• Title/Summary/Keyword: 생산승인

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Reduction of Inflammatory Reaction of PLGA Using Fibrin; in vivo Study (PLGA의 염증완화에 대한 피브린의 효과 ; In vivo 연구)

  • Kim, Su-Jin;Hong, Hyun-Hye;Kim, Soon-Hee;Kim, Hye-Lin;Kim, Se-Ho;Khang, Gil-Son
    • Polymer(Korea)
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    • v.34 no.1
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    • pp.63-68
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    • 2010
  • In this study, we evaluated the effect of fibrin, a natural material, on the local inflammatory reaction of PLGA in vivo. PLGA degradation products can decrease the pH in the surrounding tissue, causing local inflammatory reaction. To solve this problem, fibrin/PLGA scaffolds were implanted in 5-week-old Wister rats. To evaluate the influence of fibrin content on inflammatory cytokine expression induced by PLGA, RT-PCR analysis was used. Fibrous wall thickness and macrophage infiltration were evaluated by H&E and ED-1 immunohistochemical staining, respectively. In this study, we showed that fibrin/PLGA scaffolds reduced inflammatory reaction as compared to PLGA scaffold. We concluded that fibrin could reduce inflammatory response of PLGA.

Risk assessment and variety registration of transgenic crops (형질전환작물의 위해성평가와 품종등록)

  • Lee, Keun-Pyo;Kim, Dong-Hern;Kweon, Soon-Jong;Baek, Hyung-Jin;Ryu, Tae-Hun
    • Journal of Plant Biotechnology
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    • v.35 no.1
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    • pp.13-21
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    • 2008
  • Final regulatory steps for commercialization of transgenic crops are risk assessment and variety registration. The risk assessment of transgenic crops requires broad network of scientists, high cost and long term. Developers of transgenic crops, therefore, face to additional challenges to consider theoretical and strategic aspects on risk assessment. The general concept for risk assessment of genetically modified organisms was derived from chemical risk assessment. Due to the complexity of organisms, however, comparative approaches that are substantial equivalence and familarity have been developed. In practical view, the integration of risk assessment is more difficult than the evaluation of each risk factors involving gene flow, toxicity and allergenicity. Variety registration of transgenic crops requires the results of risk assessment compared with non-GM crops and agronomic data analyzed with standard varieties. For economic and fast commercialization, risk assessment process should combined with condition of cultivation test for variety registration.

KISTI-ML Platform: A Community-based Rapid AI Model Development Tool for Scientific Data (KISTI-ML 플랫폼: 과학기술 데이터를 위한 커뮤니티 기반 AI 모델 개발 도구)

  • Lee, Jeongcheol;Ahn, Sunil
    • Journal of Internet Computing and Services
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    • v.20 no.6
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    • pp.73-84
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    • 2019
  • Machine learning as a service, the so-called MLaaS, has recently attracted much attention in almost all industries and research groups. The main reason for this is that you do not need network servers, storage, or even data scientists, except for the data itself, to build a productive service model. However, machine learning is often very difficult for most developers, especially in traditional science due to the lack of well-structured big data for scientific data. For experiment or application researchers, the results of an experiment are rarely shared with other researchers, so creating big data in specific research areas is also a big challenge. In this paper, we introduce the KISTI-ML platform, a community-based rapid AI model development for scientific data. It is a place where machine learning beginners use their own data to automatically generate code by providing a user-friendly online development environment. Users can share datasets and their Jupyter interactive notebooks among authorized community members, including know-how such as data preprocessing to extract features, hidden network design, and other engineering techniques.

Design of HSE Management System in a Shipyard using object-oriented Component-Based Development Method (ooCBD방법론을 적용한 조선소의 HSE관리시스템 설계)

  • Oh, Hyun-Soo;Chang, Seong-Rok;Kim, Dong-Joon
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.19 no.1
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    • pp.71-77
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    • 2013
  • Smart work has been gaining more popularity recently. Smart work means that employees perform their works anytime and anywhere as utilizing the information and communication technology. It can be divided into four categories; the mobile office, the home office, the work-at-center and the tele-cooperation. Among them, the mobile office based on tablet personal computers(PCs) or smart phones, employees can exchange information with tablet PCs or smart phones via mobile radio communication networks and portable terminals. Smart devices such as tablet PCs and smart phones help to access intranet system for requests, approvals, information search whenever employees need. This mobile office system for real-time HSE managing can contribute to improve the productivity and work efficiency in a shipyard. In this study, the main goal is to design the specialized mobile application for the HSE management system on the shipbuilding industry. The mobile application including 10 functions is designed based on ooCBD(object-oriented Component Based Development) methodology.

Membrane and Virus Filter Trends in the Processes of Biopharmaceutical Production (바이오의약품 제조공정에서 분리막의 역할과 바이러스 필터 동향)

  • Choi, Tae Hwan;Park, Ho Bum
    • Membrane Journal
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    • v.30 no.1
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    • pp.9-20
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    • 2020
  • Membranes are used in most processes of biopharmaceutical production. It is used for pretreatment of other processes, separation of impurities in the process, virus removal, control of products concentration and buffer solution exchange. Virus filters play an important role in ensuring product efficacy and stability because viral contamination of biopharmaceuticals for humans is a sensitive issue that is directly related to serious clinical outcomes. Virus filters typically have complex multilayer structures made of various polymers such as surface-modified PVDF, PES, CRC. Depending on the manufacturer, filters have different pore structures and shapes, such as symmetric or asymmetric, and is used in the form of pleated membrane, flat sheets or hollow fibers. Virus filters are exclusively supplied by few foreign companies such as Asahi Kasei, Millipore, Pall and Sartorius. Replacing virus filters can be time consuming and expensive, including approval from regulatory agencies through validation. As localization has become important due to Japan's recent export regulations, it is necessary to increase the degree of technical independence.

21세기 한국건축의 비전(Ⅰ)

  • Korea Institute of Registered Architects
    • Korean Architects
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    • no.12 s.368
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    • pp.31-45
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    • 1999
  • 숨가쁘게 달려오던 한국사회는 문득 21세기의 문턱 앞에 서 있다. 지난 한 세기는 한국 뿐만 아니라 세계건축계에도 많은 변화와 발전이 있었다. 이렇다 할 준비없이 우리가 맞이하는 21세기는 정보와 문화가 주도할 것으로 예상된다. 새로운 밀레니엄에 대한 기대와 세기적 전환시대를 맞는 현 시점에서 그동안 한국건축은 급격한 경제성장과 아울러 새로운 서구적 건축의 유입으로 인해 우리는 건축문화에 대한 관심을 기울일 시간도 없이 양적인 성장을 계속해 왔다. 외래건축의 유입으로 인해 한국건축이 겪었던 문화적 충격은 단순한 문화적 충돌이 아니라 기존 도시구조의 대대적인 변형과 파괴에 시달려야 했으며, 이로 인한 불균형한 개발은 급조된 건축물을 생산하는 결과를 초래하게 되었고, 이와 함께 우리 건축문화의 모습은 기형적인 도시환경의 모습으로 대체되었다. 이러한 상황에서 다가올 21세기는 WTO세계무역기구의 발전과 더불어 국가간의 개방정책이 불가피하게 이루어지고 있으며, 이에 따라 사회 전분야에 걸쳐 새로운 시도는 빠르게 움직이고 있다. 건축분야 역시 문호 개방원칙에 따라 국가간 건축사자격 상호인증에 대한 각국간의 심도있는 논의와 그에 따른 교육 및 시험수준, 경력의 요구조건, 제반규제사항 등 각국의 상호 차이점에 대한 구체적인 협의가 올해 열린 UIA(세계건축사연맹) 북경 총회에서 승인되어 표준안이 공포되었다. 이에 따라 우리나라도 건축사자격 상호인증에 대한 대책 마련을 위해 공청회개최 등을 통해 본격적인 논의가 이루어지고 있다. 이제 우리 건축계도 새로운 세기를 맞는 시점에 서 있다. 이러한 상황에서 한국건축계는 급변하는 세계속에 우리의 건축문화를 계승 발전해야 할 과제를 안고 있다. 이에 본지에서는 밀레니엄 특집으로 '21세기 한국건축의 비전'이란 주제로 한국건축의 새천년의 미래를 내다보고 이를 통해 우리 건축이 담고 있는 현실과 문제의 실마리를 풀 수 있는 계기를 마련하고자 이번 특집이 계획되었으며, 또한 한국건축이 나아갈 바람직한 방향을 짚어 봄으로써 한국건축의 활로를 모색하고 세기적 전환시대를 맞는 우리 건축의 미래지향적 자료로 활용되었으면 한다.

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The evaluation of aid effectiveness using the input-output analysis: the case of Vietnam (산업연관분석을 활용한 원조의 국가단위 효과 평가 - 한국 유상원조의 베트남 지원효과를 중심으로 -)

  • Park, Bokyeong;An, Jiyoun
    • International Area Studies Review
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    • v.22 no.2
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    • pp.211-218
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    • 2018
  • The evaluation of aid effectiveness at the national level has mostly focused on qualitative evaluation. This paper attempts to quantitatively evaluate EDCF 's support for Vietnam in 1995 ~ 2016 on the economy. First, we compare the strengths and weaknesses of various methodologies that can be used for quantitative assessment: panel analysis based on growth theory, input-output analysis, social account matrix analysis, CGE model, DSGE model, and time series analysis. Using the input-output analysis, we estimate that total output and value added have been generated about $5.9 billion and $1.7 billion in Vietnam, respectively. The increase in income per capita from the support was estimated to have contributed to a 0.21%p reduction in the poverty rate in Vietnam.

International Trends in Wheelchair Power Assist Add-ons Development (휠체어 동력 보조장치 개발 국제 동향)

  • Suk-Min Lee;Ki-Won Choi;Inhyuk Moon;Sangsoo Park
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.2
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    • pp.143-150
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    • 2023
  • As Korea's per capita income increases, participation in various leisure activities to improve the quality of life of the disabled is encouraged. However, in order to participate in leisure activities, movement to the place where the leisure activities are performed must be preceded, so interest in means of transportation for leisure activities of the disabled is increasing. Since manual and electric wheelchairs have their respective disadvantages as means of transportation for leisure activities, interest in power assisting devices for wheelchairs combining the functions of electric wheelchairs with manual wheelchairs is increasing. In this study, the FDA approval process of wheelchair power-assistance products was investigated, and the characteristics of side-attached, front-attached, downward-attached, and rear-attached types of power assist devices for wheelchairs wheelchair in countries around the world were identified. These information will be of great use in helping the disabled and their assistants in Korea to choose the optimal product according to the patient's condition. More usability tests and clinical case studies are needed so that people with disabilities can choose a power assist device suitable for them.

Status of Maize Production and Distribution in South East Asia (동남아시아 옥수수 생산 및 유통현황)

  • Lee, Sang-Kyu;Song, Jun-Ho;Baek, Seong-Bum;Kwon, Young-Up;Lee, Byung-Moo
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.60 no.3
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    • pp.318-332
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    • 2015
  • The maize production in South-eastern Asian countries showed a continuous increase with increasing poultry-livestock from the beginning of the 1990s to early 2010. Also the need for a new variety development of each contries was increased rapidly in the same period. Single-Cross hybrid varieties have been developed and supplied from 2001 instead of multi-cross maize varieties since 1992 in Indonesia. In Cambodia, CP group is mainly manufacturing feeds with most of the forage maize from farmers who are growing its seeds from the company. Cambodian main cultivars are varieties of multinational corporations such as DK8868 from Monsanto, NK6326, NK7328 from Syngenta and CP333 from CP group including local business company. Vietnam is the main maze importing country in South-Eastern Asia which had imported 13 times scale of amount compared to exports in average from 1990 to 2011. Vietnamese government has developed a range of varieties for improving their efficiency in production, such as the LVN-10 with political investments. Their production has been reached to 80% of the total. According to the 2012 MIFAFF (Ministry for Food, Agriculture, Forestry and Fisheries) data in Korea, domestic edible maize cultivation area was approximately 15,000ha. It showed 74,399 tons of production, 3.8% of food self-sufficiency in maize and around 0.9% of grain self-sufficiency rate. The consumption of grain is mostly rely on imports in Korea. To overcome the limit of the domestic seed market and increase maize self-sufficiency, the need to develop maze varieties for world-class is increasing at present through analyzing the market trend and prospect of the seed industry in South-eastern Asia.

Research status of the development of genetically modified papaya (Carica papaya L.) and its biosafety assessment (GM 파파야 개발 및 생물안전성 평가 연구 동향)

  • Kim, Ho Bang;Lee, Yi;Kim, Chang-Gi
    • Journal of Plant Biotechnology
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    • v.45 no.3
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    • pp.171-182
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    • 2018
  • Papaya (Carica papaya L.) is one of the crops widely planted in tropical and subtropical areas. The papaya fruit has low calories and are plentiful in vitamins A and C and in minerals. A major problem in papaya production is a plant disease caused by the papaya ringspot virus (PRSV). The first PRSV-resistant GM papaya expressing a PRSV coat protein gene was developed by USA scientists in 1992. The first commercial GM papaya cultivars derived from the event was approved by the US government in 1997. Development of transgenic papayas has been focused on vaccine production and limited agricultural traits, including insect and pathogen resistance, long shelf life, and aluminum and herbicide tolerance. Approximately 17 countries, including the USA and China, produced transgenic papayas and/or commercialized them, which provoked studies on biosafety assessment and development of GM-detection technologies. For the biosafety assessment of potential effects on human health, effects of long-term feeding to model animals have been studied in terms of toxicity and allergenicity. Studies on environmental safety assessment include influence on soil-microbial biodiversity and transfer to soil bacteria of GM selection markers. Many countries, such as Korea, the European Union, and Japan, that have strict regulations for GM crops have serious concerns about unintended introduction of GM cultivars and food commodities using unauthorized GM crops. Transgene- and/or GM event-specific molecular markers and technologies for genomics-based detection of unauthorized GM papaya have been developed and have resulted in the robust detection of GM papayas.