Browse > Article

Reduction of Inflammatory Reaction of PLGA Using Fibrin; in vivo Study  

Kim, Su-Jin (Department of BIN Fusion Tech, Department of Polymer Nano Sci. Tech., Chonbuk National University)
Hong, Hyun-Hye (Department of BIN Fusion Tech, Department of Polymer Nano Sci. Tech., Chonbuk National University)
Kim, Soon-Hee (Department of BIN Fusion Tech, Department of Polymer Nano Sci. Tech., Chonbuk National University)
Kim, Hye-Lin (Department of BIN Fusion Tech, Department of Polymer Nano Sci. Tech., Chonbuk National University)
Kim, Se-Ho (Department of BIN Fusion Tech, Department of Polymer Nano Sci. Tech., Chonbuk National University)
Khang, Gil-Son (Department of BIN Fusion Tech, Department of Polymer Nano Sci. Tech., Chonbuk National University)
Publication Information
Polymer(Korea) / v.34, no.1, 2010 , pp. 63-68 More about this Journal
Abstract
In this study, we evaluated the effect of fibrin, a natural material, on the local inflammatory reaction of PLGA in vivo. PLGA degradation products can decrease the pH in the surrounding tissue, causing local inflammatory reaction. To solve this problem, fibrin/PLGA scaffolds were implanted in 5-week-old Wister rats. To evaluate the influence of fibrin content on inflammatory cytokine expression induced by PLGA, RT-PCR analysis was used. Fibrous wall thickness and macrophage infiltration were evaluated by H&E and ED-1 immunohistochemical staining, respectively. In this study, we showed that fibrin/PLGA scaffolds reduced inflammatory reaction as compared to PLGA scaffold. We concluded that fibrin could reduce inflammatory response of PLGA.
Keywords
fibrin; PLGA scaffold; inflammatory cytokine; in vivo;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By Web Of Science : 0  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
연도 인용수 순위
1 Y. K. Ko, S. H. Kim, H. J. Ha, M. S. Kim, C. W. Han, J. M. Rhee, Y. Son, H. B. Lee, and G. Khang, Tissue. Eng. Regen. Med., 4, 67 (2007).
2 J. M Anderson and M. S. Shive, Adv. Drug Del. Rev., 28, 5 (1997).   DOI   ScienceOn
3 H. H. Hong, S. H. Kim, A. Y. Oh, N. R. Jeon, S. H. Jung, S. J. Lee, M. Dyke, J. J. Yoo, Y. Son, J. M. Rhee, and G. Khang, Tissue. Eng. Regen. Med, 5, 4 (2008).
4 S, H, Baek, J, H. Lee, J, W. Lee, M. L. Cho, S. I. Kim, J. I. Kim, D. S. Kim, S. H. Lee, and G. T. Kim, J. Korean Rheum. Assoc., 15. 2 (2008)
5 U. Klueh, D. I. Dorsky, F. Moussy, and D. L. Kreutzer, J. Biomed. Mater. Res. A, 67, 838 (2003).
6 B. S. Choi, S. H. Kim, S. J. Yoon, H J. Ha, M. S. Kim, Y. I Yang, Y. Son, G. Khang, J. M. Rhee, and H. B Lee, Tissue. Eng. Reg. Med., 3, 295 (2006).
7 G. Khang, M. S. Kim, and S. H. Cho, Tissue. Eng. Regen. Med., 1, 9 (2004)
8 S. M. Kim, S. H. Kim, C. M. Kim, A. Y. Oh, G. A. Kim, I. W. Lee, J. M. Rhee, G. Khang, M. S. Kim, and H B. Lee, Tissue. Eng. Regen. Med., 4, 179 (2007).
9 G. Khang, S. J. Lee, and M. S. Kim, "Scaffolds; Tissue Engineering", in Webser's Biomedical Engineering Handbook, 2nd Ed., Marcel Dekker, New York, Vol 1, 336 (2006).
10 M. S. Taylor, A. U. Daniels, K. P. Andriano, and J. Heller, J. Appl. Biomater, 5, 151 (1994)   DOI   ScienceOn
11 K. Athanasiou, G. G. Niederauer, and C. M. Agrawal, Biomaterials, 17, 93 (1996)   DOI   ScienceOn
12 S. H. Kim, D. Lee, Y. S. Kang, B. H. Min, Y. Son, and G. Khang, Tissue. Eng. Regen. Med, 6, 273 (2004).
13 A. Y. Oh, S. H. Kim, S. H. Kim, I. W. Lee, M. S. Kim, J. M. Rhee, G. Khang, and H. B. Lee, Tissue. Eng. Regen. Med, 4, 60 (2007).
14 J. S. Bae, M. K. Park, and S. W. Park, Korean Chem. Eng., 47, 4 (2009).
15 J. Suganuma and H. Alexander, .J. Appl. Biomater., 4, 13 (1993)   DOI
16 E. K. Lee, J. S. Lee, and H. S. Park, Tissue. Eng. Regen. Med, 2, 94 (2005).
17 C. C Verheyen, J. R. Wijn, and C. A. Blitterswijk, J. Biomed Mater Res., 27, 1115 (1993).   DOI   ScienceOn
18 J. W. Jang, B. Lee, C. W. Han, M. S. Kim, S. H. Cho, H. B. Lee, and G. Khang, Polymer(Korea), 28, 382 (2004).
19 Y. K. Ko, S. H. Kim, J. S. Jeong, H. J. Ha, S. J. Yoon, J. M. Rhee, M. S. Kim, H. B. Lee, and G. Khang, Polymer(Korea), 31, 14 (2007)
20 S. Y. Kim, Tissue. Eng. Regen. Med, 5, 1 (2008).
21 K. J. Lee, J. G. Roper, and J. C. Wang, Spine J., 5, 217 (2005).   DOI   ScienceOn
22 G. Khang, S. J. Lee, C. W Han, J. M. Rhee, and H. B. Lee, Adv. Exp. Med Biol., 534, 235 (2003).   DOI
23 G. Khang, M. S. Kim, and B. Y. Min, Tissue. Eng. Regen. Med., 3, 376 (2004).
24 J. Y. Lim, S. H. Kim, J. W. So, J. H. Choi, J. M. Rhee, H. S. Shin, and G. Khang, Tìssue. Eng. Regen. Med, 5, 437 (2008).
25 Y. J. Shin, J. K. Lee, and H. Chung, J. Korean Ophthalmol. Soc., 43, 4 (2002).