• Sleep Medicine and Psychophysiology
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• v.1 no.1
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• pp.87-98
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• 1994

Objectives: To examine a defect in inhibitory gating of auditory evoked response in schizophrenics, to compare P3 latency and amplitude in negative and positive schizophrenics, and to assess the association of P3 with family history of the psychiatric disorders, electroconvulsive therapy, and clinical features. Methods: 54 schizophrenics(male 31, female 23) and 75 controls(male 33, female 42) were tested with event-related potential paradigm designed to elicit P3 response and Frankfurter Beschwerde Fragebogen. Results: In schizophrenics, the latency of P3 was significantly more delayed and the amplitude of P3 was significantly more reduced than in the controls. Significant differences in P3 latency and amplitude between negative and positive schizophrenics were not found. And significant difference in the P3 latency and amplitude between schizophrenics with family histories of psychiatric disorder and those without family histories of psychiatric disorder was not found also. The P3 latency and amplitude was not significantly related with electroconvulsive therapy and other clinical features such as age, duration of illness, onset of inllness, number of admission, and doses of antipsychotics etc. Conclusion: These results suggested that schizophrenics had a dysfunction in the process of selective attention and that P3 was not significantly related with family history of the psychiatric disorders, positive and negative symptoms, electro1convulsive therapy, and clinical features in schizophrenics.

• The Journal of the Acoustical Society of Korea
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• v.41 no.1
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• pp.108-113
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• 2022

Speech recognition in noise situation is an important skill for effective communication. Hearing In Noise Test (HINT) has been suggested as a clinical tool to evaluate these aspects. However, this tool has not been used widely in domestic clinics. In this study, psychophysical aspects of HINT and burdens in clinical application were analyzed to improve the applicability of the tool. The difficulty in understanding speech in the elderly population is due to hearing loss based on aging of peripheral and central auditory pathways. As typical clinical cases, HINT scores for young and elderly listeners (20s vs 70s) were compared. Four conditions of HINT test were Quiet (Q), Noise Front (NF), Noise Right (NR), and Noise Left (NL). Quantitative scores showed that the elderly listener required more Signal to Noris Ratio (SNR) values than the younger counterpart in noisy situations. Although both showed Binaural Masking Level Difference (BMLD) effect, the strength was smaller in the elder. However, the age-matched normalized data were not established in detail for clinical application. Confirmed usefulness of HINT and the related improvement in clinical measuring procedure were suggested.

• The Korean Journal of Applied Statistics
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• v.12 no.1
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• pp.175-190
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• 1999

생존시간을 비교하기 위한 임상시험에서는 생존기간과 관련된 위험인자들을 고려한 층화된 연구설계가 종종 요구된다. 이 경우 필요한 표본수가 결정은 층이 없는 경우에 비하여 다양한 연구상황과 복잡한 표본수의 산출 절차를 수반한다. 본 논문에서는 층이 있는 경우 생존시간을 비교할 때 필요한 표본수를 결정하는 방법들을 실례와 함께 설명하고, 연구자가 주어진 상황하에서 적절한 방법을 선택하는데 도움이 될 수 있도록, 다양한 상황을 설정하여 이에 대한 표본수를 비교하였다.

• Proceedings of the Korean Information Science Society Conference
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• 2003.10b
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• pp.844-846
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• 2003

국립보건원 유전체연구소는 안산-안성 지역에 거주하는 45세 이상 69세 이하의 성인을 대상으로 고혈압, 당뇨, 골다공증, 천식, 비만 등 한국인의 총 국민의료비용에서 큰 부분을 차지하는 중요 만성질환에 초점을 맞추어 코호트 연구를 수행하고 있다. 이에 검진대상자의 설문 및 임상검사를 통하여 수집되는 개인식별 데이터, 생활습관 데이터 등의 설문정보와 다양한 임상검사정보에 대한 체계적 저장ㆍ관리와 향후 수행될 대규모 정보 분석을 위해 유전체역학 정보 DB를 설계.구축하였다.

• The korean journal of orthodontics
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• v.28 no.1 s.66
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• pp.135-142
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• 1998

The purpose of the present study was to evaluate the effect of incisor protrusion on the mucogingival parameters including the width of attached gingiva. Thirty-seven young adults with lower anterior crowding were selected for this study. From the study model, the degrees of relative and absolute protrusions were measured for each lower incisor. Clinical non height, the width of keratinized gingiva, probing depth and the width of attached gingiva were measured with digital vernier calipers and Florida Probe System. Through comparing the difference of the above measurements between protruded and non-protruded incisors, and correlation analysis between each measurement, following results were obtained: 1. The protruded incisor showed narrow width of keratinized and attached gingiva comparing to non-protruded incisor. 2. The protruded incisor showed greater clinical crown height comparing to non-protruded side while there was no difference in the probing depth between protruded and non-protruded side. 3. The difference in the width of attached gingiva between protruded and non-protruded incisors showed higher significance in the lateral incisor than in the central incisor. 4. The degree of relative protrusion showed higher correlation with the width of attached gingiva than the degree of absolute protrusion. 5. Clinical crown height showed higher correlation with the width of attached gingiva than the degree of protrusion.

• The Journal of the Korea Contents Association
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• v.5 no.6
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• pp.20-30
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• 2005

In the anaerobe identification, when we develop the clinical decision support system for department of laboratory medicine, we must consider expression of an incomplete knowledge structure and addition of an evolving knowledge based on an expert's informal and heuristic knowledge is very complicated work flow. In the present study, we developed the system for anaerobe identification to advise on identification of unknown bacillus using knowledge base and inference engine. In the future, we are planning to develop the clinical decision support system for the whole bacteria not only an anaerobe but also aerobe to offer an expert's static and dynamic knowledge.

• Proceedings of the Korea Information Processing Society Conference
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• 2020.11a
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• pp.45-46
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• 2020

최근 의료데이터의 표준화를 기반으로 다양한 임상연구가 국내외에서 활발하게 진행되고 있다. 그러나 대부분 개발기술이 임상현장에 적용되지 못하는 이유는 상이한 인프라로 인한 일관성있는 결가를 도출하지 못하는 문제점과 부족한 진단지표와 기준 그리고 충분하지 못한 기술적·임상적 검증이 문제가 되고 있다. 본 논문에서는 이러한 문제점을 해결하기위한 새로운 통합 플랫폼을 제안하고자 한다. 이를 위해서 임상데이터는 OHDSI의 OMOP-CDM으로 표준화되어야 하며, 이외에 의료영상 정보를 포함한다. 제안한 플랫폼은 표준화된 데이터를 통해 지속적인 자가 학습을 수행하며, 질환별 진단에 필요한 개발 도구와 분석 소프트웨어 도구를 통해 다양한 타겟 질환연구를 지원한다. 제안한 플랫폼은 질환에 대한 비침습적 진단을 위해 의료영상을 기반으로 데이터표준화을 기반으로하며, 이를통해 인공지능 기술을 개발하고 병원 정보시스템과 연계하여 임상현장에 실증을 통해 검증하고자 한다.

• Investigative Magnetic Resonance Imaging
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• v.3 no.2
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• pp.146-153
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• 1999

Purpose : To evaluate the proton MR spectroscopy (MRS) findings of early and late ischemic infarcts and to compare these MRS findings with clinical symptoms. Materials and Methods : We obtained MRs spectra of 28 consecutive patients with early ischemic infarct (15 me, 13 women) between 2-10 (mean 6.2) days after stroke onset. Follow-up MRS was carried out between 20-32 (mean 25) days in 12 patients. The MRs spectra were acquired at 1.5T MR unit using single voxel technique with PRESS sequence, TR of 2000ms, TE of 288 (144)ms, and voxel size of 2cm x 2cm x 2cm in the three areas; an infarct lesion, the brain parenchyma adjacent to the lesion, and contralateral normal brain parenchyma. The NAA/creatine, choline/creatine, and lactate/creatine ratios were calculated in each spectrum. The spectra of MRS were compared with clinical symptoms. Results : In early infarct, decreased NAA/creatine ratio (n=22) and increased lactate/creatine ratio (n=25) were found in the infarct lesion. Choline/creastine ratio was within normal range (n=25). On follow-up MRS in late stage, NAA/creatine ratio in the infarct lesion decreased further (n=5), did not change (n=6), or increased (n=1). Lactate/creatine ratio became less elevated (n=10), or did not changed (n=2). Choline/creatine ratio had a trend for increase. The decreased NAA/creatine and increased lactate/creatine ratios were correlated well with the severity of symptoms, respectively. Conclusion : Decreased NAA/creatine and increased lactate/creatine ratios were common MRS findings characteristic in early ischemic infarct and correlated well with clinical severity. On follow-up MRS in late stage, NAA/creatine ratio decreased further or did not change, and lactate/creatine ratio became less elevated.

• Journal of Music and Human Behavior
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• v.8 no.2
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• pp.1-20
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• 2011

The purpose of this study was to examine the clinical practice-related anxiety and coping strategies in music therapists. 81 music therapists who are members of the National Korean Music Therapist Association, completed the self-report questionnaires. Results in this study showed that the highest rating scores were found with relationship anxiety, followed by musical performance anxiety and performance anxiety. As causing factors for each anxiety type, uncooperative behaviors and attitudes of clients were reported to highly affect interpersonal anxiety; improvising music during music therapy sessions for musical performance anxiety, and observations of music therapy sessions by staff and related professionals for performance anxiety. Regarding coping strategies used by the respondents, cognitively questioning anxiety issues was most frequently used to deal with performance anxiety; actively involving in behavior modification of clients for relationship anxiety, and practicing music skills for musical performance anxiety. The results provided descriptive information of anxiety and coping strategies that music therapists experienced. Also, this study indicates how music therapists would deal with anxiety-inducing situations and develop their coping strategies for better clinical practice.

• The Korean Journal of Applied Statistics
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• v.23 no.3
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• pp.511-520
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• 2010

The Pharmacokinetic model is a complex nonlinear model with pharmacokinetic parameters that is some-times represented by a complex form of differential equations. A population pharmacokinetic model adds individual variability using the random effects to the pharmacokinetic model. It amounts to the nonlinear mixed effect model. This paper, reviews the population pharmacokinetic model from a statistical viewpoint; in addition, a population pharmacokinetic model is also applied to the real clinical data along with a review of the statistical meaning of this model.