• Proceedings of the KIEE Conference
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• 1999.07g
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• pp.2846-2848
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• 1999

본 논문의 목적은 측정된 뇌자도 신호의 잡음제거 및 분석을 목적으로 하는 뇌자도 신호처리 시스템의 개발이다. 뇌자도 신호의 크기는 매우 작고 외부 노이즈 환경에 민감하게 반응하기 때문에 다양한 신호처리 기법을 이용하여 뇌자도 신호의 신뢰성을 높이는 것이 중요하다. 본 논문에서는 40채널 SQUID 시스템을 이용하여 뇌에서 발생하는 자기 신호를 측정하고, 측정된 데이터에 존재하는 노이즈 성분을 선형필터와SQUID 시스템의 레퍼런스 채널을 이용하여 제거하며, 이를 분석하는 뇌자도 신호처리 시스템을 개발하였다. 실제로 청각자극을 이용하여 뇌자도 신호를 측정, 분석 함으로써 개발된 뇌자도 신호처리 시스템의 신뢰성을 확인하였다. 또한 측정한 뇌자도 신호에서 주파수 대역에 따른 뇌자도 신호의 분포를 Map으로 구성하였으며, dipole source의 위치를 표시하였다.

• Korean Journal of Acupuncture
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• v.30 no.3
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• pp.161-170
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• 2013

Objectives : Our study aimed to investigate the sustained effects of sham (SHAM) and verum acupuncture (ACUP) into the post-stimulus resting state. Methods : In contrast to previous studies, in order to define the changes in resting state induced by acupuncture, changes were evaluated with a multi-method approach by using regional homogeneity (ReHo) and amplitude of low frequency fluctuation (ALFF). Twelve healthy participants received SHAM and ACUP stimulation right GB34 (Yanglingquan) and the neural changes between post- and pre-stimulation were detected. Results : The following results were found; in both ReHo and ALFF, the significant foci of; left and right middle frontal gyrus, left medial frontal gyrus, left superior frontal gyrus, and right posterior cingulate cortex, areas that are known as a default mode network, showed increased connectivity. In addition, in ReHo, but not in ALFF, brain activation changes in the insula, anterior cingulate cortex, and the thalamus, which are associated with acupuncture pain modulation, were found. Conclusions : In this study, results obtained by using ReHo and ALFF, showed that acupuncture can modulate the post-stimulus resting state and that ReHo, but not ALFF, can also detect the neural changes that were induced by the acupuncture stimulations. Although more future studies with ReHo and ALFF will be needed before any firm conclusions can be drawn, our study shows that particularly ReHo could be an interesting method for future clinical neuroimaging studies on acupuncture.

• Korean Journal of Acupuncture
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• v.30 no.2
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• pp.135-142
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• 2013

Objectives : This study aimed to investigate the general effects of low-frequency electrical stimulation of the ankle joint acupuncture points(BL62 and KI6) on the brain waves of elderly women as a pilot study to figure out the possibility of candidate non-invasive and non-chemical stimulation method for the enhancing the brain function. Methods : A randomized, controlled, double-blinded clinical trial was performed in 31 healthy women(mean age, 54.5 years) within a treatment duration of 12 sessions. In the experimental group, low-frequency electrical stimulation was applied using the maximum range of the individual insensible strength(mean current, $0.04{\mu}A$). The control group received sham stimulation. The background electroencephalographic activity was measured before and after the12 sessions. Results : After 12 sessions of stimulation, the relative power of the alpha wave increased(32 of 32 channels: significant difference in 11 channels, p<0.05); the theta(30 of 32 channels: significant difference in 10 channels, p<0.05), beta(31 of 32 channels), and gamma(30 of 32 channels: significant difference in 7 channels, p<0.05) powers were also decreased compared with the sham group. Conclusions : Electrical stimulation on the ankle joint acupuncture points(BL62 and KI6) seemed to stabilize the elderly women brain by inducing the alpha power and reducing beta, theta, and gamma powers. These results provide insight into the action mechanism of the stimulation and can assist the future developement of a non-invasive and non-chemical treatment technique for stressor related cognitive problems.

• Proceedings of the Korea Society of Information Technology Applications Conference
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• 2002.11a
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• pp.461-467
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• 2002

Signals reduced from the brain had been considered as a noise that is caused by the stochastic process until 1980. The recent non-linear dynamic theory researches, however, reported that these signals are meaningful and deterministic chaos signals in which they show how the brain deals with various information Since this report, a wide range of researches has been carried out and still in progress. Thus, by using the correlational dimension, one of the non-linear analytical methods, the characteristics of the brain signals can be analyzed. In this thesis, the scent of lavender, which stimulates the olfactory sense, is introduced to measure EEG with the International 10-20 electrode system on 16 channels, and to analyze the interrelationship between the original signals before the stimulation and the changed signals after the stimulation. Finally, the effect of the scent stimulation to the brain is analyzed. The purpose of this thesis is to apply these analyzed results to the computerized mapping of the brain signals and possible ways of specifying the source of the brain signals through various medical applications.

• Proceedings of the Korea Society for Industrial Systems Conference
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• 2002.11a
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• pp.461-467
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• 2002

Signals produced from the brain had been considered as a noise that is caused by the stochastic process until 1980. The recent non-linear dynamic theory researches, however, reported that these signals are meaningful and deterministic chaos signals in which they show how the brain deals with various information Since this report a wide range of researches has been carried out and still in progress. Thus, by using the correlational dimension, one of the non-linear analytical methods, the characteristics of the brain signals can be analyzed. In this thesis, the scent of lavender, which stimulates the olfactory sense, is introduced to measure EEG with the International 10-20 electrode system on 16 channels, and to analyze the interrelationship between the original signals before the stimulation and the changed signals after the stimulation. Finally, the effect of the scent stimulation to the brain is analyzed. The purpose of this thesis is to apply these analyzed results to the computerized mapping of the brain signals and possible ways of specifying the source of the brain signals through various medical applications.

• The Journal of Korean Academy of Sensory Integration
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• v.8 no.1
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• pp.41-49
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• 2010

Objective : Multisensory integration (MSI) is the essential process to use diverse sensory information for cognitive task or execution of motor action. Especially, visual and somatosensory integration is critical for motor behavior and coordination. This study was designed to explain spatial and temporal characteristics of visual and somatosensory integration by neurophysiological research method that identifies the time course and brain location of the SI process. Methods : Electroencephalography (EEG) and event-related potential (ERP) is used in this study in order to observe neural activities when integrating visual and tactile input. We calculate the linear summation (SUM) of visual-related potentials (VEPs) and somatosensory-related potentials (SEPs), and compared the SUM with simultaneously presented visual-tactile ERPs(SIM) Results : There were significant differences between the SIM and SUM in later time epochs (about 200-300ms) at contralateral somatosensory areas (C4) and occipital cortices (O1&O2). The amplitude of the SIM was mathematically larger than the summed signals, implying that the integration made some extra neural activities. Conclusion : This study provides some empirical neural evidence of that multisensory integration is more powerful than just combing two unisensory inputs in the brain and ERP data reveals neural signature relating to multisensory integrative process. Since this study is preliminary pilot study, larger population and criteria are needed for level of the significance. Further study is recommended to consider issues including effect of internally-driven attention and laterality of interaction to make the evidence by this study solid.

• Journal of Biomedical Engineering Research
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• v.15 no.3
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• pp.237-244
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• 1994

We investigated the qualitive and quantitative properties in EEG signal which responds to auditory stimulus with increaing the sound-cutting frequency from 2 Hz to 20 Hz by 2 Hz step units, by chaotic dynamics. To bigin with, general chaotic properties such as fractal mechanism, 1 If frequency spectrum and positive Lyapunov exponent are discussed in EEG signal. For evoked potential with given auditory stimulus, the route to chaos by bifurcation diagram and the changes in geometrical property of Poincare sections of 2-dimensional psedophase space is observed. For that containing spontaneous potential, seen as the random background signal, the chaotic attractors in 3-dimensional phase space are found containing the same infomation as the above mentioned evoked potential. Finally the chinges of Lyapunov exponent by various sound-cutting frequencies of stimulus and by the various spatial positions (occipital region) in a brain surface to be measured, are illustrated meaningfully.

• Science of Emotion and Sensibility
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• v.27 no.2
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• pp.81-90
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• 2024

In this study, we aimed to determine the effect on cerebral blood vessels of various stimulus intensities using transcutaneous electrical nerve stimulation (TENS). In particular, we wanted to monitor changes in blood flow and structural changes in the blood vessels in the common carotid artery (CCA) through low-intensity electrical stimulation that can cause non-perceptual sensory stimulation. Twenty-four healthy adults in their 20s participated in this study. Three stimulus intensities (below the sensory threshold, at the sensory threshold, and above the sensory threshold) were applied in random order. Changes in blood flow velocity according to the intensity of TENS stimulus were measured by placing the Doppler ultrasound transducer 1 cm below the CCA bifurcation, and the vascular structure was measured using B-mode imaging. C-mode Doppler and B-mode images were acquired before, during, and after the intervention for each stimulus, and changes in blood pressure were measured in each session. As a result, it was confirmed that peak systolic velocity (PSV) decreased significantly after the intervention in non-perceived sensory stimulation below the threshold, compared to other thresholds (p = .008). In particular, the PSV decreased by 3.04% on average compared to before stimulation (p = .011). However, there was no significant change in the CCA diameters before and after stimulation at all intensities. It was found that short-term, non-perceptual sensory stimulation was effective in reducing the blood flow rate without causing significant changes in either the blood vessel diameter or blood pressure. This change appears to be caused by a decrease in blood flow due to the effect of subtle vasodilation at non-perceptual sensory stimulation, and at stimulation intensity higher than that, the sympathetic nerves in the blood vessels are stimulated excessively and the blood vessels constrict. Therefore, this study can be rated as an important attempt to control blood flow through stimulation without such a psychological burden and sensory discomfort in the carotid area.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 1997.11a
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• pp.80-84
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• 1997

본 연구는 뇌파의 주파수 변화특성이 다양한 시각자극에 의해서 유발된 감성을 평가할 수 있는가를 알아보고자 하였다. 특히 쾌감성과 불쾌감성의 차이, 쾌감성내의 차이를 뇌파를 이용하여 객관적으로 변별할 수 있는 가를 알아보았다. 사용된 시각자극은 8개의 긍정자극과 7개의 부정자극이었다. 각각의 자극은 30초씩 무선적으로 제시되었고, 각자극의 제시사이마다 120초씩의 휴식기를 두었다. 매 자극제시 후 피험자는 제시된 자극에 대해 긍정.부정의 정도를 주관적으로 평가하였다. 실럼참가자는 20명의 대학생이었으며, 뇌파는 뇌의 21부위에서 기록되었다. 기록된 뇌파에 대해 FFT(Fast Fourier Transformation)분석을 실시한 후, normalized sensitivity를 구현하였다. 자극 중 최대긍정(the most positive stimulus), 최대부정(the most negative stimulus), 최소긍정(the least positive stimulus), 최소부정(the least negative stimulus)이라고 주관적으로 평가한 자극을 보고 있을때의 뇌파를 측정하여 비교.분석하였다. 그 결과 뇌파의 주파수 변화는 극단의 긍정감성과 부정감성의 차이를 변별할수 있고, 긍정감성내의 차이와 부전감성내의 차이를 변별할 수 있었다. 또한 부정감성을 느낄때보다는 긍정감성을 느낄수록 alpha파의 출현량은 증가하고, delta파와 beta파의 출현량은 감소하고 있음을 보여주었다. 결론적으로, 뇌파의 주파수 변화는 다양한 시각자극에 의해 유발된 감성을 측정할 수 있음을 암시한다.

• Annual Conference on Human and Language Technology
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• 2009.10a
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• pp.67-72
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• 2009

ERP의 일종인 MMN(Mismatch Negativity)은 언어의 청각 인지정보 처리과정(central auditory processing)을 규명하는 데 유용한 수단으로 이용되어 왔다. 그런데, 최근의 연구들은 이러한 MMN이 청각 자극뿐만 아니라 시각 자극에 의해서도 검출될 수 있음을 밝혀냈다. 본 연구는 이러한 시각적 MMN을 이용하여 뇌에서 이루어지는 한국어 화자의 무의식적인 한국어 문자 정보처리과정을 규명하려고 시도하였다. 본 연구에서는 한국어의 글말 최소쌍 '므'/'모'와 '므'/'무', 이에 대응되는 비언어자극 '+ㅡ'/'+ㅗ'와 '+ㅡ'/'+ㅜ'(+표시의 아래에 모음을 붙여서 만든 인공문자, 그림1 참고)를 수동적(passive) Oddball paradigm으로 제시하고 언어 자극에 대한 EEG를 비언어자극과 비교 하에 측정, 분석하였다. 본 연구의 결과, 언어자극과 비언어자극 모두에서 시각적 MMN이 검출되었다. 하지만, 언어자극의 시각적 MMN이 비언어자극의 시각적 MMN보다 높게 나타남을 확인하였다. 이는 한국어 모국어화자들이 무의식적인 인지과정에서 언어자극이 갖는 물리적인 시각 정보뿐만 아니라 한국어 문자의 언어적 정보도 함께 처리하고 있음을 보여주는 것이다. 본 연구의 결과들은 한국어 글말의 무의식적인 인지처리과정을 밝혀주는 한편, 한국어 문자가 인지과학에서 갖는 중요한 지위를 보여줄 수 있을 것으로 기대된다.