• Title/Summary/Keyword: 반응성 상호작용

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Genetic Polymorphisms of SLC8A1 Are Associated with Hypertension and Left Ventricular Hypertrophy in the Korean Population (한국인에서 SLC8A1의 유전적 다형성과 고혈압 및 좌심실 비대와 연관 연구)

  • Park, Hye-Jeong;Kim, Sung-Soo;Jin, Hyun-Seok
    • Korean Journal of Clinical Laboratory Science
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    • v.51 no.3
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    • pp.286-293
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    • 2019
  • Hypertension (HTN) is one of the major chronic diseases, and HTN is defined as being in a state of continuous high blood pressure. Left ventricular hypertrophy (LVH) is a condition in which the mass of the left ventricle has increased, and HTN is a leading cause of LVH. HTN and LVH are known to be caused by the interaction of environmental factors and genetic factors. It has been reported that the polymorphisms of SLC8A1, among the genetic factors that affect high blood pressure, are related to salt sensitivity hypertension. In this study, the genetic polymorphisms of SLC8A1 were chosen based on the Korean Genome and Epidemiology data. Logistic regression analysis was then performed for HTN and LVH. Linear regression analysis was also performed for systolic blood pressure (SBP) and diastolic blood pressure (DBP). As a result, 5 SNPs showed statistically significant associations (P<0.05) with HTN, and 10 SNPs showed statistically significant associations with LVH. rs1002671 and rs9789739 showed significant correlation at the same time with HTN and LVH. These results suggest that the polymorphisms of the SLC8A1 gene are linked to the development of HTN and LVH in Koreans. We expect these results to help us understand the pathogenic mechanisms for HTN and LVH.

Long-Term Trend of Picophytoplankton Contribution to the Phytoplankton Community in the East Sea (동해 식물플랑크톤 군집에 대한 초미소 식물플랑크톤(< 2 ㎛) 기여도 장기 경향성 연구)

  • Hyo Keun Jang;Dabin Lee;Sang Heon Lee
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.29 no.6
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    • pp.525-535
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    • 2023
  • In thi study, we unveil the intricate interplay among picophytoplankton (0.2-2 ㎛) communities, warming surface water temperatures, and major inorganic nutrients within the southwestern East Sea from 2003-2022. The observed surface temperature rise, reflecting global climate trends, defies conventional seasonal patterns in temperate seas, with highest temperatures in summer and lowest in spring. Concurrently, concentrations of major dissolved inorganic nutrient display distinct seasonality, with peaks in winter and gradually declining thereafter during spring. The time course of chlorophyll-a concentrations, a proxy for phytoplankton biomass, reveals a typical bimodal pattern for temperate seas. Notably, contributions from picophytoplankton exhibited a steady annual increase of approximately 0.5% over the study period, although the total chlorophyll-a concentrations declined slightly. The strong correlations between picophytoplankton contributions and inorganic nutrient concentrations is noteworthy, highlighting their competitively advantageous responsiveness to the shifting nutrient regime. These findings reflect significant ecological implications for the scientific insights into the marine ecosystem responses to changing climate conditions.

Revisiting the e-Government Maturity Model: Significance, Limitations, and Suggestions (전자정부 성숙도 모델의 재검토: 모델의 의의와 한계, 실증분석을 통한 제언)

  • SUNG, WOOKJOON
    • Informatization Policy
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    • v.30 no.3
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    • pp.3-28
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    • 2023
  • This study aims to analyze the usage behavior of e-government service users based on the e-government maturity model and provide suggestions for advancement of the e-government services. The changes in Korea's e-government services were analyzed as follows; 1) Proportion of use of e-government services in Korean public services, 2) E-government service types/stages use, 3) Service use by platform 4) User response to e-government service 5) Users' requests for future e-government service usage methods. For the analysis, this study used data from Korea's 2012-2020 e-government usage behavior survey data. As a result of the analysis, first, the proportion of e-government service has been continuously increasing, and second, the use of the e-participation stage is relatively low compared to the presenting information, interaction, and transaction stages. Third, by platform, e-government service has been expanded to various access platforms such as mobile, kiosk, and SNS centering on the web. Fourth, users' satisfaction with e-government service is very high. However, to vitalize e-government services, users requested improvements such as providing one-stop integrated services and simplifying authentication procedures. Based on the analysis results, this study 1) reflects the user's point of view in the maturity model of e-government, 2) considers access to various platforms according to the development of digital technology, 3) improves the e-government maturity model through data-based analysis such as user usage behavior suggested the need.

Development of Olfactory Biosensor Using Olfactory Receptor Proteins Expressed in E. coli

  • Seong, Jong-Hwan;Go, Hwi-Jin;Park, Tae-Hyeon
    • 한국생물공학회:학술대회논문집
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    • 2003.04a
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    • pp.639-642
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    • 2003
  • Olfactory receptor protein ODR10 was expressed in E.coli as fusion protein with GST and His6 Tag. Crude membrane extract of the expressed protein was coated on the surface of quartz crystal microbalance, and the interaction of the ODR10 with several odorants was examined. Although the expression level was very low, quartz crystal microbalance showed that the expressed protein interacted most strongly with diacetyl (butanedione), which is known to bind to the ODR10 protein selectively. The interaction between ODR10 and diacetyl was $5{\sim}10$ times stronger than the interaction between ODR10 and other odorants. Thus, E. coli cells expressing the olfactory receptor protein could be used as an olfactory biosensor. Also, such system could be used to test which olfactory receptor reacts specifically with which odorant molecules, since there has been no cheap and convenient way to test the interaction of olfactory receptors and odorant molecules yet.

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Meju Fermentation for a Raw Material of Korean Traditional Soy Products (조선전통 식품으로 메주발효)

  • Lee, Sang-Sun
    • The Korean Journal of Mycology
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    • v.23 no.2 s.73
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    • pp.161-175
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    • 1995
  • Meju is a raw material used to make Korean soy sauce (Kanjang) and soybean paste (Doenjang), both of them rich in plant protein. The twenty-nine fungal and a bacterial species were identified from twenty-three traditionally homemade meju cakes. Out of them, only a few species were found to be involved in the actual fermentation process of meju; The other species were contaminants during the improper subprocesses of meju fermentation. The fungal floral successions were observed to be related to two physical and biochemical changes of meju cakes during meju fermentation: drying and heat releasing processes. The zygomycetous fungi were first observed to exist mainly during the first stage. Scopulariopsis brevicaulis was observed to grow on the surface of meju cakes and then to coexist with Bacillus megatrium in the inner part of meju cakes during the second stage. Based on the biochemical tests, the proteases secreted by the different microorganisms were involved in the degradation of soybean proteins with a mutual relationship. Also, zygomycetous fungi were speculated to be important microorganisms for inducing the second stage in the traditional Korean homemade meju.

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The Effect of Military Crisis Management Communication on a Social Network Service :Focusing on the effect of message form on the crisis perception of soldiers (SNS를 통한 군(軍)의 위기관리 커뮤니케이션 전략 :메시지 형태가 장병의 위기 인식에 미치는 영향을 중심으로)

  • Kim, Tae Woong;Yang, Jong Hoon;Lee, Sang Eun
    • The Journal of the Korea Contents Association
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    • v.19 no.11
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    • pp.102-110
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    • 2019
  • The military respond well to external publics in the event of a crisis int that they are operated based on the trust of the people. Unlike other organizations, however, the Korean military has the distinctiveness that soldiers experience military life as internal publics for a certain period of time and after serving in the army, they become those who evaluate the military as external publics. Therefore, it is important to examine what would be effective crisis management strategies in terms of communicating with active-duty soldiers. Given that active-duty soldiers are accustomed to using SNS these days, this study investigated whether message forms (digital image vs. text) affect the perception of the military in crisis, acceptance of the given message, and attitude toward the military. Our empirical findings suggest that image-based messages are more likely to increase levels of message acceptance than text-based messages. Based on the results, we discussed practical implications on communication strategies for managing the military in crisis.

Adsorption Studies of Nickel(II) Ions onto Amorphous Alumina (무정형 알루미나에서의 니켈(II) 이온의 흡착에 관한 연구)

  • Park, Yeong Jae;Suh, Moo Yul;Park, Kyoung Kyun;Choi, Kwang Soon;Jee, Kwang Yong;Kim, Won Ho
    • Analytical Science and Technology
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    • v.13 no.4
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    • pp.433-439
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    • 2000
  • Adsorption behaviors of Ni(II) ions were investigated using amorphous alumina as adsorbent. In the adsorption kinetic study, it was observed that Ni(II) ions were bound to the alumina surface in two adsorption stages, the rapid and slow adsorption stages. The rapid adsorption proceeded within 1 hr, thereafter the slow adsorption occurred. The results of adsorption isotherm experiments showed that the Ni(II) adsorption obeyed the Langmuir-Freundlich isotherm, and that the adsorption enhanced with increasing pH. The change in ionic strength did not exhibit a conspicuous trend in Ni(II) adsorption, thereby suggesting that the adsorption occurs through surface complexation rather than electrostatic interactions. The amounts of adsorption were measured with varying pH at three different Ni(II) concentrations under the condition of constant ionic strength, showing that with increasing Ni(II) concentration, the percentage of adsorption decreased and the adsorption edge was shifted to a higher pH value.

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The Significance and Management of Hyporheic Zone (지표수-지하수 혼합대 의의와 관리 필요성)

  • Ko, Dongwoo;Lee, Namjoo
    • Proceedings of the Korea Water Resources Association Conference
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    • 2021.06a
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    • pp.283-283
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    • 2021
  • 혼합대는 지표수와 지하수의 수리적 교환이 일어나는 경계부로써 1) 수문학적 관점에서는 하도와 하상간의 물교환이 이루어지는 공간으로 다양한 물리적·화학적 작용이 발생, 2) 생지화학적인 관점에서는 하상 간극수 흐름에 의한 전이대(ecotone)를 형성하여 용존산소·영양물질·용존유기탄소의 이동뿐만이 아니라 지하수로부터 열에너지·무기염류의 공급을 유도하면서 높은 생지화학적 활동과 변환을 야기하는 산화·환원 반응구역, 3) 생태적인 관점에서는 저서생물과 지하 유기체종을 특징으로 하는 서식지이나 잠재적인 레퓨지움(refugium) 등의 관점에서 해석될 수 있다. 국내 하천환경의 생태학적 지속가능성을 위한 지표수-지하수 혼합대 관리에 대한 중요성이 점차 증대되고 있지만 우리나라는 여전히 지하수의 이용 및 보전과 지하수의 안정적인 수량·수질 확보를 목표로 관리를 추진하고 있다. 따라서, 실질적인 지표수-지하수 혼합대에서 발생하는 다양한 현상의 이해나 관리방안에 관한 연구는 아직 미비한 상황이다. 지표수-지하수 혼합대에 관한 보고서, 논문 등을 종합하여 혼합대의 영향인자를 살펴보면 1) 수리수문 특성에는 수리전도도·하천 수위·하천 유속·하천수 수온, 2) 수질 특성에는 유기오염물질·영양염류, 3) 수생태 특성에는 대형무척추동물 등으로 분류할 수 있다. 지금까지 단일 연구분야의 접근방법으로 다양한 현장측정기법 및 모델링을 통한 혼합대 연구가 수행되고 있지만, 혼합대가 가지는 환경적 중요성에 대한 이해와 인식이 부족하고, 혼합대 내부에서 발생하는 복합적인 프로세스로 인해 전문가들조차 연구에 어려움을 가질 것이다. 지표수-지하수 혼합대의 효율적인 관리를 위해서는 수리수문·수질·수생태 등 다양한 시각에서 접근하여 학제간 융합연구를 통해 기초 데이터를 상호교환하고, 기존의 혼합대 조사에 부족한 부분을 해결할 필요가 있다. 향후 하천 기저유출 및 혼합대 기초자료 구축, 혼합대 흐름 정량화, 하천복원사업에 의한 혼합대 영향 규명 등의 연구를 수행함으로써 혼합대를 체계적으로 관리할 수 있는 기술 방안을 제시할 필요가 있다.

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Economic Effects of Welfare Policy: An Analysis of 2003 Korean Social Accounting Matrix (정부의 복지지출이 경제부문별 소득분배에 미치는 효과 분석)

  • Noh, Yong-hwan
    • Korean Journal of Social Welfare Studies
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    • v.40 no.1
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    • pp.261-296
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    • 2009
  • I constructed the 2003 Korean 'social accounting matrix'(SAM) to analyze the multipliers of total demand for each economic activity. I find that the relative magnitude of the influence of the welfare policy to the national economy measured by input-output production multipliers tends to be underestimated compared to SAM multipliers. This is because the total demand multipliers of SAM include the private sector effects, which is not considered in the input-output model. The result also support that income inflows in public service areas including education, health and social work, generate gains in the relative income of households.

Effects of Various Rates of Nitrogen, Phosphorus, and Potassium on Fertilization Response of Flue-Cured Tobacco (질소(窒素), 인산(燐酸), 가리(加里)의 시비비율(施肥比率)이 황색종연초(黃色種煙草)의 시비반응(施肥反應)에 미치는 영향(影響))

  • Jeong, Hun-Chae;Cho, Seong-Jin;Lee, Yun-Hwan;Yuk, Chang-Soo
    • Korean Journal of Soil Science and Fertilizer
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    • v.19 no.1
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    • pp.56-62
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    • 1986
  • Fertilization response on production and quality of flue-cured tobacco as to different level of nitrogen, phosphorus, and potassium were studied in a field experiment. The results were summarized as follows: 1. Growth and yield of flue-cured tobacco were significantly better in higher nitrogen fertilization levels, regardless of soil fertility, but the negative correlation was recognized between the quality of leaves and the amounts of nitrogen application. While, both fertilizers of phosphorous and potassium did not have should little effect on the tobacco yield and quality. 2. The optimum ratio of N, P, and K fertilizer applications were decided by the appearance of the proper yield and the best quality of tobacco leaves. The proportion of N:P:K was 2:1:4. 3. The single effect (Complete plot minus Non-fertilized plot) of N, P, and K on yield and quality of cured leaf was greatly affected by nitrogen, but the combined effect (Nutrient deficiency plot minus Non-fertilzier plot) of that were only slightly affected by P and K.

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