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http://dx.doi.org/10.5351/KJAS.2010.23.3.511

A Statistical Approach to the Pharmacokinetic Model  

Lee, Eun-Kyung (Department of Statistics, Ewha Womans University)
Publication Information
The Korean Journal of Applied Statistics / v.23, no.3, 2010 , pp. 511-520 More about this Journal
Abstract
The Pharmacokinetic model is a complex nonlinear model with pharmacokinetic parameters that is some-times represented by a complex form of differential equations. A population pharmacokinetic model adds individual variability using the random effects to the pharmacokinetic model. It amounts to the nonlinear mixed effect model. This paper, reviews the population pharmacokinetic model from a statistical viewpoint; in addition, a population pharmacokinetic model is also applied to the real clinical data along with a review of the statistical meaning of this model.
Keywords
Population pharmacokinetics; mixed effect model; nonlinear function;
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