• KIPS Transactions on Software and Data Engineering
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• v.8 no.10
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• pp.421-426
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• 2019

In this paper, we propose a method to visualize the geometric features of the contact region between proteins in a protein complex. When proteins or ligands are represented as curved surfaces with irregularities, the property that the two surfaces contact each other without intersections is called shape compatibility. Protein-Protein or Protein-Ligand docking researches have shown that shape complementarity, chemical properties, and entropy play an important role in finding contact regions. Usually, after finding a region with high shape complementarity, we can predict the contact region by using residual polarity and hydrophobicity of amino acids belonging to this region. In the research for predicting the contact region, it is necessary to investigate the geometrical features of the contact region in known protein complexes. For this purpose, it is essential to visualize the geometric features of the molecular surface. In this paper, we propose a method to find the contact region, and visualize the geometric features of it as normal vectors and mean curvatures of the protein complex.

• Journal of Gifted/Talented Education
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• v.13 no.4
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• pp.119-140
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• 2003

The purpose of this study is to examine the dispute over creativity domain at schools in Korea. In other words, this study is to examine the creativity domain among all subjects, a group of high level performance, and a group of low level performance in creativity. Based on ability-differentiation hypothesis, correlation among 4 domains, correlation between divergent thinking variables of domain-generality and 4 domains of domain-speciality, and multiple linear regression have been computed. The results are opposed to the hypothesis. The group of low level performance is related to domain-speciality. The group of high level performance, however, has relationships neither domain-generality nor domain-speciality. Instead of differentiation between domain-generality and domain-speciality, the results support the domain-complementarity.

• Journal of Life Science
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• v.18 no.11
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• pp.1507-1512
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• 2008

In spite of long research period for Salmonella typhi, little information is known about the pathogenesis mechanism of human typhoid fever caused by S. typhi due to lack of infection model in animals. A wild-type of S. typhi Ty2 strain requires cysteine to grow on minimal media. We hypothesized that this cysteine requirement may restrict colonization of S. typhi in animals during infection process. Among the S. typhi strains carrying Salmonella typhimurium genomic library, we have isolated three S. typhi transformants growing on minimal media without cysteine. Although there were three ORFs in DNA of pBP71, the STM1490 ORF complemented cysteine auxotrophy of S. typhi. Analysis of the deduced amino acid sequence of the STM1490 homolog in S. typhi revealed that there are differences in two amino acids. Plasmids containing amino acid substitutions in STM1490 supported S. typhi growth on minimal media without cysteine, indicating irrelevance of these two amino acids to STM1490 function. These results tells us that there are other factors or systems involved in cysteine requirement of S. typhi.

• Applied Biological Chemistry
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• v.40 no.1
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• pp.30-33
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• 1997

About 250 bp ura5 gene (Orotate phosphoribosyl transferase) fragment was cloned from genomic DNA of entomopathogenic fungus Metarhizium anisopliae by using PCR method. Entire nucleotide sequences of cloned DNA fragment were determined and analysed as compared with other fungus ura5 genes. The amino acid sequence deduced from the nucleotide sequence showed 85.5% homology to ura5 protein of Trichoderma reesei. Using this 250 bp PCR fragment we have isolated full ura5 gene of M. anisopliae by genomic Southern hybridization and the isolated 4.4 kb DNA fragments were mapped by restrictional enzyme.

• Proceedings of the Korean Society for Information Management Conference
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• 1994.12a
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• pp.133-136
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• 1994

문헌분류는 지식분류에 입각하여야 한다는 분류의 제 1원리를 규명하기 위하여 지식의 발전과정을 인식론적 관점에서 규명하였으며. 이를 바탕으로 지식분류가 문헌분류에 어떤 영향력을 미쳤는가를 규명하였다. 주제개념은 주관적 관념론, 객관적 관념론, 실용주의, 유물론으로 구분하여 분석하였다. 분석된 결과에 따라 지식분류가 어떤 인식의 관점에서 전개되어 왔는지를 인도의 베다분류법을 비롯하여 플라톤과 아리스토텔레스의 지식분류에서부터 현재의 머시럼, 브리테니카 3의 분류법에 이르기까지 분석하였다. 또한 이를 토대로 지식분류와 문헌분류의 상보성을 규명하였다.

• Journal of the Korean Society for Precision Engineering
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• v.26 no.11
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• pp.12-19
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• 2009

• Journal of Life Science
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• v.2 no.4
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• pp.220-231
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• 1992

항체의 구조와 기능, 촉매항체의 이론적 배경과 방법론에 대하여, 특히 에스테르-아미드결합의 가수분해반응을 중심으로 기술하였다. 항체단백질은 분자량이 약 150kDa이며, 2가닥의 L사슬과 2가닥의 H사슬로 구성되어있다. 항체에 촉매작용을 도입하는 연구가 행해지고 있는데 대표적인 방법은 hapten에 대한 항체의 입체적 또는 전자적 상보성은 이용하는 것이고 둘째는 기질 특이적인 항체를 직접 화학수식 하든가 또는 부위 특이적 변이유발 등의 방법으로 촉매활성기를 도입하는 방법이다. 촉매항체의 매력은 합리적인 hapten의 설계로 원하는 촉매활성을 갖는 항체를 유도하는 데 있다.

• The Journal of the Korea Contents Association
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• v.13 no.11
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• pp.176-186
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• 2013

The purpose of this study is to investigate the economies of scale and scope in the medical service industry of Korea using the multiple output translog cost function. The results show that the single-product scale economy (SSE) estimated is highly significant and less than one, implying that Korean medical service institutes are on average enjoying the product-specific scale economy in providing their services. In addition, the ray scale economies (RSE) reflects the overall economy of the scale in individual firm, showing less than one. Thus, the medical service industry in Korea is generally operating in the region of increasing returns to scale. The findings provide evidence of the economy of scope, in particular, with the joint production of inpatient and outpatient services as well as inpatient and administrative services.

• Korean Journal of Social Welfare
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• v.57 no.2
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• pp.205-230
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• 2005

This study empirically examines if there is a certain linkage between the production regimes and welfare systems; and if linked, how they are linked. It also investigates what the different regimes performed in terms of economic growth and redistribution. As a matter of fact, we have a series of studies that explores structural diversity of production and welfare. However, the existing studies are limited in that they consider only specific facets of the structure, although the structure of welfare capitalism should be studied as a comprehensive whole. This is the gap which this study tries to overcome. The study is composed of two major parts. The first one is the cluster analysis that examines if Esping-Andersen's notion about three different welfare regime and the thesis of diversity of capitalism can be dealt within a single research framework. The second is the ANOVA analysis investigating if variables of production and welfare are to be statistically different in the trichotomy framework. According to the result of the analyses, we can find at least two important evidences about institutional complementaries of production and welfare. First, Esping-Andersen's framework is useful to comprehensively deal with production as well as welfare. Secondly, there are statistically different regimes of production and welfare in the context of political economic and social policy variables. What is the most striking conclusion of the study is that there is no difference among the regimes in terms of the level of economic efficiency; while we can find a huge differences in terms of the level of welfare effectiveness. In conclusion, there is no substantive evidence to argue that welfare is innately antithesis of economic growth.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.12 no.1
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• pp.29-35
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• 1999

접촉하는 두 물체 사이의 접합부에서는 국북적인 응력집중현상이 발생하여 기계 구조물의 마멸이나 파손의 직접적인 원인이 된다. 기존의 방법들은 복잡한 수식 처리와 반복 계산 때문에 접촉특성에 따라서 해석하기에 어려움이 많았다. 본 논문에서는 마찰이 있는 접촉문제를 반복계산 없이 효과적으로 해석하기 위해서 선형상보성 접촉조건과 가상일의 원리로부터 접촉요소를 개발하여 이를 사용한 유한요소 해석발법을 제안하였다. 연구결과로 평면 및 곡면 접촉문제나 다물체 접촉문제를 기존의 해석방법에 비해 훨씬 편리하고 정확하게 접촉현상을 규명할 수 있었다.