• Radiation Oncology Journal
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• v.13 no.4
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• pp.331-338
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• 1995

Purpose : To evaluate our clinical experience with the combination of teletherapy and intraluminal brachytherapy in patients with unresectable or inoperable esophageal cancers. Materials and Methods : From Nov 1989 to Mar 1993, twenty patients with esophageal cancer were treated with radical radiotherapy and intraluminal brachytherapy at Yonsei Cancer Center. All patients had squamous histolgy and stage distribution was as follows: stage II, 4($20{\%}$)patients; III, 15 ($75{\%}$)patients; IV, 1($5{\%}$)patients. A dose of S-12Gy/1-3weeks with intraluminal brachytherapy (3-5Gy/fraction) to 5mm from the outside of the esophageal tube using high dose rate Iridium-192 remotely afterloading brachytherapy machine was given 2 weeks after a total dose of 59-64Gy with external radiotherapy. Induction chemotherapy using cisplatin and 5-FU was performed in 13 patients with median 3 cycles(1-6 cycles), Response rate, local control rate, survival and complications were analysed retrospectively. Results : Two-year overall survival rate and median survival were $15.8{\%}$ and 13.5 months. Response rates were as follows complete remission(CR) 5($25{\%}$): partial remission a(PRa) 7($35{\%}$): partial remission b(PRb) 7($35{\%}$), no response(NR) 1($5{\%}$). Patterns of failure were as follows; local failure 13($65{\%}$), local and distant failure 3($15{\%}$), distant failure 0($0{\%}$). Ultimate local control rate was $20{\%}$. Treatment related complications included esophageal ulcer in two patients and esophageal stricture in one. Conclusion : Though poor local conrol rate, median survival was improved as compared with previous results of radiation therapy alone(8months) and chemoradiation combined treatment(11 months) in Yonsei Cancer Center High-dose-rate intraluminal brachytherapy following external irradiation is an effective treatment modality with acceptable toxicity in esophageal cancer.

• Radiation Oncology Journal
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• v.29 no.1
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• pp.36-43
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• 2011

Purpose: To evaluate the effectiveness of radiation therapy (RT) for hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) and to analyze the prognostic factors. Materials and Methods: From December 2004 to April 2009, 70 patients who had HCC with PVTT were treated with RT at Keimyung University Dongsan Medical Center. Nineteen patients whose total dose was below 30 Gy and one patient who underwent liver transplantation were excluded. The remaining 50 patients (45 males, 5 females; median age 55 years) were analyzed. According to the LCSGJ TNM stage, there were 27 patients (54.0%) with stage III and 23 (46.0%) with stage IV. Total dose of 30~54 Gy was administered (median 45). Thirty patients (60.0%) were treated with concurrent chemoradiation therapy (CCRT). The median follow-up duration was from 13.5 months (range, 3 to 70 months). Results: The median survival time from the start of RT was 9 months. One-year and 2-year overall survival rates were 24.9% and 11.2%, respectively. At the follow-up time, three patients (6.0%) displayed no evidence of disease. Seven patients (14.0%) were alive with disease, and 40 (80.0%) patients had expired due to disease progression. CCRT was associated with worse survival than RT alone (p=0.034), Response to RT (p=0.037), CLIP stage (p=0.017), and TNM stage (p=0.041) were statistically significant prognostic factors. There was no radiation-induced liver disease. Conclusion: RT is an effective and safe modality for HCC with PVTT. Further studies such as prospective randomized trials are needed to confirm the role of RT for HCC with PVTT.

• Progress in Medical Physics
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• v.3 no.1
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• pp.63-69
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• 1992

Recently, stereotactic radiosurgery plan is required with the information of 3-D image and dose distribution. The purpose of this research is to develop 3-D radiosurgery planning system using personal computer. The procedure of this research is based on three steps. The first step is to input the image information of the patient obtained from CT or MR scan into personal computer through on-line or digitizer. The position and shape of target are also transferred into computer using Angio or CT localization. The second step is to compute dose distribution on image plane, which is transformed into stereotactic frame coordinate. and to optimize dose distribution through the selection of optimal treatment parameters. The third step is to display both isodose distribution and patient image simultaneously using superimpose technique. This prototype of radiosurgery planning system was applied recently for several clinical cases. It was shown that our planning system is fast, accurate and efficient while making it possible to handle various kinds of image modelities such as angio, CT and MRI. It is also possible to develop 3-D planning system in radiation therapy using beam's eye view or CT simulation in future.

• Journal of Digestive Cancer Research
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• v.8 no.1
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• pp.71-75
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• 2020

Esophageal cancer is easy to infiltrate and metastasize because esophagus does not have serosa, and is difficult to remove it because esophagus is in the middle of the chest. Because of this, treatments of esophageal cancer do not always follow the guideline. In this situation, efforts to increase treatment efficiency and improve survival rate through multidisciplinary treatment are increasing. In this case, we report the patient with three superficial esophageal cancers (one in cervical esophagus and two in thoracic esophagus). The patient was treated with concurrent chemoradiotherapy instead of surgery through multidisciplinary discussion. The patient reached a complete remission through this discussion. This case is intended to inform the usefulness of multidisciplinary treatment in patients with esophageal cancer.

• The Journal of the Korean dental association
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• v.37 no.3 s.358
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• pp.181-187
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• 1999

치주질환은 초기에는 환자 자신이 전혀 모르는 가운데 진행되어 환자가 증상을 느낄 때 쯤되면 이미 병변이 상당히 진행된 상태가 되어 치료하기 어려운 경우가 많게 되므로 치주질환의 원인과 질병상태를 조기에 파악하여 치료하는 것이 중요하다. 치주질환을 진단하는데 있어서는 객관적인 임상적 기준을 필요로 하게되며 치주질환의 활성도를 알아보기위해서는 여러 임상적 변수가 동시에 필요하므로 우선 환자의 병력을 파악하고 구강의 및 구강내 검사를 완전히 시행한 후 환자의 치아의 치주조직상태를 검사하게 된다. 이 장에서는치주질환의 진단에 필수적인 요인인 치아와 치주조직 검사에 대하여 중점적으로 애기 하고자 한다.

• 대한두경부종양학회:학술대회논문집
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• 2001.11a
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• pp.255-255
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• 2001

• Radiation Oncology Journal
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• v.19 no.4
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• pp.359-368
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• 2001

Purpose : To determine the long-term results of bladder-preserving approach by transurethral resection of the bladder (TURB), systemic chemotherapy, and radiation therapy for muscle-invasive bladder cancer Methods and materiaals : From 1991 Jan. through 1994 Dec., 25 patients with muscle invading clinical stage T2 to T4NxM0 bladder cancer were treated with induction by maximal TURB and (arm 1, n=4) three cycles of chemotherapy [MVAC(methotrexate, vincristine, adriamycin, ciplatin)] followed by 64.8 Gy of radiation with concomitant cisplatin, or two cycles of chemotherapy [MCV (methotrexate, ciplatin, vincristine)] after irradiation with concomitant cisplatin (arm 2, n=14), or concurrent chemoradiation only (arm 3, n=7). Tumor response was scored as a clinical complete response (CR) when the cystoscopic tumor-site biopsy and urine cytology results were negative. Those with less than a CR underwent cystectomy. The median follow-up of all patients was 70 months. Resulst : Most treatment toxicities were mild to moderate. Grade 3 acute hematologic toxicity and chronic cystitis were observed in only 1 and 2 patients, respectively. Overall 5 year survival was $67.3\%$. Complete remission rate was $80\%$ (20/25). Sixty-three percent of all survivors retained their bladders. In multivariate analysis, prognostic factors that significantly affect survival were T-stage (p=0.013) and Complete remission (p=0.002). Conclusion : Combined modality therapy with TURB, chemotherapy, and radiation has a $67.3\%$ overall 5 year survival rate. This result is similar to cystectomy-based studies for patients of similar clinical stages.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.05a
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• pp.715-717
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• 2016

Conventional drug carriers such as liposomes, nanoparticles, polymer micelles, polymeric conjugate and lipid microemulsion for cancer chemotherapy shield normal tissues from toxic drugs to treat cancer cells in tumors. However, inaccurate tumor targeting uncontrolled drug release from the carriers and unwanted accumulation in healthy sites can limit treatment efficacy with current conventional drug carriers with insufficient concentrations of drugs in the tumors and unexpected side effects as a result. In this research, we examined the use of sickle red blood cells as a new drug carrier with novel tumor targeting and controlled release properties. Sickle red blood cells show natural tumor preferential accumulation without any manipulation and controlled drug release is possible using a hemolysis method with photosensitizers.

• Journal of the korean veterinary medical association
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• v.34 no.8
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• pp.566-569
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• 1998

병원성대장균에 의한 자돈의 대장균증 중 대표적인 것이 신생 및 포유자돈에서 주로 발생하는 설사병과 이유자돈의 부종병을 들 수 있다. 이러한 자돈의 대장균증은 돼지유행성설사병(PED)이나 전염성위장병(TGE)처럼 폭발적인 발생을 하지는 않지만 지역이나 계절에 관계없이 광범위하게 지속적으로 발생하고 있기 때문에 전체적인 피해는 오히려 폐사율은 높으나 주기적이고 산발적인 발생을 하는 바이러스성 설사병보다도 많을 것으로 추정된다. 이러한 자돈의 대장균설사증 대책으로 몇종의 백신이 사용되고 있으나 완벽한 장관면역을 형성시켜주는 예방약은 아직 세계적으로도 개발되어 있지 않은 실정이고, 치료대책으로 사용하고 있는 항생제도 내성균 확산으로 치료제 사용이 한계에 이르고 있다. 더욱이 부종병의 경우 치료 및 예방대책이 없어 양돈농가로서는 속수무책인 실정이다. 수의과학연구소에서는 이러한 문제점을 해결하기 위하여 대장균증을 동시에 치료, 예방할 수 있는 병원성대장균에 대한 난황항체를 개발하여 실험실 및 야외적용시험을 실시한 결과 대장균설사증은 물론 부종병치료에도 탁월한 효과를 나타내었기에 소개드리고자 한다.

• Physical Therapy Korea
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• v.10 no.4
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• pp.61-68
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• 2003

본 연구의 목적은 운동강도(최대근수축의 10, 30, 50, 70%)에 따라 유발되는 국소적인 근피로가 슬관절의 위치감각 인지에 미치는 영향을 연구함으로써 근력강화의 운동치료적 효과와 운동학습과 관련된 효과를 동시에 만족시키는 최적의 운동강도를 제시하는 것이었다. 대상자는 건강한 성인여자 40명이었다. 청각을 통한 위치감각 정보를 제공하는 장치와 원판 각도계가 부착된 등속성 Cybex를 사용하였다. 근피로의 상태를 확인하기 위해서 근전도를 이용하여 주파수 스펙트럼 분석을 실시하였다. 청각되먹임이 주어진 각도와 대상자에 의해 재생되어진 각도의 오차값들과 근피로의 변화를 비교하기 위해 일요인 분산분석을 이용하였다. 오차값들의 평균은 50%의 군에서 가장 작았으며 근피로 또한 70%의 군에서만 크게 생성되었다. 따라서 최대 근 수축력의 50%가 운동치료 시 가장 효과적인 운동강도임을 알 수 있었다.