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http://dx.doi.org/10.14406/acu.2013.30.3.161

Changes of Regional Homogeneity and Amplitude of Low Frequency Fluctuation on Resting-State Induced by Acupuncture  

Yeo, Sujung (Research Group of Pain and Neuroscience, WHO Collaborating Centre, East-West Medical Research Institute)
Publication Information
Korean Journal of Acupuncture / v.30, no.3, 2013 , pp. 161-170 More about this Journal
Abstract
Objectives : Our study aimed to investigate the sustained effects of sham (SHAM) and verum acupuncture (ACUP) into the post-stimulus resting state. Methods : In contrast to previous studies, in order to define the changes in resting state induced by acupuncture, changes were evaluated with a multi-method approach by using regional homogeneity (ReHo) and amplitude of low frequency fluctuation (ALFF). Twelve healthy participants received SHAM and ACUP stimulation right GB34 (Yanglingquan) and the neural changes between post- and pre-stimulation were detected. Results : The following results were found; in both ReHo and ALFF, the significant foci of; left and right middle frontal gyrus, left medial frontal gyrus, left superior frontal gyrus, and right posterior cingulate cortex, areas that are known as a default mode network, showed increased connectivity. In addition, in ReHo, but not in ALFF, brain activation changes in the insula, anterior cingulate cortex, and the thalamus, which are associated with acupuncture pain modulation, were found. Conclusions : In this study, results obtained by using ReHo and ALFF, showed that acupuncture can modulate the post-stimulus resting state and that ReHo, but not ALFF, can also detect the neural changes that were induced by the acupuncture stimulations. Although more future studies with ReHo and ALFF will be needed before any firm conclusions can be drawn, our study shows that particularly ReHo could be an interesting method for future clinical neuroimaging studies on acupuncture.
Keywords
fMRI; Regional homogeneity; Amplitude of low frequency fluctuation; Acupuncture; Rest; Post effect;
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1 Wu MT, Sheen JM, Chuang KH, Yang P, Chin SL, Tsai CY, et al. Neuronal specificity of acupuncture response: a fMRI study with electroacupuncture. Neuroimage. 2002 ; 16 : 1028-37.   DOI   ScienceOn
2 Cristian A, Katz M, Cutrone E, Walker RH. Evaluation of acupuncture in the treatment of Parkinson's disease: a doubleblind pilot study. Mov Disord. 2005 ; 20 : 1185-8.   DOI   ScienceOn
3 Siedentopf CM, Golaszewski SM, Mottaghy FM, Ruff CC, Felber S, Schlager A. Functional magnetic resonance imaging detects activation of the visual association cortex during laser acupuncture of the foot in humans. Neurosci Lett. 2002 ; 327 : 53-6.   DOI   ScienceOn
4 Liang XB, Luo Y, Liu XY, Lu J, Li FQ, Wang Q, et al. Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats. Neuroreport. 2003 ; 14 : 1177-81.   DOI   ScienceOn
5 Park HJ, Lim S, Joo WS, Yin CS, Lee HS, Lee HJ, et al. Acupuncture prevents 6-hydroxydopamine-induced neuronal death in the nigrostriatal dopaminergic system in the rat Parkinson's disease model. Exp Neurol. 2003 ; 180 : 93-8.   DOI   ScienceOn
6 Lee MS, Shin BC, Kong JC, Ernst E. Effectiveness of acupuncture for Parkinson's disease: a systematic review. Mov Disord. 2008 ; 23 : 1505-15.   DOI   ScienceOn
7 Hui KK, Liu J, Makris N, Gollub RL, Chen AJ, Moore CI, et al. Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects. Hum Brain Mapp. 2000 ; 9 : 13-25.   DOI   ScienceOn
8 Ng DK, Chow PY, Ming SP, Hong SH, Lau S, Tse D, et al. A double- blind, randomized, placebo-controlled trial of acupuncture for the treatment of childhood persistent allergic rhinitis. Pediatrics. 2004 ; 114 : 1242-7.   DOI   ScienceOn
9 Price DD, Rafii A, Watkins LR, Buckingham B. A psychophysical analysis of acupuncture analgesia. Pain. 1984 ; 19 : 27-42.   DOI   ScienceOn
10 Dhond RP, Yeh C, Park K, Kettner N, Napadow V. Acupuncture modulates resting state connectivity in default and sensorimotor brain networks. Pain. 2008 ; 136 : 407-18.   DOI   ScienceOn
11 Martuzzi R, Ramani R, Qiu M, Rajeevan N, Constable RT. Functional connectivity and alterations in baseline brain state in humans. Neuroimage. 2009 ; 49 : 823-34.
12 van Eimeren T, Monchi O, Ballanger B, Strafella AP. Dysfunction of the default mode network in Parkinson disease: a functional magnetic resonance imaging study. Arch Neurol. 2009 ; 66 : 877-83.
13 Bai L, Qin W, Tian J, Liu P, Li L, Chen P, et al. Time-varied characteristics of acupuncture effects in fMRI studies. Hum Brain Mapp. 2009 ; 30 : 3445-60.   DOI   ScienceOn
14 Yeo S, Lim S, Choe IH, Choi YG, Chung KC, Jahng GH, et al. Acupuncture stimulation on GB34 activates neural responses associated with Parkinson's disease. CNS Neurosci Ther. 2012 ; 18 : 781-90.   DOI   ScienceOn
15 Liu P, Zhang Y, Zhou G, Yuan K, Qin W, Zhuo L, et al. Partial correlation investigation on the default mode network involved in acupuncture: an fMRI study. Neurosci Lett. 2009 ; 462 : 183-7.   DOI   ScienceOn
16 Greicius MD, Srivastava G, Reiss AL, Menon V. Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A. 2004 ; 101 : 4637-42.   DOI   ScienceOn
17 Zhang Y, Qin W, Liu P, Tian J, Liang J, von Deneen KM, et al. An fMRI study of acupuncture using independent component analysis. Neurosci Lett. 2009 ; 449 : 6-9.   DOI   ScienceOn
18 Zang Y, Jiang T, Lu Y, He Y, Tian L. Regional homogeneity approach to fMRI data analysis. Neuroimage. 2004 ; 22 : 394-400.   DOI   ScienceOn
19 Wu T, Long X, Zang Y, Wang L, Hallett M, Li K, et al. Regional homogeneity changes in patients with Parkinson's disease. Hum Brain Mapp. 2009 ; 30 : 1502-10.   DOI   ScienceOn
20 Fransson P. Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis. Hum Brain Mapp. 2005 ; 26 : 15-29.   DOI   ScienceOn
21 Biswal B, Yetkin FZ, Haughton VM, Hyde JS. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med. 1995 ; 34 : 537-41.   DOI   ScienceOn
22 Zou Q, Wu CW, Stein EA, Zang Y, Yang Y. Static and dynamic characteristics of cerebral blood flow during the resting state. Neuroimage. 2009 ; 48 : 515-24.   DOI   ScienceOn
23 Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971 ; 9 : 97-113.   DOI   ScienceOn
24 Lim S. WHO Standard Acupuncture Point Locations. Evid Based Complement Alternat Med. 2010 ; 7 : 167-8.   DOI
25 Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci U S A. 2005 ; 102 : 9673-8.   DOI   ScienceOn
26 Zang YF, He Y, Zhu CZ, Cao QJ, Sui MQ, Liang M, et al. Altered baseline brain activity in children with ADHD revealed by resting- state functional MRI. Brain Dev. 2007 ; 29 : 83-91.   DOI   ScienceOn
27 Mezer A, Yovel Y, Pasternak O, Gorfine T, Assaf Y. Cluster analysis of resting-state fMRI time series. Neuroimage. 2009 ; 45 : 1117-25.   DOI   ScienceOn
28 Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci U S A. 2001 ; 98 : 676-82.   DOI   ScienceOn
29 Raichle ME, Snyder AZ. A default mode of brain function: a brief history of an evolving idea. Neuroimage. 2007 ; 37 : 1083-90; discussion 97-9.   DOI   ScienceOn
30 Katanoda K, Matsuda Y, Sugishita M. A spatio-temporal regression model for the analysis of functional MRI data. Neuroimage. 2002 ; 17 : 1415-28.   DOI   ScienceOn
31 Tononi G, McIntosh AR, Russell DP, Edelman GM. Functional clustering: identifying strongly interactive brain regions in neuroimaging data. Neuroimage. 1998 ; 7 : 133-49.   DOI   ScienceOn
32 Lu H, Zuo Y, Gu H, Waltz JA, Zhan W, Scholl CA, et al. Synchronized delta oscillations correlate with the resting-state functional MRI signal. Proc Natl Acad Sci U S A. 2007 ; 104 : 18265-9.   DOI   ScienceOn
33 Bluhm RL, Miller J, Lanius RA, Osuch EA, Boksman K, Neufeld RW, et al. Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default network. Schizophr Bull. 2007 ; 33 : 1004-12.   DOI   ScienceOn
34 NIH Consensus Conference. Acupuncture. JAMA. 1998 ; 280 : 1518-24.   DOI   ScienceOn
35 Staud R. Mechanisms of acupuncture analgesia: effective therapy for musculoskeletal pain? Curr Rheumatol Rep. 2007 ; 9 : 473-81.   DOI   ScienceOn
36 Casey KL. Forebrain mechanisms of nociception and pain: analysis through imaging. Proc Natl Acad Sci U S A. 1999 ; 96 : 7668-74.   DOI
37 Xu X, Shibasaki H, Shindo K. Effects of acupuncture on somatosensory evoked potentials: a review. J Clin Neurophysiol. 1993 ; 10 : 370-7.   DOI
38 Wager TD, Rilling JK, Smith EE, Sokolik A, Casey KL, Davidson RJ, et al. Placebo-induced changes in FMRI in the anticipation and experience of pain. Science. 2004 ; 303 : 1162-7.   DOI   ScienceOn
39 Peyron R, Laurent B, Garcia-Larrea L. Functional imaging of brain responses to pain. A review and meta-analysis (2000). Neurophysiol Clin. 2000 ; 30 : 263-88.   DOI   ScienceOn
40 Chae Y, Lee H, Kim H, Kim CH, Chang DI, Kim KM, et al. Parsing brain activity associated with acupuncture treatment in Parkinson's diseases. Mov Disord. 2009 ; 24 : 1794-802.   DOI   ScienceOn