• Korean Journal of Veterinary Service
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• v.29 no.3
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• pp.365-376
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• 2006

To identify immune response of leukocytes in peripheral blood of cattle vaccinated with an attenuated live Akabane virus vaccine, leukocytes were reacted with monoclonal antibodies which are specific to bovine lymphocyte surface antigens and assayed by the flow cytometry. Serum neutralizing (SN) test was used to measure antibody titers after vaccination, SN antibody was appeared to 7 days post-vaccination (PV) and 2-8 antibody titers were observed in 14 days PV. Proportion of $CD8^-$ MHC $class II^+$ expressing cells were rapidly increased at 3 days PV. $CD8^+$ MHC $class II^-$ cells were increased at 7 days PV. $CD4^+CD8^-,\;WC^+CD4^-,\;CD4^+CD8^+,\;WC1^-CD4^+, \;WC1^-CD8^+$, and $CD4^-CD8^+$ cells were highly increased at 3, 3, 7, 7, 14, 14 days PV, respectively.

• Korean Journal of Veterinary Service
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• v.31 no.3
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• pp.291-303
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• 2008

This study was performed to evaluate the effect of commercial swine mycoplasma vaccine (M+$Pac^{(R)}$, Schering-Plough Animal HealthCo.) at different vaccination time points. Total 139 piglets were moved to experimental farm after weaning and were randomly allocated to 3 treatment groups and 1 control group. Piglets of 3 treatment groups (A, B and C) were vaccinated twice at 1 and 3 weeks (A group), 3 and 5 weeks (B), and 6 and 8 weeks (C), respectively. All vaccinates showed higher antibody titers compared with nonvaccinates, and maintained to finish (P<0.001). Performance and RBC/WBC count showed no significant difference between groups. Vaccinates at 6-8 weeks showed better effect on decrease of clinical sign compared with vaccinates at 1-3 weeks and 3-5 weeks and nonvaccinates. Also, lung lesion assessment showed significant difference between vaccinates at 3-5 weeks and 6-8 weeks, and nonvaccinates and vaccinates at 1-3 weeks (P<0.05). Vaccinates at 3-5 score in comparison with other groups. In conclusion, these results suggested that vaccination at 3-5 weeks or later may be more effective than earlier vaccination.

• Clinical and Experimental Pediatrics
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• v.49 no.3
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• pp.242-250
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• 2006

Haemophilus influenzae type b(Hib) conjugate vaccines prevent Hib disease in individuals and reduce the carriage and transmission of the organism in the community. The incidence of Hib disease has been decreased dramatically in a diverse range of countries through the use of a variety of conjugate vaccines and vaccine schedules. In some countries, the vaccine has caused a near-disappearance of invasive Hib disease through a combination of direct protection and herd immunity. The effectiveness of the vaccine was not modified by the type of conjugate vaccine, the number of doses given(two, three or four), age at first vaccination(two months, 42 to 90 days, three months) and whether the vaccine was tested in an industrialized or developing country. Over 15 years of international experience with vaccines has also demonstrated that they are safe. In 2004, Hib vaccines were adapted in routine immunization in 92 countries in the world. Decisions regarding the use of the Hib vaccine in routine immunization schedules depend not only on the effectiveness and efficacy of the vaccine but also on factors such as burden of disease, vaccine cost, and competing priorities. In Korea, Hib disease burden seemed to be lower than other developed countries(~10/100,000). Moreover Hib vaccines showed excellent immunogenicity in Korean children in many studies. Therefore, a potential approach to economize the cost of Hib vaccines could be to explore the possibilities of using reduced vaccine doses for immunization as some other countries.

• Journal of Preventive Medicine and Public Health
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• v.18 no.1
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• pp.51-57
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• 1985

To attempt to measure the effect of domestic product P.H.A. kit 'Hepa-S' after completion of 'Hepa-Vax' vaccination schedule, P.H.A. test and R.I.A. test on the 330 healthy adults were carried out. The results obtained were as follow ; 1. The positive anti HBs rate after completion of 'Hepa-Vax' vaccination were; in P.H.A. test with domestic product P.H.A. kit 81.2%, in P.H.A. test with foreign product P.H.A. kit 82.7%, and in R.I.A. test 95.8% 2. Using the result of R.I.A. test as the standard, sensitivity of P.H.A. test with domestic product P.H.A. kit was 84.8% and specificity was 100.0% 3. Using the result of R.I.A. test as standard, sensitivity of P.H.A. test with foreign P.H.A. kit was 86.4% and specificity was 100.0%. 4. The concordance rate of P.H.A. test with domestic product and foreign product kit was 98.5%. On the result of this study, there was no significant difference in the validity between the domestic product P.H.A. kit 'Hepa-S' and the foreign P.H.A. kit $'Hebsgencell^{TM}'$. So that it is recommendable to use domestic product P.H.A. kit instead of foreign product P.H.A. kit.

• Women's Health Nursing
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• v.23 no.2
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• pp.126-134
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• 2017

Purpose: The purpose of this study was to identify impacts of HPV-related knowledge, attitude to HPV vaccination, and health beliefs on infection preventive behavioral intention targeting female university students. Methods: With correlational survey design, subjects of this study were 120 female students at universities located in B metropolitan city and G city. A total sample agreed to participate in the study. Data were analyzed using descriptive statistics, t-test, ANOVA, correlation, and stepwise multiple regression. Results: Attitude to HPV vaccination, experience of smoking, and HPV-related health beliefs were significant factors influencing the HPV-related infection preventive behavioral intention. These factors accounted for 19.0% of the HPV-related infection preventive behavioral intention. Conclusion: The most significant factor for HPV infection prevention was the attitude to HPV vaccination. These findings may be useful to develop strategies to improve the HPV infection preventive behavioral intention of the female university students who have a high risk of the HPV infection.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.21 no.4
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• pp.457-465
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• 2014

Purpose: The purpose of this study was to apply Ajzen's theory of planned behavior to identify factors that affect undergraduate women's decisions to receive human papillomavirus(HPV) vaccination. Method: The research design for this study was a descriptive survey design using convenience sampling. Data collection was done using self-report questionnaires with 254 undergraduate students in G city. Data were analyzed using percentage, mean, standard deviation, t-test, ANOVA, Mann-Whitney U test, Pearson correlation analysis and multiple regression with the SPSS Win 20.0 Program. Results: The mean score of intention to receive HPV vaccine was $3.88{\pm}1.05$ out of a possible 7. Intention to receive HPV vaccine showed a significantly positive correlation with attitudes (r=.26, p<.001), subjective norm (r=.51, p<.001), perceived behavior control (r=.41, p<.001) to receive HPV vaccination. In the multiple regression analysis, subjective norm and perceived behavior control to receive HPV vaccine were significant predictors and explained 33.7% of intention to receive HPV vaccine. Conclusion: Results of this study show that there are significant factors affecting the intention of undergraduate women to receive HPV vaccination. Also, strategies emphasizing subjective norm and perceived behavior control in obtaining HPV vaccination should be taken into account in developing educational programs.

• 건강소식
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• v.26 no.2 s.279
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• pp.6-13
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• 2002

세계에서 매년 약 1,000만명의 새로운 암환자가 발생하고 있으며, 650만명이 암으로 사망하고 있다. 우리나라에서도 매년 약 85,000명의 새로운 암환자가 등록되고 있으며, 55,000명이 암으로 사망하고 있다. 이는 우리나라 전체 사망자의 20%를 차지하는 수치로서 사망원인으로는 단연 1위에 해당한다. 이처럼 암 발생과 암으로 인한 사망이 급격하게 증가함에 따라 암을 일으키는 원인인자를 밝히고 이러한 원인을 제거하여 암을 예방하려는 노력들이 활발하게 이루어지고 있다. 실제로 몇몇 암의 경우에는 그 발생 원인들이 일부 밝혀지고 있는데, 대표적으로 금연을 통하여 폐암의 발생을 예방하고 간염백신 접종을 통해 간암을 예방하는 경우 등이다. 한편, 세계보건기구에서는 의학적인 관점에서 암 발생인구 가운데 1/3은 예방가능하고, 1/3은 조기진단만 되면 완치가 가능하며, 나머지 1/3의 환자도 적절한 치료를 한다면 완치가 가능한 것으로 보고하고 있다. 특히 우리나라에서 가장 흔한 위암, 유방암, 자궁경부암, 대장암 등은 조기에 발견할 경우 거의 완치가 가능하기 때문에, 이러한 암들에 대해서 정기적으로 검진을 실시할 겨우 암으로 인한 사망을 상당수 줄일 수 있을 것으로 기대된다. 이에 정부는 2002년부터 저소득층을 대상으로 위암, 유방암, 자궁경부암에 대해 조기검진을 무료로 실시하고 있으며, 암 예방 교육 및 홍보를 통하여 국민들에게 암에 대한 정확한 지식과 조기검진의 중요성을 전달하고, 나아가 생활양식의 변화를 유도하여 암을 예방하도록 하는 마스터플랜을 추진하고 있다.

• Korean Journal of Veterinary Service
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• v.24 no.2
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• pp.147-159
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• 2001

This Study was conducted to determine vaccination programs for the control of Newcastle Disease(ND) in chickens and investigate protective effect against Newcastle disease virus (NDV) after live ND vaccination. Maternal HI antibody titer level of chickens according to day(age) 1, 7, 14, 21, 28 and 35 were decreased gradually as 7.10$\pm$0.74, 6.57$\pm$0.74, 3.71$\pm$1.25, 2.20$\pm$1.03, 1.20$\pm$1.23 and 0.50$\pm$0.71. As a result of HI test and ELISA, both chickens vaccinated with VG/GA strain live vaccine at 1-day-old and chickens not vaccinated do not have antibody titer for protection against NDV at 14-day-old. Except for LaSota strain vaccine, in case of vaccination with VG/GA spray and VG/GA, B1 and LaSota strain drinking water at 14-day-old, the protective effect was 100% in chickens inoculated NDV($10^{7.2}$ $EID_{50}$/50${\mu}\ell$, eye drop) at 21-day-old, but not 10～50% at 28-day-old. These data suggest that live NDV vaccination should be given at 10-day-old 20-25day-old for protect against NDV at periodic outbreaks of ND caused by velogenic viscerotropic NDV in the environment of a farm.

• Journal of Korean Biological Nursing Science
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• v.20 no.2
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• pp.114-121
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• 2018

Purpose: The purpose of this study was to investigate the rate of human papilloma virus (HPV) vaccinations among 12-year-old daughters and to analyze factors influencing the mothers' decisions to vaccinate their daughters. Methods: A cross sectional descriptive study was conducted using a convenience sample of 139 mothers. Data was analyzed using SPSS WIN 23.0. Descriptive statistics and a logistic regression analysis were conducted. Results: The vaccination rate of HPV among children was 43.9%. Mothers showed a higher knowledge of the HPV vaccination than of cervical cancer and of human papilloma virus. In self-efficacy scores, the subscores of self-regulation efficacy were higher than self-confidence and task difficulty preference. The factors influencing the vaccination of daughters included the age of the daughters at the time of the vaccination, the provision of information on the HPV vaccine, knowledge of the HPV vaccination, and self-confidence. Conclusion: In order to increase the HPV vaccination rate, it is necessary to provide accurate scientific knowledge to mothers. A variety of intervention strategies should be developed to enhance the confidence of mothers so that mothers who want to provide the HPV vaccination to their daughters are able to follow through and provide the vaccination.

• Korean Journal of Veterinary Research
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• v.59 no.3
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• pp.151-155
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• 2019

Equine influenza (EI) is the main cause of respiratory illness in equines across the globe and is caused by equine influenza A virus (EIV-A), which has impacted the equine industry internationally because of the marginal mortality and high morbidity. In the present study, the immune responses after equine influenza vaccination were evaluated in 4,144 horses in Korea using the hemagglutination inhibition (HI) assay. The equine influenza virus (EIV), A/equine/South Africa/4/03 (H3N8), was used as the antigen in the HI assay. The mean seropositive rates were 89.2% (97.4% in 2016, 77.6% in 2017, and 92.4% in 2018). This paper highlights the advances in understanding the effects of vaccines and control strategies for mitigating the emerging menace by EIV.