• Korean Journal of Medicinal Crop Science
• /
• v.10 no.5
• /
• pp.399-402
• /
• 2002

Angiotensin converting enzyme(ACE) belongs to the class of zinc protease and plays an important role in the regulation of blood pressure. In this experiment, we investigated the inhibitory activities of medicinal plant extracts on ACE. Fifty medicinal plants were selected and the extracts were prepared by refluxing with 70% methanol. Among the extracts, eleven medicinal plant extracts such as Sedum sarmentosum Bunge, Petasites japonicus(s.et z.) Max, Rubus coreanus, Morus bombycis Koidz, Acorus calamus var. angustatus, Glycyrhiza glabra, Equisetum hyemale, Portulaca oleracea L., Prunella vulgaris var. lilacina Nakai, Sorbus commixta Hedl, Allium thunbergii showed more than 50% inhibitory activities, and Paeonia suffruticosa Andr., lnula helenium, Acanthopanax senticosus Harms, Dendrobium moniliforme, Juglans mandshurica, Zizyphus jujuba, Leonurus artemisia, Aster scaber Thunb, Vitex rotundifolia, Platycodon grandiflorum, Prunus persica, Ligularia fischeri showed $40{\sim}49%$ inhibitory activities. Therefore these extracts which contain high ACE inhibitory activities may be useful as antihypertension agents and to the treatment of hypertension.

• Journal of Food Hygiene and Safety
• /
• v.3 no.2
• /
• pp.89-97
• /
• 1988

The possible effeets of some oriental herbs, whleh have been used to treat eaneerllke dllleue In Korea, on growth and afIatonn production by Aspergillus parasiticus R-716 were investigated. Zedoaria rhizoma, Curcuma longa, Cyperus rotundus, Angelica gigas, Paeonia albiflora, Paeonia mountan, Atractylis ovata, and Pulsatilla koreana were extracted with chloroform. Among them the extract of paeonia mountan was remarkably effective on the growth inhibition, and Curcuma longa, Zedoaria rhizoma, Cyperus rotundus, Paeonia albiflora, Atractylis ovata also inhibited the growth. The ertraet of Atractylis ovata and Curcuma longa, also Inhibited the afIatoxin production but the others showed no effect at all or sometimes stimulated effect. With the addition of O.2ml extract of Atractylis ovata in 30ml SLS medium, the growth was delayed for about 2 days, and after 9 days, mycellum weight was 0.953g, and total afatoxin was reduced 5O%($792\mu\textrm{g}$)of that produced in the control($1547\mu\textrm{g}$). Aflatoxin per mycelium weight was decreased 32%($992\mu\textrm{g}$) of that produced in the control($1467\mu\textrm{g}$), but NADPH oxidase was higher as compared to the control. The extract of Atractylis ovata appeared to have a inhibitory effect on the growth and the aflatoxin production of Aspergillus parasiticus R-716.

• Korean Journal of Medicinal Crop Science
• /
• v.6 no.3
• /
• pp.232-238
• /
• 1998

To analyse the management and production of medicinal crops in Uisong region, cultural conditions and standard income of 147 farms were investigated. Location quotient of medicinal crops cultivated was high as following order ; Paeonia lactiflora > Cornus ofidnalis> Bupleurm falcatum > Anemarhena asphodeloides > Rehmannia glutinosa > Eucommia ulmoides > Paeonia suffruticosa > Angelica dahurica. The average cultivated area per farm was 1.92ha : 1.35ha of upland field, 0.56ha of paddy field. Distribution of agricultural land in each farm was average 10.2 fields in 3.1 locations. Ratio of labor input in the medicinal plant sector was 31.1 %. The number of medicinal crops cultivated was 36 species among 147 farms and 2.4 species per farm. Among the cultivated medicinal plant, peony (Paeonia lactiflora) was the most popular medicinal plant, which was cultivated in 30.72ha of 85 farms. Income from medicinal plants was high in order of Carthamus tinctorius, Polygonatum stenophyllum, Angelica genuilexa. Medicinal crops should be selected based on farm condition, risk level and price settlement in order to maximize productivity and income.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.42 no.2
• /
• pp.145-152
• /
• 2016

Epidermis is continuously regenerated by keratinocyte stem cells (KSCs) residing in basement membrane, which is critical to the survival of an organism. KSCs are believed to persist during the whole lifetime and generate an enormous number of keratinocytes, required for the maintenance of epidermis, through transit amplifying cells dividing definite times until they become differentiated. In this report, we have developed a phenolic compound, paeonol, purified from Moutan Cortex, as a KSC proliferation activator, by screening about 350 herbal compounds. The cell proliferation activation by paeonol is specific for KSC not for keratinocyte, and no significant difference in the expression of p63 protein, a KSC marker, in KSCs treated with paeonol was observed in FACS analysis with anti-p63 antibody. In the colony forming assay, paeonol-treated KSC showed improved colony forming activity more than 1.3 fold. In addition, the result of PCR array shows that the activity of paeonol is through several signal pathways involving stem cell functions. These results suggest that paeonol could enhance KSC proliferation activity without reduction in stemness and could be applied to cosmetics as a KSC activating ingredient.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.57 no.1
• /
• pp.22-28
• /
• 2012

This experiment was conducted to find out high antioxidant activity varieties of chinese matrimony from the 131 accessions which conserved at Cheongyang Gugija Experiment Station. The status of the 131 accessions were composed 21 of local varieties, 20 of introduced species and 90 of improved races. The anti-oxidant activity using DPPH and $IC_{50}$, 45 accessions out of 90 showed high activity in free radical scavenging ability as less than $200{\mu}g/m{\ell}$ in improved races, while nine and six accessions from the introduced species and local varieties, respectively. At the stem part, the highest three anti-oxidant varieties among 131 accessions are "C0148-94", "D0148-72" and "Cheongdae", while China collection 1 in leaf part. Since "Cheongdae" is the progeny from the "Cheongyang Jaerae 5" and "Myungan" and those two varieties, "C0148-94" and "D0148-72" are from the Myungan and Cheongdae, high anti-oxidant activity can be inherited in Chinese matrimony vine.