• Journal of the Korean Data and Information Science Society
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• v.28 no.5
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• pp.1069-1076
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• 2017

Recently, with the development of advanced medical technology and the introduction of most advanced medical equipments, life expectancy increases accordingly. Many people want to live long-lived in health. Therefore, if it is possible to pre-diagnose the sub-health condition and formulate an appropriate treatment plan, we can prevent the disease and reduce social expenditure costs. In this study, we statistically analyzed the data in responding to each questionnaire for healthy biorhythm and sub-health among targeted members of a specific group. The analysis for the effects of healthy biorhythm to male and female showed that there was a significant difference between male and female. In the analysis of the effects of the conditions of healthy biorhythm to the 10 sub-health indicators, the significant effects of good and bad condition has been observed. The results of the decision tree analysis showed that all the respondents with poor hormone and urological sub-health status have bad healthy biorhythms. In summary, in this paper we have shown that it may be possible to improve the sub-health condition and prevent disease in advance if the healthy biorhythm is well controlled.

• 대한예방의학회:학술대회논문집
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• 2002.10a
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• pp.543-543
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• 2002

• Journal of Marine Life Science
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• v.3 no.2
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• pp.59-66
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• 2018

The assessment of level of health of the tidal flats can be evaluate by health of organisms inhabit the tidal flats. It is possible to evaluate the precise health level of organisms inhabit the tidal flats using analysis of expression of biomarker genes. The purpose of this research is to evaluate the health of the tidal flats on the west coast using biomarker genes such as heat shock protein 70 (Hsp70), heat shock protein 90 (Hsp90), glutathione S-transferases (GST) and thioredoxin (TRX). These genes are stress, immune, and antioxidant related genes that can be used to look at the health of an organism through gene expression. In this study, we collected manila clam (Ruditapes philippinarum) in 8 analysis areas on the west coast. Expression of the genes was analyzed by RT-qPCR method. Results showed that, the expression of Hsp70, Hsp90, GST and TRX genes were differentially expressed in the 8 analysis areas. In particular, the expression of Hsp90 and GST or the expression of Hsp70 and TRX were similar. This means that there is a substance that reacts specifically to each gene. Therefore, I think suggest that the based on the results of physicochemical analysis, it can be selected genes suitable for analysis. These results suggest that Hsp70, Hsp90, GST and TRX were played roles in biomarker for assessment of the health of tidal flats.

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2002.10a
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• pp.164-164
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• 2002

에스트로젠을 처리한 송사리의 간으로부터 choriogenin vitellogenin estrogen receptor의 발현량을 전사수준에서 Real-time을 사용하여 정량.비교하였다. 시험어종으로는 부화 후 5개월 이상된 성숙한 수컷 송사리(Oryzias latipes)를(체중 약 250mg/마리)를 사용하여 17$\beta$-estradiol(25ppt, 50ppt, 100ppt)에 24시간 노출시켰다. Fluorescence dye는 choriogenin vitellogenin estrogen receptor의 경우 FAM (6-carboxyfluorescein)을 사용하였으며, $\beta$-actin의 경우는 VIC를 사용하였다. 프로브에 사용하는 quencher dye는 TAMRA(6-carboxy-N',N',N',N'-tetramethyl rhodamine)을 사용하였다. Internal control로 사용된 $\beta$-actin은 17$\beta$-estradiol의 농도에 상관 없이 0~10pM 범위에서 일정하게 발현됨을 보여주었다. vitellogenin choriogenin L 및 choriogenin H는 17$\beta$-estradiol의 농도에 의존하여 발현이 증가되는 용량-반응양상(Dose-dependent)을 나타내었다. 반면, estrogen receptor는 모든 처리군에서 $10^{-2}$pM 정도로 발혐됨에 따라 본 시험농도의 17$\beta$-estradiol에 의해서는 거의 유도발현이 되지 않음을 보여주었다. choriogenin L, choriogenin H, vitellogenin I 및 estrogen receptor 발현감수성을 비교한 결과, 25ppt 및 50ppt의 17$\beta$-esoadiol 농도에서는 ChgL > ChgH > VTG I >ER의 순으로 감수성이 높았으며, 100ppt 노출에서는 ChgL > VTG I > Chg H > ER의 순으로 감수성이 높게 나타났다. 결론적으로 choriogenin이 에스트로젠물질에 의한 가장 민감한 생체지표임을 알 수 있었다.

• Journal of Korean Biological Nursing Science
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• v.15 no.2
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• pp.74-81
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• 2013

Purpose: This study was conducted to explore the health effects of exposure to oil-contaminated water in G village near the area of Daecheon beach on which air force had test fired. Methods: Eighty residents consented and were divided into three groups; 33 residents(drinking well water and still living there), 23 residents(drinking well water but do not live there any more), and 24 residents(did not drink well water but live there now: control group). Data were collected from August to September, 2010 from the survey questionnaires, general health examination, specific functional test, and biological marker tests. Results: Current residents showed higher levels of body mass index, blood pressure, and fasting blood glucose that are related to adult diseases. 64 participants received specific test for cancer. Only one person had esophageal cancer. Perchloroethylene was not found in the Urine Samples. Current residents showed a higher level of 8-hydroxydeoxyguanosine, an indicator of oxidative damage, and there was a statistically significant difference after correcting the confounding variables. Conclusion: We need education programs for managing the risk factors that are related to adult diseases in people who are now living in this village. We also need to expand further studies for investigating oxidative damage indicators.

• Proceedings of the Korean Society of Disaster Information Conference
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• 2015.11a
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• pp.315-316
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• 2015

이 논문에서는 생체정보를 활용하여 심리적 흥분의 측정 가능성에 대한 연구를 하였다. 지능형 전자발찌의 도입에 있어서 생체정보와 감정의 관계를 연구하는 것은 매우 필요하다. 위험상황을 예측하는데 있어서 부착자의 감정을 측정할 수 있다는 것은 하나의 중요한 지표가 될 수 있다. 자율신경계와 감정은 밀접한 관게가 있으며 교감신경은 신체적 반응을 불러일으키는 역할을 하므로 심박을 통해서 감정의 변화, 즉, 심리적 흥분을 측정하는 것은 가능할 것으로 예측된다.

• Korean Journal of Agricultural and Forest Meteorology
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• v.15 no.4
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• pp.282-290
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• 2013

Biophysical and biochemical processes through which crops interact with the atmosphere have been simulated using land surface models and crop growth models. The Noah Multi Physics (MP) model and the CERES-Rice model, which are a land surface model, and a crop growth model, respectively, were used to simulate and compare rice growth and evapotranspiration (ET) in the areas near Haenam flux tower in Korea. Simulations using these models were performed from 2003 to 2012 during which flux measurements were obtained at the Haenam site. The Noah MP model failed to simulate the pattern of temporal change in leaf area index (LAI) after heading. The simulated aboveground biomass with the Noah MP model was underestimated by about 10% of the actual biomass. The ET simulated with the Noah MP model was as low as 21% of those with the CERES-Rice model. In comparison with actual ET measured at Haenam flux site, the root mean square error (RMSE) of the Noah MP model was 1.8 times larger than that of the CERES-Rice model. The Noah MP model seems to show less reliable simulation of crop growth and ET due to simplified phenology processes and assimilates partitioning compared with the CERES-Rice model. When ET was adjusted by the ratio between leaf biomass simulated using CERES-Rice model and Noah MP model, however, the RMSE of ET was reduced by 30%. This suggests that an improvement of the Noah MP model in representing rice growth in paddy fields would allow more reliable simulation of matter and energy fluxes.

• Korean Journal of Environmental Biology
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• v.36 no.2
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• pp.131-139
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• 2018

The warming of water as a result of climate change affects fish habitat. Variations in water temperature affect fish physiology almost totally. The rise in water temperature due to climate change leads to hypoxia following decreased oxygen solubility and decreased binding capacity of oxygen-carrying hemoglobin. This study was conducted to evaluate the health status of Atlantic salmon (Salmo salar) fry at elevated water temperatures($20^{\circ}C$) compared with optimum water temperature ($15^{\circ}C$). The method facilitated the detection of biomarker genes using NGS RNAseq analysis and evaluation of their expression pattern using RT-qPCR analysis. The biomarker genes included interferon alpha-inducible protein 27-like protein 2A transcript variant X3, protein L-Myc-1b-like, placenta growth factor-like transcript variant X1, fibroblast growth factor receptor-like 1 transcript variant X1, transferrin, intelectin, thioredoxin-like, c-type lectin lectoxin-Thr1-like, ladderlectin-like and calponin-1. The selected biomarker genes were sensitive to changes in water temperature based on NGS RNAseq analysis. The expression patterns of these genes based on RT-qPCR were similar to those of NGS RNAseq analysis.

• Science of Emotion and Sensibility
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• v.3 no.1
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• pp.33-40
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• 2000

감성공학과제에서는 연구보고서, 문헌, 지표, 생체데이터, 감성유발자극 등 많은 자료가 산출되고 있지만 단위연구과제에서 분산, 관리되고 있어 연구자원의 공유가 쉽지 않은 상황이다. 본 연구는 감성공학연구원과 감성응용제품 개발기업으로 사용자를 분류하고 요구분석, 설계 구축 단계를 거쳐 감성데이터베이스를 제작하여 연구자원을 공유할 수 있는 기반을 구축하였다. 데이터베이스 모델에는 연구보고서로부터 추출된 감성지표와 더불어 실험과 관련하여 독립변수, 종속변수, 실험자극, 생체데이터 등에 포함되었다. 이러한 데이터모델을 기초로 감성공학 데이터가 체계적으로 축적되면 사용자 웹에서 원하는 자료를 복합 검색할 수 있게 된다. 감성공학시스템은 사용하기 쉽도록 메뉴를 구성하였고 현재 한국표준과학연구원에서 운용하고 있다.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 1999.11a
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• pp.348-351
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• 1999

시청각 관련 지표 개발은 3차원 시청각 환경 제시기술, 시청각 감성을 활용한 Audio의 개발과 시청각 감성 측정기술 및 DB개발 등에 대하여 진행되었다. 3차원 시청각 환경 제시기술 개발은 VR 환경 제시 기술 개발과 모의 시뮬레이터를 통한 평가 단계 및 인간의 공간 인식 특성에 관한 연구로 이루어져 있다. 따라서 지표화 과정에서 VR 제시 시스템 관련 지표(3개), VR평가 지표(3개), 그리고 정보물(2개) 등 총 8개의 지표가 완성되었다. 시청각 감성을 활용한 Audio 개발과 시청각 감성 측정기술 및 DB개발에서는 시청각 감성에 대하여 주관적 평가 실시 후, 이를 이용한 제품개발 및 DB화하는 과정으로 구성되었으며, 각각의 연구물에 대하여 각각 6개와 13개의 지표가 완성되었다. 시청각 감성을 활용한 Audio 개발과 시청각 감성 측정기술 및 DB개발은 감성측정방법에서 제시 자극과 실험육법에서의 다소의 차이는 있었으나, 감성어휘 도출을 통한 SD척도법, 생체신호 측정, 자료처리방법 및 평가기준 등에서 유사성이 있었다. 따라서 각각의 연구물에 대한 지표 개발뿐만 아니라 지표간의 관련성을 비교ㆍ분석함으로써 체계화된 지표 표준화 과정이 필요한 것으로 보인다.