%) and ipsilateral CH to BGH in 2 (11.8%) and bilateral CH in 1 (5.9%). Conclusion: The cerebellar hyperperfusion and basal ganglia hyperperfusion during seizures of TLE can be contralateral, ipsilateral or bilateral to the seizure focus. The presence of additional frontal or basal ganglia hyperperfusion was more frequently associated with contralateral hemispheric CH to their sides. However, temporal lobe hyperperfusion appears to be related with both ipsilateral and contralateral hemispheric CH.

• Journal of the Korean Institute of Intelligent Systems
• /
• v.24 no.6
• /
• pp.609-614
• /
• 2014

Cerebellar ataxia is a steadily progressive neurodegenerative disease associated with loss of motor control, leaving patients unable to walk, talk, or perform activities of daily living. Direct motor instruction in cerebella ataxia patients has limited effectiveness, presumably because an inappropriate closed-loop cerebellar response to the inevitable observed error confounds motor learning mechanisms. Recent studies have validated the age-old technique of employing motor imagery training (mental rehearsal of a movement) to boost motor performance in athletes, much as a champion downhill skier visualizes the course prior to embarking on a run. Could the use of EEG based BCI provide advanced biofeedback to improve motor imagery and provide a "backdoor" to improving motor performance in ataxia patients? In order to determine the feasibility of using EEG-based BCI control in this population, we compare the ability to modulate mu-band power (8-12 Hz) by performing a cued motor imagery task in an ataxia patient and healthy control.

• Proceedings of the Korea Contents Association Conference
• /
• 2015.05a
• /
• pp.195-196
• /
• 2015

태아의 소뇌는 임신주수에 따라 성장하며 소뇌횡직경 길이의 측정은 태아성장 예측의 중요한 지표로 활용하고 있다. 임신주수에 따른 태아 소뇌횡직경의 성장을 회귀곡선으로 표시하였고 선형회귀방정식에서 결정계수를 얻었다. 3차원초음파를 이용한 소뇌횡직경의 측정법은 통계적으로 유의(P<0.001)하였으며, 태령을 예측함에 유용하다는 것을 알 수 있었다. 또한 성장장애가 있는 태아의 경우에도 임신주수의 예측이 가능하다. 본 연구를 기초자료로 하여 지속적인 연구가 시행된다면 정확한 임신주수 예측에 유용할 것으로 기대한다.

• Science of Emotion and Sensibility
• /
• v.12 no.4
• /
• pp.425-432
• /
• 2009

The purposes of the study were to examine cerebellar areas and lateralization responsible for visuospatial and verbal tasks using functional Magnetic Resonance Imaging(fMRI). Eight healthy male college students($21.5\;{\pm}\;2.3$ years) and eight male college students($23.3\;{\pm}\;0.5$ years) participated in this fMRI study of visuospatial and verbal tasks, respectively. Functional brain images were taken from 3T MRI using the single-shot EPI method. All functional images were aligned with anatomical images using affine transformation routines built into SPM99. The experiment consisted of four blocks. Each block included a control task(1 minute) and a cognitive task(1 minute). A run was 8 minutes long. Using the subtraction procedure, activated areas in the cerebellum during the visuospatial and verbal tasks were color-coded by t-score. A cerebellar lateralization index was calculated for both cognition tasks using number of activated voxels. The activated cerebellar regions during the both cognition tasks of this study agree with previous results. Since the number of activated voxels of the left and right cerebellar hemisphere was almost same, there was no cerebellar lateralization for both cognition tasks.

• The Korean Journal of Nuclear Medicine
• /
• v.29 no.1
• /
• pp.9-14
• /
• 1995

뇌졸증환자의 뇌 SPECT 소견상 나타나는 소뇌교차해리현상(crossed cerebellar diaschisis)은 잘 알려진 현상이다. 한편 간질 환자의 발작시 뇌 SPECT에서 반대편 소뇌에 혈류증가를 보이는 역교차해리현상(reverse type of crossed cerebellar diashisis)은 드물게 보고되었었다. 따라서 본 저자들은 발작시 뇌 SPECT에서 역교차해리현상의 빈도 및 간질병소를 찾는데 있어서의 유용성에 대해 알아보고자 하였다. 복합부분발작환자 중 임상적, 뇌파검사상 및 SPECT 소견등에서 간질병소가 일치하는 12명의 환자를 대상으로 하였다. 환자 모두에서 시행한 발작시 스캔은 발작중 혹은 환자가 aura를 호소할때 $^{99m}Tc$-HMPAO 15-20mCi를 정맥주입 후 시행하였으며 발작간 스캔은 11명의 환자에서 발작시 스캔 후 적어도 3일 간격을 두고 시행하였다. 간질병소는 우측측두엽이 6예, 좌측측두엽이 4예, 우측후두엽이 1예, 좌측전두엽이 1예 등이었다. 발작시 스캔상 간질병소 및 반대편 소뇌에 혈류가 증가하는 역해리현상은 모두 8명(75%)의 환자에서 나타났으며 특히 2명의 환자에서는 간질병소보다 반대편 소뇌의 동위원소 섭취가 더욱 뚜렸했다. 역해리현상을 보였던 환자의 발작간 스캔소견에서는 발작시 증가되었었던 소뇌의 동위원소 섭취가 7예에서 정상화되었고 나머지 1예에서는 감소되었다. 따라서 소뇌의 역교차해리현상은 발작시 뇌 SPECT의 자주 볼 수 있는 현상으로 간질병소의 편측화에 도움을 줄 수 있을 것으로 생각된다.

• The Journal of Dong Guk Oriental Medicine
• /
• v.9
• /
• pp.25-33
• /
• 2000

Dizziness is one of the common symptoms in many patients. The disorders of the labyrinth, vestibular nerve, vestibular neclei, or their central connections are responsible for practically all vertigo. Most disorders of the central connections are the vascular diseases and tumors. This study is based on the clinical consideration of one patient who sufferd from the cerebellar infarction and the upper respiratory infection. The patient, 61 - year - old man was diagnosed as the cerebellar infarction has been troubled with dizziness, a headache, a sore throat, a cough etc. The symptoms are classed as the Sanchopungyeul.(上焦風熱) Pungdam(風痰), and we prescribed Qingyanligetang(淸咽利膈湯) for him and his symptoms took a tum for the better.

• Journal of Biomedical Engineering Research
• /
• v.2 no.1
• /
• pp.47-54
• /
• 1981

This paper deals with a new approach to the modelling of neural interactions in the cerebellar cortex to construct a general purpose electronic simulation model. Since physiological data show that cerebellar neural activity changes in an approximately pulse manner in response to pulse stimulation, the differences in timing between excitation and inhibition of cerebellar cells will be treated as pure time delays and the transfer functions of the cells will be presented by pure gains. The parameters to be discussed in this paper are the coupling coefficients between a cell and its several inputs, the magnitude of a coupling coefficient which is presented as a measure of how much influnce a particular has on its target cell. And also this paper has been proposed that the cerrbellum engaged in improving the overall performance of the motor control system, i.e., the cerebellum is a compensator.