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Loading Behavior of pH-Responsive P(MAA-co-EGMA) Hydrogel Microparticles for Intelligent Drug Delivery Applications (지능형 약물전달시스템을 위한 pH 감응형 P(MAA-co-EGMA) 수화젤 미세입자의 탑재거동)

  • Shin, Young-Chan;Kim, Kyu-Sik;Kim, Bum-Sang
    • Polymer(Korea)
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    • v.32 no.5
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    • pp.421-426
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    • 2008
  • pH-responsive P(MAA-co-EGMA) hydrogel microparticles were synthesized via dispersion photo polymerization and the feasibility of the particles as the cosmetic formulation was investigated. Rh-B and the functional materials for the cosmetic application such as ascorbic acid, adenosine, EGCG, and arbutin were loaded in the P (MAA-co-EGMA) hydrogel microparticles in order to examine the interaction between the hydrogel and the loaded materials. In the loading experiments, Rh-B showed the highest loading efficiency to the P(MAA-co-EGMA) hydrogels due to the electrostatic attraction between the negative charge of the hydrogels and the positive charge of Rh-B at the ionized states. However, the functional materials showed relatively low loading efficiencies because of the electrostatic repulsions between the negative charges of both the hydrogels and the materials at the ionized states. In addition, P(MAA-co-EGMA) hydrogel microparticles showed pH-responsive release behavior of Rh-B according to the external pH changes.

Recent Progress of Antibacterial Coatings on Solid Substrates Through Antifouling Polymers (박테리아 부착억제 고분자 기반 고체 표면의 항균 코팅 연구 동향)

  • Ko, Sangwon;Lee, Jae-Young;Park, Duckshin
    • Applied Chemistry for Engineering
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    • v.32 no.4
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    • pp.371-378
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    • 2021
  • The formation of hydrophilic surface based on polymers has received great attention due to the anti-adhesion of bacteria on solid substrates. Anti-adhesion coatings are aimed at suppressing the initial step of biofilm formation via non-cytotoxic mechanisms, and surfaces applied hydrophilic or ionic polymers showed the anti-adhesion effect for bioentities, such as proteins and bacteria. This is attributed to the formation of surface barrier from hydration layers, repulsions and osmotic stresses from polymer brushes, and electrostatic interactions between ionic polymers and cell surfaces. The antifouling polymer coating is usually fabricated by the grafting method through the bonding with functional groups on surfaces and the deposition method utilizing biomimetic anchors. This mini-review is a summary of representative antifouling polymers, coating strategies, and antibacterial efficacy. Furthermore, we will discuss consideration on the large area surface coating for application to public facilities and industry.

Design of a Height Adjustable Bunker Bed Using a Gas Spring (가스 스프링을 이용한 높이조절 벙커침대 설계)

  • Jung, Gyuhong
    • Journal of Drive and Control
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    • v.18 no.4
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    • pp.19-27
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    • 2021
  • A bunker bed is a type of furniture that efficiently utilizes a narrow indoor space by having a high bed and using the empty space below as a living and storage space. The demand for multi-purpose furniture is increasing due to the recent increase in single-person households and wide-spread shared accommodation. According to the consumer research, one of the major drawbacks of a bunker bed was to get on and off the bed through a ladder or stairs. In order to overcome these problems, it was confirmed that the height adjustment function that can easily adjust the minimum and maximum heights of the bed was necessary. In this study, a height adjustable bunker bed was designed by using a gas spring that generates a repulsive force by the compressed gas inside. The design process consisted of the following three steps: Firstly, the hysteresis characteristics due to a friction and spring constant of a commercial gas spring were confirmed by measuring the repulsive force vs. compressed displacement. Secondly, requirements of the vertical lifting force exerted on the bed against gravity force were derived. Finally, the height-adjustable bed using the four-bar link mechanism was designed with 4 parameters so that the bed weight of 60-70 kgf could be adjusted to 800 mm in height by an affordable initial operation force. The performance was verified through prototype production and the results of vertical displacement and force to move were nearly the same as designed. In addition, an electrically operated height-adjustable bed was also designed with linear actuators and the performance was proved with the prototype.

The Effects of Trunk Movement and Ground Reaction Force during Sit to Stand Using Visual Feedback (시각 되먹임을 이용한 앉은 자세에서 일어서기 시 몸통의 동작과 지면 반발력에 미치는 영향)

  • Yeong-Geon Koh;Tae-Young Oh;Jae-Ho Lee
    • Journal of The Korean Society of Integrative Medicine
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    • v.11 no.2
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    • pp.207-219
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    • 2023
  • Purpose : This study was conducted to investigate the changes in trunk movement and ground reaction during sit to stand motion using visual feedback. Methods : Fifteen adults (average age: 23.53±1.77 years) participated in this study. An infrared reflective marker was attached to the body each participant for motion analysis, and the participants performed sit to stand motion while wearing a hat attached with a laser pointer, which provided visual feedback. First, the sit to stand action was repeated thrice without obtaining any visual feedback, followed by a three minute break. Next, the laser pointers attached to hats were irradiated on a whiteboard, located at a distance of 5 m in front of the chairs, on which the participants sat; a baseline was set, and the participants performed stand up movements three times under this condition. A visual feedback was provided to the participants to prevent the laser pointers from crossing the set baseline. During each stand-up movement, the position of the reflective marker attached to the subject's body was recorded in real time using an infrared camera for motion analysis. The trunk movement and ground reaction force were extracted through recorded data and analyzed according to the presence or absence of visual feedback. Results : The results indicated that in the presence of a visual feedback during the sit-to-stand movements, the range of motion of the trunk and hip joints decreased, whereas that of the knee and ankle joints increased in the sagittal plane. The rotation angle of the trunk in the horizontal plane decreased. The left and right movement speed of the center of pressure increased, the pressing force decreased, and the forward and backward movement speed of the trunk decreased. Conclusion : The results suggest that the efficiency and stability of the stand up movement of a body increase when a visual feedback is provided.

Towards reducing acoustical high-frequency noise of a direct current relay via contact structure (직류 계전기의 접촉구조에 의한 고주파수 소음저감)

  • Junhyeok, Yang;Jongseob, Won;Wonjin, Kim
    • The Journal of the Acoustical Society of Korea
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    • v.41 no.6
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    • pp.691-697
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    • 2022
  • In this work, a straightforward component design of a direct current (DC) relay equipped in electric vehicles is discussed. The work aims to provide and evaluate effective measures for reducing high-frequency sound from the DC relay carrying electric power. From the operation experiments for the relay, it is observed that noise is caused by the resonance from the forced vibration by the electromagnetic repulsive force originating at the area of electric contacts with a resonance frequency of around 710 Hz ~ 730 Hz. A finite element model for the relay was established to conduct vibration mode analysis, consisting of stationary and movable contacts and a contact spring. Vibration mode analysis indicates that in the resonance frequency, the movable contact with two-point contacts experiences rotational vibration mode. For the proposed relay with a three-point contact, vibration mode analyses give reasonable results of reducing noise at that frequency. Furthermore, for the fabricated relays with the three-point contact, similar results have been obtained. In conclusion, one can see that the proposed measures provide one of the feasible solutions to the reduction of relay noise.

Phase Equilibrium Study on the Ternary System of SBR/EPDM/Solvent (SBR, EPDM 및 Solvent로 이루어진 삼성분계의 상 평형에 관한 연구)

  • Go, Jin-Hwan;Park, Byung-Ho
    • Elastomers and Composites
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    • v.37 no.4
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    • pp.211-216
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    • 2002
  • The polymer-polymer interaction parameter, x 23t, of the styrene-butadiene polymer (SBR) and ethylene-propylene-diene terpolymer (EPDM) was investigated by observing the phase behavior of the ternary system of SBR/EPDM/solvent. The solvent used in this study was benzene acting as a good solvent for SBR but as a poor solvent for EPDM. Ternary solutions with various concentrations and mixing ratios of the two component polymers were separated into two phases by temperature change The cloud point curves (CPC) showed that the differerence of solvent affinities toward each polymer and the repulsive interaction between two polymers considerably affect the shape of CPC near 15℃. In the temperature range of 5℃ ~ 25℃, incompatible behaviours arised from both the difference of mixing ratios and concentration were clearly observed. Also the phase separation temperature greatly influenced on the composition of each separated phase. The calculated x 23t values from Flory-Huggins theory were in the range of 0.6301 ~ 1.0775, which suggest that the SBR/EPDM systems are incompatible.

The Gait Analysis of Hemiplegic Patients After Stroke I. Spatio-Temporal Parameters, Pelvic Anterior Tilting and Ground Reaction-Vertical Force (뇌졸중으로 인한 편마비환자의 보행분석 I. 시간-거리변수, 골반경사각 및 지면반발력 -수직력 중심)

  • Kwon Young-Sil;Kim Jin-Sang
    • The Journal of Korean Physical Therapy
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    • v.10 no.1
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    • pp.127-138
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    • 1998
  • This study was carried out tn invstigate and compare biomechanical characteristics during free speed gait in hemiplegic patients after stroke who took therapeutic exercise by analyzing kinematic and kinetic data in the sagital plane and electromyographic data. Six patients($41\~69$ years old) and age-matched six volunteers in good health(51-61 years old) wire studied. The patients were sorted into two groups, depending on their self-speed of walking : fast speed group(3 patients) and slow speed group(3 patients). The results were as fellows. : 1. In spatio-temparal parameters, affected and unaffected side of fast group showed symetry but blew group showed asymetry of single limb support, opposite foot contact and stance phase (p<0.05). Compared with normal group, patient group showed slower velocity, shoter stride length and longer double limb support (p<0.05). 2. In the pelvic anterior tilt, patient group showed lower valued than normal group. It. In the ground reaction force-vertical force, fast group showed similar double peak gragh compared with normal group, butvslow group showed lower values without double peak (p<0.05).

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Investigation of the effect of water chemistry on biologically mediated flocculation in the aquatic environment (수질화학 조성이 수자원환경에서의 미세 부유입자 응집 거동에 미치는 영향 연구)

  • Choi, Jeong Wooa;Lee, Byung Joon
    • Journal of Korea Water Resources Association
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    • v.50 no.11
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    • pp.715-723
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    • 2017
  • Extracellular Polymeric Substances (EPS) in the water environment assemble fine, colloidal particles, such as clays, microorganisms and biomass, in large flocs, which are eventually subject to sedimentation and deposition and determine water/sediment quality and quantity. This study hence aimed to investigate the way that water and colloidal chemistry affects EPS-mediated flocculation of colloidal particles, using a jar-test experiment. Especially, ionic strength, divalent cation and humic substances concentrations were selected as experimental variables in the jar-test experiments, to elucidate their effects on EPS-mediated flocculation. A higher ionic strength increased flocculation capability, reducing electrostatic repulsion between EPS-attached colloidal particles and enhancing particle aggregation. 0.1 M NaCl ionic strength had higher flocculation capability, with 3 times larger floc size and 2.5 times lower suspended solid concentration, than 0.001 M NaCl. Divalent cations, such as $Ca^{2+}$, built divalent cationic bridges between colloidal particles and EPS (i.e., $colloid-Ca^{2+}-EPS$ or $EPS-Ca^{2+}-EPS$) and hence made colloidal particles to build into large, settelable flocs. A small $Ca^{2+}$ concentration enhanced flocculation capability, reducing suspended solid concentration 20 times lower than the initial dosed concentration. However, humic substances, adsorbed on colloidal particles, reduced flocculation, because they blocked EPS adsorption on colloidal particles and increased negative charges and electrostatic repulsion of colloidal particles. Suspended solid concentration in the tests with humic substances remained as high as the initial dosed concentration, indicating stabilization rather than flocculation. Findings about EPS-mediated flocculation in this research will be used for better understanding the fate and transport of colloidal particles in the water environment and for developing the best management practices for water/sediment quality.

MO Studies of Configuration and Conformation (XV). Through-Space and Through-Bond Interactions In Ethylene Diamine (배치와 형태에 관한 분자궤도론적 연구 (제15보). 에틸렌 디아민의 Through-Space 및 Through-Bond 상호작용)

  • Ikchoon Lee;Chang Kook Sohn;Chang Hyun Song
    • Journal of the Korean Chemical Society
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    • v.26 no.2
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    • pp.65-72
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    • 1982
  • STO-3G level computations were performed on n-propylamine, n-propylamine radical and cis-and trans-ethylene diamines in order to investigate structural contributions of (n${\pi}$/m) and (n-${\sigma}^*$) structures to the energy variations accompanying the conformational changes. It was found that (5${\pi}$/5) and (4${\pi}$/4) structures had attractive and repulsive nonbonded interactions, respectively, which were approximately additive. anti(n-${\sigma}^*$) structures had more stabilzing hyperconjugative interactions than syn(n-${\sigma}^*$) structures, but due to the large internuclear repulsion the net effect was destabilizing inthe former in contrast with the net stabilizing contribution in the latter. Moreover it was found that the stabilizing ${\pi}$-nonbond structure, (5${\pi}$/5) was always cooperatively reinforced by the more stabilizing anti(n-${\sigma}^*$) interaction, whereas the destabilizing (4${\pi}$/4) structure was accompanied by the less stabilizing syn(n-${\sigma}^*$) interaction. This type of cooperativity was found general through-bond interaction of the terminal lone pair lobes split the energy levels into two, $n_+ = \frac{1}{\sqrt{2}}(n_1 + n_2)$ and $n_- = \frac{1}{\sqrt{2}}(n_1 - n_2)$, the latter being the lower level, which can be shown using simple overlap patterns of the two lobes with a common vicinal ${\sigma}^*$ orbital.

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Gait Phases Classification using Joint angle and Ground Reaction Force: Application of Backpropagation Neural Networks (관절각과 지면반발력을 이용한 보행 단계의 분류: 역전파 신경망 적용)

  • Chae, Min-Gi;Jung, Jun-Young;Park, Chul-Je;Jang, In-Hun;Park, Hyun-Sub
    • Journal of Institute of Control, Robotics and Systems
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    • v.18 no.7
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    • pp.644-649
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    • 2012
  • This paper proposes the gait phase classifier using backpropagation neural networks method which uses the angle of lower body's joints and ground reaction force as input signals. The classification of a gait phase is useful to understand the gait characteristics of pathologic gait and to control the gait rehabilitation systems. The classifier categorizes a gait cycle as 7 phases which are commonly used to classify the sub-phases of the gait in the literature. We verify the efficiency of the proposed method through experiments.