• 발명특허
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• v.29 no.6 s.336
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• pp.36-40
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• 2004

• Proceedings of the Korea Information Processing Society Conference
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• 2013.11a
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• pp.1661-1664
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• 2013

본 연구는 만성 뇌졸중 환자 5 명을 대상으로 상지 운동(Affected hand의 주먹 쥐기/펴기운동)시 참가자의 운동의지와 운동 수행의 유무에 따라 차이가 있을 것을 가정하고, 운동 수행 및 운동의지가 존재하는 Active movement와 운동 수행을 하지만 운동의지가 없는 Passive movement, 운동 수행은 없지만 운동의지가 있는 Motor Imagery(MI)의 세가지 task에 따른 뇌파의 연결성을 비교하고자 한다. 이 때 EEG 영역 간의 연결성을 보기 위한 분석 방식 중 하나인 Phase locking value(PLV)를 통해 각 task 간의 차이를 비교 및 분석했다. 운동 수행은 동일하지만 운동의지 유무에 따른 차이는 Passive movement가 전반적으로 뇌 영역간 연결이 감소하고 Active movement가 motor task 시작 후 375ms를 기점으로 급격히 증가함을 보이는 데에서 발견할 수 있었으며, 운동 수행 유무에 따른 차이는 687.5ms 이후 Active movement에 비해 MI에서 뇌 영역 간 연결 수가 확연히 감소하는 데에서 큰 차이를 나타내었다. 이에 따라 본 연구에서는 만성 뇌졸중 환자의 상지운동 시의 motor task에 따른 EEG 영역간의 연결성을 토대로 운동의지 검출이 가능성이 있음을 밝혔다.

• Journal of Biomedical Engineering Research
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• v.44 no.1
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• pp.85-91
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• 2023

Stress urinary incontinence (SUI) occurs when abdominal pressure increases, such as sneezing, exercising, and laughing. Surgical and non-surgical treatments are the common methods of SUI treatment; however, the conventional treatments still require continuous and invasive treatment. Laser have been used to treat SUI, but excessive temperature increase often causes thermal burn on urethra tissue. Therefore, the optimal conditions must be considered to minimize the thermal damage for the laser treatment. The current study investigated the feasibility of the laser irradiation condition for SUI treatment using non-ablative 980 nm laser from a safety perspective through numerical simulations. COMSOL Multiphysics was used to analyze the numerical simulation model. The Pennes bioheat equation with the Beer's law was used to confirm spatio-temporal temperature distributions, and Arrhenius equation defined the thermal damage caused by the laser-induced heat. Ex vivo porcine urethral tissue was tested to validate the extent of both temperature distribution and thermal damage. The temperature distribution was symmetrical and uniformly observed in the urethra tissue. A muscle layer had a higher temperature (28.3 ℃) than mucosal (23.4 ℃) and submucosal layers (25.5 ℃). MT staining revealed no heat-induced collagen and muscle damage. Both control and treated groups showed the equivalent thickness and area of the urethral mucosal layer. Therefore, the proposed numerical simulation can predict the appropriate irradiation condition (20 W for 15 s) for the SUI treatment with minimal temperature-induced tissue.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.54 no.6
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• pp.912-917
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• 2021

We investigated the distribution, molecular characteristics, and antimicrobial resistance of Vibrio vulnificus isolated from seawater at Gadeok Island, the Republic of Korea between June to October. Interestingly no isolates were detected between December to February. The detection rate of V. vulnificus was high (80-100%) from July to September 2019 and from June to September 2020. This coincided with the relatively low salinity of the seawater, which ranged from 7.8-29.9 practical salinity units for that period. Additionally, V. vulnificus had a high detection rate at sampling stations near the Nakdong river. The detection rates of virulence genes, such as vvhA, viuB, and vcgC, among the isolates were 97.1%, 44.1%, and 57.4% in 2019 and 100%, 43.0%, and 50.0% in 2020, respectively. Notably, viuB and vcgC were detected in V. vulnificus isolated between June to October when water temperature was above 20℃. The antimicrobial susceptibility analysis of 80 isolates revealed that most of the strains were susceptible to most antimicrobial agents. However, some isolates showed intermediate resistance to cefepime (18.8%), cefoxitin (58.8%), and erythromycin (22.5%). Of note, 3.8% of the tested strains were resistant to cefoxitin. The minimum inhibitory concentration of highly cefoxitin-resistant strains was determined to be less than 32 ㎍/mL.

• The Science & Technology
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• s.511
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• pp.50-53
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• 2011

• Photonics industry news
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• s.16
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• pp.66-73
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• 2003

• Journal of Biomedical Engineering Research
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• v.45 no.1
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• pp.20-25
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• 2024

Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by cells. EVs act as messengers for cell-to-cell communication. Inside, it contains various substances that show biological activity, such as proteins, lipids, nucleic acids, and metabolites. The study of EVs extracted from terrestrial organisms and stem cells on inflammatory environments and tissue regeneration have been actively conducted. However, marine organisms-derived EVs are limited. Therefore, we have extracted EVs from sea urchins belonging to the Echinoderm group with their excellent regenerative ability. First, we extracted extracellular matrix (ECM) from sea urchin gonads treated with hypotonic buffer, followed by collagenase treatment, and filtration to collect ECM-bounded EVs. The size of sea urchin gonad-derived EVs (UGEVs) is about 20-100 nm and has a round shape. The protein content was higher after EVs burst than before, which is evidence that proteins are contained inside. In addition, proteins of various sizes are distributed inside. PKH-26 was combined with UGEVs, which means that UGEVs have a lipid membrane. PHK-26-labeled UGEVs were successfully uptaken by cells. UGEVs can be confirmed to have the same characteristics as traditional EVs. Finally, it was confirmed that Schwann cells were not toxic by increasing proliferation after treatment.

• Proceedings of the Korean Society of Computer Information Conference
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• 2018.01a
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• pp.163-164
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• 2018

최근 생물학 등 여러 학문이 결합한 바이오닉스 기술을 이용하여 시력을 회복시키려는 인공 시각 전달 장치의 개발이 시도되고 있다. 본 논문에서는 인간의 물체 지각의 특성인 자기유사성에 적합한 영상 압축 기법에 대하여 조사하여 영상인식을 위한 최적의 학습 데이타 구성에 대하여 제안하고자 한다. 실험결과, 레인지 블록 크기에 따라 인식율의 변화는 나타나지만 레인지 크기가 작아질수록 별 차이가 없음을 알 수 있었다.

• Journal of Biomedical Engineering Research
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• v.43 no.1
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• pp.61-70
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• 2022

Natural and synthetic forms of calcium phosphate cement (CPC) have been widely used in bone repair and augmentation. The major challenge of injectable CPC is to deliver the cells without cell death in order to regenerate new bone. The study objective was to investigate for the potential of stem cell-laden gelatin fibers containing injectable, nanocrystalline CPC to function as a delivery system. Gelatin noddle fiber method was developed to delivered cells into nCPC. Experimental groups were prepared by mixing cells with nCPC, mixing cell-laden gelatin fibers with nCPC and mixing cell-laden gelatin fibers containing BMP-2 with nCPC. Media diffusion test was conducted after dissolving the gelatin fibers. SEM examined the generated channels and delivered cell morphology. Fibers mixed with nCPC showed physical setting and hardening within 20 min after injection and showed good shape maintenances. The gelatin fibers mixed nCPC group had several vacant channels generated from the dissolved gelatin. Particularly, proliferation and attachment of the cells were observed inside of the channels. While live cells were not observed in the cell mixed nCPC group, cells delivered with the gelatin fibers into the nCPC showed good viability and increased DNA content with culture. Cell-laden gelatin fiber was a novel method for cell delivery into nCPC without cell damages. Results also indicated the osteogenic differentiation of gelatin fiber delivered cells. We suggest that the cell-laden gelatin fibers mixed with nCPC can be used as an injectable cell delivery vehicle and the addition of BMP-2 to enhances osteogenesis.

• 전기의세계
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• v.23 no.1
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• pp.29-33
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• 1974

의용생체공학은 생체시스템에 대한 생물학적, 의학적인 지식과 공학기술을 응용하여 이들 개개의 시스템을 조화시키고, 도 생체시스템과 공학시스템간의 기능조화를 시키며, 양 시스템에 존재하는 환경의 조화를 추구하는 학문이다. 이렇게 볼때 응용생체공학에서 다루는 분야는 크게 4가지로 나눌 수 있게 된다. 1. 생체시스템의 계측, 진단 및 치료에 공학적 수법(수단, 기술, 장치등)을 사용하는 분야.. 의용전자공학, 2. 생체시스템을 공학적으로 해석하고 미지의 생체부분을 예측 또는 해명하는 분야, 사이버네틱스, 3. 생체시스템의 우수한 기능을 모방해서 새로운 공학시스템을 창조하는 분야, 바이오닉스, 4. 공학적 수법을 사용하여 생체기능에 적합한 공학시스템 또는 환경을 개량하는 분야, 인간공학, 환경공학, 그러므로 여기서는 의용생체공학에 속한 여러문제가 전기공학과 더불어 발전하여 온 과정을 먼저 더듬어 보고 전기공학분야와 관련을 갖고 다루어지고 있는 과제를 중심으로 살펴보고져 한다.