• Title/Summary/Keyword: 무작위 대조군 실험연구

Search Result 263, Processing Time 0.027 seconds

Effects of Dietary Supplementation with Galla Rhois on Growth Performance and Diarrhea Incidence in Postweaning Piglets (이유자돈에 있어서 성장증체 및 설사발생에 미치는 오배자의 급여 효과)

  • Cha, Chun-Nam;Yu, Eun-Ah;Park, Eun-Kee;Kim, Suk;Lee, Hu-Jang
    • Journal of Veterinary Clinics
    • /
    • v.30 no.5
    • /
    • pp.353-358
    • /
    • 2013
  • A study investigated the effects of Galla Rhois (GR) on growth performance and diarrhea incidence of postweaning piglets. One hundred 28-day-old piglets were randomly assigned into five experimental groups, which were a basal diet alone (NC), chlortetracycline 0.3 g/kg feed (PC) and supplemented with GR 1.0 g/kg feed (GR 1), GR 2.0 g/kg feed (GR 2), and GR 4.0 g/kg feed (GR 3). After 28 days of administration, final body weight (BW) and feed conversion ratio of PC, GR 2 and GR 3 was significantly different compared to those of NC (p < 0.05). Additionally, the average daily gain (ADG) and average daily feed intake (ADFI) of PC and all groups treated with GR was significantly different compared to those of NC (p < 0.05). Especially, final BW, ADG, ADFI and feed conversion ratio (FCR) of GR 2 and GR 3 were not significant different compared to those of PC. In fecal scores and duration of diarrhea, PC and all groups treated with GR were significantly different compared to NC (p < 0.05). In hematogolical and serum biochemical analysis, there were no significant differences in any of the hematogolical and serum biochemical parameters examined in either NC or all groups treated with GR. The results of this study indicated that GR could be a potential candidate as feed additives for the improvement of growth performance and incidence of diarrhea in piglets.

Effectiveness of herbal acupuncture of Carthami semen(Honghwa) vs its cotreatment with spiral taping for the treatment of acute low back pain : A randomized controlled trial (급성요통의 치료에 홍화약침과 홍화약침+첩대요법의 비교연구 : 무작위 대조군 임상실험)

  • Jeong, Min-Su
    • Journal of Pharmacopuncture
    • /
    • v.5 no.2
    • /
    • pp.25-38
    • /
    • 2002
  • Spiral taping shows great effectiveness in relieving musculoskeletal pains. The purpose of this research is to compare effectiveness of herbal acupuncture of Carthami semen(Honghwa) vs its cotreatment with spiral taping for the treatment of acute low back pain. The target patients were those who satisfied with all of the following conditions. 1. Those who suffered from acute low back pain but without past history of the pain in the last six weeks. 2. The pain wasn't radiated to the lower limbs and were without any neurotic symptoms. A computerized randomization was used to set the patients in two groups. The control group was consisted of 41 patients and treated with herbal acupuncture. The experimental group was consisted of 49 patients and treated with spiral taping as well as herbal acupuncture. The treatment was given two times a week and the nurses measured the ROM and VAS evaluation before every treatment. The patients wrote ODI by themselves before the first treatment and after the 3rd treatment. After three months, an interview of the patients' condition through a follow up survey was done. In terms of acute low back pain in both the control group and experimental group, significant treatment effects were found by assessing VAS, ROM and ODI. By comparing the control group and the experimental group, there was more significant improvement in the experimental group than the control group of VAS and ROM, but no significant effect was found between the groups of ODI. This study shows that the herbal acupuncture of Carthami Semen plays a significant role in relieving acute low back pain. It also shows that spiral taping of the experimental group was more highly effective. As a result, spiral taping can be used with acupunture of Carthami Semen for a highly effective treatment for acute low back pain.

Evaluation of Leather Meal and Meat and Bone Meal as the Fish Meal Replacer in Israeli Carp Diets (잉어사료에 있어서 피혁분과 육골분의 어분대체원으로서의 평가)

  • 배승철;장혜경;김경희
    • Journal of Aquaculture
    • /
    • v.10 no.2
    • /
    • pp.153-161
    • /
    • 1997
  • This study was conducted to evaluate the possible utilization and the replacing range of leather meal (LM) or meat and bone meal (MBM) as a fish meal replacer for the dietary animal protein source of growing israeli carp, Cyprinus carpio. Five different diets were formulated on isonitrigenous and isocaloric basis of 38.5% curde protein and 15.3 KJ/g diet. Percentage of the graded levels of replacement of white fish meal (WFM) by LM/MBM on the basis of crude protein were at follows : diet 1, 100% WFM (control) ; diet 2, 75% WFM+25% LM ; diet 3, 50% LM ; diet 4, 75% WFM+25% MBM ; diet 5, 50 WFM+50% MBM and LM or MBM, and approximately 64.5% of plant protein. After one week of conditioning period, fish averaging 10g were divided into five groups and fed one of the experimental diets for 12 weeks. In the first and the second 4 weeks of feeding trials, there were no significant differences in weight gain between two groups of fish fed diet 1 (control) and 2 (P>0.05), while fish fed diet 3, 4 and 5 had a significantly lower body weight gain than fish fed diet 1 (P<0.05). In contrast to those two periods, all diet groups were not significantly different compared to diet 1 in body weight gain during the third 4 weeks of feeding trial (P<0.05). These results indicated that LM and MBM could be used as a fishmeal replacer up to 50% in growing israeli carp.

  • PDF

Effect of calcium silicate-based sealer to bone tissue of mandible of rats (칼슘 실리케이트 계열 실러가 흰쥐의 하악골 조직에 미치는 영향)

  • Jee-Seon Tae;Ki-Yeon Yoo;Jin-Woo Kim;Kyung-Mo Cho;Yoon Lee;Se-Hee Park
    • Journal of Dental Rehabilitation and Applied Science
    • /
    • v.40 no.1
    • /
    • pp.1-12
    • /
    • 2024
  • Purpose: To histologically evaluate the effects of three calcium silicate-based sealers on rat mandible tissue. Materials and Methods: Rats were randomly divided as follows: A group that sacrificed immediately after cavity preparation, a group that sacrificed two weeks after cavity preparation, a group that sacrificed two weeks after CeraSeal (CS), AH Plus Bioceramic (AHB), or One-Fil (OF) sealer injection, respectively. After tissue processing for all groups, the bone tissue area (%) and the number of osteoclasts in and around the cavity were measured under a microscope. The results of each group were compared and statistical analysis was performed using one-way ANOVA and Tukey's test. Results: The formation of bone tissue and the presence of osteoclasts in the cavity were observed in the group that sacrificed two weeks after cavity preparation and the group sacrificed two weeks after AHB sealer injection, and these groups showed significantly higher average bone tissue area (%) than the other groups. In the other groups, no inflammation or foreign body reaction occurred in the cavity, and no osteoclasts were observed. Conclusion: All calcium silicate-based sealers used in this study showed a favorable bone tissue response when injected into the rat mandible. In particular, higher bone formation in the cavity was observed in AHB.

Effect of Backward Walking Training on Balance Capability and Gait Performance in Patients With Stroke (후방보행 훈련이 뇌졸중 환자의 균형능력 및 보행에 미치는 영향)

  • Choi, Hyun-Suk;Jeon, Seon-Bok
    • Journal of Digital Convergence
    • /
    • v.13 no.1
    • /
    • pp.367-373
    • /
    • 2015
  • The purpose of this study was to examine the effect of backward walking training on the balance capability(Functional Gait Assessment; FGA, Timed Up & Go Test; TUG) and gait performance(10 meter Walking Test; 10 mWT) of stroke patients. Eighteen with stroke patients were randomly allocated to an experimental and contral group of nine patients each. both groups received general neurorehabilitative physical therapy for 45 minutes per day 5 times per week during 4 weeks. The experimental group also performed additional backward walking training for 20 minutes per day 3 times per week during 4 weeks. There were signicantly increase by backward walking training in outcome of the balance capability from the FGA was increase from $17.67{\pm}1.00scores$ to $19.22{\pm}1.00scores$(p<.05), TUG was decrease from $26.45{\pm}1.37sec$ to $23.28{\pm}1.35sec$(p<.05) and 10 mWT was decreased from $21.74{\pm}1.35sec$ to $18.33{\pm}1.10sec$ (p<.05). These result suggest that backward walking training for stroke patients is effective in improving balance capability(FGA, TUG) and gait performance(10 mWT).

Multicenter clinical study on birth weight and associated anomalies of single umbilical artery (단일 배꼽 동맥 환아의 출생체중과 동반기형에 관한 다기관 연구)

  • Bae, Su-Nam;Lim, Jae-Woo;Ko, Kyong-Og;Jin, Hyun-Seung;Kim, Min-Hee;Lee, Bo-Young;Kim, Chun-Soo;Kim, Eun-Ryoung;Park, Sang-Kee;Lee, Jung-Joo
    • Clinical and Experimental Pediatrics
    • /
    • v.52 no.6
    • /
    • pp.655-660
    • /
    • 2009
  • Purpose : To compare birth weight between infants with a single umbilical artery (SUA) and normal infants, investigate the associated anomalies of infants with SUA and isolated SUA (no abnormality of external appearance on birth, except SUA), and determine the prognosis of infants with isolated SUA. Methods : Live-born infants with SUA (n=59) detected by physical examination from among 15,193 live births in seven university hospitals in Korea between January 1, 2004, to August 1, 2007, were reviewed retrospectively, with 236 normal infants serving as the control group. Results : A statistical difference was observed between the groups in birth weight and in vitro fertilization. The incidence of infants with SUA was 0.37%. Congenital malformations were observed in 21 infants with cardiovascular (n=15, 25.4%), gastrointestinal (n=2, 3.4%), genitourinary (n=9, 15.3%), neuromusculoskeletal (n=6, 10.2%), central nervous system (n=1, 1.7%), chromosomal (n=1, 1.7%), and other (n=3, 5.1%) abnormalities. There were 49 (83.1%) infants with isolated SUA in this study population; among them, the associated congenital malformations were cardiovascular (n=6, 12.2%) and genitourinary (n=6, 12.2%) abnormalities. Two infants with cyanotic heart disease were operated and four infants with acyanotic heart disease showed improvements without any treatment. Six infants with genitourinary abnormalities on renal ultrasound had mild hydronephrosis without further consequences. Conclusion : The incidence of structural abnormalities in the cardiovascular and genitourinary systems is high and the genitourinary anomalies associated with isolated SUA have relatively good prognosis.

Bond strength of orthodontic brackets bonded to enamel with a self-etching primer after bleaching and desensitizer application (미백과 탈감작제 도포 후 셀프 에칭 프라이머를 이용한 브라켓 접착 시 법랑질과 브라켓 간의 결합 강도)

  • Attar, Nuray;Korkmaz, Yonca;Kilical, Yasemin;Saglam-Aydinatay, Banu;Bicer, Ceren Ozge
    • The korean journal of orthodontics
    • /
    • v.40 no.5
    • /
    • pp.342-348
    • /
    • 2010
  • Objective: The aim of this study was to compare the shear bond strengths (SBS) of orthodontic brackets bonded to enamel with a self-etching primer after bleaching, desensitizer application and combined treatment. Methods: Forty-eight premolars were randomly divided into four groups, each with n = 12 premolar samples. The four groups were; Group1: 15% hydrogen-peroxide office bleaching agent (Illumin$\acute{e}$ Office-IO), Group 2: IO + BisBlock Oxalate Dentin-Desensitizer, Group 3: Bis Block Oxalate Dentin-Desensitizer, Group 4: No treatment (control). Twenty-four hours after bonding, the specimens were tested in SBS at a crosshead speed of 5 mm/min until the brackets debonded. The failure mode of the brackets was determined by a modified adhesive remnant index. Results: Bleaching, bleaching and desensitizer treatment, and desensitizer treatment alone all significantly reduced SBS of the orthodontic brackets ($p$ = 0.001). No statistically significant difference was found between Group 1, Group 2 and Group 3 (Group 1-Group 2, $p$ = 0.564; Group 1-Group 3, $p$ = 0.371; Group 2-Group 3, $p$ = 0.133). The predominant mode of failure for the treatment groups (Group1, Group 2 and Group 3) was at the enamel-adhesive interface leaving 100% of the adhesive on the bracket base. Conclusions: Bleaching and desensitizer treatment should be delayed until the completion of orthodontic treatment.

Evaluation of Balance and Activities of Daily Living in Children with Spastic Cerebral Palsy using Virtual Reality Program with Electronic Games (전자게임을 이용한 가상현실프로그램이 경직성 뇌성마비 아동의 균형과 일상생활활동에 미치는 영향)

  • Han, Ji-Hye;Ko, Joo-Yeon
    • The Journal of the Korea Contents Association
    • /
    • v.10 no.6
    • /
    • pp.480-488
    • /
    • 2010
  • The aim of this study were to examine the effects of virtual reality program on balance and activities of daily living in children with spastic cerebral palsy (CP) using the Pediatric Balance Scale (PBS) and the Functional Independence Measure for Children (WeeFIM), and to measure relationship between the PBS and the WeeFIM. For this, A total of 20 spastic CP classified as the Gross Motor Function Classification System (GMFCS) I and II were employed. The Participant's were allocated randomly to 2 groups: a virtual reality group (n=10) and the control group (n=10). Both groups received muscle strengthening exercise for 3 sessions, 30 minutes per week over a 12 week period. The virtual reality group practiced additional virtual reality program. The virtual reality group showed significant increases in balance (p<0.05) and activities of daily living (p<0.05). There were a significant correlation between the PBS and the WeeFIM (p<0.05). Application of the virtual reality program to treat the spastic CP will be feasible and suitable. And the PBS was a useful tool to predict activities of daily living in the spastic CP.

The Effect of Dual Task Program on Cognitive Function in Patients with Mild Cognitive Impairment in Korea: A Systematic Review and Meta Analysis (국내 경도인지장애 환자에 적용한 이중과제 프로그램이 인지기능에 미치는 효과: 체계적 문헌 고찰 및 메타분석)

  • Jae-Hun Jung
    • Journal of Industrial Convergence
    • /
    • v.21 no.12
    • /
    • pp.101-111
    • /
    • 2023
  • This study conducted systematic review and meta-analysis to analyze the effectiveness of a dual-task for cognitive function in patients with MCI in Korea. A search was conducted using eight databases, and the search terms were MCI, cognition, and dual task. This study includes RCT and nonRCT published from January 2013 to July 2023. A total of 682 studies were searched, and 8 studies that fulfilled the inclusion and exclusion criteria were finally analyzed. Methodological quality was assessed with the RoB, RoBANS. The meta-analysis used CMA 4.0 ver. As a result of the analysis, the overall effect size of the dual task was medium effect size. The effect size according to the outcome variables was large for orientation and executive function, and medium effect size for global cognitive function, visuospatial function, memory, and attention. As a result of analysis according to the intervention period, the effect was greater when applied for 4 to 8 weeks, and the effect size was larger when applied for 24 to 30 sessions. This study presented clinical evidence on the effectiveness and application method of a dual-task applied to improve cognitive function in patients with MCI.

Comparative Hepatotoxicity Assessment of Cadmium and Nickel with Isolated Perfused Rat Liver(IPRL) (적출간 관류법을 이용한 카드뮴과 니켈의 간독성 비교)

  • Cha, Bong-Suk;Chang, Sei-Jin;Lee, Jung-Woo;Wang, Seung-Jun
    • Journal of Preventive Medicine and Public Health
    • /
    • v.33 no.1
    • /
    • pp.117-124
    • /
    • 2000
  • Objectives : It is the objective of this study to compare hepatotoxicity of nickel chloride and cadmium chloride with each other through IPRL(Isolated Perfused Rat Liver) method. Methods : Biochemical indicator of hepatic function such as AST(aspartate aminotransferase), ALT(alanine aminotransferase), LDH(lactate dehydrogenase) and perfusion flow rate were used as the indicator of hepatotoxicity. Oxygen consumption rate were used as vability indicator. $300({\pm}50)g$ - weighted rats were allocated randomly to each group($0{\mu}M,\;50{\mu}M,\;200{\mu}M\;NiCl_2\;and\;CdCl_2$ exposure) by 5, totally 25. After Krebs-Ringer bicarbonate butler solution flowed into the penal vein and passed the liver cell, it flowed out of vena cava. Liver was administered with each $NiCl_2\;and\;CdCl_2$ of each concentration and observed with buffer solution sampling time. Butler which got out of liver was sampled and then biochemical indicator of hepatotoxicity was measured. Results : AST, ALT, and LDH in buffer increased with sampling time much more in $CdCl_2$ exposure group than $NiCl_2$ exposure group in both 50 and $200{\mu}M$ and statistical significance w3s verified with 2-way repeated ANOVA. Viability was decreased more and more in all substances during passed time. Conclusions : It is inferred that $CdCl_2$ has stronger hepatotoxicity than $NiCl_2$. IPRL method would be used widely for acute hepatotoxicity when considerating the benefit of it.

  • PDF