• Korean Chemical Engineering Research
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• v.59 no.3
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• pp.366-372
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• 2021

Cadherin-Catenin complex is thought to play an essential role in the transmission of force at adherens junction. Due to the lack of proper tools to visualize and detect mechanical force signals, the underlying mechanism by which the cadherin-catenin complex regulates force transmission at intercellular junctions remains elusive. In this study, we visualize cadherin-mediated force transmission using an engineered α-Catenin sensor based on fluorescence resonance energy transfer. Our results reveal that α-catenin is a key force transducer in cadherin-mediated mechanotransduction at cell-cell junctions. Thus, our finding will provide important insights for studying the effects of chemical and physical signals on cell-cell communication and the relationship between physiological and pathological phenomena.

• Applied Chemistry for Engineering
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• v.22 no.3
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• pp.272-276
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• 2011

The separation of metallic and semiconducting single-wall carbon nanobubes (SWCNTs) by agarose gel method was carried out in this study. The effect of concentration of agarose, SDS (sodium dodecyl sulfate), and pH in the solution on separation behavior was investigated. With increasing the concentration of agarose in the solution, it showed that the ratio of metallic SWCNTs, which was analyzed from UV-vis-NIR spectroscopy, was increased in the solution phase, while the overall concentration of SWCNTs was decreased. With increasing the concentration of SDS, we could observe that the ratio of metallic SWCNTs was increased due to more affinity between SDS molecules and metallic SWCNT. The highest metallic SWCNTs ratio was reached up to 58.4% when the pH of solution was 8.2.

• Journal of Korean Academy of Nursing
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• v.51 no.3
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• pp.280-293
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• 2021

Purpose: This study aimed to identify the risk factors for diabetic foot ulceration (DFU) to develop and evaluate the performance of a DFU prediction model and nomogram among people with diabetes mellitus (DM). Methods: This unmatched case-control study was conducted with 379 adult patients (118 patients with DM and 261 controls) from four general hospitals in South Korea. Data were collected through a structured questionnaire, foot examination, and review of patients' electronic health records. Multiple logistic regression analysis was performed to build the DFU prediction model and nomogram. Further, their performance was analyzed using the Lemeshow-Hosmer test, concordance statistic (C-statistic), and sensitivity/specificity analyses in training and test samples. Results: The prediction model was based on risk factors including previous foot ulcer or amputation, peripheral vascular disease, peripheral neuropathy, current smoking, and chronic kidney disease. The calibration of the DFU nomogram was appropriate (χ² = 5.85, p = .321). The C-statistic of the DFU nomogram was .95 (95% confidence interval .93~.97) for both the training and test samples. For clinical usefulness, the sensitivity and specificity obtained were 88.5% and 85.7%, respectively at 110 points in the training sample. The performance of the nomogram was better in male patients or those having DM for more than 10 years. Conclusion: The nomogram of the DFU prediction model shows good performance, and is thereby recommended for monitoring the risk of DFU and preventing the occurrence of DFU in people with DM.

• Journal of the Microelectronics and Packaging Society
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• v.28 no.1
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• pp.67-71
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• 2021

In this study, graphene layer was grown on metal microwire using chemical vapor deposition. The difference of carbon solubility between copper and nickel resulted in the formation of mono-layer and multi-layer graphene were formed on the surfaces of copper and nickel microwires, respectively. During the growth of graphene at high temperature, copper and nickel were recrytallized and the grain size increased. The ampacity of graphene/copper microwire was improved by approximately 27%, 1.91×105 A/㎠, compared to pristine copper microwire. Similar to this behavior, the ampacity of multilayer graphene/nickel microwire was 4.41×104 A/㎠ which is about about 36% improved compared to the pure nickel microwire. The excellent electrical properties of graphene/metal composites are beneficial for supplying the electrical energy to the high-power electronic devices and equipment.

• Journal of Aerospace System Engineering
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• v.16 no.3
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• pp.35-41
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• 2022

UAM (Urban Air Mobility) is a new safe, secure, and more sustainable air transportation system for passengers and cargo in urban environments. Commercial operations of UAM are expected to start in 2025. Since production rates of UAM are expected to be closer to cars than conventional aircraft, the airworthiness methodology for UAM must be prepared for mass production. Composite materials are expected to be mainly used for UAM structures to reduce weight. In this paper, the composite material qualification method was derived and the materials were applied for small aircraft application. It is expected to reduce the airworthiness certification time by applying composite material qualification system and its database.

• Journal of the Microelectronics and Packaging Society
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• v.29 no.2
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• pp.1-10
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• 2022

Recently, semiconductor devices have been used in many fields owing to various applications of mobile electronics, wearable and flexible devices and substrates. During the semiconductor chip bonding process, the mismatch of coefficient of therm al expansion (CTE) between the substrate and the solder, and the excessive heat applied to the entire substrate and components affect the performance and reliability of the device. These problems can cause warpage and deterioration of long-term reliability of the electronic packages. In order to improve these issues, many studies on low-melting temperature solders, which is capable of performing a low-temperature process, have been actively conducted. Among the various low-melting temperature solders, such as Sn-Bi and Sn-In, Sn-58Bi solder is attracting attention as a promising low-temperature solder because of its advantages such as high yield strength, moderate mechanical property, and low cost. However, due to the high brittleness of Bi, improvement of the Sn-Bi solder is needed. In this review paper, recent research trends to improve the mechanical properties of Sn-Bi solder by adding trace elements or particles were introduced and compared.

• Transactions of Materials Processing
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• v.31 no.1
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• pp.29-38
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• 2022

Recently, the composite material market is gradually growing. Various composite forming processes have been developed in order to reduce the production cost of the composite material. Unlike the conventional forming process, the microwave composite forming process has the advantage of reducing the processing time because the composite material is heated directly or indirectly at the same time. Due to this advantage, in this study, a double cantilever beam test was conducted with specimens manufactured by the microwave composite forming process. The purpose of this study was to compare mode-I energy release rate for specimens manufactured by prepreg compression forming and microwave composite forming processes. First, a microwave oven was proposed to conduct the microwave composite forming process. Double cantilever beam specimens were manufactured. After that, the double cantilever beam test was conducted to obtain the mode-I energy release rate. Mode-I energy release rates of specimens manufactured by the microwave composite forming and prepreg compression forming processes were then compared. As a result, mode-I energy release rates of specimens fabricated by the microwave composite forming process were similar to those fabricated with the prepreg compression forming process with a relatively reduced process time.

• Journal of the Korean Society of Industry Convergence
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• v.25 no.6_2
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• pp.1119-1125
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• 2022

The depletion of resources and waste disposal caused by the continuous development of industry have emphasized the need to reduce consumption and production, recycle and reuse, and the importance of remanufacturing has increased in recent years. The spindle part of the aging planner miller, which is currently being remanufactured, is one of the factors that has the greatest impact on the performance of the machine tool. When designing the spindle part of the spindle shaft, there are considerations such as the configuration size bearing performance of the main shaft, but the diameter of the main shaft, the dangerous speed bearing, and the arrangement that affect the machining accuracy should be basically considered. As such, various studies have been conducted on the design of machine tool spindle spindles, but research on the reverse engineering of existing aging machine tool spindle spindles is poor. Reverse engineering is designing in the direction of improving performance by extracting specifications from already finished products, and first scanning the reverse engineered object through a 3D scanner, 3D modeling is performed based on the collected data, and then the process of deriving improvement plans by reverberating to improve performance by identifying wear and damage conditions is followed. Therefore, in this study, the purpose of this study is to provide data on reverse engineering by deriving improvement plans through optimal design for the bearing position of the aging planar Miller spindle spindle using central composite programming.

• Journal of the Korean Society of Industry Convergence
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• v.25 no.6_2
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• pp.1097-1102
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• 2022

With the continuous development of the current industry, the current global environment is in a very serious situation, with resource supply and demand dependent on imports and huge costs for waste disposal due to the depletion of resources and mass generation of industrial waste. Its limitations have already been revealed in many fields, and the importance of re-manufacturing is drawing attention as a countermeasure to these problems. Re-manufacturing aims to recover products that are in the aging and disposal stages, recover to performance close to new products, and re-commercialize them. Among them, most of the machine tools are made of materials such as steel and cast iron with large structures, and raw materials are widely used when producing new products. In addition, since a lot of carbon is generated due to production, it is an object that can obtain a great re-manufacturing effect. Planner millers belonging to large machine tools are one of the machine tool equipment that can greatly reduce resources and energy through re-manufacturing because the structure is very large and the casting is several to tens of tons. Through this machine tool, performance tests and results are derived on the development of re-manufacturing source technology and domestic servo motor and CNC control device.

• Journal of the Korean Society of Industry Convergence
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• v.25 no.6_2
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• pp.1111-1117
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• 2022

Recently, interest in the circular economy has emerged in the industry. As a result, interest in Re-manufacturing, which makes old equipment similar to new products, is growing. In the machine tool industry with many aging equipment, the Re-manufacturing industry is essential, and among them, research on the performance improvement of gear type oil pumps was conducted. The purpose was to achieve the target performance of flow rate and volume efficiency by changing the shape of the gear pump housing clearance and inlet/outlet, and Computational Fluid Analysis and Central Composite Design were conducted using ANSYS CFX 2022 R2 and MINITAB®. The level of each determined factor was determined. 20 design points were derived, and the Flow Rate at each design point was calculated, and the Theoretical Flow Rate was calculated to obtain Volumetric Efficiency. The optimal design point was obtained when the Flow Rate was 140 lpm and the Volumetric Efficiency was maximum, the optimal design point was obtained when both were maximum, and the Surface Plot for each factor was obtained to identify the tendency.