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Screening of Inhibitory activities on Angiotensin Converting Enzyme from Medicinal plants  

Choi, Geun-Pyo (Dept. of Food & Life Science, Gangwon Provincial University)
Chung, Byung-Hee (School of Biotechnology and Bioengineering, Kangwon National University)
Lee, Dong-Il (School of Biotechnology and Bioengineering, Kangwon National University)
Lee, Hyeon-Yong (School of Biotechnology and Bioengineering, Kangwon National University)
Lee, Jin-Ha (School of Biotechnology and Bioengineering, Kangwon National University)
Kim, Jong-Dai (School of Biotechnology and Bioengineering, Kangwon National University)
Publication Information
Korean Journal of Medicinal Crop Science / v.10, no.5, 2002 , pp. 399-402 More about this Journal
Abstract
Angiotensin converting enzyme(ACE) belongs to the class of zinc protease and plays an important role in the regulation of blood pressure. In this experiment, we investigated the inhibitory activities of medicinal plant extracts on ACE. Fifty medicinal plants were selected and the extracts were prepared by refluxing with 70% methanol. Among the extracts, eleven medicinal plant extracts such as Sedum sarmentosum Bunge, Petasites japonicus(s.et z.) Max, Rubus coreanus, Morus bombycis Koidz, Acorus calamus var. angustatus, Glycyrhiza glabra, Equisetum hyemale, Portulaca oleracea L., Prunella vulgaris var. lilacina Nakai, Sorbus commixta Hedl, Allium thunbergii showed more than 50% inhibitory activities, and Paeonia suffruticosa Andr., lnula helenium, Acanthopanax senticosus Harms, Dendrobium moniliforme, Juglans mandshurica, Zizyphus jujuba, Leonurus artemisia, Aster scaber Thunb, Vitex rotundifolia, Platycodon grandiflorum, Prunus persica, Ligularia fischeri showed $40{\sim}49%$ inhibitory activities. Therefore these extracts which contain high ACE inhibitory activities may be useful as antihypertension agents and to the treatment of hypertension.
Keywords
Angiotensin converting enzyme; hypertension; medicinal plants;
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