Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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A Study on the Analysis of Ciliary Beat Frequency in Human Respiratory Tract n Vivo

레이저 산란 기법을 이용한 인체 기도 내 섬모 운동 신호의 분석에 관한 연구

  • 이원진 (서울대학교 의학연구원 의용생체공학연구소) ;
  • 이재서 (서울대학교 의과대학 의공학 교실) ;
  • 이재서 (서울대학교 의과대학 이비인후과학 교실) ;
  • 이철희 (서울대학교 의과대학 이비인후과학 교실) ;
  • 권태영 (서울대학교 의과대학 이비인후과학 교실)
  • Published : 2000.08.01
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Abstract

The mucociliary system is one of the most important airway defense mechanisms in human body and impairment of ciliary movement results in various diseases in respiratory tract. In this study, we have developed a system that can measure ciliary movement in vivo and quantified ciliary beat frequency (CBF) through autoregressive (AR) power spectrum. To measure the frequency in vivo, we applied a photoelectric method that was composed of a laser light and a fiber optic probe. Scattered signals are transferred to a PC in which they are displayed on the monitor and its CBF is determined by the AR method in were acquired. For 8 normal subjects, the analyzed CBFs ranged from 5 to 10Hz and its mean was 7.3${\pm}$1.1Hz. This result showed similar aspects to the reported results of CBFs to data. We expect that this result will be applied in various clinical studies such as analysis of CBF changes by drugs or by diseaes.

기도에 존재하는 섬모는 인체의 방어기전으로서 중요한 역할을 하며 섬모운동의 장애는 여러 가지 기도질환을 유도하는 원인이 된다. 본 연구에서는 기도 내 섬모의 운동을 생채 내에서 측정할 수 있는 시스템을 개발하여 섬모 운동 주파수(ciliary beat frequency, CBF)를 autoregressive(AR) 스펙트럼 분석을 통하여 정량화하였다. 생체 내에서 운동하고 있는 섬모의 주파수를 측정하기 위해서 레이저와 광섬유 프루브를 사용하는 광전신호(photoelectric signal)방법을 응용하였다. 섬모운동에 의해 산란된 레이저 빛은 광섬유 프루브에 의해 탐지되어 포토 다이오드에서 전기적인 신호로 전환된다. 시리얼 통신을 통하여 PC로 전송된 디지털 섬모운동 신호는 화면에 디스플레이 되며 AR 스펙트럼 방법에 의해 실시간으로 CBF가 결정될 수 있다. 인체의 비강 중비갑개 전단부(anterior end of middle turbinate)에서 직접적으로 프루브를 적용하여 획득된 신호를 분석하였다. 8명의 정상인에 대하여 분석한 결과 CBF는 5에서 10Hz 사이에서 분포했으며 평균적으로 7.3$\pm$1.1Hz 값을 나타냈다. 이는 현재까지 알려진 CBF 값과 유사한 결과이며 측정된 값들의 표준편차도 또한 보고된 결과와 유사한 양상을 나타냈다. 본 연구 결과는 약물에 대한 섬모운동의 영향 및 질별 발달 과정에서의 섬모 운동의 변화 분석 등의 임상 연구에 활용할 수 있을 것으로 기대된다.

Keywords

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