Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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EEG Changes due to Low-Frequency Electrical Stimulation to the BL62 and KI6 of Elderly Women

노년 여성의 신맥.조해 저주파 자극이 뇌파에 미치는 영향

  • Lee, Sanghun (Acupuncture, Moxibustion & Meridian Research Group, Korea Institute of Oriental Medicine) ;
  • Choi, Kwang-Ho (Acupuncture, Moxibustion & Meridian Research Group, Korea Institute of Oriental Medicine) ;
  • Cho, Seong Jin (Acupuncture, Moxibustion & Meridian Research Group, Korea Institute of Oriental Medicine) ;
  • Choi, Sun-Mi (Acupuncture, Moxibustion & Meridian Research Group, Korea Institute of Oriental Medicine) ;
  • Hong, Kwon Eui (Department of Acupuncture and Moxibustion, Daejeon University) ;
  • Ryu, Yeon-Hee (Acupuncture, Moxibustion & Meridian Research Group, Korea Institute of Oriental Medicine)
  • 이상훈 (한국한의학연구원 의료연구본부 침구경락연구그룹) ;
  • 최광호 (한국한의학연구원 의료연구본부 침구경락연구그룹) ;
  • 조성진 (한국한의학연구원 의료연구본부 침구경락연구그룹) ;
  • 최선미 (한국한의학연구원 의료연구본부 침구경락연구그룹) ;
  • 홍권의 (대전대학교 침구의학교실) ;
  • 류연희 (한국한의학연구원 의료연구본부 침구경락연구그룹)
  • Received : 2013.05.27
  • Accepted : 2013.06.14
  • Published : 2013.06.27
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Abstract

Objectives : This study aimed to investigate the general effects of low-frequency electrical stimulation of the ankle joint acupuncture points(BL62 and KI6) on the brain waves of elderly women as a pilot study to figure out the possibility of candidate non-invasive and non-chemical stimulation method for the enhancing the brain function. Methods : A randomized, controlled, double-blinded clinical trial was performed in 31 healthy women(mean age, 54.5 years) within a treatment duration of 12 sessions. In the experimental group, low-frequency electrical stimulation was applied using the maximum range of the individual insensible strength(mean current, $0.04{\mu}A$). The control group received sham stimulation. The background electroencephalographic activity was measured before and after the12 sessions. Results : After 12 sessions of stimulation, the relative power of the alpha wave increased(32 of 32 channels: significant difference in 11 channels, p<0.05); the theta(30 of 32 channels: significant difference in 10 channels, p<0.05), beta(31 of 32 channels), and gamma(30 of 32 channels: significant difference in 7 channels, p<0.05) powers were also decreased compared with the sham group. Conclusions : Electrical stimulation on the ankle joint acupuncture points(BL62 and KI6) seemed to stabilize the elderly women brain by inducing the alpha power and reducing beta, theta, and gamma powers. These results provide insight into the action mechanism of the stimulation and can assist the future developement of a non-invasive and non-chemical treatment technique for stressor related cognitive problems.

목적 : 본 연구는 노년층의 여성에게 신맥(BL62), 조해(KI6)혈에 대한 저주파자극이 뇌파에 어떠한 영향을 미치는지 알아보고 뇌 기능을 개선하는데 비화학적이고 비침습적인 자극 방법의 후보로써 가능성을 탐구해보고자 실시된 탐색적 연구이다. 방법 : 31명의 건강한 여성 피험자(평균연령, 54.5세)를 대상으로 이중맹검 무작위배정 임상연구가 12세션동안 실시되었다. 시험군에서는 감지할 수 없는 최대의 저주파자극이 실시되었으며(평균전류량, $0.04{\mu}A$), 대조군에서는 거짓자극이 실시되었다. 결과분석을 위해 12세션을 전후로 배경뇌파가 측정되었다. 결과 : 12세션의 자극이 실시된 후 대조군에 비해 실험군의 알파파 상대값은 11채널에서 유의한 증가를 보였으며(p<0.05), 감마파의 상대값은 7채널에서, 세타파의 상대값은 10채널에서 유의한 감소를 보였다. 결론 : 발목관절에 있는 신맥(BL62), 조해(KI6)혈에 대한 저주파 자극은 노년의 여성의 뇌에 베타, 세타, 감마파의 감소를 일으키는 반면 알파파를 선택적으로 증가시켜 뇌를 안정시키는 효과가 있는 것으로 보인다. 이러한 결과는 저주파자극이 향후 스트레스와 관련된 인지 문제를 치료하는 비침습적이고 비화학적인 도구로써의 가능성을 제공할 수 있을 것으로 보이며, 그 기전에 대한 추가적 연구가 필요할 것으로 보인다.

Keywords

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