• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.3
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• pp.32-50
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• 2005

Purpose : This study was carried out to investigated the effects of Saenghyeolbosu-Tang on the morphometric changes of femur, and on the hormones and cytokines associated with bone metabolism in ovariectomized rats. Methods : Twenty-four female Sprague-Dawley rats were divided into sham operated group(normal), ovariectomized group(control), and treated with extract of Saenghyeolbosu-Tang group(treated). Each group was evaluated the changes of body weight at 0, 3, 6, 8, weeks after ovariectomy. Morphometric analysis(femur weight, femur/body weight, femur ash weight, femur ash/body weight, cross sectional area of compact bone and cancellous bone of femur) and histopathological examination were performed at 8 weeks after ovariectomy. Estrogen and cytokines($TNF-{\alpha},\;IL-1{\beta}$, IL-6) assay were performed at 8 weeks after ovariectomy. Results : 1. The femur weight(g) of treated group(1.59${\pm}$0.08) was significantly increased(p<0.05)compared with the control group(1.50${\pm}$0.07) at 8 weeks. 2. The femur/body weight(g) of treated group(5.27${\pm}$0.36) was significantly increased(p<0.05) compared with the control group(4.78${\pm}$0.37) at 8 weeks. 3. In the cross sectional area of cancellous bone of femur(${mm^2}$) the treated group(1.60${\pm}$0.20)was significantly increased(p<0.01) compared with the control group(1.19${\pm}$0.19) at 8 weeks. 4. The serum estrogen level(pg/ml) of treated(83.67${\pm}$27.44) and control group(800.49${\pm}$22.27)showed no significantly different changes at 8 weeks. 5. The serum $TNF-{\alpha}$ level(pg/ml) of treated(33.71${\pm}$6.43) and control group(41.35${\pm}$8.47) showed no significantly different changes at 8 weeks. 6. The serum $IL-1{\beta}$ level(pg/ml) of treated group(53.78${\pm}$10.83) was significantly decreased(p<0.001) compared with the control group(79.80${\pm}$11.40) at 8 weeks. 7. The serum IL-6 level(pg/ml) of treated group(55.52${\pm}$9.02) was significantly decreased(p<0.01) compared with the control group(69.69${\pm}$7.95) at 8 weeks. Conclusion : This study shows that Saenghyeolbosu-Tang inhibits bone resolution in ovariectomized rats. These results may be related to the inhibitory effect of Saenghyeolbosu-Tang on the secretion of $IL-1{\beta}$ and IL-6 in the Pathogenesis of　osteoporosis.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.1
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• pp.55-63
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• 2005

Purpose : 자하거(Hominis Placenta; HP)는 건강한 사람의 태반을 홍제(烘製)하여 건조한 것으로 한의학에서는 기혈(氣血)을 대보(大補)하고 신정(腎精)을 보익(補益)시켜 구병(久病)으로 인한 신체허약(身體虛弱)이나 혹은 체질허약(體質虛弱)과 혈기부족(氣血不足) 및 신허정휴(腎虛精虧) 등 등(證)을 치료(治療)하는데 단미(單味) 또는 복방(複方)에 배오(配伍)하여 쓰여왔다. 또한 자하거는 면역학적으로 골대사 활성이 있는 것으로 알려져 있어 본 연구에서는 자하거의 항골다공증 활성을 분자세포생물학적으로 검정하고자 하였다. Methods : Osteoblast cells에서 자하거가 COX-2 mRNA의 발현과 $PGE_2$ 생합성을 억제시키는지를 관찰하기 위해 먼저 TNF-${\alpha}$, IL-${\beta}$ 와 IL-6를 처리한 후 $PGE_2$의 생합성과 더불어 COX-2 mRNA의 발현을 확인하였다. 그 후 TGF-${\beta}$, 자하거(紫河車)와 이 둘의 조합인 자하거+TGF-${\beta}$가 COX-2 mRNA 발현과 $PGE_2$ 생합성을 저해시키는지 관찰하였다. 또한 자하거가 IL-1${\beta}$로 유발된 흰쥐의 과칼슘혈증을 감소시키는지를 확인하였다. Results : IL-6, IL-1${\beta}$와 TNF-${\alpha}$를 동시에 처리하면 이것을 단독으로 처리한 것과 비교해 볼 때 $PGE_2$의 생합성과 더불어 COX-2 mRNA의 수치가 상승작용을 일으키며 증가하였다. TGF-${\beta}$, 자하거와 이 둘의 조합인 자하거+TGF-${\beta}$은 COX-2 mRNA 발현, $PGE_2$ 생합성 및 골재흡수를 감소시켰다. 자하거(紫河車)는 IL-1${\beta}$, TNF-${\alpha}$와 IL-6 각각 또는 이들의 조합으로 인해 증가하는 COX-2 mRNA 발현과 $PGE_2$ 생성을 감소시키는 반면 COX-1 mRNA 발현에는 유의성 있는 영향을 미치지 않았다. 한편 자하거는 농도의존적으로 IL-1${\beta}$로 유발된 흰쥐의 과칼슘혈증을 감소시켰다. 이러한 결과는 흰쥐의 두개골 골아세포에서 $PGE_2$ 생산에 대한 IL-${\beta}$, TNF-${\alpha}$, IL-6의 상승작용이 COX-2의 유전자 발현 증가에 기인함을 보여주었다. Conclusions : 이러한 결과들로부터 자하거가 골대사과정중 골재흡수를 억제하는데 효과적임을 밝히게 되었으며, 자하거의 골다공증의 억제기전이 골재흡수관련 단백질들의 전사조절에 있음을 최초로 해명하게 되었다.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.1
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• pp.128-141
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• 2005

Objective : This study was undertaken to investigate the effects of Eucommiae Cortex on the osteoporosis in ovariectomized rats. Materials and Methods : We used Sprague-Dawley female rats in 8-week-old. They were divided into three groups. Sample group was ovariectomized and administered with 10 mg/100 g/day Eucommiae Cortex extract solution for 10 weeks. Control group was ovariectomized and sham group was conducted by sham's operation. And control group and sham group were administered with normal saline as the same way. We measured rats's body and uterus weight and also measured the serum levels of Ca, phosphorus and ALP. We stained the specimens of rat's tibial bones with Goldner's modified Masson's Trichrome and then examined bone histomorphometry with Bioquant computer program of image analysis system. We measured the thickness of osteoid and callus as static parameters and measured bone volume and mineral apposition rate as dynamic parameters. We observed the expressions of RANKL and OPG mRNA of the tibial bone by RT-PCR. Results : The body weight was significantly (p<0.05) increased in control and sample groups compared with sham group, respectively. The uterus weight was significantly (p<0.05) decreased in control and sample group compared with sham group. In the change of Ca, phosphorus and ALP there were no significant changes among three groups. There were no significant changes of trabecula cortical and osteoid bones' thickness and volume. But trabecula mineral apposition rate (MAR) was significantly (p<0.05) increased in sham and sample group compared with control group. In the expression of RANKL mRNA, sample group was decreased compared with control group, and in that of OPG mRNA, sample group was increased compared with control group. Conclusion : This study shows that Eucommiae Cortex has the beneficial effects on bone histomorphometry and metabolism in the ovariectomized rats. We suggest that Eucommiae Cortex be useful for the treatment of osteoporosis.

• Applied Microscopy
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• v.33 no.2
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• pp.105-116
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• 2003

In Vitro fertilization of U. unicinctus eggs observed by immunofluorescence and electron microscopes revealed an overview of the meiotic pattern of the tide animals. The eggs have been fertilized early at germinal vesicle stage, followed by germinal vesicle break down (GVBD), but pre-mitotic aster like structure could not be resolved by the methods employed in this work. The meiotic features, such as rotation-shift movement of spindle fibers, behavior of spermatozoonmonaster in the egg cytoplasm and active spindle fiber of the 1st polar body, have been observed. The antitubulin-FITC fluorescence show the 2nd meiotic apparatus appeared firstly parallel to the tangential line of the oolemma, proceeding the meiosis, its bipolarity is rotated and shifted towards the oolemma. The polar bodysite of the oolemma was not amorphous, but active in a sense of anti-tubulin-FITC reactions during the extrusions of the polar bodies. The immunofluorescence reactions of the spermatozoon centriole appeared at a later stage of the 2nd meiosis. During the time periods, the fertilized spermatozoon resided in the egg cytoplasm. Activating the centrioles, spermatozoon approaches towards the chromosomal materials of the 2nd oocyte. This suggests that spermatozoon centrioles initiate and play a roll to fuse male and female pronuclei.

• (The) Research of the performance art and culture
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• no.19
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• pp.379-418
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• 2009

This study is a link in a chain which grope for the description of puppet performance history. This study imply my intention which is not a description of puppet performance 'history' but a description of 'puppet performance' history. Object materials of this study is materials connected with puppet performance from ancient times to Chosun dynasty. Object materials of this study include not only records but also remains and pictures. Discussion start with regulation of puppet performance materials and establishment of a classification criterion. As a result of that discussion, the age of puppet performance is as follows: 'the age of diverse use of puppet', 'the age of ritual puppet performance of worship', 'the age of play puppet performance of handling', 'the age of ritual puppet performance of display', 'the age of ritual puppet performance of expulsion', 'the age of ritual puppet performance of handling', 'the age of play puppet performance of display', 'the age of play puppet performance of handling and voice-acting'. According to the internal division of age, the description of puppet performance history which is spread chronologically is attempted. As a result of the description, I confirm that puppet performance reveal a one's unfolding process. And a distinct aspect from the general cultu! re history is found. The development process which is a changeover that is 'from ritual puppet performance to play puppet performance' is amended by a circulation of ritual puppet performance and play puppet performance'. And the development process which is a changeover 'from static puppet to dynamic puppet' is amended by a circulation of static puppet and dynamic puppet'. Like this the thing which is laid in the inside which is not a one sided changeover but is a circulation is said that from one age of puppet performance to other age of puppet performance is not a close of former puppet performance tradition. Unfolding from one age to other age, on the other hand former puppet performance reveal aspect which is a continuance and change with a one's vitality. And a relation of mutual influence is exist between the ritual puppet performance and the play puppet performance on a large scale, among the puppet performance types on a small scale. this also don't overlook in cas! e of a groping of puppet performance history.

• The Journal of the Korea Contents Association
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• v.20 no.5
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• pp.500-512
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• 2020

This research aimed to verify organizational culture of resort underlying bottom of organization and shared by employees. Healing-seeking and life style oriented experiences are in prevailing recently, which resort industry insomuch as presumably held from its origin. Unfortunately, it is also widely recognized that resort lost its entity, blurring business domains with hotel industry or yielding integrated resort by imitating theme park. In order to probe organizational culture, in-depth interview with 16 resort experts conducted in resort setting, prepared by Gremeis actant model which is effective in finding myth(story) structure of interviewees. Firstly, interviewer matched six actants with resort business involving-group and asked interviewee to metaphor freely based on 3 night resort experiences. Results showed that sender, receiver, subject, object, helper and opponent were matched with resort, visitor, company, product & service, supporters, and opponent group in orderly manners and also interviewees made each actant into metaphor as healing, patient, medical doctor, medicine, helper and charlatan, respectively. Significance and limitation of research were included in the end of article.

• Journal of Korean Medical classics
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• v.20 no.2
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• pp.269-288
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• 2007

"표유부(標幽賦)"포라료침구경락적기본이론화자오유주침법(包羅了鍼灸經絡的基本理論和子午流注鍼法) 유주팔법등침구임상이론(流注八法等鍼灸臨床理論), 역우기송(易于기송), 통과대차(通過對此)"표유부(標幽賦)"급역대주석가대(及歷代注釋家對) "표유부(標幽賦)" 주석적연구(注釋的硏究). 금득출여하결론(今得出如下結論): 1. "표유부(標幽賦)"중출현적두한경적학술사상(中出現的竇漢卿的學術思想), 시재계승(是在계承)"내경(內經)"화(和)"난경(難經)"적침구학(的鍼灸學), 이론적기본상(理論的基本上), 진일보발전이성적(進一步發展而成的). 대후세침구학적발전산생료중요적영향(對後世鍼灸學的發展産生了重要的影響). 2. 유우폐경적경기유운문혈수출(由于肺經的經氣由雲門穴輸出), 연경락순행체표(沿經絡循行體表), 우시사운문혈구유료통경행기적주치작용(于是使雲門穴具有了通經行氣的主治作用), 고이불설'혈출중부'(故而不說'穴出中府'), 이제출'혈출운문'(而提出'穴出雲門'), 저시두한경재침구이론방면적독도지외(抵是竇漢卿在鍼灸理論方面的獨到之外). 3. 소우침구보사(소于鍼灸補瀉), 인위수지보사법적작용중우호흡보사(인위手指補瀉法的作用重于呼吸補瀉), 제시료순(提示了循), 문, 제(堤), 안(按), 탄(彈), 염, 차, 반(盤), 추, 내(內), 동(動), 요(搖), 조(爪), 절적십사종침자보사수법(切的十四종鍼刺보瀉手法). 4. 제출침자전요관찰확인침구유무이상손상(提出鍼刺前要觀察確인鍼具有无이常損상), 시침전요냉침온난(施鍼前要냉鍼온暖), 시침시요예방절침화피부근육적손상(施鍼時要預防折鍼和皮膚筋肉的損傷), 제출좌수당중이다안침혈(提出左手當重而多按鍼穴), 우수경이서서염전자입적수법(右手경而徐徐捻轉자入的手法), 인위사용쌍수진침위호(인위使用쌍手進鍼위好). 5. 호침가관통경락기혈운행적통로(毫鍼可관通經絡氣血運行的通路), 여오행상응(與五行相應), 인이가평오장지한열(因而可平五臟之寒熱), 가조육부지허실(可調六腑之虛實), 유견사부정지공(有견邪扶正之功), 재구침중응용최위광범(在九鍼中응用最위광泛). 6. 제출침자시요관찰본신(提出鍼刺時要관察本神), 대우'본신'구체가간주시환자적'맥기'화'혈기'(對于'本神'具체可看做是患者的'脈氣'和'穴氣'), 종대적방면간가간주시환자적정신(종大的方面看可看做是患者的精神). 7. 제시료참조전후좌우지혈정확취혈적방법(提示了參照前後左右之血正確取穴的方法), 여참조주변경락확정경락적방법(여參照周邊經絡確定經絡的方法), 병강조요준조골도분촌화굴신수족관절적방법취혈재능취혈정확(병强調要遵照骨度分寸和屈伸手足關節的方法取穴才能取穴正確). 8. 소우두면오관(소于頭面五官).인후경항(咽喉頸項).흉복부(胸腹部), 요배부(腰背部), 부인(婦人) 소아(小兒) 사지등질환(四肢等疾患), 개소료침구치료적경험화심득(介沼了療鍼灸治療的經驗和心得), 제시료자오유주축일안시개혈침법여영구팔법등안시취혈침법(提示了子午流注逐日按時開穴鍼法여靈驅八法等按時取穴鍼法), 성위후세각종안시개혈침법적기초(成위後世各種按時開穴鍼法的基초).

• Journal of Convergence Society for SMB
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• v.6 no.2
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• pp.19-24
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• 2016

A Study on the Information Security System of Fin-Tech Business In traditional electronic commerce, there have not been severe issues of trading information through documents in paper or the closed EDI. The scale of e-commerce has increased as internet develops, however, turning to the online e-commerce, which caused a number of issues such as authentication, information forgery, and non-repudiation between the parties. To prevent conflicts from such troubles and perform the post management, security technologies are applied throughout the process of e-commerce, certificates intervening. Lately, meanwhile, FinTech has been creating a sensation around the mobile payment service. Incidents of information leakage from card corporations and hackings imply the need of securing safety of the financial service. Development and evolution of FinTech industry must be accompanied by information protection. Therefore, this research aims to inquire into the information security system of leading FinTech company in a foreign country.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.21 no.12
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• pp.3056-3068
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• 1996

This papre presents the RDM algorithm for composition of bit. After this, we propose a digital signature scheme for facsimile document using RDM algorithm. We modify the even-odd feature in distance of changing pel between coding line and multiple reference line which have been scanned before, and run-length in coding line. The time to take in signature is reduced by spreading of signature. Non-repudiation in origin, the 3rd condition of digital signature is realized by proposed digital signature scheme. The transmitter embeds the signature secretly and tensfers it, and the receiver makes a check of any forgery on the signature and the document. This scheme is compatible with the ITU-T.4(G3 or G4 facsimile standard). The total amount of data transmitted and the quality of image are about the same to that of the original document, thus a third party does not notics signature embeded on the document.

• Therapeutic Science for Rehabilitation
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• v.2 no.1
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• pp.48-56
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• 2013

Purpose : To identify the correlation between CBS and pencil and paper test, and to test the sensitivity of above tests about unilateral neglect. Mostly used tool of pencil and paper test is line bisection and albert test. CBS is behavioral neglect test. Methods : The subjects of study were 44 stroke patients with left hemiplegia. Data were analyzed for Pearson correlation, paired t-test and ANOVA using SPSS program. The significance level was ${\alpha}<.01$. Results : The results of the study was as follow: 1. CBS had a significant correlation of line bisection and Albert test. 2. CBS was more sensitive than the pencil and paper in unilateral neglect. 3. CBS had high correlations with ADL than the pencil and paper test. Conclusion : The result showed that CBS was more useful than a pencil and paper test to distinguish unilateral neglect and available to diagnose anosognosia. Therefore, it should be considered applying CBS to inspect and cure unilateral neglect.