• Radiation Oncology Journal
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• v.29 no.2
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• pp.107-114
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• 2011

Purpose: To assess the degree and clinical impact of location error of the dens on the X-axis during radiotherapy to brain and head and neck tumors. Materials and Methods: Twenty-one patients with brain tumors or head and neck tumors who received three-dimensional conformal radiation therapy or intensity-modulated radiation therapy from January 2009 to June 2010 were included in this study. In comparison two-dimensional verification portal images with initial simulation images, location error of the nasal septum and the dens on the X-axis was measured. The effect of set-up errors of the dens was simulated in the planning system and analyzed with physical dose parameters. Results: A total of 402 portal images were reviewed. The mean location error at the nasal septum was 0.16 mm and at the dens was 0.33 mm (absolute value). Location errors of more than 3 mm were recorded in 43 cases (10.7%) at the nasal septum, compared to 133 cases (33.1%) at the dens. There was no case with a location error more than 5 mm at the nasal septum, compared to 11 cases (2.7%) at the dens. In a dosimetric simulation, a location error more than 5 mm at the dens could induce a reduction in the clinical target volume 1 coverage (V95: 100%${\rightarrow}$87.2%) and overdosing to a critical normal organ (Spinal cord V45: <0.1%${\rightarrow}$12.6%). Conclusion: In both brain and head and neck radiotherapy, a relatively larger set-up error was detected at the dens than the nasal septum when using an electronic portal imaging device. Consideration of the location error of the dens is necessary at the time of the precise radiation beam delivery in two-dimensional verification systems.

• The Journal of Korean Academy of Prosthodontics
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• v.57 no.2
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• pp.160-170
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• 2019

The anterior guidance is one of the important factors in prosthodontic treatment of anterior teeth. The lingual surface shape of anterior restorations is so critical that small errors of treatment procedure can cause discomfort of the patient and disharmony of the dentition. If the anterior restorations are achieved harmonious anterior guidance through the fabrication and adjustment of provisional restorations, it is important to accurately reproduce the lingual surface shape of provisional restorations as the final prosthesis. In this case report, it was used the modified Dahl principle and copy-milled technique of computer-aided design/computer-aided manufacturing (CAD/CAM) system for systematic diagnosis and treatment. Therefore, we tried to reconstruct the restoration shape more precisely by setting the appropriate anterior guidance and superimposing the digital image of the abutment teeth and the provisional restorations. Thus, by promoting functional and esthetic recovery, this case report demonstrates satisfying results to both the patients and dentist.

• Therapeutic Science for Rehabilitation
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• v.12 no.3
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• pp.61-77
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• 2023

Objective : This study analyzed the correlation between cognitive function and oral health-related quality of life (OHQoL). Methods : Demographic and clinical characteristics were extracted and utilized for subjects aged 45 years or older who participated in the 8th Korean Longitudinal Study on Aging in 2020. The dependent variable was the Geriatric Oral Health Assessment Index, and the independent variable was the level of cognitive function classified by the Mini-Mental State Examination scores. The analysis method used inverse probability of treatment weighting (IPTW). Then, the association between cognitive function and OHQoL was analyzed by multiple regression analysis. Results : Among the participants, 4,367 (71.40%) had normal cognition, 1,155 (18.89%) had moderate cognitive impairment, and 594 (9.71%) had severe cognitive impairment. As a result of analysis by applying IPTW, there was a negative correlation between the cognitive function group and OHQoL (normal vs. moderate: β = -2.534, p < .0001; normal vs. severe: β = -2.452, p < .0001). Conclusion : After propensity score matching, mild cognitive impairment showed a more negative association than severe cognitive impairment. Therefore, patients with cognitive impairment require oral health management education to improve OHQoL regardless of the level of cognitive impairment.

• The Journal of Korean Academy of Prosthodontics
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• v.57 no.3
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• pp.254-262
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• 2019

As implant can be covered by National Health Insurance Service (NHIS), it was increased the interest in the removable partial denture (RPD) with the surveyed fixed prosthesis supported by implant fixture. To achieve predictable result, it needs the prudent implant planning by basic principles of RPD and patient's residual ridge. This 67 years old age male had a few unilateral remaining teeth, and hoped the treatment covered by NHIS. As using CAD software, the position of implant is planned with regarding to occlusal table of provisional denture, basic principles of RPD, and resorbed residual ridge. The definitive prostheses can ensure the stability and retention of removable prosthesis. When planning implant fixed prostheses, the digital technique was utilized to consider basic principle of RPD and resorbed residual ridge. As a result, it provided satisfactory prostheses.

• Journal of Digital Convergence
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• v.14 no.3
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• pp.235-241
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• 2016

Among recent issues emerging in the areas related to the society, health has received the most attention. In this paper, for a patient unable to do self-care because of worsened diseases, a biological information transfer method is proposed by which the disease information can be securely managed, by attaching an implantable device into the body. Our method object of the invention is to prevent a third party from illegally intercepting and interfering with the biological information attached to the insertion device in the body. In the proposed technique to improve the safety of the patient between the hospital and physician by assigning each code to the biometric information of the patient in order to prevent a third party tapping and interfering. In addition, our method is assigned a code necessary for encoding in advance to confirm the biological information between the patient and the hospital (doctor) in a manner dividing the bio-information code. In particular, the proposed technique makes a third party unable to illegally tap or interfere in, by previously generating a code used for encoding so that it can be stored in the database of the hospital, which not only decreased hospital care time to 6.9%, but also increased work efficiency rate up to 12.7%.

• Korean Journal of Clinical Laboratory Science
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• v.56 no.1
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• pp.73-84
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• 2024

A pulsed electromagnetic field (PEMF) enhances the efficacy of several anticancer drugs. Doxorubicin (DOX) is an anticancer agent used to treat various malignancies, including breast cancer. This study examined whether a PEMF increases the anticancer effect of DOX on MCF-7 human breast cancer cells and elucidated the underlying mechanisms affected by PEMF stimulation in DOX-treated MCF-7 human breast cancer cells. A cotreatment with DOX and a PEMF potentiated the reduction in MCF-7 cell viability compared to the treatment with DOX alone. The PEMF elevated DOX-induced G1 arrest by affecting cyclin-dependent kinase 2 phosphorylation and the expression of G1 arrest-related molecules, including p53, p21, cyclin E2, and polo like kinase 1. In addition, PEMF increased the DOX-induced upregulation of proapoptotic proteins, such as Fas and Bcl-2-associated X, and the downregulation of antiapoptotic proteins, including myeloid leukemia 1 and survivin. PEMF promoted the DOX-induced activation of caspases-8, -9, and -7 and poly (adenosine diphosphate-ribose) polymerase cleavage in MCF-7 cells. In conclusion, PEMF enhances the anticancer activity in DOX-treated MCF-7 breast cancer cells by increasing G1 cell cycle arrest and caspase-dependent apoptosis. These findings highlight the potential use of a PEMF as an adjuvant treatment for DOX-based chemotherapy against breast cancer.

• Journal of Digital Convergence
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• v.13 no.8
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• pp.503-514
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• 2015

The effects of Flavonol contents from Ginkgo biloba leaf on anti-atopy activity have not rarely been verified. This study is to investigate the effects of flavonol on Th2 cytokine production in MC/9 mast cells. For this, flavonol was analyzed by ELISA and Real-time PCR. Analysis results showed that flavonol significantly suppressed production of Th2 cytokines(IL-13, MIP-1a) in a dose dependent manner. The mRNA expression of IL-4, IL-5, IL-13, TNF-a were effectively restrained by Flavonol at the concentration 25,50,$100{\mu}g/m{\ell}$. And decrease of expression of NFAT-1, c-jun protein was confirmed by western blot analysis. These results indicate that flavonol has effects of decreasing the Th2 cytokine production in the MC/9 mast cell causing inhibition of transcription factors such as NFAT-1, c-jun. Thus, we would like to brief that flavonol may have the applicability as therapeutic agent for atopic dermatitis.

• The Journal of Korean Academy of Prosthodontics
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• v.52 no.2
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• pp.121-127
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• 2014

Comprehensive prosthetic treatment requires considerations from various points of view. The anterior guidance is important factor in prosthodontic treatment of anterior teeth. Lingual surface contour of anterior restoration is so critical that a small mistake of laboratory or clinical process can cause discomfort of patient and disharmony of entire dentition. There are no guidelines for lingual surface contour that fit all patients. Therefore the lingual surface of provisional restoration is most accurately described as a customized one. The dentist transfers the exact information of anterior guidance that has made through long term provisional restoration to the technician. This case introduce that the duplication technique of CAD/CAM system to reproduce the anterior guidance of provisional restoration. This method can improve satisfaction of both patient and dentist.

• Journal of Digital Convergence
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• v.15 no.8
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• pp.417-422
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• 2017

This study conducted frequency analysis for male and female patients aged 60 and over from the results of analyzing improvement strategies for inconvenience due to wearing alopecia wigs. When the patoent started perceive their depilatory diseases was right after treatment of anticancer drugs or radiotherapy, and they were found to suffer from inconveniences of being dried, etc. After treatment of chemotherapy, as for the falling-out parts, eyebrows were found to be the highest 52.1%, and pubic hair 38%, axilla hair 29% in that order. And the inconvenience level of wearing wigs among the patients with the different background of education indicates that the professions of the patients affect the ease of use. It is presumed that the easiness in use which the college graduates, high school graduates, and postgraduates showed is attributable to the age difference. to improve the inconveniences from cancer patients wearing wigs, scape troubles and close adhesion are constantly needed.

• Journal of Digital Convergence
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• v.12 no.11
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• pp.487-497
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• 2014

This study was to examine the effect of the Self-efficacy Promotion Exercise Program to the elderly hypertensive with Stage 1. This research was the quasi-experimental study. The Self-efficacy Promotion Exercise Program combined to Aerobic exercise which is incrementally at a level of 40~60% HRmax and the source of the Self-efficacy Promotion Exercise. This research was carried out to experimental(33 patients) and control(32 patients), 60 minutes per day, 3 times a week for 12 weeks. The Self-efficacy Promotion Program was effect on enhancing the general(p<.001) and exercise self-efficacy(p<.001), the self-care behaviors(p<.001) and decreasing the systolic blood pressure(p<.001) to the elderly hypertensives. The 12 weeks Self-efficacy Promotion Exercise Program will be considering to useful for various care settings to the elderly hypertensives.