• Journal of Pharmaceutical Investigation
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• v.32 no.1
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• pp.21-26
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• 2002

The primary culture of human nasal epithelial cell monolayer was performed on a Transwell. The effect of various factors on the tight junction formation was observed in order to develop an in vitro experimental system for nasal transport studies. Human nasal epithelial cells, collected from human normal inferior turbinates, were plated onto diverse inserts. After 4 days, media of the apical surface was removed for air-liquid interface (ALI) culture. Morphological characteristics was observed by transmission electron microscopy (TEM). A polyester membrane of $0.4\;{\mu}m$ pore size was determined as the most effective insert based on the change in the transepithelial electric resistance (TEER) value as well as the $^{14}C-mannitol$ transport study. The ALI method was effective in developing the tight junction as observed in the further increase in the TEER value and reduction in the permeability coefficient $(P_{app})$ of $^{14}C-mannitol$ transport. Results of the transport study of a model drug, budesonide, showed that the primary culture system developed in this study could be further developed and applied for in vitro nasal transport studies.

• Journal of Pharmaceutical Investigation
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• v.34 no.2
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• pp.131-138
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• 2004

This study was aimed to investigate the feasibility of nasal delivery of caffeine for the elimination of sleepiness. The effects of various vehicles, solubilizers, and enhancers on the permeation of caffeine through rabbit nasal mucosa was observed. The permeation study was carried out using a Franz-type permeation system at $37^{\circ}C$, and the amount of caffeine permeated though the rabbit nasal mucosa was determined by a validated HPLC. The apparent solubility and phys iochemical stability of caffeine in various nasal formulations were was determined. The effect of hydrotropes and modified cyclodextrins on the solubility of caffeine in water was determined by equilibrium solubility method. The solubility of caffeine in water was 29 mg/mL at $30^{\circ}C$. The addition of sodium benzoate and nicotinamide at 10% improved the solubility of caffeine (115 and 132 mg/mL, respectively) in aqueous solution. The flux of caffeine though the nasal mucosa from aqueous solution was $2.1{\pm}0.26\;mg/cm^2/hr$. The addition of sodium benzoate reduced its permeation $(1.4{\pm}0.01\;mg/cm^2/hr)$, but sodium benzoate with 5% $2HP{\beta}CD$ and 0.03% monoterpenes increased its permeation $(2.4{\pm}0.04\;mg/cm^2/hr)$ markedly. The addition of nicotinamide also increased also increased its permeation $(2.5{\pm}0.36\;mg/cm^2/hr)$. markedly. As the concentration of caffeine in nasal formulation increased, the permeation flux increased linearly. Caffeine was stable physicochemically and enzymatically in the nasal mucosa extract at $37^{\circ}C$. These results suggest that caffeine can be efficiently delivered nasally and the development of nasal formulation will be feasible.

• Korean Journal of Materials Research
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• v.9 no.12
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• pp.1181-1187
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• 1999

PZT(53/47) precursor 1M sols were prepared using a diol based Sol-Gel process, and thin films were deposited by spin coating onto Pt/Ti/$SiO_2$/Si substrates. With a single coating, final film thickness of aproximately 0.9${\mu}m $ was achieved from diol-based PZT sol. Since PZT crystallized in a ferroelectric perovskite phase from an intermediate nonferroelectric pyrochlore phase, the effects of the presence of perovskite PZT seeds on the phase transformation of PZT were investigated. Seeded PZT films were prepared from the seeded PZT 1M sols in which seeds with less than 0.2${\mu}m $ in size and 1wt% were dispersed in n-propanol before mixing with the PZT stock solution. The seeding effects were confirmed by the fact that the formation temperature of perovskite phase decreased by 50$^{\circ}C$ with less than 1wt% seeds.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.18 no.1
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• pp.33-38
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• 2007

Background and Objectives: It has been suggested that tonsillectomy possibly causes changes of voice because the morphology of the vocal tract is altered. This may cause serious problems for professional voice users. Materials and Method: Subjects were 26 patients. The oral and nasal sound spectrum of oral vowel /a/, /e/ and /i/ were measured before and after tonsillectomy. The formant frequencies and intensities for oral and nasal spectra were compared. The nasality and fundamental frequencies for oral vowel were measured. Results: The first formant frequencies for oral spectra of all vowels were not changed after surgery, but the second formant frequencies were increased significantly after surgery in the vowel /e/ and /i/. The first and second formant intensities for oral spectra were increased significantly after surgery in the all vowels. The first and second formant frequencies for nasal spectra of all vowels were not changed after surgery, but their intensities for nasal spectra were increased after surgery. The nasalities for oral vowel were not changed after surgery. Conclusion : Tonsillectomy appeared to change the spectral features of oral and nasal components of oral vowel, especially spectral intensities.

• Journal of Biomedical Engineering Research
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• v.21 no.4
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• pp.339-344
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• 2000

The mucociliary system is one of the most important airway defense mechanisms in human body and impairment of ciliary movement results in various diseases in respiratory tract. In this study, we have developed a system that can measure ciliary movement in vivo and quantified ciliary beat frequency (CBF) through autoregressive (AR) power spectrum. To measure the frequency in vivo, we applied a photoelectric method that was composed of a laser light and a fiber optic probe. Scattered signals are transferred to a PC in which they are displayed on the monitor and its CBF is determined by the AR method in were acquired. For 8 normal subjects, the analyzed CBFs ranged from 5 to 10Hz and its mean was 7.3${\pm}$1.1Hz. This result showed similar aspects to the reported results of CBFs to data. We expect that this result will be applied in various clinical studies such as analysis of CBF changes by drugs or by diseaes.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.463-463
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• 2018

우리나라의 공공용수역에서는 오염배출규제 및 하수도 정비에 의한 점오염원 부하량의 삭감에 의해 수질개선이 진행되어 왔다. 그러나, 비점오염원부하는 상대적으로 증가하는 경향에 있음에도 불구하고 그것을 실증하기 위한 강우시의 오염부하유출의 관측은 충분히 실시되지 않고 있다. 본 연구에서는 영주댐 유입하천을 대상으로 강우시 유입 오염부하량 파악 및 수질변동모의 예측을 위한 기초자료 획득을 위한 강우시 유입부하량 특성 및 수질영향이 분석되었다. 영주댐의 조사지점은 석표교, 멀내교의 총 2개 지점으로 본류인 내성천, 지류인 토일천에 각각 1곳씩 선정하였다. 유입수 샘플링은 자동모니터링 장치를 설치하여 채수하였고, 유랑조사는 교각에 설치된 자동수위측정기를 이용하여 측정하였다. 조사기간은 누적 강우량 133mm가 내린 2017년 7월 2일부터 5일간 실시하였다. 수질 시료 분석결과, 비강우시대비 COD 및 영양염류 부하량이 큰 폭으로 증가하는 것으로 나타났다. 토일천에서 채수된 시료의 경우 T-P는 비강우시 유입농도보다 최대 60배 높고, T-N은 비강우시에 비해 약 2.3배 높은 것으로 분석되었다. 강우유출 발생 시의 수질은 비강우시의 수질보다 COD 및 영양염류 부하량이 큰 폭으로 증가하였다. 비 강우시 유입되는 영양염류농도에 비해 강우시에는 강우강도에 비례하여 높은 농도의 인과 질소성분이 유입되고 있었고, 댐 저수량의 많은 부분이 강우시의 유입수량으로 채워지는 점을 고려할 때, 강우시 유입 수질이 댐 저수지 수질변화에 큰 영향을 주고 있을 것으로 판단된다. 영주댐 유역의 강우유출 특성은 강우유출이 시작 된 후, 수 시간 이내에 오염물질 농도가 급격히 증가하였고 유량의 증감속도와 유출량은 비례하였다. COD, 질소 계열 및 인 계열 물질의 유량과 비례한 증감을 확인하였다. 이를 통해 강우시 질소와 인의 유출이 강우량과 영향이 있음을 알 수 있었으나, 계절적인 유출 특성의 유무를 무시 할 수 없기 때문에 이에 대한 보다 상세한 조사 및 검토가 필요할 것으로 사료된다.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.34 no.4
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• pp.117-133
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• 2021

Objectives : Pityriasis rosea is an acute and subacute papular scaly disease, and is a disease that mainly resolves spontaneously. However, since the outbreak of COVID-19, the possibility that the disease may occur as a sequelae of the disease and side effects of vaccination has been announced. Methods : We searched articles related to oriental treatment of pityriasis rosea at organized in domestic and foreign DBs. Articles were searched for RCT. The results were summarized in tables and graphs, and meta-analysis was performed. Also, we assessed the risk or bias. Results : As a result of setting the herbal medicine alone treatment as an intervention for pityriasis rosea and Western medicine alone as the control group, total 9 articles were searched. We analyzed them and got the results. The efficient rate of the treatment group was statistically significantly higher than that of the control group. In addition, adverse events were significantly less in the treatment group than in the control group. Conclusions : Herbal medicine treatment can be more effective than Western therapy(mainly anti-histamines and glycyrrhizin injection) for pityriasis rosea. In addition, herbal medicine treatment can be superior to Western treatment for safety. However, the limitations of this study include the small number of articles, no other evaluation indicators other than the efficient rate, and insufficient data such as pathological examination.

• Journal of Convergence for Information Technology
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• v.11 no.1
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• pp.45-53
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• 2021

This study was a retrospective descriptive study to identify frequency and change of palliative care provided for older patients with terminal stage of cardiopulmonary disease before and after life-sustaining treatment (LST) decision making. As a result of chart review of 124 older patients in a university hospital, oral analgesics medication, cold and hot therapy for pain management, antibiotics medication and urine culture for urinary infection, oral care, hair wash, and partial bath were provided significantly less after LST decision making. Provision of praying and relaxation therapy for pain control, oral and nasal care, and emotional care were not changed before and after LST decision making. Spiritual care was the least provided care. Therefore, non-pharmacological pain management, emotional care, and spiritual care need to be improved for older patients with terminal cardiopulmonary disease at the end of life.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.2
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• pp.733-738
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• 2021

Recently, people's interest in marine leisure has been increasing, and research and development on leisure boats are actively being carried out to pioneer overseas markets. These days, the materials used for leisure boats are fiber-reinforced plastic (FRP) and aluminum alloy. However, FRP is hygroscopic and causes environmental problems, and aluminum alloy has high thermal conductivity and fire susceptibility. Therefore, titanium alloy is being adopted as a material for leisure boats instead. In this study, hull thicknesses and design pressures were calculated while considering dynamic effects for titanium boats. Four sets of rules and regulations were used: ISO 12215-5, RINA Pleasure Yacht, LR Special Service Craft, and KR High-speed Light Craft. The maximum bottom slamming loads were in the order of ISO, KR, LR, and RINA, and the required hull thicknesses were in the same order. This research might be helpful for understanding the rules, regulations, and overseas export of leisure boats.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.23 no.6
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• pp.137-149
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• 2020

This study was carried out to analyze the monthly runoff concentration on non rainfall days in order to prepare basic data to compare the runoff concentration on rainfall days in 7 forest watersheds in the Republic of Korea. Forest stream water has been collected through 15 times of sampling in each watershed and analyzed based on the changes in concentration of Biochemical Oxygen Demand(BOD), Chemical Oxygen Demand(COD), Total Organic Carbon(TOC), Total Nitrogen(TN), and Total Phosphorus(TP). The average concentration was 0.8 mg/L for BOD, 1.4 mg/L for COD, 0.8 mg/L for TOC, 1.85 mg/L for TN and 0.002 mg/L for TP during non rainfall days. Coniferous forested watersheds showed higher value of TN and TP concentration. Concentrations of BOD and TP in early March (p<0.01) were affected by melt water flow input in spring season. Significant differences (p<0.01) in concentrations were observed in BOD and TOC, indicating seasonal rainfall and vegetation growth impacts on forest stream quality. Concentration of TN and TP showed significant positive correlation, and weak negative correlation was found in the concentration of BOD and TOC. It is expected that result of forest stream water on non rainfall days could be basic information in managing non-point source from forest watersheds.