• Title/Summary/Keyword: 생물학적 정보

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Evaluation of Stability using Monte Carlo Simulation in 2 People Isolation Treatment Room of Radiation Iodine (몬테카를로 모의 모사를 이용한 방사성옥소 2인 치료병실의 안전성 평가)

  • Jang, Dong-Gun;Ko, Sung-Jin;Kim, Chang-Soo;Kim, Jung-Hoon
    • Journal of radiological science and technology
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    • v.39 no.3
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    • pp.385-390
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    • 2016
  • Radioactive iodine treatment that uses the 2 people isolation room is to cause unnecessary radiation exposure between patients. This research is to be tested safety of 2 people Isolation treatment room and dose-rate through conservative perspective except physiology characteristic and biology information on the assumption that patient have iodine without excretion in 2 people isolation treatment room. This research shows that 364 keV gamma rays emitted by the radioiodine was to determine that the air layer about 30 cm or lead shield 3 mm a half-layer. In addition, In addition, patients in the distance, and lead shielding, length of hospital stay (48 hours) for external radiation exposure that is received from the other patients, two of treatment as appears to be lower than the legal isolation standard dose less than 5 mSv isolation room effective analyzed that manageable.

The Differential Distribution of Ganglioside GM3 in Atre tic Follicles During Follicular Development of Adult Rat Ovary (성숙한 난소의 난포 발달이 진행되는 동안 폐쇄난포에서의 Ganglioside GM3의 서로 다른 분포)

  • 추영국
    • The Korean Journal of Zoology
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    • v.39 no.4
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    • pp.410-418
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    • 1996
  • Gangilosides are ubiquitous membrane components in mammalian cells and are suggested to play essential roles in cellular phenomena such as cell-cell interadion, differentiation, and signal transduction. Rat ovary contained GM3 as major gangiloside. Nn order to study GM3 distribution in the atretic follicles and its possible changes during follicular development, frozen sections were stained with spedfic monocional antibodies against eleven gangilo-series gangliosides including GM3. In the atretic follicles, Glf3 was expressed in a spatlo-temporally different manner during foilicular development, but GM1 and other gangliosides were not immunohistochemicaily detected. in atretic follicle from primary follicle stage, GM3 was expressed in all the theca cells and some granulosa cells adjacent to oocyte. In atretic follicle from secondary follicle stage, GM3 were expressed in all theca cells and granulosa cells. in atretic follicles from developing Graaflan follicle stages, GM3 was similarly expressed as in secondary follicle stage.

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MiR-24 Simultaneously Regulates Both Oxytocin and Vasopressin (바소프레신과 옥시토신을 동시에 조절 마이크로RNA, miR-24)

  • Lee, Heon-Jin
    • Journal of Life Science
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    • v.29 no.1
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    • pp.118-122
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    • 2019
  • Oxytocin (Oxt) and vasopressin (Avp) are mainly synthesized in neuronal cells of the hypothalamus and are released from the posterior pituitary. The structure and sequences of Oxt and Avp genes imply that they are closely related and that they are the result of a duplication event during evolution. A previous study suggested that a small regulatory microRNA (miRNA), miR-24, regulated Oxt after binding. However, it is not clear whether this miRNA can modulate Avp simultaneously. The aim of the present study was to investigate putative targeting miRNAs of Avp, including miR-24. Targeted candidate miRNA oligonucleotides were transfected into COS-7 cells to elucidate the binding activity of miRNAs and Avp using dual-luciferase assays. The luciferase assay showed that only miR-24 displayed elevated binding activity with Avp as compared to a control and other candidate miRNAs. Transfection with seed mutants of Avp and miR-24 inhibitors clearly showed that miR-24 can directly bind to the Avp gene. These results provide new insight into the regulatory mechanism of neurohypophysial hormones by a single miRNA.

Effects of Melatonin on the Reproductive Endocrine System in Male Golden Hamsters (골든 햄스터의 생식내분비계에 미치는 멜라토닌의 영향)

  • 최돈찬;우대균;임시내
    • Korean Journal of Environmental Biology
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    • v.20 no.3
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    • pp.224-231
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    • 2002
  • Photoperiod (length of light per day) is a major factor in regulating reproductive function in golden hamsters. The information of photoperiod is transmitted to the reproductive endocrine system by melatonin. Thus the effects of melatonin aye investigated in male golden hamsters exposed to photoperiods. Paired testicular weights were markedly reduced in the animals housed in short photoperiod $(SP,\le{12\;hours\;day^{-1})$ and injected with melatonin in the evening, but not in long photoperiod $(LP,\le{12.5}\;hours\;day^{-1})$ and injected with melatonin in the morning. The histological examination of regressed testes showed reduction of tubular lumen diameter including the numbers of cells and Leydig cell number. The mean values of both follicle stimulating hormone (FSH) and luteinizing hormone (LH) were also lowered in the sexually inactive animals than in the sexually active animals. Melatonin receptor was identified by reverse-transcription polymerase chain reaction (RT-PCR) and its expression was examined in various tissues to scrutinize the action site of melatonin. It turned out 309 nucleotides and was definitely expressed in hypothalamus and pituitary including spleen, retina, and epididymis. And gonadotropin releasing hormone (GnRH) gene, which is a key element in regulating reproduction, was identified by RT-PCR but the expression of GnRH was not modified by the treatment of melatonin. Taken together, photoperiod via melatonin indirectly affects reproductive endocrine system, possibly through the release of GnRH, not the synthesis of GnRH.

Current status and prospects of kiwifruit (Actinidia chinensis) genomics (참다래 유전체 연구 동향)

  • Kim, Seong-Cheol;Kim, Ho Bang;Joa, Jae-Ho;Song, Kwan Jeong
    • Journal of Plant Biotechnology
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    • v.42 no.4
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    • pp.342-349
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    • 2015
  • Kiwifruit is a new fruit crop that was commercialized in the late 1970s. Recently, its cultivation and consumption have increased rapidly worldwide. Kiwifruit is a dioecious, deciduous, and climbing plant having fruit with hairs and various flesh colors and a variation in ploidy level; however, the industry consists of very simple cultivars or genotypes. The need for efficient cultivar improvement together with the evolutional and biological perspectives based on unique plant characteristics, have recently encouraged genome analysis and bioinformatics application. The draft genome sequence and chloroplast genome sequence of kiwifruit were released in 2013 and 2015, respectively; and gene annotation has been in progress. Recently, transcriptome analysis has shifted from previous ESTs analysis to the RNA-seq platform for intensive exploration of controlled genetic expression and gene discovery involved in fruit ascorbic acid biosynthesis, flesh coloration, maturation, and vine bacterial canker tolerance. For improving conventional breeding efficiency, molecular marker development and genetic linkage map construction have advanced from basic approaches using RFLP, RAPD, and AFLP to the development of NGS-based SSR and SNP markers linked to agronomically important traits and the construction of highly saturated linkage maps. However, genome and transcriptome studies have been limited in Korea. In the near future, kiwifruit genome and transcriptome studies are expected to translate to the practical application of molecular breeding.

Importance and Application of Ichnology (생흔학의 중요성 및 활용)

  • Kim, Jong-Kwan;Chun, Seung-Soo;Baek, Young-Sook;Chang, Eun-Kyong;Shin, Sun-Ja
    • The Korean Journal of Petroleum Geology
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    • v.12 no.1
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    • pp.34-42
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    • 2006
  • Ichnology is the study of traces made by various organisms, which includes classification and description of traces, and interpretation of sedimentary process, behavior of organism and depositional environment based on traces and organism behavior. Ichnofacies, which is defined as the association of several traces related together with substrate characteristics and sedimentary processes, is closely related to depositional environment. Ichnology has been applied to sedimentology (to understand physical characteristics of depositional environment, sedimentation pattern and event bed), sequence stratigraphy (to recognize sequence boundaries and biostratigraphic discontinuities such as MFS, TSE and RSE), oil exploration (providing of many information without big cost) and palaeocology. Preliminary ichnological study on the Ganghwa intertidal flat shows that dominant ichofacies are changing with season and location, suggesting that their seasonal variation would be a good indicator to understand the seasonal change of sedimentary processes, the small- scale change of sedimentary environment and the preservation potential of such units. Ichnology on intertidal flat in western coast of Korea has a great potential to apply its results to petroleum geology as well as sedimentology.

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Study on the correlation between the soil bacterial community and growth characteristics of wild-simulated ginseng(Panax ginseng C.A. Meyer) (토양세균군집과 산양삼 생육특성 간의 상관관계 연구)

  • Kim, Kiyoon;Um, Yurry;Jeong, Dae Hui;Kim, Hyun-Jun;Kim, Mahn Jo;Jeon, Kwon Seok
    • Korean Journal of Environmental Biology
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    • v.37 no.3
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    • pp.380-388
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    • 2019
  • The studies regarding soil bacterial community and correlation analysis of wild-simulated ginseng cultivation area are insufficient. The purpose of this study was to investigate the correlation between soil bacterial community and growth characteristics of wild-simulated ginseng for selection of suitable cultivation area. The bacterial community was investigated by high throughput sequencing technique (Illumina platform). The correlation coefficient between soil bacterial community and growth characteristics were analyzed using Spearman's rank correlation. The soil bacterial community from soil samples of 8 different wild-simulated ginseng cultivated area exhibited two distinct clusters, cluster 1 and cluster 2. The relative abundance of Proteobacteria (35.4%) and Alphaproteobacteria(24.4%) was observed to be highest in all soil samples. The lower soil pH and higher abundance of Acidobacteria resulted in increased growth of wild-simulated ginseng. Additionally, abundance of Acidobacteriia (class) and Koribacteraceae (family) demonstrated significant positive correlation with fresh weight of wild-simulated ginseng. The results of this study clearly state the correlation between growth characteristic and soil bacterial community of wild-simulated ginseng cultivation area, thereby offering effective insight into selection of suitable cultivation area of wild-simulated ginseng.

Biodegradation of Biphenyl by Sphingbium yanoikuyae BK-10 (Biphenyl의 Sphingobium yanoikuyae BK-10에 의한 분해 특성)

  • Lee Jung-Bok;Kim Dong-Geol;Choi Chung-Sig;Sohn Ho-Yong;Kim Jang-Eok;Kwon Gi-Seok
    • Microbiology and Biotechnology Letters
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    • v.34 no.2
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    • pp.174-179
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    • 2006
  • Bacterium capable of using biphenyl as a sole source of carbon and energy were isolated from soil, and based on the results of 16S rDNA sequence, strain BK10 identified as a Sphingobium yanoiktiyae. The optimum cultural conditions were as follows; $NH_4NO_3$ 1g, $K_2HPO_4$ 1g, $MgSO_4{\cdot}7H_2O$ 0.5g, $CaCO_3$ 0.2 g per 1 liter of distilled water. The Sphingobium yanoikuyae BK10 strain was completely utilized biphenyl in mineral salt media containing biphenyl at concentration 500 $\mu$g/ml of biphenyl as a sole carbon and energy source within 48 hours. Optimumal pH and temperature for biphenyl degradation and cell growth of strains were 6.0$\sim$8.0 and 20$\sim$50$^{\circ}C$, respectively. Especially, at 30$^{\circ}C$, cell-growth were higher than other temperature. Cell grown on biphenyl has been shown to have a higher removal rate for biphenyl than grown on sucrose. This study shows that Sphingobium yanoikuyae BK10 strain had a high biodegradation capability of biphenyl and can be simulate a candidate compounds the bioremediation of PCBs (Polychlorinated biphenyl) contaminant soil and water.

Two Class Approximation of TLB (Tomato Late Blight) Activity Data (토마토 역병균 항균 활성 데이터의 이분번 근사모델링)

  • Hahn, Hoh-Gyu;M.D., Ashek Ali;Cho, Seung-Joo
    • The Korean Journal of Pesticide Science
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    • v.9 no.2
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    • pp.140-145
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    • 2005
  • Quantitative Structure Activity Relationship (QSAR) assumes the relatedness between physical property and biological activity. However, activity data measured at single concentration such as percent activity have not been used extensively for modeling purpose. This probably comes from the fact that these values are qualitative instead of quantitative. To utilize percent activity data for molecular modeling, we classified the whole data into two classes. One class represents the active while the other signifies the inactive. The percent activity data of ${\beta}$-Ketoacetoanilides measured for TLB (Tomato Late Blight) were investigated. CoMFA (Comparative Molecular Field Analysis) was used as a discriminant function. Using CoMFA provides 3D (three dimensional) information, which is crucial for chemical insight. It can also serve as a predictive model. The resultant model classified the given data correctly (98%). When LOO (leave-one-out) crossvalidation procedure was applied, the classification accuracy was 69%. Therefore two class approximation of percent activity data with CoMFA can be utilized to understand the relationship between chemical structure and biological activity and design subsequent chemical analogs.

Face Tracking Method based on Neural Oscillatory Network Using Color Information (컬러 정보를 이용한 신경 진동망 기반 얼굴추적 방법)

  • Hwang, Yong-Won;Oh, Sang-Rok;You, Bum-Jae;Lee, Ji-Yong;Park, Mig-Non;Jeong, Mun-Ho
    • Journal of the Institute of Electronics Engineers of Korea SC
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    • v.48 no.2
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    • pp.40-46
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    • 2011
  • This paper proposes a real-time face detection and tracking system that uses neural oscillators which can be applied to access regulation system or control systems of user authentication as well as a new algorithm. We study a way to track faces using the neural oscillatory network which imitates the artificial neural net of information handing ability of human and animals, and biological movement characteristic of a singular neuron. The system that is suggested in this paper can broadly be broken into two stages of process. The first stage is the process of face extraction, which involves the acquisition of real-time RGB24bit color video delivering with the use of a cheap webcam. LEGION(Locally Excitatory Globally Inhibitory)algorithm is suggested as the face extraction method to be preceded for face tracking. The second stage is a method for face tracking by discovering the leader neuron that has the greatest connection strength amongst neighbor neuron of extracted face area. Along with the suggested method, the necessary element of face track such as stability as well as scale problem can be resolved.