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Leukocyte subpopulations of peripheral blood in Korean indigenous cattle vaccinated with attenuated live Akabane virus vaccine  

Park Young-Nam (Kangwon Veterinary Service Laboratory)
Son Sung-Mi (Kangwon Veterinary Service Laboratory)
Shin Myung-Kyun (Kangwon Veterinary Service Laboratory)
Kwon Myung-Sang (College of Veterinary Medicine, Kangwon National University)
Publication Information
Korean Journal of Veterinary Service / v.29, no.3, 2006 , pp. 365-376 More about this Journal
Abstract
To identify immune response of leukocytes in peripheral blood of cattle vaccinated with an attenuated live Akabane virus vaccine, leukocytes were reacted with monoclonal antibodies which are specific to bovine lymphocyte surface antigens and assayed by the flow cytometry. Serum neutralizing (SN) test was used to measure antibody titers after vaccination, SN antibody was appeared to 7 days post-vaccination (PV) and 2-8 antibody titers were observed in 14 days PV. Proportion of $CD8^-$ MHC $class II^+$ expressing cells were rapidly increased at 3 days PV. $CD8^+$ MHC $class II^-$ cells were increased at 7 days PV. $CD4^+CD8^-,\;WC^+CD4^-,\;CD4^+CD8^+,\;WC1^-CD4^+, \;WC1^-CD8^+$, and $CD4^-CD8^+$ cells were highly increased at 3, 3, 7, 7, 14, 14 days PV, respectively.
Keywords
Leukocyte surface antigen; Monoclonal antibodies; Attenuated live Akabane virus vaccine;
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