• Clinical and Experimental Pediatrics
• /
• v.48 no.7
• /
• pp.772-778
• /
• 2005

Purpose : Kawasaki disease(KD) is a systemic panvasculitis that causes coronary artery lesions. KD is accompanied by immunoregulatory abnormalities. Nitric oxide(NO) can induce relaxation of blood vessels by activating guanylate cyclase in smooth muscle cells and high levels of NO may result in coronary artery lesions. We investigated tumor necrosis factor$(TNF)-{\alpha}$ and NO production before and after intravenous immunoglobulin(IVIG) therapy to study the roles of NO and $TNF-{\alpha}$ in KD with coronary artery lesions. Methods : Serum levels of NO and $TNF-{\alpha}$ were measured in 24 patients with KD(group I, eight patients with normal coronary artery; group II, 16 patients with coronary artery lesions) and 23 controls(group III, 13 afebrile controls; group IV, 10 febrile controls). Blood samples from each subject were drawn before and after IVIG therapy and in the convalescent stage. Serum concentrations of NO and $TNF-{\alpha}$ were measured by enzyme linked immuno sorbent assay. Results : The NO levels before IVIG therapy were significantly higher in group II than in group I, group III and group IV. After IVIG therapy the levels of NO were significantly higher in group I and group II than in group III. The $TNF-{\alpha}$ levels before IVIG therapy were significantly higher in group I and group II than in group III. The serum $TNF-{\alpha}$ and NO levels were higher before IVIG therapy and decreased through the convalescent stage in KD patients. In the acute stage of KD patients with coronary artery lesions, serum NO levels significantly correlated with white blood cells (r=0.43, P<0.05). Conclusion : The serum concentration levels of $TNF-{\alpha}$ and NO were abnormally high in KD patients and NO concentrations were statistically higher in the KD patients with coronary artery abnormalities than those without coronary abnormality during the early stage of the KD. These results suggest NO may be involved in the development of coronary artery lesions.

• Journal of Life Science
• /
• v.20 no.4
• /
• pp.555-560
• /
• 2010

The objective of this study was to investigate levels of serum creatinine, CuSOD and MnSOD protein expression in the kidney after renal ischemic reperfusion with pre-exercise using heat shock protein 70.1 in knock-out mice (KO). The C57/BL6 strain (Wild type: WT) and KO were divided into 4 groups as follows: Sham control group (Sham), pre-exercise group (Ex), pre-exercise +ischemia group (Ex+IR), and ischemia group (IR). CuSOD and MnSOD expression were significantly decreased (p<0.01, p<0.05) and blood creatinine concentration was significantly increased (p<0.01) in the IR group of KO. In contrast, CuSOD and MnSOD expression in the Ex+IR group of KO were higher than the IR group, while creatinine concentration was significantly lower. These results suggest that Hsp70 is directly correlated to renal ischemic reperfusion injury. Pre-exercise in renal ischemia might prevent or inhibit positive oxidative stress inhibitory effects by increasing anti-oxidative enzymes (CuSOD, MnSOD) within the kidney and improve to prevent renal function. Thus, pre-exercise may have a protective role against renal injury after renal ischemia.

• Journal of the East Asian Society of Dietary Life
• /
• v.19 no.5
• /
• pp.750-760
• /
• 2009

In this study, the various effects of Salicornia herbacea, including antioxidative function, antibiotic, and anti-inflammatory effect, and the effect of sebiparous reduction due to intervention of the DHT hormone were investigated using. The result of this study Based on this analysis, the serum total cholesterol, triglyceride, and WBC were found to be significantly decreased and SOD, Ca, K, and Zn were shown to be significantly increased significantly in the group that received the SH pill group after trial fora 12 week trials. Testosterone and DHT were increased in the SH pill group, but it was not statistically significant. In the case of the skin condition measurements, the number of blackhead pores, skin oiliness, keratin and, MIC were significantly decreased, and the pH was decreased to normal pH in the SH pill group. Therefore, it was confirmed that overall skin condition was improved due to Salicornia herbacea diet. The results of this research result can contribute so demonstrate the potential of actively using that the Salicornia herbacea can be actively developed as a health supplement, and a medication.

• Geophysics and Geophysical Exploration
• /
• v.11 no.2
• /
• pp.137-147
• /
• 2008

Fault rupture directivity of the Odaesan earthquake, which was inferred to be the main cause of the high PGAvalue (> 0.1 g) unusually observed at the near-source region, was analyzed by using the data from the nearby (R < 100 km) dense seismic stations. The Boatwright's method (2007) was adopted for this purpose in which the azimuth and takeoff angle of the unilateral rupture directivity function could be estimated based on the relative peak ground-motions of seismic stations resulting from the nature of the rupture directivity. In this study, the approximate values of the relative peak ground-motions was derived from the difference between the log residuals of the point-source spectral model (Boore, 2003) for the main and secondary events based on the Random Vibration Theory. In this derivation, the spectral difference for a frequency range between the source corner frequencies of main and secondary events was considered to reflect only the effect of the fault directivity. The inversion result of the model parameters for the fault directivity function showed that the fault-plane of NWW-SEE direction dipping steeply to the North with high rupture velocity near upward in SE direction is responsible for the observed high level of ground-motion at the near-source region.

• Journal of Yeungnam Medical Science
• /
• v.12 no.2
• /
• pp.306-318
• /
• 1995

To evaluate the intractability of partial epileptic patients by variables, the author studied 113 patients (uncontrolled: 45, controlled: 68) who were admitted to the Department of Neurology, College of Medicine, Yeungnam University from January, 1991 to August, 1993. The results were as follows. The items related to complex partial seizures, multiple seizure types and a histories of status epilepticus or clusters of seizures were significantly associated with drug-refractoriness (p<0.01). A high frequency of seizures before evaluation was associated with a poor outcome(p<0.01). The presences of known etiology of seizures, neurologic abnormalities and psychiatric disturbance were associated with limited treatment responses(p<0.01, p<0.05, p<0.01). An abnormal EEG findings such as background slowing, focal slowing, epileptiform discharges or secondarily bilateral synchrony were statistically significant (p<0.01). Age at onset, sex, distribution of epileptic foci, duration of seizure before evaluation, family history and abnormal neuroradiologic findings were not statistically significant. By these results, it was suggested that having at least four factors of the above variables were associated with limited treatment response.

• Journal of the Korean Orthopaedic Association
• /
• v.54 no.4
• /
• pp.353-360
• /
• 2019

Purpose: In the treatment of Dupuytren's contracture, the aim of optical treatment is to lower the recurrence rate and reduce complications. This paper reports the results of subtotal fasciectomy in Dupuytren's contracture, extending the excision of palmar fascial structures from the diseased to normal appearing adjacent fascial structure. Materials and Methods: From 2007 to 2017, 45 patients with Dupuytren's contracture treated by subtotal fasciectomy were reviewed retrospectively. The mean follow-up period was 45.9 months. Ninety-two digits were involved (index: 2, middle: 10, ring: 44, little: 36). The predisposing factors and affected joint were reviewed and the preoperative and postoperative contracture was measured. For clinical results, quick disabilities of the arm, shoulder, and hand (quick DASH) were used. Complications, including wound or skin problems, nerve injuries, hematoma, and complex regional pain syndrome, were assessed. Results: Preoperative flexion contracture was 43.2° in the proximal interphalangeal joint and 32.9° in the metacarpophalangeal joint. In nine cases, patients had residual contracture of 9.7° (range, 5°-20°) on average and if the total number of cases were included, the mean residual contracture was 2.3° on average. The quick DASH score at the 12 months follow-up was 12.4. The overall complication rate was 26.6%. Conclusion: Subtotal fasciectomy can be a good surgical treatment option for Dupuytren's contracture with a low recurrence and low complication rate compared to other open procedures.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• 2000.04a
• /
• pp.10-10
• /
• 2000

램제트 엔진은 비추력이 높고 추력 레벨은 낮으므로, 2단 추진기관에 적합한 추진 시스템이다. 1단-추진기관의 작동이 끝나고, 2단 램제트 엔진이 점화 후 안정된 연소에 도달되기까지 비행체의 속도는 항력에 의하여, 초당 약 마하수 0.1 정도씩 감소된다. 1단 연소 후 2단 램제트로 전환되는 지연시간이 길수록 1단에서 요구되는 종말 가속도는 증가되므로, 1단이 차지하게되는 부피는 증가되고 비행체의 크기 또한 늘어나게 된다. 따라서 1단에서 2단 램제트로 천이되는데 소요되는 시간을 가능한 짧게 하는 것이 효과적이다. 그러나 램제트 엔진의 특성상 선결되어야할 다음과 같은 여러 문제들이 있다. 첫째, 1단 작동 시 공기 흡입구와 연소실은 차단벽으로 분리되어 있다가, 1단 연소후 차단막이 제거되어 외부공기가 램제트 연소실로 흡입된다. 흡입되는 공기는 흡입구의 형상에 의하여 램 압축되지만 초음속으로 연소실을 통과하게된다. 연료 주입 구에서 공급되는 연료는 연소실에서 유동의 흐름방향(streamline)에 따라서 연소실로 확산되는데, 연소되기 전에는 유속이 빠르게 노즐로 빠져 나가므로 램제트 연료가 재순환 구역(recirculation zone)으로 침투하는데 쉽지가 않다. 둘째, 연소실 입구에서 발생되는 와류 (ring vortex)는 1단 연료의 고온 연소 가스를 연소실로 확산시키는데, 비 균일한 온도 분포를 유발하여 램제트 연료의 점화에너지가 공급되는 시간이 적당하지 않을 경우 균일한 화염 전파에 악영향을 준다. 셋째, 연소실에서의 빠른 유동 조건은 연료가 연소실에 머무를 수 있는 시간을 감소시키며, 연소실 입구에서 강한 전단 응력이 발생되어 화염이 안정화되는데 악 영향을 미치게된다. 본 논문은 공기 흡입구, 연소실 및 노즐을 통합하여 수치해석을 하였으며 열유동/점화/연소등의 미케니즘을 이해하고, 주요 인자들 중 와류의 영향에 초점을 맞추었다.다고 판단되며 배기 가스 자체에 대기 공기중에 함유되어 있던 습기가 얼어붙는(Icing화) 문제가 발생하기 때문에 배기가스의 Icing을 방지하기 위하여 압축기 끝단에서 공기를 추출하여 배기부분에 송출할 필요성이 있는 것으로 판단되었다. 출구가스의 기체 유동속도가 매우 빠르므로 (100-l10m.sec) 이를 완화하기 위한 디퓨저의 설계가 요구된다고 판단된다. 또 연소기 후방에 물을 주입하는 경우 열교환기 및 기타 부분품에 발생할 수 있는 부식 및 열교환 효율 저하도 간과할 수 없는 문제로 파악되었다. 이러한 기술적 문제가 적절히 해결되는 경우 비활성 가스 제너레이터는 민수용으로는 대형 빌딩, 산림, 유조선 등의 화재에 매우 적절히 사용되어 질 수 있을 뿐 아니라 군사적으로도 군사작전 중 및 공군 기지의 화재 그리고 지하벙커에 설치되어 있는 고급 첨단 군사 장비 등의 화재 뿐 아니라 대간첩작전 등에 효과적으로 활용될 수 있을 것으로 판단된다.가 작으며, 본 연소관에 충전된 RDX/AP계 추진제의 경우 추진제의 습기투과에 의한 추진제 물성 변화는 미미한 것으로 나타났다.의 향상으로, 음성개선에 효과적이라고 사료되었으며, 이 방법이 편측 성대마비 환자의 효과적인 음성개선의 치료방법의 하나로 응용될 수 있으리라 생각된다..7%), 혈액투석, 식도부분절제술 및 위루술·위회장문합술을 시행한 경우가 각 1례(2.9%)씩이었다. 13) 심각한 합병증은 9례(26.5%)에서 보였는데 그중 식도협착증이 6례(17.6%), 급성신부전증 1례(2.9%), 종격동기흉과 폐염이 병발한 경우와 폐염이 각 1례(2.9%)였다. 14) 식도경 시행회수는 1회가 17례(54.8%), 2회가 9례(29.0%), 3회 이상이 5례(16.1%)였다.EX>$IC_{50}$/ 값이 210 $\mu\textrm{g}$/$m\ell$로서 효과적

• Journal of The Korean Society of Grassland and Forage Science
• /
• v.31 no.3
• /
• pp.277-284
• /
• 2011

To investigate the effects of arbuscular mycorrhizal (AM) symbiosis on N uptake and its assimilation under drought-stressed conditions in white clover, total $^{15}N$ amount and $^{15}N$ amount incorporated into $NO_3^-$, amino acids and soluble proteins were quantified by $^{15}N$ tracing during 7 days of water treatment. Under well-watered conditions, there were no significant effects of AM symbiosis on all parameters analyzed in this study. Drought stress decreased total $^{15}N$ amount both in AM and non-AM plants, with a lower rate in AM plants (-13.8%) relative to non-AM plants (-28.5%) at day 7. Drought significantly increased $^{15}N-NO_3^-$ amount in non-AM plants. The amount of $^{15}N$-amino acids was 1.26-fold and 1.33-fold higher, respectively, in leaves and roots of AM plants compared to those of non-AM ones. Drought decreased the amount of $^{15}N$-soluble proteins in leaves at day 7, with a higher rate in non-AM plants than in AM ones. These results clearly indicate that AM colonization effectively alleviating the decrease in N uptake, amino acids and proteins synthesis caused by drought stress.

• Journal of Korean Society of Forest Science
• /
• v.111 no.4
• /
• pp.530-537
• /
• 2022

This study was conducted to compare the physical and chemical properties of soils in Quercus acutissima, Q. mongolica, Q. serrata, and Q. variabilis stands. A total of 423 plots (Q. acutissima 72 plots, Q. mongolica 150 plots, Q. serrata 97 plots, and Q. variabilis: 104 plots) were examined to determine the soil properties of A and B horizons throughout the country. The physical and chemical properties of soils were significantly different among the four different Quercus spp. stands. The sand content in both horizons was significantly higher in Q. acutissima stands than in the other three oak stands, whereas the clay content was lowest among the four stands. The soils in Q. mongolica and Q. serrata stands were more acidified than those in Q. acutissima and Q. variabilis stands. The concentrations of organic carbon and total nitrogen in both soil depths were significantly higher in Q. mongolica stands than in Q. serrata, Q. variabilis, and Q. acutissima stands. The content of available phosphorus was significantly higher in Q. mongolica and Q. serrata stands than in Q. acutissima and Q. variabilis stands; whereas the contents of exchangeable potassium, calcium, and magnesium were lower in Q. mongolica and Q. serrata stands than in Q. acutissima and Q. variabilis stands. The cation exchange capacity was highest in Q. mongolica stands, followed by that in Q. serrata, Q. variabilis, and Q. acutissima stands. These data indicate the need to design a nutrient management plan to enhance the low soil pH and exchangeable cation in Q. mongolica and Q. serrata stands.

• Clinics in Shoulder and Elbow
• /
• v.15 no.2
• /
• pp.79-85
• /
• 2012

Objective: It has been expected that patient with posttraumatic recurrent anterior shoulder dislocation might have limited daily life activity because of pain and apprehension of dislocation. But there have been only a small number of investigations regarding the rotator strength in this patient. The aim of this study is to find the characteristics about rotator strength of patient with posttraumatic recurrent anterior shoulder dislocation using an isokinetic testing. Method: We enrolled thirteen patients with posttraumatic recurrent anterior shoulder dislocation and fifteen sex, age-matched healthy nonathletic subjects in this controlled study. All participants were male and there were no significant differences between the two groups in age, height, weight, BMI. Isokinetic internal rotator and external rotator strength was evaluated with a Biodex Isokinetic Testing machine (Biodex Medical Systems, Shirley, NY, USA), tests were performed at 60 deg/sec and 180 deg/sec for both sides. Peak torque normalized to body weight, external rotator to internal rotator ratio, total work and fatigue were calculated for each angular velocity. The association between internal rotator and external rotator strength and shoulder instability was analyzed by comparisons with a control group. Results: Any notable differences could not be found between the two groups given all data from no symptomatic left shoulder. There were no significant differences between the two groups statistically in internal rotation strength of right shoulder. However, there has been a tendency that at all angular velocities, external rotator peak torque to body weight, total work and external rotator to internal rotator ratio were significantly lower in the anterior instability group than the control group at all angular velocities. There was no substantial difference between those groups with respect to the fatigue of external rotator and internal rotator in our study. Conclusion: The prominent characteristics of posttraumatic recurrent anterior shoulder dislocation are external rotator weakness and loss of balance with external rotator and internal rotator. Therefore selective training using this information rotator might be helpful in conservative treatment and rehabilitation.