• Title/Summary/Keyword: 리드 변이

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Genotype-Calling System for Somatic Mutation Discovery in Cancer Genome Sequence (암 유전자 배열에서 체세포 돌연변이 발견을 위한 유전자형 조사 시스템)

  • Park, Su-Young;Jung, Chai-Yeoung
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.17 no.12
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    • pp.3009-3015
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    • 2013
  • Next-generation sequencing (NGS) has enabled whole genome and transcriptome single nucleotide variant (SNV) discovery in cancer and method of the most fundamental being determining an individual's genotype from multiple aligned short read sequences at a position. Bayesian algorithm estimate parameter using posterior genotype probabilities and other method, EM algorithm, estimate parameter using maximum likelihood estimate method in observed data. Here, we propose a novel genotype-calling system and compare and analyze the effect of sample size(S = 50, 100 and 500) on posterior estimate of sequencing error rate, somatic mutation status and genotype probability. The result is that estimate applying Bayesian algorithm even for 50 of small sample size approached real parameter than estimate applying EM algorithm in small sample more accurately.

Biological Characteristics of Lycorma delicatula and the Control Effects of Some Insecticides (꽃매미(Lycorma delicatula)의 생태 특성 및 약제 살충 효과)

  • Park, JI-Doo;Kim, Min-Young;Lee, Sang-Gil;Shin, Sang-Chul;Kim, Jun-Heon;Park, Il-Kwon
    • Korean journal of applied entomology
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    • v.48 no.1
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    • pp.53-57
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    • 2009
  • Biological Characteristics of Lycorma delicatula and insecticidal activity of some insecticides against nymphs of L. delicatula was investigated. Nymph of L. delicatula had 4 instars, and color of body was black. There were white spots on the body of 1st-3rd nymph. Upper body became red at 4th nymph. Adult forewings were brownish, and had black spots. Color of hind wing were red. The egg mass was covered with a yellowish brown secretion. The adult of L. delicatula emerged once a year. Among test insecticides, deltamethrin 1% EC and fenitrothion 50% EC showed very quick and strong insecticidal activity against the 2nd-3rd nymphs of L. delicatula. Imidacloprid 4% SL and clothianidin 8% SC showed 100% insecticidal activity at 24h after treatment. Thiacoprid 10% SC revealed the weakest insecticidal activity among the insecticides tested.

Aeromechanical stability analysis and control of helicopter rotor blades (헬리콥터 회전날개깃의 안정성 해석과 제어)

  • Kim, J.S.;Chattopadhyay, Aditi
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.9 no.1
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    • pp.59-69
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    • 2001
  • The rotor blade is modeled using a composite box beam with arbitrary wall. The active constrained damping layers are bonded to the upper and lower surfaces of the box beam to provide active and passive damping. A finite element model, based on a hybrid displacement theory, is used in the structural analysis. The theory is capable of accurately capturing the transverse shear effects in the composite primary structure, the viscoelastic and the piezoelectric layers within the ACLs. A reduced order model is derived based on the Hankel singular value. A linear quadratic Gaussian (LQG) controller is designed based on the reduced order model and the available measurement output. However, the LQG control system fails to stabilize the perturbed system although it shows good control performance at the nominal operating condition. To improve the robust stability of LQG controller, the loop transfer recovery (LTR) method is applied. Numerical results show that the proposed controller significantly improves rotor aeromechanical stability and suppresses rotor response over large variations in rotating speed by increasing lead-lag modal damping in the coupled rotor-body system.

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The design of microscopic system using zoom structure with a fixed magnification and the independency on the variation of object distance (줌 구조를 이용하여 물체거리가 변해도 상면과 배율이 고정되는 현미경 광학계의 설계)

  • 류재명;조재흥;임천석;정진호;전영세;이강배
    • Korean Journal of Optics and Photonics
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    • v.14 no.6
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    • pp.613-622
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    • 2003
  • The multi-configurative microscopic system for inspecting the wire-bonding of reed frame is designed. Rays refracted by objective lens group which is composed of common lens group of x2 and x6 are splitted by beam-splitter, and Rays through the central region and the boundary region of the object imaged at x2 and x6 through imaging lens groups, respectively. The depth of wire structure on the reed frame has about $\pm$3 mm, in order to observe by uniform magnification without the dependency on the variation of objective distance generated by the depth of wire structure on the reed frame, imaging lens groups should be moved on nonlinear locus like mechanically compensated zoom lenses. The nonlinear equations for zoom locus are derived by using the Gaussian bracket. Refraction powers and positions of each groups are numerically determined by solving the equations, and initial design data for each groups is obtained by using Seidel third order aberration theory. The optimization technique is finally utilized to obtain this microscopic system.

A CNV detection algorithm based on statistical analysis of the aligned reads (정렬된 리드의 통계적 분석을 기반으로 하는 CNV 검색 알고리즘)

  • Hong, Sang-Kyoon;Hong, Dong-Wan;Yoon, Jee-Hee;Kim, Baek-Sop;Park, Sang-Hyun
    • The KIPS Transactions:PartD
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    • v.16D no.5
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    • pp.661-672
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    • 2009
  • Recently it was found that various genetic structural variations such as CNV(copy number variation) exist in the human genome, and these variations are closely related with disease susceptibility, reaction to treatment, and genetic characteristics. In this paper we propose a new CNV detection algorithm using millions of short DNA sequences generated by giga-sequencing technology. Our method maps the DNA sequences onto the reference sequence, and obtains the occurrence frequency of each read in the reference sequence. And then it detects the statistically significant regions which are longer than 1Kbp as the candidate CNV regions by analyzing the distribution of the occurrence frequency. To select a proper read alignment method, several methods are employed in our algorithm, and the performances are compared. To verify the superiority of our approach, we performed extensive experiments. The result of simulation experiments (using a reference sequence, build 35 of NCBI) revealed that our approach successfully finds all the CNV regions that have various shapes and arbitrary length (small, intermediate, or large size).

A Study on Shape Optimum Design for Stability of Elastic Structures (탄성 구조물의 안정성을 고려한 형상최적설계)

  • Yang, Wook-Jin;Choi, Joo-Ho
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.20 no.1
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    • pp.75-82
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    • 2007
  • This paper addresses a method for shape optimization of a continuous elastic body considering stability, i.e., buckling behavior. The sensitivity formula for critical load is analytically derived and expressed in terms of shape variation, based on the continuum formulation of the stability problem. Unlike the conventional finite difference method (FDM), this method is efficient in that only a couple of analyses are required regardless of the number of design parameters. Commercial software such as ANSYS can be employed since the method requires only the result of the analysis in computation of the sensitivity. Though the buckling problem is more efficiently solved by structural elements such as a beam and shell, elastic solids have been chosen for the buckling analysis because solid elements can generally be used for any kind of structure whether it is thick or thin. Sensitivity is then computed by using the mathematical package MATLAB with the initial stress and buckling analysis of ANSYS. Several problems we chosen in order to illustrate the efficiency of the presented method. They are applied to the shape optimization problems to minimize weight under allowed critical loads and to maximize critical loads under same volume.

The Study of Diffusion and Outlook for Smart Phone in Smart Nomad Era (스마트 노매드 시대 스마트폰의 확산과 전망에 대한 연구)

  • Nam, Chong-Hoon
    • Journal of Digital Contents Society
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    • v.11 no.3
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    • pp.315-322
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    • 2010
  • This study focused on mobile trend in diffusion of smart phone. Presently, it has been evolved from digital nomad to smart nomad. Smart nomad era is based on digital technology with mobility and being smart. Smart nomad that is made up high-end device and intellectual content has changed structure of industry and life style. Smart phone is a core key in smart nomad era. In 2010 smart phone has been distributed about 2.5 hundreds million which is 20% of whole mobile phone sales and the volume of smart phone sales will be getting bigger and bigger in near future. Although, there are various reasons for success of smart phone market, this research focused 4 reasons: first, development of mobile device, second, evolution of mobile content distribution, third, support of government system, fourth, success of Docomo i-mode and Apple i phone. Smart phone will grow up more rapidly. Smart phone eco-system will be more competitive in the world. In Korea, smart phone eco-system also will be very competitive. For success in the middle of this competitive environment, Korea should lead the competitive phase with development of ability of creation software and content, construction of various partnership and evolution of next generation technology and service.

Polydnavirus Replication and Ovipositional Habit of Cotesia plutellae (프루텔고치벌(Cotesia plutellae) 폴리드나바이러스 복제와 산란 습성)

  • Kim Yonggyun;Bae Sangki;Lee Sunyoung
    • Korean journal of applied entomology
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    • v.43 no.3 s.136
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    • pp.225-231
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    • 2004
  • An endoparasitoid wasp, Cotesia plutellae, has been used for a biological control agent against the diamondback moth, Plutellae xylostella. It has a symbiotic polydnavirus in their reproductive tract, which is required for its successful parasitization. Here, we measured a specific replication time of the polydnavirus during female development of C. plutellae. We, also, analyzed the reproductive potentials of female C. plutellae under mating or different host conditions. At $25^{\circ}C$, pupal C. plutellae began to develop adult tissues such as compound eyes and wings since day 2. At day 5, all adult tissues including antennae were developed and were ready to emerge. With polyclonal antibody raised against C. plutellae polydnavirus, an immunobloting could confirm virus replication at day 4 during pupal stage. Virus particles could be visualized by transmission electron microscope in the oviduct lumen of day 5 pupae. After adult eclosion, venom gland and ovarian calyx increased in size, though ovarioles did not. Mated females layed large number of eggs (over $60\%$) at first 4 days during their mean longevity of ca. 8 days at $25^{\circ}C$. Unmated females showed less active ovipositional behavior, where all the eggs developed into males. C. Plutellae parasitized both P. xylostella and fall webworm, Hyphantria cunea. However, C. Plutellae developed faster and showed higher successful paarasitization in P. xylostella than in H. cunea.

Cost Efficient Virtual Machine Brokering in Cloud Computing (가격 효율적인 클라우드 가상 자원 중개 기법에 대한 연구)

  • Kang, Dong-Ki;Kim, Seong-Hwan;Youn, Chan-Hyun
    • KIPS Transactions on Computer and Communication Systems
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    • v.3 no.7
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    • pp.219-230
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    • 2014
  • In the cloud computing environment, cloud service users purchase and use the virtualized resources from cloud resource providers on a pay as you go manner. Typically, there are two billing plans for computing resource allocation adopted by large cloud resource providers such as Amazon, Gogrid, and Microsoft, on-demand and reserved plans. Reserved Virtual Machine(VM) instance is provided to users based on the lengthy allocation with the cheaper price than the one of on-demand VM instance which is based on shortly allocation. With the proper mixture allocation of reserved and on-demand VM corresponding to users' requests, cloud service providers are able to reduce the resource allocation cost. To do this, prior researches about VM allocation scheme have been focused on the optimization approach with the users' request prediction techniques. However, it is difficult to predict the expected demands exactly because there are various cloud service users and the their request patterns are heavily fluctuated in reality. Moreover, the previous optimization processing techniques might require unacceptable huge time so it is hard to apply them to the current cloud computing system. In this paper, we propose the cloud brokering system with the adaptive VM allocation schemes called A3R(Adaptive 3 Resource allocation schemes) that do not need any optimization processes and kinds of prediction techniques. By using A3R, the VM instances are allocated to users in response to their service demands adaptively. We demonstrate that our proposed schemes are able to reduce the resource use cost significantly while maintaining the acceptable Quality of Service(QoS) of cloud service users through the evaluation results.

Induction coordination of the 154KV system with direct grounding (154KV 계통직접접지전환에 따른 유도협조)

  • 손필영;원준희
    • 전기의세계
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    • v.18 no.1
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    • pp.33-37
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    • 1969
  • 한전은 1968년 11월 3일 오전 10시 04분을 기하여 154KV 전계통의 직접접지방식 전환을 단행하였다. 종전의 P.C(소고선륜) 중성점접지방식을 직접접지방식으로 전환한것으로서 전력사상 특기 할 만한 근대화사업이며 다년간을 두고 추진해온 중요과제였다. 전력계통의 확대와 복잡화는 선진국가에서도 실시하고 있는 직접접지방식의 채택을 불가변하게 하였고 또한 1차 AID송배전차관도 이의 채택을 조건부로 승인되었던 것으로서 1968년 이후에 건설되는 송변전기기는 직접접지계에서만 운전할 수 있는 절연Level 650KV급이 도입되어 부산화력발전소 3호기가 준공되는 1968년 10월말까지는 직접접지전환이 반드시 이루어져야 하는 실정에 놓여 있었다. 그런데 직접접지방식의 단점인 인접통신선에 미치는 유도장해를 해결하는 문제가 다년간을 두고 진지하게 검토되어 왔으나 해결이 늦어지고 있었다. 사유는 154KV 계통에 인근된 통신선이라면 체신부, 내무부, 교통부, 국방부등 여러기관의 것이 있는데, 유도장해보안방법과 유도보상비문제에 대하여 전력측(상공부, 한전)과 통신측(상기의 체신부등)의 견해차가 해소되지 않기 때문이었다. 그것이 1968년 5월에 와서 전력.통신쌍방이 범국가적입장에서 제반애로를 무릅쓰고 최소한의 투자로 가능한 범위내의 보안책으로서 우선 Arrester 보안방식을 채택하기로 합의되어 경제장관회의를 거쳐 시공하기에 이른것이다. 이 란을 빌려 이 사업의 필요성과 경위및 통신선유도장해방지를 위한 보안방식내용을 간단히 소개함으로써 앞으로 이 분야의 항구적인 유도대책연구에 다소나마 참고가 된다면 다행으로 생각하겠다.면서 예측강우의 질이 저하되기 시작하였으나 QPM을 합성함으로써 생산한 BQPF는 보다 신뢰성있고 양호한 결과를 얻을 수 있었다. 이러한 결과들은 향후 정량적 분포형강우 예측을 이용한 실시간 홍수유출 예측시 댐운영자는 리드타임(홍수선행시간)을 충분히 확보함으로서 안정적이고 예측 가능한 홍수조절을 하는데 도움을 줄 수 있을 것으로 기대된다. 이와 같이 다양한 단기저수지 유입량의 예측정보 제공으로 다목적댐 저수지 운영모형의 효용성을 제고하여 향후 실제 저수지 유입량 예측에 이용함으로써 저수지 단기운영효율 개선에 기여할 수 있을 것으로 사료된다.다. 이것은 여름철 강수량이 증가하고, 호우발생빈도, 특히 8월의 강수일수가 증가하고 있다는 것과 밀접한 관련이 있다. 여름과 가을에 우리나라에 영향을 미치는 태풍의 수는 뚜렷한 추세를 보이지 않으나, 2002년 루사, 2003년 매미로 인하여 각각 6조원, 4조원 이상의 막대한 피해가 발생하였다. 태풍에 의한 피해액은 GDP 대비 약 0.9%(태풍 루사)로 최근 경제상장률과 비교해 보면, 상당한 비율을 차지한다. 우리나라에 영향을 미치는 태풍은 연근해의 해수면 온도가 높아지면 세기가 강해질 가능성이 높다. 폭설과 한파일수도 평년대비 최근 10년 감소하였고 일최저기온이 영하 $10^{\circ}C$ 이하인 날도 연간 발생일수가 감소하였다. 최근 10년간 우리나라 기후의 변화특성은 기온상승과 더불어 서리종료일이 앞당겨지고 열대야가 증가하고 폭설, 한파, 겨울철 일최저기온 영하 10도 이하인 날의 감소 등이 나타나고, 여름철 재해의 원인인 호우일수는 증가하는 추세이다.

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