• Title/Summary/Keyword: 무게 감소

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Inhibitory Effects of CD99-derived Peptide CD99CRIII3 on the Extravasation of Monocytes and Inflammatory Reactions in Contact Dermatitis Mouse Model (접촉성 피부염 마우스 모델에서 단핵구의 유출 및 염증 반응에 대한 CD99-유래 펩타이드 CD99CRIII3의 억제 효과)

  • Ju, Hyun-Mi;Park, Kyeong-Han
    • Anatomy & Biological Anthropology
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    • v.31 no.4
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    • pp.143-149
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    • 2018
  • Leucocyte extravasation has been known to play an important role in inflammatory reactions including contact dermatitis. Previous studies suggested that CD99 regulates ${\beta}1$ integrin activity and may be a novel therapeutic target molecule for inflammatory diseases. In this study, the effects of CD99-derived peptide, CD99CRIII3, on inflammatory reactions in contact dermatitis mouse model were investigated. CD99CRIII3 decreased ${\beta}1$-integrin activity in human monocytic U937 cells. CD99CRIII3 inhibited the adhesion of U937 monocytes to human umbilical vein endothelial cells and their extravasation through human umbilical vein endothelial cells. CD99CRIII3 reduced inflammation in the phorbol myristate acetate-induced contact dermatitis mice in a dose-dependent manner. These results indicate that CD99CRIII3 suppresses the extravasation of monocytes and inflammatory reactions in the animal model of the contact dermatitis, suggesting that CD99CRIII3 could be a new drug candidate against inflammatory skin diseases.

High Temperature Corrosion Effect of Superheater Materials by Alkali Chlorides (염화알칼리에 의한 과열기 소재의 고온부식 영향)

  • Kim, Beomjong;Jeong, Soohwa;Kim, Hyesoo;Ryu, Changkook;Lee, Uendo
    • Clean Technology
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    • v.24 no.4
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    • pp.339-347
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    • 2018
  • In order to cope with environmental problems and climate change caused by fossil fuels, renewable energy supply is increasing year by year. Currently, waste energy accounts for 60% of renewable energy production. However, waste has a lower calorific value than fossil fuels and contains various harmful substances, which causes serious problems when applied to power generation boilers. In particular, the chlorine in the waste fuel increases slagging and fouling of boiler heat exchangers, leading to a reduction in thermal efficiency and the main cause of high temperature corrosion, lowering facility operation rate and increasing operating cost. In this study, the high temperature corrosion experiments of superheater materials (ASME SA213/ASTM A213 T2, T12 and T22 alloy steel) by alkali chlorides were conducted, and their corrosion characteristics were analyzed by the weight loss method and SEM-EDS. Experiments show that the higher the temperature and chloride content, the more corrosion occurs, and KCl further corrodes the materials compared to NaCl under the same condition. In addition, the higher the chromium content of the material, the better the corrosion resistance to the alkali chlorides.

Toxicokinetics and oral toxicity of Maesil-cheongs with reduced amygdalin levels (아미그달린 저감화 매실청의 독성동태학적 및 경구독성 연구)

  • Kim, Hyeon-Jin;Go, Mi-Ran;Yu, Jin;Hwang, Ji-Soo;Choi, Hyun Woo;Kim, Hyun-Seok;Choi, Soo-Jin
    • Korean Journal of Food Science and Technology
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    • v.50 no.6
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    • pp.629-635
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    • 2018
  • In this study, the safety aspect of Maesil-cheongs with reduced amygdalin levels was investigated in terms of toxicokinetics and repeated oral toxicity. Plasma or UVC treatment was utilized to obtain Maesil-cheongs with reduced amygdalin levels. The toxicokinetic study demonstrated that the oral absorption of amygdalin decreased remarkably after a single-dose oral administration of both plasma- and UVC-treated Maesil-cheongs. The fourteen-day repeated oral toxicity study revealed that plasma- or UVC-treated Maesil-cheongs did not cause changes in body weight, food intake, water consumption, and absolute and relative organ weights. No significant effects on hematological and serum biochemical parameters were found. Histopathological examination showed no abnormality or toxicological change. These findings suggest that plasma- and UVC-treated Maesil-cheongs have no toxicity potential, and these processes will be useful to obtain products with safe, reduced amygdalin levels.

Quality characteristics of noodles supplemented with rice flour and alkaline reagent (쌀가루와 알칼리제를 첨가한 국수의 품질특성)

  • Jeong, Gyeong A;Han, Su Hee;Park, Ji Young;Shin, Ye Lim;Lee, Sue Jung;Lee, Chang Joo
    • Korean Journal of Food Science and Technology
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    • v.51 no.3
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    • pp.237-242
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    • 2019
  • The purpose of this study was to investigate the optimal amount of alkaline reagent (0.2 or 0.4%) and rice flour (10-40%) for noodle and supplementation, and compare quality characteristics with those of wheat noodles. Texture properties, pH, tension profiles, and cooking quality of noodles supplemented with rice flour and alkaline reagent were measured. Wheat noodles with 0.4% alkaline reagent added displayed increased b values (Hunter's color), pH, hardness, chewiness, tension profiles, and turbidity, and decreased L, and a values, gumminess, weight, and water absorption compared to wheat noodles with 0.2% alkaline reagent added. Hardness and springiness of wheat noodles with 0.4% alkaline reagent added were 35.2 and 0.0118 N, respectively. These values for rice doodles with 0.4% alkaline reagent and 20% rice flour were similar (36.3, 0.0117 N, respectively). This suggests that addition of 0.4% alkaline reagent and 20% rice flour may be the optimal parameters for producing rice noodle.

Structural Analysis and Design of B-pillar Reinforcement using Composite Materials (복합소재를 활용한 B필러 강화재의 구조해석 및 설계)

  • Kang, Ji Heon;Kim, Kun Woo;Jang, Jin Seok;Kim, Ji Wook;Yang, Min Seok;Gu, Yoon Sik;Ahn, Tae Min;Kwon, Sun Deok;Lee, Jae Wook
    • Composites Research
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    • v.34 no.1
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    • pp.35-46
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    • 2021
  • This paper aims to reduce weight by replacing the reinforcements of the B-pillar used in vehicles with CFRP(Carbon Fiber Reinforced Plastics) and GFRP(Glass Fiber Reinforced Plastics) from the existing steel materials. For this, it is necessary to secure structural stability that can replace the existing B-pillar while reducing the weight. Existing B-pillar are composed of steel reinforcements of various shapes, including a steel outer. Among these steel reinforcements, two steel reinforcements are to be replaced with composite materials. Each steel reinforcement is manufactured separately and bonded to the B-pillar outer by welding. However, the composite reinforcements presented in this paper are manufactured at once through compression and injection processes using patch-type CFRP and rib-structured GFRP. CFRP is attached to the high-strength part of the B-pillar to resist side loads, and the GFRP ribs are designed to resist torsion and side loads through a topology optimization technique. Through structural analysis, the designed composite B-pillar was compared with the existing B-pillar, and the weight reduction ratio was calculated.

Hydrophobicity and Adhesion of SiO2/Polyurethane Nanocomposites Topcoat for Aircraft De-icing with Different Pre-curing Time (선경화 시간에 따른 항공기 De-icing용 나노실리카/폴리우레탄 복합재료 탑코트의 소수성 및 접착특성 평가)

  • Kim, Jong-Hyun;Shin, Pyeong-Su;Kwon, Dong-Jun;Park, Joung-Man
    • Composites Research
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    • v.33 no.6
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    • pp.365-370
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    • 2020
  • The icing formation at aircraft occur problems such as increasing weight of the body, fuel efficiency reduction, drag reduction, the error of sensor, and etc. The viscosity of polyurethane (PU) topcoat was measured at 60℃ in real time to set the pre-curing time. SiO2 nanoparticles were dispersed in ethanol using ultra-sonication method. The SiO2/ethanol solution was sprayed on PU topcoat that was not cured fully with different pre-curing conditions. Surface roughness of SiO2/PU nanocomposites were measured using surface roughness tester and the surface roughness data was visualized using 3D mapping. The adhesion property between SiO2 and PU topcoat was evaluated using adhesion pull-off test. The static contact angle was measured using distilled water to evaluate the hydrophobicity. Finally, the pre-curing time of PU topcoat was optimized to exhibit the hydrophobicity of SiO2/PU topcoat.

Effect of Addition of β-TCP on Bioactivity and Mechanical Properties of Biodegradable PLA/β-TCP Composites (β-TCP 첨가량에 따른 생분해성 PLA/β-TCP 복합체의 생체활성과 기계적 특성 평가)

  • Moon, Hee-Jung;Kim, Seol-Ak;Kim, Dong-Ae
    • The Journal of the Korea Contents Association
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    • v.21 no.3
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    • pp.609-615
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    • 2021
  • The aim of the present study was to investigate the mechanical properties of melt-injected poly lactic acid (PLA) composites with β-tricalcium phosphate (β-TCP). The PLA mixed with calcined PLA/β-TCP powder to be contents of 0, 10, 30, 50 wt%, respectively, was dissolved in chloroform solvent under stirring for 24 h. Then the liquid mixtures were dropped into ethanol to extract solvent. After drying, the well-dispersed PLA/β-TCP composites were granulated and melt-injected to prepare specimens for various mechanical testing. PLA/β-TCP induced the precipitation of an apatite bone-mineral phase on the surface after immersion in a human simulated body fluid (SBF) for 90 days, showing in bioactivity. Mean various mechanical properties PLA/β-TCP composite were increased up to 10-30 wt% with significantly in part and composite were decreased 50 wt% of showing in mechanical properties. In conclusion, Over 30 wt% addition of β-TCP to PLA may be not advisable to improve the mechanical properties of melt-injected polymeric composites. Results indicated that β-TCP can be used considered as potential reinforcing agent for increasing mechanical properties for PLA. Therefore, it was suggest that the additional effects of β-TCP and research on a wide range of substances.

Development trends of Solar cell technologies for Small satellite (소형위성용 태양전지 개발 동향 및 발전 방향)

  • Choi, Jun Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.5
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    • pp.310-316
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    • 2021
  • Conventional satellites are generally large satellites that are multi-functional and have high performance. However, small satellites have been gradually drawing attention since the recent development of lightweight and integrated electric, electronic, and optical technologies. As the size and weight of a satellite decrease, the barrier to satellite development is becoming lower due to the cost of manufacture and cheaper launch. However, solar panels are essential for the power supply of satellites but have limitations in miniaturization and weight reduction because they require a large surface area to be efficiently exposed to sunlight. Space solar cells must be manufactured in consideration of various space environments such as spacecraft and environments with solar thermal temperatures. It is necessary to study structural materials for lightweight and high-efficiency solar cells by applying an unfolding mechanism that optimizes the surface-to-volume ratio. Currently, most products are developed and operated as solar cell panels for space applications with a triple-junction structure of InGaP/GaAs/Ge materials for high efficiency. Furthermore, multi-layered junctions have been studied for ultra-high-efficiency solar cells. Flexible thin-film solar cells and organic-inorganic hybrid solar cells are advantageous for material weight reduction and are attracting attention as next-generation solar cells for small satellites.

Toxic Effects on Lethal Concentration 50%, Heamatological Parameters and Plasma Components of Crucian carp, Carassius carassius by Acute Waterborne Nickel Exposure (수인성 니켈 급성 노출이 붕어, Carassius carassius의 반수치사농도, 혈액학적 성상 및 혈장 성분에 미치는 독성 영향)

  • Chang-Hoon, Joo;A-Hyun, Jo;Su-Min, Hong;Ji-Ho, Jeong;Yun-A, Ryu;Seock-Won, Jo;Jae-Hee, Song;Jun-Hwan, Kim
    • Journal of Marine Life Science
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    • v.7 no.2
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    • pp.102-112
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    • 2022
  • Crucian carp, Carassius carassius (Weight 39.7±3.1 g, Length 14.8±0.5 cm) were exposed to waterborne nickel at 0, 10, 20, 40, 80 and 160 mg Ni2+/l. The lethal concentration 50 (LC50) of C. carassius exposed to waterborne nickel was 117.69 mg Ni2+/l. In hematological parameters, RBC counts was significantly increased at 48 hours, whereas a significant decrease was observed at 96 hours. The MCV and MCH were significantly increased in the concentration of 80 mg Ni2+/l at 96 hours. The plasma components such as calcium, magnesium, glucose, cholesterol, total protein, AST, ALT and ALP were significantly changed by waterbonre nickel exposure. The results of this study suggest that the nickel exposure to C. carassius affects the survival rates, hematological parameters and plasma components as toxicity

Effects on Lethal Concentration 50%, Hematological Parameters and Plasma Components of Crucian carp, Carassius carassius Exposed to Waterborne Zinc (수인성 아연 급성 노출이 붕어, Carassius carassius의 반수치사농도, 혈액학적 성상 및 혈장 성분에 미치는 영향)

  • Ji-Ho, Jeong;Chang-Hoon, Joo;A-Hyun, Jo;Su-Min, Hong;Yun-A, Ryu;Seock-Won, Jo;Jun-Hwan, Kim
    • Journal of Marine Life Science
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    • v.7 no.2
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    • pp.129-138
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    • 2022
  • Crucian carp, Carassius carassius (Weight 42.4 ± 9.0 g, Length 15.0 ± 1.0 cm) were exposed to waterborne zinc at 0, 5, 10, 20, 40 and 80 mg Zn2+/l for 96 hours. The lethal concentration 50 (LC50) at 96 hours of crucian carp, C. carassius exposed to waterborne zinc was 51.58 mg Zn2+/l. In hematological parameters, the RBC count was significantly decreased in the concentration of 40 mg Zn2+/l at 48 hours, whereas the hematocrit was significantly increased by zinc exposure. The MCV (mean corpuscular volume) (µl) and MCH (mean corpuscular hemoglobin) (pg) were significantly increased in the concentration of 40 mg Zn2+/l at 48 hours. The plasma components such as calcium, magnesium, glucose, cholesterol, total protein and ALT (Alanine aminotransminase) were significantly changed by zinc exposure. The results of this study suggest that the zinc exposure to C. carassius induced the significant physiological changes in the hematological parameters and plasma components as toxicity.